Tezepelumab (anti-TSLP)
Based on 1 Customer Validation
Tezepelumab (anti-TSLP) is human monoclonal antibody (IgG2λ) that binds specifically to TSLP, blocking it from interacting with its heterodimeric receptor. Tezepelumab can be used for the research of severe, uncontrolled asthma.
For research use only. We do not sell to patients.
- Purity: ≥99.0%
- CAS No.: 1572943-04-4
- Molecular Weight:144.6 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Human IgG2 lambda
Human
TSLP
Tezepelumab (anti-TSLP) blocks thymic stromal lymphopoietin, an epithelial-cell-derived cytokine implicated in the pathogenesis of asthma[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Q969D9-1
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Human IgG2 lambda
ELISA, FACS, Functional assay
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Immobilized TSLP-ECD-GSV0-His can bind Tezepelumab. The EC50 for this effect is 51.8 ng/mL.
Chemical Information
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CAS No. 1572943-04-4
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Appearance Liquid
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Molecular Weight 144.6 kDa
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Color Colorless to light yellow
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SMILES
[Tezepelumab (anti-TSLP)]
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Synonyms
AMG 157 (anti-TSLP); MEDI 19929 (anti-TSLP); Tezepelumab-ekko (anti-TSLP)
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (256 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)