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Cat. No.: HY-144197

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CCR8 antagonist 1

Name: CCR8 antagonist 1
Brand: MedChemExpress
SKU: HY-144197
Price: 135.00 USD
Availability: InStock
Rating: 5 (1 reviews)

고객리뷰

Based on 1 Customer Validation

CCR8 antagonist 1 (Compound 15) is a potente human CCR8 antagonist with a K_i of 1.6 nM. CCR8 antagonist 1 has high safety and metabolic stability. CCR8 antagonist 1 can be used to study diseases such as asthma and multiple sclerosis.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity : 99.50%
CAS No.: 723304-76-5
화학식: C₂₆H₂₉N₃O₅S
분자량:495.59

보관:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

CCR8 antagonist 1 Chemical Structure

CAS No.: 723304-76-5

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Parmacokinetics
Chemical Information
용액&용해도
- In Vitro
순도&문서
References
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

^[1]

CCR8

1.6 nM (Ki)

All CCR Isoforms :

Parmacokinetics

Species	Dose	Route	T_1/2	V_ss	CL	F
Dog^[1]	1 mg/kg	i.v.	3.7 h	1.5 L/h/kg	0.42 L/kg	/
Dog^[1]	10 mg/kg	p.o.	/	/	/	10 %
Rat^[1]	1 mg/kg	i.v.	2.6 h	1.6 L/kg	1.4 L/h/kg	/
Rat^[1]	10 mg/kg	p.o.	/	/	/	2 %

Chemical Information

CAS No. 723304-76-5
Appearance Solid
분자량 495.59
화학식 C₂₆H₂₉N₃O₅S
Color White to off-white
SMILES

O=C(N1CCC(NS(=O)(C2=C3C=CC=CC3=C(NC(C4=CC=CC=C4C)=O)C=C2)=O)CC1)OCC
선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

용액&용해도

In Vitro:

DMSO : 25 mg/mL (50.44 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.0178 mL

10.0890 mL

20.1780 mL

5 mM

0.4036 mL

2.0178 mL

4.0356 mL

10 mM

0.2018 mL

1.0089 mL

2.0178 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Jenkins TJ, et al. Design, synthesis, and evaluation of naphthalene-sulfonamide antagonists of human CCR8. J Med Chem. 2007;50(3):566-584. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.0178 mL	10.0890 mL	20.1780 mL	50.4449 mL
	5 mM	0.4036 mL	2.0178 mL	4.0356 mL	10.0890 mL
	10 mM	0.2018 mL	1.0089 mL	2.0178 mL	5.0445 mL
	15 mM	0.1345 mL	0.6726 mL	1.3452 mL	3.3630 mL
	20 mM	0.1009 mL	0.5044 mL	1.0089 mL	2.5222 mL
	25 mM	0.0807 mL	0.4036 mL	0.8071 mL	2.0178 mL
	30 mM	0.0673 mL	0.3363 mL	0.6726 mL	1.6815 mL
	40 mM	0.0504 mL	0.2522 mL	0.5044 mL	1.2611 mL
	50 mM	0.0404 mL	0.2018 mL	0.4036 mL	1.0089 mL

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
용액&용해도
- In Vitro
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

CCR8 antagonist 1

All CCR Isoforms

Biological Activity

제품 설명

IC50 & Target

Parmacokinetics

Chemical Information

용액&용해도

In Vitro:

순도&문서

References

Help & FAQs

Complete Stock Solution Preparation Table