Ccr8 - chemokine (C-C motif) receptor 8 Gene

Also Known as C-C; CCR-8; CKR-8; mCCR8; Cmkbr8; CC-CKR-8; C-C CKR-8

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12776

About Ccr8

Chromosome 9: 119,921,180-119,923,972 forward strand.GRCm39:CM001002.3

This gene has 1 transcript (splice variant), 236 orthologues, 25 paralogues and is associated with 7 phenotypes. Biased expression in thymus adult (RPKM 6.3), mammary gland adult (RPKM 1.1) and 3 other tissues.

Summary

Enables C-C Chemokine Receptor activity. Acts upstream of or within chemotaxis. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in external side of plasma membrane. Is expressed in central nervous system; retina; and thymus primordium. Orthologous to human CCR8 (C-C motif Chemokine Receptor 8). [provided by Alliance of Genome Resources, Apr 2022]

Ccr8 Products (1)

mRNA Protein Name
NM_007720.2 NP_031746.1 C-C chemokine receptor type 8

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables C-C chemokine receptor activity IDA
IDA: Inferred from direct assay
9670926 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9670926 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within chemotaxis IDA
IDA: Inferred from direct assay
9670926 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ccr8 Protein Structure

7tmA_CCR8

7tmA_CCR8: cd15187 (33 - 308)

7tmA_CCR8

7tmA_CCR8: cd15187 (33 - 60)

7tmA_CCR8

7tmA_CCR8: cd15187 (67 - 92)

7tmA_CCR8

7tmA_CCR8: cd15187 (103 - 133)

7tmA_CCR8

7tmA_CCR8: cd15187 (145 - 167)

7tmA_CCR8

7tmA_CCR8: cd15187 (192 - 221)

7tmA_CCR8

7tmA_CCR8: cd15187 (228 - 258)

7tmA_CCR8

7tmA_CCR8: cd15187 (276 - 301)

  • 0
  • 100
  • 200
  • 300
  • 353 a.a.
Protein Preferred Names Protein Names

C-C chemokine receptor type 8

  • C-C motif chemokine receptor 8

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (6)
Cat. No. Product Name Effect
Purity Phase
HY-P990914 Denikitug 99.00% Phase 2
HY-P991481 S-531011 Inhibitor 98.38% Phase 2
HY-P991061 Tagmokitug Inhibitor 99.9% Phase 1
HY-P991942 Lanerkitug Inhibitor 97.00% Phase 1
HY-P991944 ZL-1218 Inhibitor / Phase 1
HY-P991135 Enzelkitug Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-119217 AZ084 Antagonist 99.70% Unkown
HY-122219 R243 Antagonist 98.09% Unkown
HY-124416 ML604086 Inhibitor 99.78% Unkown
HY-121885 LMD-009 Agonist 99.35% Unkown
HY-101038A ZK756326 dihydrochloride Agonist 99.87% Unkown
HY-144197 CCR8 antagonist 1 Antagonist 99.50% Unkown
HY-176799 LMD-584 Agonist / Unkown
HY-176800 LMD-902 Agonist / Unkown
HY-153669 SB-649701 Antagonist / Unkown
HY-184668 CCR8 agonist 2 Agonist / Unkown
HY-160647 CCR8 antagonist 3 Antagonist / Unkown
Inhibitory Antibodies (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991942A Lanerkitug (FUT8-KO) Inhibitor 99.27% Unkown
HY-P991481A S-531011 (FUT8-KO) Inhibitor 99.10% Unkown
HY-P991944A ZL-1218 (FUT8-KO) Inhibitor / Unkown
HY-P992334 CM369 Inhibitor / Unkown
HY-P991135A Enzelkitug (FUT8-KO) Inhibitor / Unkown
HY-P992365 HFB101110 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ccr8 NCBI NCBI:1237