61463-04-5
Chemical Structure
Diuvaretin
- CAS No.: 61463-04-5
- Formula:C30H28O6
- Molecular Weight:484.55
IUPAC Name: 1-(2,4-dihydroxy-3,5-bis(2-hydroxybenzyl)-6-methoxyphenyl)-3-phenylpropan-1-one
InChIKey: KDEMELRYKGOXDL-UHFFFAOYSA-N
SMILES: O=C(C=1C(O)=C(C(O)=C(C1OC)CC=2C=CC=CC2O)CC=3C=CC=CC3O)CCC=4C=CC=CC4
Biological Activity: Diuvaretin is an antimalarial agent and a C-phenylated dihydrochalcone. Diuvaretin can be isolated from the roots of U. acuminata. Diuvaretin increases the activity of Caspase-3 and triggers Apoptosis. Diuvaretin exhibits antiparasitic activity against Plasmodium falciparum. Diuvaretin can be used in the research of promyelocytic leukemia and malaria[1][2].
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Diuvaretin | Diuvaretin is an antimalarial agent and a C-phenylated dihydrochalcone. Diuvaretin can be isolated from the roots of U. acuminata. Diuvaretin increases the activity of Caspase-3 and triggers Apoptosis. Diuvaretin exhibits antiparasitic activity against Plasmodium falciparum. Diuvaretin can be used in the research of promyelocytic leukemia and malaria. | |||||||||||||||||||||
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References
- [1]. Nakatani N, et al. Induction of apoptosis in human promyelocytic leukemia cell line HL-60 by C-benzylated dihydrochalcones, uvaretin, isouvaretin and diuvaretin. Biol Pharm Bull. 2005 Jan;28(1):83-6. [Content Brief]
- [2]. Makangara JJ, et al. A novel phenanthrenolide and C-benzyl dihydrochalcones from Uvaria puguensis. Nat Prod Lett. 2002;16(4):267-272. [Content Brief]
