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Cat. No.: HY-118970

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LG190155

LG190155 is a nonsteroidal vitamin D receptor (VDR) agonist. LG190155 activates VDR in mesenchymal stem cells, thereby upregulating the BMP6-IL6 autocrine axis. Pretreatment of mesenchymal stem cells with LG190155 significantly enhances their ability to induce differentiation of acute myeloid leukemia cells, without inducing hypercalcemia. LG190155 is applicable to research related to acute myeloid leukemia (AML).

For research use only. We do not sell to patients.

CAS No.: 233268-78-5
Formula: C₃₁H₄₄O₄
Molecular Weight:480.68

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Please store the product under the recommended conditions in the Certificate of Analysis.

LG190155 Chemical Structure

CAS No.: 233268-78-5

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
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References
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Bioz

Biological Activity

Description

All TGF-β Receptor Isoforms :

All Interleukin Related Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
Caco-2	IC₅₀	16.9 μM Compound: LG190155	Antipoliferative activity against human Caco2 cells after 48 hrs by MTT assay Antipoliferative activity against human Caco2 cells after 48 hrs by MTT assay	[PMID: 26562542]
HEK293	IC₅₀	>10 μM Compound: 5a, 5c, LG190155	Antagonist activity at human androgen receptor expressed in HEK293 cells assessed as inhibition of transcriptional activity by luciferase and beta-galactosidase reporter gene assay Antagonist activity at human androgen receptor expressed in HEK293 cells assessed as inhibition of transcriptional activity by luciferase and beta-galactosidase reporter gene assay	[PMID: 23462715]
HepG2	IC₅₀	>50 μM Compound: LG190155	Antipoliferative activity against human HepG2 cells after 48 hrs by MTT assay Antipoliferative activity against human HepG2 cells after 48 hrs by MTT assay	[PMID: 26562542]
HL-60	EC₅₀	0.59 μM Compound: LG190155	Agonist activity at vitamin D3 receptor in human HL-60 cells assessed as induction of cell differentiation after 96 hrs by NBT dye-based microscopic analysis Agonist activity at vitamin D3 receptor in human HL-60 cells assessed as induction of cell differentiation after 96 hrs by NBT dye-based microscopic analysis	[PMID: 26562542]
HL-60	EC₅₀	30 nM Compound: 5a, 5c, LG190155	Induction of monocytic cell differentiation in human HL60 cells Induction of monocytic cell differentiation in human HL60 cells	[PMID: 23462715]
HL-60	ED₅₀	410 nM Compound: 1	Vitamin D3 agonistic activity as effective dose for HL-60 monocytic cell differentiation Vitamin D3 agonistic activity as effective dose for HL-60 monocytic cell differentiation	[PMID: 16019211]
L02	IC₅₀	5.1 μM Compound: LG190155	Cytotoxicity against human L02 cells after 48 hrs by MTT assay Cytotoxicity against human L02 cells after 48 hrs by MTT assay	[PMID: 26562542]
LNCaP	EC₅₀	20 nM Compound: 5a, 5c, LG190155	Growth inhibition of human LNCAP cells Growth inhibition of human LNCAP cells	[PMID: 23462715]
MCF7	IC₅₀	7.8 μM Compound: LG190155	Antipoliferative activity against human MCF7 cells after 48 hrs by MTT assay Antipoliferative activity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 26562542]
PC-3	IC₅₀	>50 μM Compound: LG190155	Antipoliferative activity against human PC3 cells after 48 hrs by MTT assay Antipoliferative activity against human PC3 cells after 48 hrs by MTT assay	[PMID: 26562542]
SC-3	IC₅₀	1900 nM Compound: 1	Androgen antagonistic activity as inhibitory concentration against testosterone-induced SC-3 cell proliferation Androgen antagonistic activity as inhibitory concentration against testosterone-induced SC-3 cell proliferation	[PMID: 16019211]

In Vitro

Treatment of human umbilical cord mesenchymal stem cells (LMSC) with LG190155 (2-8 µM, 24 h) enhances the ability of LMSC to induce differentiation of AML cells, and this effect is not caused by the cytotoxicity of LG190155 itself against MSC^[1].
LG190155 drives BMP6 gene transcription and autocrine signaling by activating VDR in MSCs, thereby enhancing the synthesis and secretion of IL-6^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

LG190155-pretreated LMSCs (1×10⁶ cells per mouse; tail vein injection; once weekly; continued until day 28) significantly extends the median overall survival of AML-bearing NOD-SCID mice to 48 days and reduces the leukemia cell burden in their peripheral blood, bone marrow, liver and spleen^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 233268-78-5
Molecular Weight 480.68
Formula C₃₁H₄₄O₄
SMILES

CCC(C1=CC=C(C(C)=C1)OCC(C(C)(C)C)=O)(CC)C2=CC=C(C(C)=C2)OCC(C(C)(C)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Sun L, et al. A chemically adjustable BMP6-IL6 axis in mesenchymal stem cells drives acute myeloid leukemia cell differentiation. Biochem Pharmacol. 2024;225:116262. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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LG190155

All TGF-β Receptor Isoforms

All Interleukin Related Isoforms