HZ-1127

Cat. No.: HY-P992378: Data Sheet
FAQs
Technical Support

HZ-1127 is a thymic stromal lymphopoietin (TSLP) inhibitor. HZ-1127 selectively binds to TSLP, blocks receptor complex interaction, inhibits STAT5 activation, downstream inflammatory signaling, and TSLP-induced CCL17 and CCL22 secretion. HZ-1127 can be used for the research of allergic diseases and cancer.

For research use only. We do not sell to patients.

HZ-1127 Chemical Structure

Size		Stock
MOQ		Minimum order quantity
1 mg		Get quote
5 mg		Get quote
10 mg		Get quote
Other size		Get quote

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This product is a controlled substance and not for sale in your territory.

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•Related Small Molecules:

•Related Proteins:

View All CCR Isoform Specific Products:

View All Isoforms

CCR1 CCR2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9

View All STAT Isoform Specific Products:

View All Isoforms

STAT3 STAT5 STAT6 STAT1

Biological Activity
Purity & Documentation
References
Customer Review

Description

Species Reactivity

Human

IC₅₀ & Target^[1]

STAT5

In Vitro

HZ-1127-IgG1 and HZ-1127-IgG2 (Increasing concentrations; 2 h) bind to recombinant human TSLP-hFc with EC₅₀ values of 0.023 μg/mL and 0.015 μg/mL, respectively, demonstrating potent dose-dependent binding^[1].
HZ-1127 (12.5 μg/mL; 2 h) binds to an epitope on recombinant human TSLP that is either identical or highly similar to the epitope targeted by Tezepelumab (HY-P99366A)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Gene ID

85480 [NCBI]

Accession

Q969D9-1

Target

TSLP

Application

ELISA, FACS, Functional assay

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Formulation

Please refer to the lot-specific COA for specific buffer information.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Inhibitory Antibodies User Guide (603 KB)

References

[1]. Liu X, et al. Development of a novel humanized anti-TSLP monoclonal antibody HZ-1127 with anti-allergic diseases and cancer potential. Antib Ther. 2024;7(2):123-130. Published 2024 Feb 27.

HZ-1127 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HZ-1127HZ1127HZ 1127CCRSTATCC chemokine receptorSTAT5allergic diseasesCCL17TSLP receptor complexinflammatory signalingcancerthymic stromal lymphopoietinhuman PBMCsHEK293F cellsCCL22Inhibitorinhibitorinhibit

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