1. MAPK/ERK Pathway
    Stem Cell/Wnt
    Apoptosis
  2. ERK
    Caspase
    Apoptosis
  3. Tauroursodeoxycholate dihydrate

Tauroursodeoxycholate dihydrate (Synonyms: TUDCA dihydrate; UR 906 dihydrate; Taurolite dihydrate)

Cat. No.: HY-19696B Purity: >97.0%
Handling Instructions

Tauroursodeoxycholate dihydrate (TUDCA dihydrate; UR 906 dihydrate; Taurolite dihydrate) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

For research use only. We do not sell to patients.

Tauroursodeoxycholate dihydrate Chemical Structure

Tauroursodeoxycholate dihydrate Chemical Structure

CAS No. : 117609-50-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
50 mg USD 60 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 8 publication(s) in Google Scholar

Other Forms of Tauroursodeoxycholate dihydrate:

Top Publications Citing Use of Products

    Tauroursodeoxycholate dihydrate purchased from MCE. Usage Cited in: Fundam Clin Pharmacol. 2018 Aug;32(4):363-377.

    Effect of TUDCA and Fluoxetine on chronic unpredictable stress (CUS)-induced increase in Iba-1 protein expression in mice hippocampus and prefrontal cortex.

    Tauroursodeoxycholate dihydrate purchased from MCE. Usage Cited in: Biochem Pharmacol. 2018 May 24;154:278-292.

    TUDCA treatment inhibits the secretion of active IL-1β into cell culture media by Acetaminophen (APAP).
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    Description

    Tauroursodeoxycholate dihydrate (TUDCA dihydrate; UR 906 dihydrate; Taurolite dihydrate) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK[1][2].

    IC50 & Target

    ERK[1]
    Caspase-3, Caspase-12[2]

    Molecular Weight

    535.73

    Formula

    C₂₆H₄₉NO₈S

    CAS No.

    117609-50-4

    SMILES
    Shipping

    Room temperature in continental US; may vary elsewhere

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 83.33 mg/mL (155.54 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.8666 mL 9.3331 mL 18.6661 mL
    5 mM 0.3733 mL 1.8666 mL 3.7332 mL
    10 mM 0.1867 mL 0.9333 mL 1.8666 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.08 mg/mL (3.88 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.08 mg/mL (3.88 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.08 mg/mL (3.88 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References
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    Product Name:
    Tauroursodeoxycholate dihydrate
    Cat. No.:
    HY-19696B
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