2. Apoptosis Anti-infection
  3. Caspase Apoptosis Parasite
  4. Diuvaretin

Diuvaretin is an antimalarial agent and a C-phenylated dihydrochalcone. Diuvaretin can be isolated from the roots of U. acuminata. Diuvaretin increases the activity of Caspase-3 and triggers Apoptosis. Diuvaretin exhibits antiparasitic activity against Plasmodium falciparum. Diuvaretin can be used in the research of promyelocytic leukemia and malaria.

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Diuvaretin

Diuvaretin Chemical Structure

CAS No. : 61463-04-5

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Diuvaretin Related Antibodies

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Description

Diuvaretin is an antimalarial agent and a C-phenylated dihydrochalcone. Diuvaretin can be isolated from the roots of U. acuminata. Diuvaretin increases the activity of Caspase-3 and triggers Apoptosis. Diuvaretin exhibits antiparasitic activity against Plasmodium falciparum. Diuvaretin can be used in the research of promyelocytic leukemia and malaria[1][2].

IC50 & Target[1][2]

Caspase-3

 

Plasmodium

 

In Vitro

Diuvaretin (48 h) potently inhibits the proliferation of promyelocytic leukemia HL-60 cells, with an IC50 value of 6.1 μM[1].
Diuvaretin (10-20 μM; 24-48 h) induces morphological changes of apoptosis (chromatin condensation and nuclear degradation) in promyelocytic leukemia HL-60 cells[1].
Diuvaretin (5-20 μM; 6-24 h) induces G1 phase arrest and sub-G1 peak formation in promyelocytic leukemia HL-60 cells, while 5 μM Diuvaretin has no effect on cell cycle distribution[1].
Diuvaretin inhibits the growth of Plasmodium falciparum with an IC50 of 3.5 mg/mL[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Diuvaretin Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: human promyelocytic leukemia HL-60 cells
Concentration: dose-response
Incubation Time: 48 h
Result: Exhibited dose-dependent growth inhibition of HL-60 cells, with an IC50 value of 6.1 μM.
Showed stronger cytotoxicity than isouvaretin and slightly stronger cytotoxicity than uvaretin.

Cell Cycle Analysis[1]

Cell Line: human promyelocytic leukemia HL-60 cells
Concentration: 5 μM, 10 μM, 20 μM
Incubation Time: 6 h, 12 h, 24 h
Result: Induced accumulation of cells in the G1 phase and the appearance of a sub-G1 peak (indicative of apoptotic cells) at 10 μM or 20 μM for 12 h or 24 h.
Showed no cell cycle changes with 5 μM across 6-24 h incubation times.
Molecular Weight

484.55

Formula

C30H28O6
CAS No.
SMILES

O=C(C=1C(O)=C(C(O)=C(C1OC)CC=2C=CC=CC2O)CC=3C=CC=CC3O)CCC=4C=CC=CC4
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Diuvaretin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Diuvaretin61463-04-5CaspaseApoptosisParasiteDNA fragmentationG1-phase cell cycle arrestHL-60 cellsKB cell cultureshuman promyelocytic leukemiaapoptosisnuclear degradationchromosomal condensationPlasmodium falciparumcaspase-3Inhibitorinhibitorinhibit

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