1. MAPK/ERK Pathway
    Stem Cell/Wnt
    Apoptosis
  2. ERK
    Caspase
  3. Tauroursodeoxycholate dihydrate

Tauroursodeoxycholate dihydrate (Synonyms: TUDCA dihydrate; UR 906 dihydrate; Taurolite dihydrate)

Cat. No.: HY-19696B Purity: >97.0%
Handling Instructions

Tauroursodeoxycholate dihydrate (TUDCA dihydrate; UR 906 dihydrate; Taurolite dihydrate) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

For research use only. We do not sell to patients.

Tauroursodeoxycholate dihydrate Chemical Structure

Tauroursodeoxycholate dihydrate Chemical Structure

CAS No. : 117609-50-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
50 mg USD 60 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

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Description

Tauroursodeoxycholate dihydrate (TUDCA dihydrate; UR 906 dihydrate; Taurolite dihydrate) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK[1][2].

IC50 & Target

ERK[1]
Caspase-3, Caspase-12[2]

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 83.33 mg/mL (155.54 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8666 mL 9.3331 mL 18.6661 mL
5 mM 0.3733 mL 1.8666 mL 3.7332 mL
10 mM 0.1867 mL 0.9333 mL 1.8666 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (3.88 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.88 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.88 mM); Clear solution

*All of the co-solvents are provided by MCE.
Molecular Weight

535.73

Formula

C₂₆H₄₉NO₈S

CAS No.

117609-50-4

SMILES
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Product Name:
Tauroursodeoxycholate dihydrate
Cat. No.:
HY-19696B
Quantity:

Tauroursodeoxycholate dihydrate

Cat. No.: HY-19696B