2. Others Stem Cell/Wnt MAPK/ERK Pathway Apoptosis Metabolic Enzyme/Protease
  3. Isotope-Labeled Compounds ERK Caspase Apoptosis Endogenous Metabolite
  4. Tauroursodeoxycholate-d4 sodium

Tauroursodeoxycholate-d4 sodium  (Synonyms: Tauroursodeoxycholic acid-d4 sodium; TUDCA-d4 sodium; UR 906-d4 sodium)

製品番号: HY-19696AS
COA 取扱説明書 Technical Support

Tauroursodeoxycholate-d4 (sodium) is the deuterium labeled Tauroursodeoxycholate sodium. Tauroursodeoxycholate (Tauroursodeoxycholic acid; TUDCA) sodium is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

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Tauroursodeoxycholate-d<sub>4</sub> sodium

Tauroursodeoxycholate-d4 sodium 構造式

CAS 番号 : 2410279-95-5

容量 価格（税別） 在庫状況
1 mg $170 見積もりとリードタイムを求めるのご確認

* アイテムを追加する前、数量をご選択ください

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Other 在庫あり Forms of Tauroursodeoxycholate-d4 sodium:

Other Forms of Tauroursodeoxycholate-d4 sodium:

Tauroursodeoxycholate-d4 sodium 関連抗体

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ERK アイソフォーム固有の製品をすべて表示:

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ERK ERK1 ERK2 ERK5 ERK8

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

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製品説明

Tauroursodeoxycholate-d4 (sodium) is the deuterium labeled Tauroursodeoxycholate sodium. Tauroursodeoxycholate (Tauroursodeoxycholic acid; TUDCA) sodium is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

体外実験

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tauroursodeoxycholate-d4 sodium 関連抗体
分子量

525.71

分子式

C26H40D4NNaO6S
CAS 番号
Unlabeled CAS
Appearance

Solid

Color

White to off-white

SMILES

C[C@H](CCC(NCCS(=O)(O[Na])=O)=O)[C@H]1CC[C@@]2([H])[C@]3([H])[C@@H](O)C[C@]4([H])C([2H])([2H])[C@H](O)C([2H])([2H])C[C@]4(C)[C@@]3([H])CC[C@]12C
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
体外: 

DMF : ≥ 25 mg/mL (47.55 mM)

DMSO : ≥ 20 mg/mL (38.04 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : ≥ 1 mg/mL (1.90 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9022 mL 9.5109 mL 19.0219 mL
5 mM 0.3804 mL 1.9022 mL 3.8044 mL
10 mM 0.1902 mL 0.9511 mL 1.9022 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

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In Vivo Dissolution Calculator
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純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol / DMSO / DMF 1 mM 1.9022 mL 9.5109 mL 19.0219 mL 47.5547 mL
DMSO / DMF 5 mM 0.3804 mL 1.9022 mL 3.8044 mL 9.5109 mL
10 mM 0.1902 mL 0.9511 mL 1.9022 mL 4.7555 mL
15 mM 0.1268 mL 0.6341 mL 1.2681 mL 3.1703 mL
20 mM 0.0951 mL 0.4755 mL 0.9511 mL 2.3777 mL
25 mM 0.0761 mL 0.3804 mL 0.7609 mL 1.9022 mL
30 mM 0.0634 mL 0.3170 mL 0.6341 mL 1.5852 mL
DMF 40 mM 0.0476 mL 0.2378 mL 0.4755 mL 1.1889 mL
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Tauroursodeoxycholate-d4 sodium Related Classifications

  • Molarity Calculator

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tauroursodeoxycholate-d42410279-95-5Tauroursodeoxycholic acid-d4TUDCA-d4UR 906-d4Isotope-Labeled CompoundsERKCaspaseApoptosisEndogenous MetaboliteExtracellular signal regulated kinasesInhibitorinhibitorinhibit

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製品番号:
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