Anti-Mouse CCR8 Antibody (C8Mab-2)
Anti-Mouse CCR8 Antibody (C8Mab-2) is an antibody targeting mouse CCR8. Anti-Mouse CCR8 Antibody (C8Mab-2) induces antibody-dependent cellular cytotoxicity and antibody-dependent cellular phagocytosis to eliminate CCR8-expressing cells. Anti-Mouse CCR8 Antibody (C8Mab-2) eliminates regulatory T cells in the tumor microenvironment, increases CD8+ T cell infiltration and inhibits tumor growth. Anti-Mouse CCR8 Antibody (C8Mab-2) recognizes the N-terminal amino acid region 1-33 of mouse CCR8, in which Thr20 serves as the core binding epitope amino acid. Anti-Mouse CCR8 Antibody (C8Mab-2) is applicable to research related to colon cancer, breast cancer and bladder cancer.
For research use only. We do not sell to patients.
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Rat IgG2b kappa
Mouse
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CCR8 |
Anti-Mouse CCR8 Antibody (C8Mab-2) binds to CHO/mCCR8 cells with moderate affinity as measured by flow cytometry[2].
Anti-Mouse CCR8 Antibody (C8Mab-2) (10 μg/mL; 30 min at 4°C) selectively binds the N-terminal region (1-33 amino acids) of mouse CCR8 expressed on CHO-K1 and CHO/mCCR8 cells[3].
Anti-Mouse CCR8 Antibody (C8Mab-2) (10 μg/mL; 30 min at 4°C) binding to mouse CCR8 expressed on CHO-K1 cells is dependent on the presence of Thr20, which functions as a central amino acid of the antibody's epitope[3].
Anti-Mouse CCR8 Antibody (C8Mab-2) (10 μg/mL; 30 min at 4°C) binding to mouse CCR8 expressed on CHO-K1 cells requires the 17-DFFTAP-22 amino acid sequence in the mCCR8 N-terminal region[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
P56484
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Product Image
Flow cytometry; Western blotting; Immunofluorescence
Chemical Information
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Roider HG, et al. Selective depletion of tumor-infiltrating regulatory T cells with BAY 3375968, a novel Fc-optimized anti-CCR8 antibody. Clinical and experimental medicine. 2024 Jun 10;24(1):122. [Content Brief]
[2]. Saito M, et al. Development of an Anti-Mouse CCR8 Monoclonal Antibody (C8Mab-1) for Flow Cytometry and Immunocytochemistry. Monoclon Antib Immunodiagn Immunother. 2022 Dec;41(6):333-338. [Content Brief]
[3]. Kobayashi H, et al. Epitope Mapping of an Anti-Mouse CCR8 Monoclonal Antibody C8Mab-2 Using Flow Cytometry. Monoclon Antib Immunodiagn Immunother. 2024 Aug;43(4):101-107. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-Mouse CCR8 Antibody (C8Mab-2) Related Classifications
HY-P991782 Related Classifications
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