2. Signaling Pathways
  3. GPCR/G Protein
    Immunology/Inflammation
  4. CCR

CCR

CC chemokine receptor

CCR

Related Products

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CCR (Chemokine receptors) are cytokine receptors found on the surface of certain cells that interact with a type of cytokine called achemokine. There have been 19 distinct chemokine receptors described in mammals. Each has a 7-transmembrane (7TM) structure and couples to G-protein for signal transduction within a cell, making them members of a large protein family of G protein-coupled receptors. Following interaction with their specific chemokine ligands, chemokine receptors trigger a flux in intracellular calcium (Ca2+) ions (calcium signaling). This causes cell responses, including the onset of a process known as chemotaxis that traffics the cell to a desired location within the organism. Chemokine receptors are divided into different families, CXC chemokine receptors, CC chemokine receptors, CX3C chemokine receptors and XC chemokine receptors that correspond to the 4 distinct subfamilies of chemokines they bind. Specific chemokine receptors provide the portals for HIV to get into cells, and others contribute to inflammatory diseases and cancer.

CCR Isoform Specific Products:

CCR Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-RS02155
    Ccr3 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Ccr3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ccr3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Ccr3 Mouse Pre-designed siRNA Set A
  • HY-P991653
    HGS004
    		Inhibitor
    HGS004 is a humanized IgG4 monoclonal antibody inhibitor targeting CCR5. HGS004 has potent antivival activity against a diverse panel of CCR5-tropic HIV-1 and durg (such as Maraviroc (HY-13004))-resistant strains. HGS004 can be used for HIV-1 infections research.
    HGS004
  • HY-RS02158
    Ccr4 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Ccr4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ccr4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Ccr4 Mouse Pre-designed siRNA Set A
  • HY-162512
    CB-0821
    		Inhibitor
    CB-0821 is a high affinity CCR5 inhibitor with a Ki of 0.04 nM. CB-0821 binds efficiently to the hydrophobic pocket of the CCR5 protein, to inhibit the interactions between viral protein and CCR5, thereby inhibiting viral entry. CB-0821 has the potential for anti-HIV research.
    CB-0821
  • HY-181708
    PROTAC IRAK4 degrader-14
    		Inhibitor
    PROTAC IRAK4 degrader-14 is an orally active IRAK4 PROTAC degrader with a DC50 of 2.4 nM. PROTAC IRAK4 degrader-14 inhibits proinflammatory responses in multiple cell types including T cells, monocytes and keratinocytes. PROTAC IRAK4 degrader-14 is applicable to research related to psoriasis.
    PROTAC IRAK4 degrader-14
  • HY-P992365
    HFB101110
    		Inhibitor
    HFB101110 is a human-derived inhibitor and Treg depleter that specifically targets CCR8. It does not bind to the homologous CCR4 receptor and is mainly used in research on solid tumors, renal cell carcinoma and colorectal cancer. HFB101110 blocks hCCL1 binding by interacting with the N-terminal extracellular domain of hCCR8, thereby inhibiting hCCL1-induced calcium influx, chemotaxis and downstream signaling pathways. Meanwhile, HFB101110 can mediate ADCC effects to specifically deplete CCR8-positive cells, including intratumoral Tregs. HFB101110 exhibits favorable anti-tumor activity and pharmacokinetic properties.
    HFB101110
  • HY-N11723
    Catenarin
    		Inhibitor
    Catenarin, an anthraquinone compound, inhibits CCR5- and CXCR4-mediated chemotaxis. Catenarin reduces the phosphorylation of mitogen-activated protein kinases (p38 and JNK) and their upstream kinases (MKK6 and MKK7), and calcium mobilization. Catenarin shows anti-inflammatory effect and suppresses leukocyte migration in the diabetes. Catenarin exhibits significant inhibitory effects against Gram-positive bacteria. Catenarin prevents type 1 diabetes (T1D) in nonobese diabetic mice[1][2].
    Catenarin
  • HY-P990653
    R707
    		Inhibitor
    R707 is a human antibody expressed in CHO cells that targets CCR7/CD197. R707 contains huIgG1 heavy chain and huκ light chain, with a predicted molecular weight (MW) of 145.36 kDa. The isotype control for R707 can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).
    R707
  • HY-P992378
    HZ-1127
    		Inhibitor
    HZ-1127 is a thymic stromal lymphopoietin (TSLP) inhibitor. HZ-1127 selectively binds to TSLP, blocks receptor complex interaction, inhibits STAT5 activation, downstream inflammatory signaling, and TSLP-induced CCL17 and CCL22 secretion. HZ-1127 can be used for the research of allergic diseases and cancer.
    HZ-1127
  • HY-165528
    Histamine glutarimide
    		Inhibitor
    Histamine glutarimide (XC8) is an orally active anti-asthma agent. Histamine glutarimide blocks the maturation of chemokines (CCL2, CCL7, CCL8, CCL13) and inhibits the migration of eosinophils and the degranulation of mast cells. In asthma models induced by carrageenan and rat ovalbumin, Histamine glutarimide can reduce airway resistance and the count of eosinophils in bronchoalveolar lavage fluid. Histamine glutarimide can be used in asthma research.
    Histamine glutarimide
  • HY-RS02172
    CCR9 Human Pre-designed siRNA Set A
    		Inhibitor

    CCR9 Human Pre-designed siRNA Set A contains three designed siRNAs for CCR9 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    CCR9 Human Pre-designed siRNA Set A
  • HY-123902
    Ophiobolin C
    		Inhibitor
    Ophiobolin C inhibits CCR5 binding to the envelop protein gp120 and CD4, which is responsible for mediating the entry of HIV-1 into cells. Ophiobolin C is also cytotoxic to chronic lymphocytic leukemia cells.
    Ophiobolin C
  • HY-185661
    IBS007125
    		Inhibitor
    IBS007125 is a c-Maf inhibitor. IBS007125 does not alter the protein level or post-translational modification of c-Maf. IBS007125 inhibits some target genes of c-Maf (such as ITGB7 and CCR1). IBS007125 exerts anticancer effects on multiple myeloma expressing c-Maf. IBS007125 can be used for the research of multiple myeloma.
    IBS007125
  • HY-148100C
    Emapticap pegol scramble negative control
    		Inhibitor
    Emapticap pegol scramble negative control, an oligonucleotide aptamer, is the negative control of Emapticap pegol (HY-148100).
    Emapticap pegol scramble negative control
  • HY-P990677
    VLST-002
    		Inhibitor
    VLST-002 is a humanized antibody expressed in CHO cells, targeting CCL5/RANTES. VLST-002 has a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for VLST-002 can refer to Human IgG1 kappa, Isotype Control (HY-P99001).
    VLST-002
  • HY-P990296
    Anti-Mouse CCR3/CD193 Antibody (6S2-19-4)
    		Inhibitor 99.13%
    Anti-Mouse CCR3/CD193 Antibody (6S2-19-4) is a rat-derived IgG2b λ type antibody inhibitor, targeting to mouse CCR3/CD193. Anti-Mouse CCR3/CD193 Antibody (6S2-19-4) can deplete eosinophils. Anti-Mouse CCR3/CD193 Antibody (6S2-19-4) can be used for the researches of cancer, infection, inflammation and immunology, such as lymphoma, ileitis and strongyloides stercoralis infection.
    Anti-Mouse CCR3/CD193 Antibody (6S2-19-4)
  • HY-164630
    CCR5/CXCR3-IN-1
    		Inhibitor
    CCR5/CXCR3-IN-1 (compound 1) is a CXCR3 and CCR5 inhibitor. CCR5/CXCR3-IN-1 inhibits chemotaxis of CXCR3 and CCR5-expressing transformed cells, and does not inhibits the chemotaxis of transfected cells expressing CXCR4. CCR5/CXCR3-IN-1 can be used for the study of chronic arthritic rheumatism.
    CCR5/CXCR3-IN-1
  • HY-N2609R
    7,4'-Dihydroxyflavone (Standard)
    		Inhibitor
    7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid, which can be isolated from Glycyrrhiza uralensis. 7,4'-Dihydroxyflavone is eotaxin/CCL11 inhibitor and CBR1 inhibitor (IC50=0.28 μM). 7,4'-Dihydroxyflavone has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production. 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2.7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC50 value of 1.4 µM.
    7,4'-Dihydroxyflavone (Standard)
  • HY-P991745
    Anti-Mouse CCR2 Antibody (C2Mab-6)
    		Inhibitor
    Anti-Mouse CCR2 Antibody (C2Mab-6) is raised against and binds to the N-terminal sequence of CCR2. Recommend Isotype Controls: Rat IgG1 kappa, Isotype Control (HY-P99979).
    Anti-Mouse CCR2 Antibody (C2Mab-6)
  • HY-P991782
    Anti-Mouse CCR8 Antibody (C8Mab-2)
    		Inhibitor
    Anti-Mouse CCR8 Antibody (C8Mab-2) reacts with an epitope within the N-terminal region of mouse CCR8. Anti-Mouse CCR8 Antibody (C8Mab-2) recognizes the N-terminal region (1-33 amino acids) of mouse CCR8. Recommend Isotype Controls: Rat IgG2b kappa, Isotype Control (HY-P990682).
    Anti-Mouse CCR8 Antibody (C8Mab-2)
Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name / Synonyms Application Reactivity
CCR Isoform Comparison

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