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  4. Histamine glutarimide

Histamine glutarimide (XC8) is an orally active anti-asthma agent. Histamine glutarimide blocks the maturation of chemokines (CCL2, CCL7, CCL8, CCL13) and inhibits the migration of eosinophils and the degranulation of mast cells. In asthma models induced by carrageenan and rat ovalbumin, Histamine glutarimide can reduce airway resistance and the count of eosinophils in bronchoalveolar lavage fluid. Histamine glutarimide can be used in asthma research.

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Histamine glutarimide

Histamine glutarimide Chemical Structure

CAS No. : 1464897-15-1

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Histamine glutarimide Related Antibodies

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Description

Histamine glutarimide (XC8) is an orally active anti-asthma agent. Histamine glutarimide blocks the maturation of chemokines (CCL2, CCL7, CCL8, CCL13) and inhibits the migration of eosinophils and the degranulation of mast cells. In asthma models induced by carrageenan and rat ovalbumin, Histamine glutarimide can reduce airway resistance and the count of eosinophils in bronchoalveolar lavage fluid. Histamine glutarimide can be used in asthma research[1].

Clinical Trial
Molecular Weight

207.23

Formula

C10H13N3O2
CAS No.
SMILES

O=C1N(CCC2=CN=CN2)C(CCC1)=O
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Histamine glutarimide Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Histamine glutarimide1464897-15-1XC8XC 8XC-8CCRCC chemokine receptorPhase 1 clinical trialhistamine glutarimideasthma treatmentpharmacokineticssafety profiledose proportionalityhealthy volunteersoral anti-asthmatic agentInhibitorinhibitorinhibit

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