EGFR/BRAFV600E-IN-2 

EGFR/BRAFV600E-IN-2 (compound 3g) is a potential multi-target inhibitor of EGFR, BRAF^V600E, and EGFR^T790M, and an inducer of apoptosis. EGFR/BRAFV600E-IN-2 can activate caspase-3, 8, and Bax, and downregulate the anti-apoptotic protein Bcl2, inducing apoptosis. EGFR/BRAF V600E-IN-2 also has antioxidant activity and DPPH free radical scavenging potency^[1].

EGFR/BRAFV600E-IN-2 (comound 3g) effectively inhibits four human cancer cell lines: Panc-1 (pancreatic cancer cell line), MCF-7 (breast cancer cell line), HT-29 (colon cancer cell line), and A-549 (human epithelial cancer cell line), with better effective activity than Erlotinib (HY-50896)^[1].
EGFR/BRAFV600E-IN-2 displays promising antioxidant activity at 10 µM, with DPPH radical scavenging of 70.6%^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

406.44

C₂₅H₁₈N₄O₂

O=C1NC2=C(C=C(C)C=C2)C(N3N=NC(C(C4=CC=CC=C4)=O)=C3C5=CC=CC=C5)=C1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. El-Sheref EM, et al. Synthesis, Antioxidant and Antiproliferative Actions of 4-(1,2,3-Triazol-1-yl)quinolin-2(1H)-ones as Multi-Target Inhibitors. Int J Mol Sci. 2023 Aug 27;24(17):13300.  [Content Brief]