2. Apoptosis Stem Cell/Wnt MAPK/ERK Pathway Anti-infection Immunology/Inflammation
  3. Apoptosis Wnt ERK Bacterial Interleukin Related
  4. Elaidic acid

エライジン酸  (Synonyms: Elaidic acid)

製品番号: HY-113016 純度: 99.81%
COA 取扱説明書 Technical Support

Elaidic acid is an orally active trans fatty acid. Elaidic acid enhances the stemness of colorectal cancer cells by activating the Wnt/ERK1/2 pathway, thereby promoting cell proliferation, invasion and metastasis, and inhibiting apoptosis. Elaidic acid also inhibits the growth of Lactobacillus and alters the cell surface hydrophobicity of Lactobacillus. Elaidic acid reduces basal 2-deoxyglucose uptake in muscle cells and adipocytes. Elaidic acid can be used in research on colorectal cancer, insulin and other related areas.

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Elaidic acid

エライジン酸 構造式

CAS 番号 : 112-79-8

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 33 在庫あり
Solution
10 mM * 1 mL in DMSO USD 33 在庫あり
Solid
100 mg $30 在庫あり
500 mg $65 在庫あり
1 g $100 在庫あり
5 g $200 在庫あり
10 g   お問い合わせ  
50 g   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 4 publication(s) in Google Scholar

Other Forms of Elaidic acid:

エライジン酸 関連抗体

Top Publications Citing Use of Products

Wnt アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
Wnt1 Wnt3 Wnt5 Wnt7 Wnt11

ERK アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
ERK ERK1 ERK2 ERK5 ERK8

Interleukin Related アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

  • 生物活性

  • 純度とドキュメンテーション

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製品説明

Elaidic acid is an orally active trans fatty acid. Elaidic acid enhances the stemness of colorectal cancer cells by activating the Wnt/ERK1/2 pathway, thereby promoting cell proliferation, invasion and metastasis, and inhibiting apoptosis. Elaidic acid also inhibits the growth of Lactobacillus and alters the cell surface hydrophobicity of Lactobacillus. Elaidic acid reduces basal 2-deoxyglucose uptake in muscle cells and adipocytes. Elaidic acid can be used in research on colorectal cancer, insulin and other related areas[1][2][3].

IC50 & Target[3]

IL-15

 

体外実験

Elaidic acid (0-35 μM; 24-48 h) dose-dependently promotes the growth, reduces the apoptosis and enhances the invasive ability of CT26 and HT29 colorectal cancer cells[1].
Elaidic acid (35 μM; 1 week) enhances the sphere-forming capacity of CT26 colorectal cancer cells under concurrent treatment, pre-treatment, and hypoxic conditions[1].
Elaidic acid upregulates the expression of stem cell markers (nucleostemin, CD133, Oct4) and dedifferentiation marker (c-Myc), while downregulates the expression of differentiation markers (MUC1, MUC2, CDX2) in CT26 colorectal cancer spheres[1].
Elaidic acid (0-500 mg/L; 0-24 h) inhibits the growth of L. rhamnosus, L. paracasei, L. zeae, <L. acidophilus and L. plantarum, but exerts no effect on the growth of L. casei[2].
Elaidic acid (200 mg/L; 0-24 h) reduces the cell surface hydrophobicity of L. paracasei and L. casei[2].
Elaidic acid (20-500 μM; 24 h) dose-dependently upregulates the mRNA level of TNF-α, decreases the mRNA level of IL-15, and does not enhance insulin-stimulated glucose uptake in differentiated C2C12 myotubes[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

エライジン酸 関連抗体

RT-PCR[3]

Cell Line: C2C12 myotubes
Concentration: 20, 100, 500 μM
Incubation Time: 24 h
Result: Reduced the mRNA levels of IL-15.
Did not affect IL-6 levels.
Increased TNF-α mRNA levels.
体内実験

Elaidic acid (10 mg/mouse; i.p.) promotes the growth and metastasis of CRC tumors in BALB/c mice and upregulates the expression of tumor differentiation markers[1].
Elaidic acid (0-0.2 mg/kg; i.g.; every 7 days; 4 weeks) increases the number of liver CRC metastatic foci and CD133-positive cells in BALB/c mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c (male, 5 weeks old)[1]
Dosage: 10 mg/mouse
Administration: i.p.
Result: Increased subcutaneous CT26 or HT29 tumor growth.
Enhanced peritoneal metastasis size of CT26 or HT29 cells.
Enhanced liver metastasis of CT26 or HT29 cells.
Enhanced lung metastasis of CT26 or HT29 cells.
Increased expression of differentiation markers MUC1, MUC2, and CDX2.
臨床実験
分子量

282.46

分子式

C18H34O2
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

CCCCCCCC/C=C/CCCCCCCC(O)=O
Structure Classification
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

Ethanol : ≥ 100 mg/mL (354.03 mM)

DMSO : 13.5 mg/mL (47.79 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5403 mL 17.7016 mL 35.4032 mL
5 mM 0.7081 mL 3.5403 mL 7.0806 mL
10 mM 0.3540 mL 1.7702 mL 3.5403 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 1.35 mg/mL (4.78 mM); Clear solution

    This protocol yields a clear solution of ≥ 1.35 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (13.5 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション

純度: 99.81%

COA (237 KB) HNMR (160 KB) RP-HPLC (209 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / Ethanol 1 mM 3.5403 mL 17.7016 mL 35.4032 mL 88.5081 mL
5 mM 0.7081 mL 3.5403 mL 7.0806 mL 17.7016 mL
10 mM 0.3540 mL 1.7702 mL 3.5403 mL 8.8508 mL
15 mM 0.2360 mL 1.1801 mL 2.3602 mL 5.9005 mL
20 mM 0.1770 mL 0.8851 mL 1.7702 mL 4.4254 mL
25 mM 0.1416 mL 0.7081 mL 1.4161 mL 3.5403 mL
30 mM 0.1180 mL 0.5901 mL 1.1801 mL 2.9503 mL
40 mM 0.0885 mL 0.4425 mL 0.8851 mL 2.2127 mL
Ethanol 50 mM 0.0708 mL 0.3540 mL 0.7081 mL 1.7702 mL
60 mM 0.0590 mL 0.2950 mL 0.5901 mL 1.4751 mL
80 mM 0.0443 mL 0.2213 mL 0.4425 mL 1.1064 mL
100 mM 0.0354 mL 0.1770 mL 0.3540 mL 0.8851 mL
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Elaidic acid Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Elaidic acid112-79-8ApoptosisWntERKBacterialInterleukin RelatedExtracellular signal regulated kinasesILERK1/2HT29 colorectal cancer cellsIL-15C2C12 myotubesTNF-αcolorectal cancerCT26 colorectal cancer cellsinsulin resistanceInhibitorinhibitorinhibit

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