2. PI3K/Akt/mTOR Epigenetics Cell Cycle/DNA Damage Apoptosis
  3. PI3K HDAC Apoptosis
  4. Fimepinostat mesylate

Fimepinostat mesylate  (Synonyms: CUDC-907 mesylate)

製品番号: HY-155890
取扱説明書 Technical Support

Fimepinostat mesylate potently inhibits class I PI3Ks as well as classes I and II HDAC enzymes with an IC50 of 19/54/39 nM and 1.7/5.0/1.8/2.8 nM for PI3Kα/PI3Kβ/PI3Kδ and HDAC1/HDAC2/HDAC3/HDAC10 , respectively.

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CAS 番号 : 1401998-36-4

容量 在庫状況
50 mg   お問い合わせ  
100 mg   お問い合わせ  
250 mg   お問い合わせ  

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Other 在庫あり Forms of Fimepinostat mesylate:

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Fimepinostat mesylate 関連抗体

Top Publications Citing Use of Products

    Fimepinostat mesylate purchased from MedChemExpress. Usage Cited in: J Clin Invest. 2025 Jun 2;135(11):e187490.  [Abstract]

    The indicated cell lines were treated with Fimepinostat , and cell viability was measured by CellTiter-Glo assays. IC50 values are shown.

    Fimepinostat mesylate purchased from MedChemExpress. Usage Cited in: J Clin Invest. 2025 Jun 2;135(11):e187490.  [Abstract]

    The indicated cell lines were treated with 5 nM Fimepinostat, 2 nM Romidepsin, or 500 nM Entinostat for 48 hours. The indicated proteins were measured by Western blot. Histone H3 serves as loading control.

    Fimepinostat mesylate purchased from MedChemExpress. Usage Cited in: J Clin Invest. 2025 Jun 2;135(11):e187490.  [Abstract]

    NSG mice were implanted with DNPC BCaP-1 PDXs and treated with vehicle, Fimepinostat (75 mg/kg orally, 5 times per week), or Romidepsin (1.5 mg/kg intraperitoneally, 2 times per week). Tumor volume (top) and mouse body weight (bottom) are shown.

    Fimepinostat mesylate purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2020 Oct 17;39(1):219.  [Abstract]

    DNA damage detected by comet assay in SCLC cells upon treatment with 10 nM CUDC-907 or 10 μM olaparib alone and in combination for 48 h.

    Fimepinostat mesylate purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2020 Oct 17;39(1):219.  [Abstract]

    Representative immunohistochemistry images of Ki67, cleaved-caspase3 (CC3), c-MYC, Rad51, and Ku80 on PDX tumors treated with CUDC-907 (75 mg/kg) and olaparib alone or in combination.

    Fimepinostat mesylate purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2019 May;40(5):677-688  [Abstract]

    Aspc-1 and Capan-1 cells are collected for Western blotting with the indicated antibodies after treatment with CUDC-907 for 48 h.

    PI3K アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

    HDAC アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

    • 生物活性

    • 純度とドキュメンテーション

    • 参考文献

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    製品説明

    Fimepinostat mesylate potently inhibits class I PI3Ks as well as classes I and II HDAC enzymes with an IC50 of 19/54/39 nM and 1.7/5.0/1.8/2.8 nM for PI3Kα/PI3Kβ/PI3Kδ and HDAC1/HDAC2/HDAC3/HDAC10 , respectively.

    分子量

    604.66

    分子式

    C24H28N8O7S2
    CAS 番号
    SMILES

    O=C(C1=CN=C(N(CC2=CC3=NC(C4=CC=C(OC)N=C4)=NC(N5CCOCC5)=C3S2)C)N=C1)NO.CS(=O)(O)=O
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    Please store the product under the recommended conditions in the Certificate of Analysis.
    純度とドキュメンテーション
    参考文献
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    Fimepinostat mesylate Related Classifications

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      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Fimepinostat1401998-36-4CUDC-907CUDC907CUDC 907PI3KHDACApoptosisPhosphoinositide 3-kinaseHistone deacetylasesInhibitorinhibitorinhibit

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    製品番号:
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