688352-84-3
688352-84-3
Chemical Structure
R243
- CAS No.: 688352-84-3
- Formula:C21H27NO4
- Molecular Weight:357.44
IUPAC Name: 7-(2-(((3s,5s,7s)-adamantan-1-yl)oxy)ethyl)-7,8-dihydro-6H-[1,3]dioxolo[4',5':4,5]benzo[1,2-e][1,3]oxazine
InChIKey: JJMLDSFDOODCIR-MSMDPAEMSA-N
SMILES: [C@@H]12CC(C[C@H](C3)C1)(C[C@@H]3C2)OCCN4CC(C=C(OCO5)C5=C6)=C6OC4
Biological Activity: R243 is a potent and selective CCR8 antagonist. R243 inhibits CCL1/CCR8 interaction and inhibits CCR8 signaling and chemotaxis. R243 has antinociceptive and anti-inflammatory effects[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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R243 | 98.09% | R243 is a potent and selective CCR8 antagonist. R243 inhibits CCL1/CCR8 interaction and inhibits CCR8 signaling and chemotaxis. R243 has antinociceptive and anti-inflammatory effects. | ||||||||||||||||||||
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References
- [1]. Tomoyuki Oshio, et al. Chemokine Receptor CCR8 Is Required for Lipopolysaccharide-Triggered Cytokine Production in Mouse Peritoneal Macrophages. PLoS One. 2014 Apr 8;9(4):e94445. [Content Brief]
- [2]. Mario García-Domínguez, et al. The Systemic Administration of the Chemokine CCL1 Evokes Thermal Analgesia in Mice Through the Activation of the Endocannabinoid System. Cell Mol Neurobiol. 2019 Nov;39(8):1115-1124. [Content Brief]
