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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
42 Results for "
mouse spleen
" in MedChemExpress (MCE) Product Catalog:
Products (42)
42 Results for "mouse spleen" in MCE Product Catalog:
2
2 Cited Publications
Cat. No.: HY-W013755
CAS No.: 117-84-0
Synonyms: DNOP; Di-n-octyl phthalate; Phthalic acid dioctyl ester
Research Areas:
Dioctyl phthalate (DNOP) is a plasticizer. Dioctyl phthalate increases the activities of alanine aminotransferase (ALT) and alkaline phosphatase (ALP) in the liver, as well as the levels of creatinine and urea in the kidney. Exposure to Dioctyl phthalate disrupts the homeostasis of the intestinal microbial community, increases the abundance of pathogenic bacteria, and reduces the abundance of beneficial bacteria such as Lactobacillus. Dioctyl phthalate induces significant and dose-dependent inflammatory responses in the liver, spleen and kidney of mice .
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1 Cited Publications
Cat. No.: HY-168374
CAS No.: 1829524-73-3
Research Areas:
DSPE-PEG 2000-Mannose is a mannose-containing lipid. DSPE-PEG 2000-Mannose is used to prepare mannose-conjugated Liposome (Man-lipo) for siRNA delivery. Mannose-modified liposomes encapsulating IDO siRNA (Man-lipo-siIDO) preferentially knock down IDO expression in the draining lymph nodes and spleens of melanoma-bearing mice. Man-lipo-siIDO delays the onset time of melanoma and reduces tumor volume .
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YM-341619 (AS1617612) is a potent and orally active STAT6 inhibitor with an IC50 of 0.70 nM. YM-341619 inhibits Th2 differentiation in mouse spleen T cells induced by IL-4 (IC50=0.28 nM) without affecting Th1 cell differentiation . YM-341619 is a promising compound for the the research of allergic diseases, such as allergic asthma .
1
1 Cited Publications
Cat. No.: HY-76293
CAS No.: 331963-29-2
I2906 is an orally active isocitrate lyase (ICL) inhibitor with a Mycobacterium tuberculosis IC50 of 134.3 μg/mL. I2906 inhibits the growth of Mycobacterium tuberculosis. I2906 can be used for the research of tuberculosis .
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1 Cited Publications
Cat. No.: HY-P790035
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: DNASE1L3; Deoxyribonuclease Gamma; Deoxyribonuclease 1L3; Liver And spleen DNase; DNAS1L3; DNase I-Like 3; LSD; DNaseY; DNase Gamma; DHP2; LS-DNase; Deoxyribonuclease I-Like III; D3; Deoxyribonuclease I Like 3; DNase I Homolog Protein DHP2; DNase I Homolo
Cat. No.: HY-N1470
CAS No.: 78708-33-5
Category:
Plantaginaceae Flavonoids Flavonones Metabolic Disease Phenols Polyphenols Plantago asiatica L. Plants Disease Research Fields
Target:
Cat. No.: HY-P990273
Cat. No.: HY-164485
CAS No.: 2549050-07-7
Target:
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INI-4001 is a TLR7/8 agonist and vaccine adjuvant. INI-4001 regulates innate and adaptive immune responses by activating murine TLR7 and human TLR7/TLR8. INI-4001 enhances IgG and neutralizing antibody responses against Powassan virus (POWV), reduces viral loads in the brain, liver and spleen, provides complete protection against lethal POWV challenge, and skews immune responses toward a Th1 phenotype. When INI-4001 is used in combination with Al (OH)3 and SARS-CoV-2 RBD antigen, it efficiently adsorbs to Al (OH)3, promotes Th1 immunity and enhances SARS-CoV-2 neutralizing antibody responses. INI-4001 is applicable to research related to Powassan virus infection and COVID-19 .
Cat. No.: HY-149760
CAS No.: 3032975-48-4
Target:
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PVD-06 is a selective PROTAC PTPN2 degrader with a DC50 of 217 nM (selectivity index >60-fold over PTP1B). PVD-06 induces PTPN2 degradation via a VHL-, ubiquitin, and proteasome-dependent pathway. PVD-06 can promote T cell activation and amplify IFN-γ-mediated anticancer activity. PVD-06 can be used to further investigate PTPN2 in diseases such as leukemia and melanoma .
Cat. No.: HY-N0600
CAS No.: 62025-50-7
Category:
Panax ginseng C. A. Meyer Triterpenes Terpenoids Plants Disease Research Fields Inflammation/Immunology Araliaceae
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Dihydralazine sulfate is an antihypertensive hydrazine derivative and also a low-potency genotoxic agent. Dihydralazine sulfate is a direct-acting mutagen with a mixed gene mutation mechanism, which induces DNA fragmentation in the lung, kidney and spleen of mice, and induces sister chromatid exchange in mouse bone marrow cells. Dihydralazine sulfate specifically kills DNA repair-deficient bacteria. Dihydralazine sulfate is a vasodilator and antihypertensive agent that reduces systemic vascular resistance, increases cardiac output and heart rate, thereby lowering blood pressure. Dihydralazine sulfate can be used in research related to hypertension and severe early-onset preeclampsia .
Cat. No.: HY-173247
CAS No.: 2199491-27-3
Cat. No.: HY-W115716
CAS No.: 26266-58-0
Synonyms: Span 85
Research Areas:
Sorbitan trioleate (Span 85) is an orally active non-ionic surface active agent. Sorbitan trioleate can be used as an excipient, such as surfactant, emulsifier, lubricant, wetting agent, dispersant, thickener, defoamer .
Cat. No.: HY-P990144
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Cat. No.: HY-P991112
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Cat. No.: HY-P990157
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Cat. No.: HY-W013755S
CAS No.: 93952-13-7
Synonyms: DNOP-d4; Di-n-octyl phthalate-d4; Phthalic acid dioctyl ester-d4
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
