2. Vitamin D Related/Nuclear Receptor TGF-beta/Smad Immunology/Inflammation
  3. VD/VDR TGF-β Receptor Interleukin Related
  4. LG190155

LG190155 is a nonsteroidal vitamin D receptor (VDR) agonist. LG190155 activates VDR in mesenchymal stem cells, thereby upregulating the BMP6-IL6 autocrine axis. Pretreatment of mesenchymal stem cells with LG190155 significantly enhances their ability to induce differentiation of acute myeloid leukemia cells, without inducing hypercalcemia. LG190155 is applicable to research related to acute myeloid leukemia (AML).

For research use only. We do not sell to patients.

LG190155

LG190155 Chemical Structure

CAS No. : 233268-78-5

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LG190155 Related Antibodies

Top Publications Citing Use of Products

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ALK1 ALK2 ALK3 ALK4 ALK5 ALK6 ALK7 TGFβR2 ACVR2A ACVR2B BMP GDF15

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Description

LG190155 is a nonsteroidal vitamin D receptor (VDR) agonist. LG190155 activates VDR in mesenchymal stem cells, thereby upregulating the BMP6-IL6 autocrine axis. Pretreatment of mesenchymal stem cells with LG190155 significantly enhances their ability to induce differentiation of acute myeloid leukemia cells, without inducing hypercalcemia. LG190155 is applicable to research related to acute myeloid leukemia (AML)[1].

Cellular Effect
Cell Line Type Value Description References
Caco-2 IC50
16.9 μM
Compound: LG190155
Antipoliferative activity against human Caco2 cells after 48 hrs by MTT assay
Antipoliferative activity against human Caco2 cells after 48 hrs by MTT assay
[PMID: 26562542]
HEK293 IC50
>10 μM
Compound: 5a, 5c, LG190155
Antagonist activity at human androgen receptor expressed in HEK293 cells assessed as inhibition of transcriptional activity by luciferase and beta-galactosidase reporter gene assay
Antagonist activity at human androgen receptor expressed in HEK293 cells assessed as inhibition of transcriptional activity by luciferase and beta-galactosidase reporter gene assay
[PMID: 23462715]
HepG2 IC50
>50 μM
Compound: LG190155
Antipoliferative activity against human HepG2 cells after 48 hrs by MTT assay
Antipoliferative activity against human HepG2 cells after 48 hrs by MTT assay
[PMID: 26562542]
HL-60 EC50
0.59 μM
Compound: LG190155
Agonist activity at vitamin D3 receptor in human HL-60 cells assessed as induction of cell differentiation after 96 hrs by NBT dye-based microscopic analysis
Agonist activity at vitamin D3 receptor in human HL-60 cells assessed as induction of cell differentiation after 96 hrs by NBT dye-based microscopic analysis
[PMID: 26562542]
HL-60 EC50
30 nM
Compound: 5a, 5c, LG190155
Induction of monocytic cell differentiation in human HL60 cells
Induction of monocytic cell differentiation in human HL60 cells
[PMID: 23462715]
HL-60 ED50
410 nM
Compound: 1
Vitamin D3 agonistic activity as effective dose for HL-60 monocytic cell differentiation
Vitamin D3 agonistic activity as effective dose for HL-60 monocytic cell differentiation
[PMID: 16019211]
L02 IC50
5.1 μM
Compound: LG190155
Cytotoxicity against human L02 cells after 48 hrs by MTT assay
Cytotoxicity against human L02 cells after 48 hrs by MTT assay
[PMID: 26562542]
LNCaP EC50
20 nM
Compound: 5a, 5c, LG190155
Growth inhibition of human LNCAP cells
Growth inhibition of human LNCAP cells
[PMID: 23462715]
MCF7 IC50
7.8 μM
Compound: LG190155
Antipoliferative activity against human MCF7 cells after 48 hrs by MTT assay
Antipoliferative activity against human MCF7 cells after 48 hrs by MTT assay
[PMID: 26562542]
PC-3 IC50
>50 μM
Compound: LG190155
Antipoliferative activity against human PC3 cells after 48 hrs by MTT assay
Antipoliferative activity against human PC3 cells after 48 hrs by MTT assay
[PMID: 26562542]
SC-3 IC50
1900 nM
Compound: 1
Androgen antagonistic activity as inhibitory concentration against testosterone-induced SC-3 cell proliferation
Androgen antagonistic activity as inhibitory concentration against testosterone-induced SC-3 cell proliferation
[PMID: 16019211]
In Vitro

Treatment of human umbilical cord mesenchymal stem cells (LMSC) with LG190155 (2-8 µM, 24 h) enhances the ability of LMSC to induce differentiation of AML cells, and this effect is not caused by the cytotoxicity of LG190155 itself against MSC[1].
LG190155 drives BMP6 gene transcription and autocrine signaling by activating VDR in MSCs, thereby enhancing the synthesis and secretion of IL-6[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

LG190155 Related Antibodies
In Vivo

LG190155-pretreated LMSCs (1×106 cells per mouse; tail vein injection; once weekly; continued until day 28) significantly extends the median overall survival of AML-bearing NOD-SCID mice to 48 days and reduces the leukemia cell burden in their peripheral blood, bone marrow, liver and spleen[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

480.68

Formula

C31H44O4
CAS No.
SMILES

CCC(C1=CC=C(C(C)=C1)OCC(C(C)(C)C)=O)(CC)C2=CC=C(C(C)=C2)OCC(C(C)(C)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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LG190155 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LG190155233268-78-5LG 190155LG-190155VD/VDRTGF-β ReceptorInterleukin RelatedVitamin DVitamin D receptorTransforming growth factor beta receptorsILacute myeloid leukemia cellsmesenchymal stem cellsNOD-SCID miceBMP6-IL6 autocrine axisbone marrowliverperipheral bloodvitamin D receptorspleenacute myeloid leukemia mouse modelInhibitorinhibitorinhibit

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