Anti-Mouse CD38 Antibody (NIMR5)
Based on 1 Customer Validation
Anti-Mouse CD38 Antibody (NIMR5) is an anti-mouse CD38 IgG2a monoclonal antibody. Anti-Mouse CD38 Antibody (NIMR5) can activate the ERK signaling pathway and promote cell apoptosis. Anti-Mouse CD38 Antibody (NIMR5) can restore T cell function. Anti-Mouse CD38 Antibody (NIMR5) upregulates the expression of CD1d protein and enhances spleen cell proliferation, dendritic cell (DC) and natural killer T cell (NKT) expansion. Anti-Mouse CD38 Antibody (NIMR5) can be used for researches on cancer and immunology such as melanoma and colon cancer.
For research use only. We do not sell to patients.
- Purity : 95.00%
- Molecular Weight:150 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Isotype
Rat IgG2a kappa
Recommend Isotype Controls
Species Reactivity
Mouse
IC50 & Target
[3]|
CD1d |
In Vitro
Anti-Mouse CD38 Antibody (NIMR5) (50 µg/mL, 4-12 h) induces ERK phosphorylation and promotes cell apoptosis in Ba/F3 cells and bone marrow B cell precursor[1].
Anti-Mouse CD38 Antibody (NIMR5) (1.0 μg/mL, 5-7 days) significantly inhibits the growth of tumor organoids MDOTS from wild-type female C57BL/6J mice bearing B16-ova tumors and BALB/c mice bearing CT26-GFP tumors combined with PD-1 mAb[2].
Anti-Mouse CD38 Antibody (NIMR5) (1 µg/mL, 6-48 h) significantly increases CD1d protein expression and has a synergistic effect with retinoic acid (RA) in THP-1 cells[3].
Anti-Mouse CD38 Antibody (NIMR5) (1 µg/mL, 4 days) enhances the proliferation of splenic cells and the expansion of dendritic cells (DC) and natural killer-T (NKT) cells induced by αGalCer, but have no significant effect on the production of cytokines (IL-4 and IFNγ)[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Ba/F3 cells
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Concentration:50 µg/mL
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Incubation Time:5 and 10 min
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Result:Increased the level of pERK.
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Cell Line:Ba/F3 cells and bone marrow B cell precursor
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Concentration:50 µg/mL
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Incubation Time:4 h for Ba/F3 cells and 12 h for bone marrow B cell precursor
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Result:Promoted an increase in apoptosis rate.
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Cell Line:THP-1 cells
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Concentration:1 µg/mL, combined with RA (HY-14649) (20 nM)
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Incubation Time:6, 24, 48 h
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Result:Upregulated the level of CD1d protein.
Gene ID
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Product Image
Application
in vivo CD38 stimulation; in vitro CD38 stimulation; in vitro B cell activation; Immunofluorescen
Chemical Information
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Appearance Liquid
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Molecular Weight 150 kDa
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Color Colorless to light yellow
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SMILES
[Anti-Mouse CD38 Antibody (NIMR5)]
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (262 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[2]. Revach OY, et al. Overcoming resistance to immunotherapy by targeting CD38 in human tumor explants. Cell Rep Med. 2025 Jul 15;6(7):102210. [Content Brief]
[3]. Chen Q, et al. All-trans-retinoic acid and CD38 ligation differentially regulate CD1d expression and α-galactosylceramide-induced immune responses. Immunobiology. 2015 Jan;220(1):32-41. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-Mouse CD38 Antibody (NIMR5) Related Classifications
HY-P990273 Related Classifications
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