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ADDA 5 hydrochloride 

Cat. No.: HY-U00448 Purity: 98.07%
Handling Instructions

ADDA 5 hydrochloride is a partial non-competitive inhibitor of cytochrome c oxidase (CcO), with IC50s of 18.93 μM and 31.82 μM for purified CcO from human glioma and bovine heart, respectively.

For research use only. We do not sell to patients.

ADDA 5 hydrochloride Chemical Structure

ADDA 5 hydrochloride Chemical Structure

CAS No. : 473268-46-1

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 77 In-stock
Estimated Time of Arrival: December 31
5 mg USD 70 In-stock
Estimated Time of Arrival: December 31
10 mg USD 120 In-stock
Estimated Time of Arrival: December 31
25 mg USD 280 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
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Description

ADDA 5 hydrochloride is a partial non-competitive inhibitor of cytochrome c oxidase (CcO), with IC50s of 18.93 μM and 31.82 μM for purified CcO from human glioma and bovine heart, respectively.

IC50 & Target

IC50: 18.93 μM (CcO, human glioma), 31.82 μM (CcO, bovine heart)[1]

In Vitro

ADDA 5 hydrochloride is a partial non-competitive inhibitor of CcO, with IC50s of 18.93 μM and 31.82 μM for purified CcO from human glioma and bovine heart, respectively. ADDA 5 inhibits CcO activity in UTMZ and Jx22-derived GSCs, with IC50s of 21.4 ± 3.9 μM and 15.5 ± 2.8 μM. ADDA 5 (25 μM) shows a growth inhibitory effect on UTMZ cells, with an EC50 of 8.17 μM[1].

In Vivo

ADDA 5 (8 mg/kg, i.p.) significantly suppresses the growth of tumor in mice. ADDA 5 does not causes detectable toxicity at up to 80 mg/kg in mice[1].

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 65 mg/mL (160.10 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4631 mL 12.3153 mL 24.6305 mL
5 mM 0.4926 mL 2.4631 mL 4.9261 mL
10 mM 0.2463 mL 1.2315 mL 2.4631 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.12 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.12 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.12 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Animal Administration
[1]

UTMZ cells are transplanted into mice at 6 weeks of age, and after 12 days the mice are treated intraperitoneally with ADDA 5 (8 mg/kg) or DMSO-saline as a control. Tumor volume is measured once each week, starting at day 28 when tumors become visible. At 43 days, animals reach the end point and are killed, and the final tumor volume of both groups is determined[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

406.00

Formula

C₂₄H₃₆ClNO₂

CAS No.

473268-46-1

SMILES

OC(COCCC1(C2)CC3CC2CC(C3)C1)CN4CC5=C(C=CC=C5)CC4.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
ADDA 5 hydrochloride
Cat. No.:
HY-U00448
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ADDA 5 hydrochloride

Cat. No.: HY-U00448