CCR8 Antagonist
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AZ084
0 ImagesAZ084 is a potent, selective, allosteric and oral active CCR8 allosteric antagonist, with a Ki of 0.9 nM. Has potential to treat asthma. AZ084 restrains the formation of the immunologically tolerant pre-metastatic niche (PMN) and tumor cells metastasis in lung by downregulating Treg differentiation. AZ084 can be used in studies of asthma and cancer.
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CCR8 antagonist 1
0 ImagesCCR8 antagonist 1 (Compound 15) is a potente human CCR8 antagonist with a Ki of 1.6 nM. CCR8 antagonist 1 has high safety and metabolic stability. CCR8 antagonist 1 can be used to study diseases such as asthma and multiple sclerosis.
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SB-649701
0 ImagesCat. No.: HY-153669CAS No.: 935262-95-6SB-649701 is a potent human CCR8 antagonist, with a pIC50 of 7.7. AZ084 can be used for the research of asthma.
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CCR8 antagonist 3
0 ImagesCat. No.: HY-160647CAS No.: 912463-57-1CCR8 antagonist 3 (compound 2) is a CCR8 antagonist with an IC50 value of 0.062 µM. CCR8 antagonist 3 shows human microsomal stability.
