1. Anti-infection
  2. Bacterial
  3. I2906

I2906 

Cat. No.: HY-76293 Purity: 99.92%
Handling Instructions

I2906 showed antimycobacterial and cytotoxic activity against mycobacterium tuberculosis.

For research use only. We do not sell to patients.

I2906 Chemical Structure

I2906 Chemical Structure

CAS No. : 331963-29-2

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 118 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 118 In-stock
Estimated Time of Arrival: December 31
Solid
100 mg USD 107 In-stock
Estimated Time of Arrival: December 31
500 mg USD 357 In-stock
Estimated Time of Arrival: December 31
1 g   Get quote  
5 g   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

1 Publications Citing Use of MCE I2906

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

I2906 showed antimycobacterial and cytotoxic activity against mycobacterium tuberculosis. IC50 Value: Target: Antibacterial Under in vitro conditions, I2906 showed excellent antimycobacterial activities and low cytotoxicity. In a murine model infected with M. tuberculosis H37Rv, the reductions on bacterial loads of both lungs and spleen were statistically significant (p < 0.05) between I2906-treated mice and untreated controls after 4 weeks. Further, the colony-forming unit counts in the lungs were dramatically lower (p < 0.05) than that of isoniazid-treated mice by the addition of I2906 after 8 weeks. Moreover, survival rate was increased by I2906 treatment. For multidrug-resistant strain infection, bacterial counts were reduced significantly in the lungs and spleen due to I2906 treatment in comparison with data from untreated controls (p < 0.05).

Molecular Weight

443.58

Formula

C25H37N3O4

CAS No.
SMILES

O=C1C(C(NNC(CCCCCCCCCCCC)=O)=O)=C(O)C2=CC=CC=C2N1CC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (56.36 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2544 mL 11.2719 mL 22.5438 mL
5 mM 0.4509 mL 2.2544 mL 4.5088 mL
10 mM 0.2254 mL 1.1272 mL 2.2544 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.5 mg/mL (5.64 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.64 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.92%

References
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Product Name:
I2906
Cat. No.:
HY-76293
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