WIKI4

Name: WIKI4
Brand: MedChemExpress
SKU: HY-16910
Rating: 5.0 (4 reviews)

Cat. No.: HY-16910 Pureza: 99.61%: Ficha de datos
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WIKI4 is a potent tankyrase inhibitor with an IC₅₀ of 26 nM for TNKS2. WIKI4 potently inhibits Wnt/β-catenin signaling and that its half-maximal response dose is 75 nM. WIKI4 mediates its effects on Wnt/β-catenin signaling by inhibiting the enzymatic activity of TNKS2. WIKI4 is cytotoxic to SCLC cells with an IC₅₀ value of 0.02 μM.

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No. CAS : 838818-26-1

Tamaño	Stock	Cantidad

Muestra gratis (0.1 - 0.2 mg)	Solicite ahora
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	En stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	En stock	Estimated Time of Arrival: December 31
Solid
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
25 mg	En stock	Estimated Time of Arrival: December 31
50 mg	En stock	Estimated Time of Arrival: December 31
100 mg	En stock	Estimated Time of Arrival: December 31
500 mg	En stock	Estimated Time of Arrival: December 31
1 g	En stock	Estimated Time of Arrival: December 31
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Revisión del cliente

Based on 4 publication(s) in Google Scholar

Other Forms of WIKI4:

WIKI4 (GMP) Obtener un presupuesto

4 Publications Citing Use of MCE WIKI4

RT-PCR

: WIKI4 purchased from MedChemExpress. Usage Cited in: Dig Dis Sci. 2018 Sep;63(9):2341-2350. [Abstract]; The expression of c-myc and Cyclin D1 is further decreased after adding β-catenin inhibitor (WIKI4) in protein level.

: WIKI4 purchased from MedChemExpress. Usage Cited in: Dig Dis Sci. 2018 Sep;63(9):2341-2350. [Abstract]; The expression of c-myc and Cyclin D1 is further decreased after adding β-catenin inhibitor (WIKI4) in mRNA level.

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Ver todos los productos específicos de isoformas PARP:

Ver todas las isoformas

PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

Ver todos los productos específicos de isoformas Wnt:

Ver todas las isoformas

Wnt1 Wnt3 Wnt5 Wnt7 Wnt11

Actividad biológica
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Descripciòn

WIKI4 is a potent tankyrase inhibitor with an IC₅₀ of 26 nM for TNKS2. WIKI4 potently inhibits Wnt/β-catenin signaling and that its half-maximal response dose is 75 nM. WIKI4 mediates its effects on Wnt/β-catenin signaling by inhibiting the enzymatic activity of TNKS2^[1]^[2]. WIKI4 is cytotoxic to SCLC cells with an IC₅₀ value of 0.02 μM^[3].

IC₅₀ & Target^[2]

TNKS2

26 nM (IC₅₀)

In Vitro

WIKI4 (100 nM, 1 μM; 6 days; DLD1 cells) inhibits growth of DLD1 cells relative to DMSO controls in media containing low serum. WIKI4 inhibits expression of β-catenin target genes and cellular responses to Wnt/β-catenin signaling^[1].
WIKI4 (1 μM; 2 hours, 4 hours, 6 hours, or 24 hours; DLD1 cells) significantly increases the steady-state abundance of AXIN1 and AXIN2^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	DLD1 cells
Concentration:	100 nM, 1 μM
Incubation Time:	6 days
Result:	Inhibited growth of DLD1 cells.

Western Blot Analysis^[1]

Cell Line:	DLD1 cells
Concentration:	1 μM
Incubation Time:	2 hours,4 hours,6 hours, or 24 hours
Result:	Significantly increased the steady-state abundance of AXIN1 and AXIN2.

Peso molecular

521.59

Fòrmula

C₂₉H₂₃N₅O₃S

No. CAS

838818-26-1

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C1N(CCCSC2=NN=C(C3=CC=NC=C3)N2C4=CC=C(OC)C=C4)C(C5=CC=CC6=CC=CC1=C56)=O

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvente y solubilidad

In Vitro:

DMSO : 6.8 mg/mL (13.04 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9172 mL	9.5861 mL	19.1721 mL
5 mM	0.3834 mL	1.9172 mL	3.8344 mL
10 mM	0.1917 mL	0.9586 mL	1.9172 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Pureza y Documentación

Purity: 99.93%

Select Batch:

Ficha de datos (278 KB) SDS (537 KB)

COA (254 KB) LCMS (269 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. James RG, et al. WIKI4, a novel inhibitor of tankyrase and Wnt/ß-catenin signaling. PLoS One. 2012;7(12):e50457. [Content Brief]

[2]. Haikarainen T, et al. Structural basis and selectivity of tankyrase inhibition by a Wnt signaling inhibitor WIKI4. PLoS One. 2013 Jun 6;8(6):e65404. [Content Brief]

[3]. Sadava D, et al. The effect of brassinolide, a plant steroid hormone, on drug resistant small-cell lung carcinoma cells. Biochem Biophys Res Commun. 2017 Nov 4;493(1):783-787. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.9172 mL	9.5861 mL	19.1721 mL	47.9304 mL
	5 mM	0.3834 mL	1.9172 mL	3.8344 mL	9.5861 mL
	10 mM	0.1917 mL	0.9586 mL	1.9172 mL	4.7930 mL

WIKI4 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WIKI4838818-26-1WIKI 4WIKI-4PARPβ-cateninWntpoly ADP ribose polymerase Beta cateninInhibitorinhibitorinhibit

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WIKI4

Revisión del cliente

Other Forms of WIKI4:

WIKI4 Related Antibodies

4 Publications Citing Use of MCE WIKI4

Recomendaciones destacadas

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Ver todos los productos específicos de isoformas PARP:

Ver todos los productos específicos de isoformas Wnt:

Actividad biológica

Pureza y Documentación

Referencias

Revisión del cliente

WIKI4 Related Antibodies

Calculadora de molaridad

Calculadora de dilución

Complete Stock Solution Preparation Table

WIKI4 Related Classifications

Keywords:

Productos vistos recientemente:

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