Diuvaretin
Diuvaretin is an antimalarial agent and a C-phenylated dihydrochalcone. Diuvaretin can be isolated from the roots of U. acuminata. Diuvaretin increases the activity of Caspase-3 and triggers Apoptosis. Diuvaretin exhibits antiparasitic activity against Plasmodium falciparum. Diuvaretin can be used in the research of promyelocytic leukemia and malaria.
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- CAS 番号: 61463-04-5
- 分子式: C30H28O6
- 分子量:484.55
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Caspase-3 |
Plasmodium |
Diuvaretin (48 h) potently inhibits the proliferation of promyelocytic leukemia HL-60 cells, with an IC50 value of 6.1 μM[1].
Diuvaretin (10-20 μM; 24-48 h) induces morphological changes of apoptosis (chromatin condensation and nuclear degradation) in promyelocytic leukemia HL-60 cells[1].
Diuvaretin (5-20 μM; 6-24 h) induces G1 phase arrest and sub-G1 peak formation in promyelocytic leukemia HL-60 cells, while 5 μM Diuvaretin has no effect on cell cycle distribution[1].
Diuvaretin inhibits the growth of Plasmodium falciparum with an IC50 of 3.5 mg/mL[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human promyelocytic leukemia HL-60 cells
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Concentration:dose-response
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Incubation Time:48 h
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Result:Exhibited dose-dependent growth inhibition of HL-60 cells, with an IC50 value of 6.1 μM.
Showed stronger cytotoxicity than isouvaretin and slightly stronger cytotoxicity than uvaretin.
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Cell Line:human promyelocytic leukemia HL-60 cells
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Concentration:5 μM, 10 μM, 20 μM
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Incubation Time:6 h, 12 h, 24 h
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Result:Induced accumulation of cells in the G1 phase and the appearance of a sub-G1 peak (indicative of apoptotic cells) at 10 μM or 20 μM for 12 h or 24 h.
Showed no cell cycle changes with 5 μM across 6-24 h incubation times.
化学情報
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CAS 番号 61463-04-5
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分子量 484.55
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分子式 C30H28O6
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SMILES
O=C(C=1C(O)=C(C(O)=C(C1OC)CC=2C=CC=CC2O)CC=3C=CC=CC3O)CCC=4C=CC=CC4
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Nakatani N, et al. Induction of apoptosis in human promyelocytic leukemia cell line HL-60 by C-benzylated dihydrochalcones, uvaretin, isouvaretin and diuvaretin. Biol Pharm Bull. 2005 Jan;28(1):83-6. [Content Brief]
[2]. Makangara JJ, et al. A novel phenanthrenolide and C-benzyl dihydrochalcones from Uvaria puguensis. Nat Prod Lett. 2002;16(4):267-272. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Diuvaretin 関連分類
HY-N13034 関連分類
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