2. Cell Cycle/DNA Damage
  3. CDK
  4. (R)-Roscovitine

(R)-Roscovitine  (Synonyms: Seliciclib; CYC202)

Cat. No.: HY-30237 Pureté: 99.53%
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(R)-Roscovitine (Seliciclib) is an orally bioavailable, selective and BBB-permeable CDKs inhibitor with IC50s of 0.2 μM, 0.65 μM, and 0.7 μM for CDK5, Cdc2, and CDK2, respectively.

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CAS No. : 186692-46-6

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Based on 34 publication(s) in Google Scholar

Other Forms of (R)-Roscovitine:

(R)-Roscovitine Related Antibodies

Top Publications Citing Use of Products

34 Publications Citing Use of MCE (R)-Roscovitine

Flow Cytometry
Cell Imaging/Staining
WB

    (R)-Roscovitine purchased from MedChemExpress. Usage Cited in: J Virol. 2023 Jun 29;97(6):e0037023.  [Abstract]

    Cell cycle distribution of T24 and UMUC-3 cells was analyzed 48 h posttreatment with 10 mM nutlin-3a, 10 mM LEE011, 1 mM CI-1040, and 10 mM roscovitine. Then, 24 h posttreatment, cells were infected with 100 MOI dl70-3. After further 24-h cultivation, cells were fixed, PI stained, and FACS analyzed using a BD FACS Calibur Flow Cytometry System.

    (R)-Roscovitine purchased from MedChemExpress. Usage Cited in: J Virol. 2023 Jun 29;97(6):e0037023.  [Abstract]

    The levels of Rb and pRb expression were analyzed using immunoblotting in T24, UMUC-3, and A549 cells after 24-h treatment with the indicated concentrations of nutlin-3a, CI 1040, LEE011, and roscovitine.

    (R)-Roscovitine purchased from MedChemExpress. Usage Cited in: J Virol. 2023 Jun 29;97(6):e0037023.  [Abstract]

    Roscovitine (10 μM; 48 h). Visualization and GFP expression analyses were performed in UMUC-3 cells 48 hours postinfection with E1-GFP/RGD with and without 10 mM LEE011.

    (R)-Roscovitine purchased from MedChemExpress. Usage Cited in: Mol Cancer Res. 2020 Jan;18(1):91-104.  [Abstract]

    EW8 cells were released from a thymidine double block in the presence of LY2603618 (1 μM), Roscovitine (10 μM), or the combination of LY2603618 and Roscovitine. Cellular lysates were collected for immunoblotting 4 h after release from the block.

    (R)-Roscovitine purchased from MedChemExpress. Usage Cited in: Neuroreport. 2018 Mar 7;29(4):241-246.  [Abstract]

    R-E 235da1 exposure increases Cdk5 activity. Protein expression levels of P-histone H1 and Cdk5. P-histone H1 levels represent the activity of Cdk5. Bands for Cdk5 are the input. R-E 235da1 exposure increased Cdk5 activity.

    Voir tous les produits spécifiques à Isoform CDK:

    Voir toutes les isoformes
    CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

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    Description

    (R)-Roscovitine (Seliciclib) is an orally bioavailable, selective and BBB-permeable CDKs inhibitor with IC50s of 0.2 μM, 0.65 μM, and 0.7 μM for CDK5, Cdc2, and CDK2, respectively.

    IC50 & Target[1]

    cdc2/cyclin B

    0.65 μM (IC50)

    cdk2/cyclin A

    0.7 μM (IC50)

    Cdk2/cyclin E2

    0.7 μM (IC50)

    CDK5/p35

    0.16 μM (IC50)

    GST-erk1

    30 μM (IC50)

    erk1

    34 μM (IC50)

    erk2

    14 μM (IC50)

    IR tyrosine kinase

    70 μM (IC50)

    Cellular Effect
    Cell Line Type Value Description References
    786-0 GI50
    25.1 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human 786-0 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human 786-0 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    786-0 GI50
    25.1 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human 786-0 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human 786-0 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    786-0 GI50
    25.1 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human 786-0 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human 786-0 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    A2780 GI50
    12.5 3
    Compound: 1, alphaR-1, CYC202, Seliciclib, R-roscovitine
    Growth inhibition of cisplatin-resistant human A2780 cells after 96 hrs by sulforhodamine B assay
    Growth inhibition of cisplatin-resistant human A2780 cells after 96 hrs by sulforhodamine B assay
    		[PMID: 21982796]
    A2780 GI50
    12.5 3
    Compound: 1, alphaR-1, CYC202, Seliciclib, R-roscovitine
    Growth inhibition of cisplatin-resistant human A2780 cells after 96 hrs by sulforhodamine B assay
    Growth inhibition of cisplatin-resistant human A2780 cells after 96 hrs by sulforhodamine B assay
    		[PMID: 21982796]
    A2780 GI50
    4.45 3
    Compound: 1, alphaR-1, CYC202, Seliciclib, R-roscovitine
    Growth inhibition of cisplatin-susceptible human A2780 cells after 96 hrs by sulforhodamine B assay
    Growth inhibition of cisplatin-susceptible human A2780 cells after 96 hrs by sulforhodamine B assay
    		[PMID: 21982796]
    A2780 GI50
    4.45 3
    Compound: 1, alphaR-1, CYC202, Seliciclib, R-roscovitine
    Growth inhibition of cisplatin-susceptible human A2780 cells after 96 hrs by sulforhodamine B assay
    Growth inhibition of cisplatin-susceptible human A2780 cells after 96 hrs by sulforhodamine B assay
    		[PMID: 21982796]
    A-375 IC50
    11.79 3
    Compound: Roscovitine
    Antiproliferative activity against human A-375 cells assessed as reduction in cell growth incubated for 72 hrs by CCK-8 assay
    Antiproliferative activity against human A-375 cells assessed as reduction in cell growth incubated for 72 hrs by CCK-8 assay
    		[PMID: 32361064]
    A-375 IC50
    11.79 3
    Compound: Roscovitine
    Antiproliferative activity against human A-375 cells assessed as reduction in cell growth incubated for 72 hrs by CCK-8 assay
    Antiproliferative activity against human A-375 cells assessed as reduction in cell growth incubated for 72 hrs by CCK-8 assay
    		[PMID: 32361064]
    A498 GI50
    50.1 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human A498 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human A498 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    A498 GI50
    50.1 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human A498 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human A498 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    A549 IC50
    > 10 3
    Compound: Roscovitine
    Antiproliferative activity against human A549 cells measured after 72 hrs by CCK8 assay
    Antiproliferative activity against human A549 cells measured after 72 hrs by CCK8 assay
    		[PMID: 31272794]
    A549 GI50
    15 3
    Compound: Roscovitine
    Antiproliferative activity against human A549 cells after 72 hrs by sulforhodamine B assay
    Antiproliferative activity against human A549 cells after 72 hrs by sulforhodamine B assay
    		[PMID: 21080703]
    A549 GI50
    12.6 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human A549 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human A549 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    A549 GI50
    12.6 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human A549 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human A549 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    A549 IC50
    14.7 3
    Compound: Roscovitine
    Antiproliferative activity against human A549 cells after 3 days by SRB assay
    Antiproliferative activity against human A549 cells after 3 days by SRB assay
    		[PMID: 20361800]
    A549 IC50
    14.14 3
    Compound: (R)-roscovitine
    Cytotoxicity against human A549 cells after 48 hrs by SRB assay
    Cytotoxicity against human A549 cells after 48 hrs by SRB assay
    		[PMID: 23036956]
    A-375 IC50
    11.79 3
    Compound: Roscovitine
    Antiproliferative activity against human A-375 cells assessed as reduction in cell growth incubated for 72 hrs by CCK-8 assay
    Antiproliferative activity against human A-375 cells assessed as reduction in cell growth incubated for 72 hrs by CCK-8 assay
    		[PMID: 32361064]
    A549 IC50
    14.7 3
    Compound: Roscovitine
    Antiproliferative activity against human A549 cells after 3 days by SRB assay
    Antiproliferative activity against human A549 cells after 3 days by SRB assay
    		[PMID: 20361800]
    A2780 GI50
    12.5 3
    Compound: 1, alphaR-1, CYC202, Seliciclib, R-roscovitine
    Growth inhibition of cisplatin-resistant human A2780 cells after 96 hrs by sulforhodamine B assay
    Growth inhibition of cisplatin-resistant human A2780 cells after 96 hrs by sulforhodamine B assay
    		[PMID: 21982796]
    A549 IC50
    >10 3
    Compound: Roscovitine
    Antiproliferative activity against human A549 cells measured after 72 hrs by CCK8 assay
    Antiproliferative activity against human A549 cells measured after 72 hrs by CCK8 assay
    		[PMID: 31272794]
    A549 IC50
    2.18 3
    Compound: 1
    Cytotoxicity against human A549 cells after 48 hrs by MTT assay
    Cytotoxicity against human A549 cells after 48 hrs by MTT assay
    		[PMID: 23623491]
    A549 GI50
    15 3
    Compound: Roscovitine
    Antiproliferative activity against human A549 cells after 72 hrs by sulforhodamine B assay
    Antiproliferative activity against human A549 cells after 72 hrs by sulforhodamine B assay
    		[PMID: 21080703]
    A2780 GI50
    4.45 3
    Compound: 1, alphaR-1, CYC202, Seliciclib, R-roscovitine
    Growth inhibition of cisplatin-susceptible human A2780 cells after 96 hrs by sulforhodamine B assay
    Growth inhibition of cisplatin-susceptible human A2780 cells after 96 hrs by sulforhodamine B assay
    		[PMID: 21982796]
    A549 IC50
    2.18 3
    Compound: 1
    Cytotoxicity against human A549 cells after 48 hrs by MTT assay
    Cytotoxicity against human A549 cells after 48 hrs by MTT assay
    		[PMID: 23623491]
    A549 IC50
    14.14 3
    Compound: (R)-roscovitine
    Cytotoxicity against human A549 cells after 48 hrs by SRB assay
    Cytotoxicity against human A549 cells after 48 hrs by SRB assay
    		[PMID: 23036956]
    A498 GI50
    50.1 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human A498 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human A498 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    ACHN GI50
    12.6 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human ACHN cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human ACHN cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    ACHN GI50
    12.6 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human ACHN cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human ACHN cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    A498 IC50
    13.2 3
    Compound: Chemicel probe : R-CYC202
    Cytotoxicity against p53 wild-type human A498 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
    Cytotoxicity against p53 wild-type human A498 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
    		[PMID: 12432547]
    ACHN IC50
    2.88 3
    Compound: 1
    Cytotoxicity against human ACHN cells after 48 hrs by MTT assay
    Cytotoxicity against human ACHN cells after 48 hrs by MTT assay
    		[PMID: 23623491]
    ACHN IC50
    2.88 3
    Compound: 1
    Cytotoxicity against human ACHN cells after 48 hrs by MTT assay
    Cytotoxicity against human ACHN cells after 48 hrs by MTT assay
    		[PMID: 23623491]
    ASPC1 IC50
    17767 1
    Compound: Roscovitine
    Antiproliferative activity against human AsPC1 cells after 72 hrs by prestoblue assay
    Antiproliferative activity against human AsPC1 cells after 72 hrs by prestoblue assay
    		[PMID: 30343954]
    Oocyte IC50
    0.65 1
    Compound: 3; CYC202
    Inhibition of starfish oocyte CDK1/Cyclin B using histone H1 as substrate incubated for 10 mins in presence of [gamma-32P]ATP by scintillation counter analysis
    Inhibition of starfish oocyte CDK1/Cyclin B using histone H1 as substrate incubated for 10 mins in presence of [gamma-32P]ATP by scintillation counter analysis
    		[PMID: 35485642]
    Caco-2 IC50
    10 3
    Compound: Roscovitine
    Antiproliferative activity against human Caco2 cells after 48 hrs by Hoechst 33342 staining-based assay
    Antiproliferative activity against human Caco2 cells after 48 hrs by Hoechst 33342 staining-based assay
    		[PMID: 30655216]
    BXPC-3 IC50
    15284 1
    Compound: Roscovitine
    Antiproliferative activity against human BxPC3 cells after 72 hrs by prestoblue assay
    Antiproliferative activity against human BxPC3 cells after 72 hrs by prestoblue assay
    		[PMID: 30343954]
    Caco-2 IC50
    10 3
    Compound: Roscovitine
    Antiproliferative activity against human Caco2 cells after 48 hrs by Hoechst 33342 staining-based assay
    Antiproliferative activity against human Caco2 cells after 48 hrs by Hoechst 33342 staining-based assay
    		[PMID: 30655216]
    Caco-2 IC50
    3 3
    Compound: Roscovitine
    Antiproliferative activity against human Caco2 cells after 48 hrs by Hoechst 3342 staining analysis
    Antiproliferative activity against human Caco2 cells after 48 hrs by Hoechst 3342 staining analysis
    		[PMID: 27019296]
    Caco-2 IC50
    10 3
    Compound: Roscovitin
    Cytotoxicity against human Caco2 cells after 48 hrs by Hoechst-33342 staining-based imaging analysis
    Cytotoxicity against human Caco2 cells after 48 hrs by Hoechst-33342 staining-based imaging analysis
    		[PMID: 21944287]
    Caco-2 IC50
    6 3
    Compound: Roscovitine
    Antiproliferative activity against human Caco-2 cells after 72 hrs by imaging analysis
    Antiproliferative activity against human Caco-2 cells after 72 hrs by imaging analysis
    		[PMID: 19665384]
    Caco-2 IC50
    12.9 3
    Compound: Rosco
    Cytotoxicity against human Caco2 cells assessed as cell viability after 48 hrs by Hoechst 33342 staining based assay
    Cytotoxicity against human Caco2 cells assessed as cell viability after 48 hrs by Hoechst 33342 staining based assay
    		[PMID: 28214231]
    Caco-2 IC50
    5 3
    Compound: Roscovitine
    Antiproliferative activity against human Caco2 cells incubated for 48 hrs by Hoechst 3342 dye staining based assay
    Antiproliferative activity against human Caco2 cells incubated for 48 hrs by Hoechst 3342 dye staining based assay
    		[PMID: 23063566]
    Caco-2 IC50
    14 3
    Compound: Roscovitine
    Cytotoxicity against human Caco-2 cells assessed as reduction in cell viability after 48 hrs
    Cytotoxicity against human Caco-2 cells assessed as reduction in cell viability after 48 hrs
    		[PMID: 34601029]
    A549 GI50
    12.6 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human A549 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human A549 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    Caco-2 IC50
    10 3
    Compound: Roscovitin
    Cytotoxicity against human Caco2 cells after 48 hrs by Hoechst-33342 staining-based imaging analysis
    Cytotoxicity against human Caco2 cells after 48 hrs by Hoechst-33342 staining-based imaging analysis
    		[PMID: 21944287]
    Caco-2 IC50
    16 3
    Compound: Roscovitin
    Cytotoxicity against human Caco2 cells assessed as cell growth inhibition
    Cytotoxicity against human Caco2 cells assessed as cell growth inhibition
    		[PMID: 26934105]
    Caco-2 IC50
    17 3
    Compound: Roscovitine
    Cytotoxicity against human CaCo-2 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst-33342 staining based cell counting method (Rvb > 25 microM)
    Cytotoxicity against human CaCo-2 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst-33342 staining based cell counting method (Rvb > 25 microM)
    		[PMID: 33422908]
    A549 GI50
    15 3
    Compound: Roscovitine
    Antiproliferative activity against human A549 cells after 72 hrs by sulforhodamine B assay
    Antiproliferative activity against human A549 cells after 72 hrs by sulforhodamine B assay
    		[PMID: 21080703]
    Caco-2 IC50
    12.9 3
    Compound: Rosco
    Cytotoxicity against human Caco2 cells assessed as cell viability after 48 hrs by Hoechst 33342 staining based assay
    Cytotoxicity against human Caco2 cells assessed as cell viability after 48 hrs by Hoechst 33342 staining based assay
    		[PMID: 28214231]
    Caco-2 IC50
    3 3
    Compound: Roscovitine
    Antiproliferative activity against human Caco2 cells after 48 hrs by Hoechst 3342 staining analysis
    Antiproliferative activity against human Caco2 cells after 48 hrs by Hoechst 3342 staining analysis
    		[PMID: 27019296]
    A549 IC50
    14.14 3
    Compound: (R)-roscovitine
    Cytotoxicity against human A549 cells after 48 hrs by SRB assay
    Cytotoxicity against human A549 cells after 48 hrs by SRB assay
    		[PMID: 23036956]
    Caco-2 IC50
    14 3
    Compound: Roscovitine
    Cytotoxicity against human Caco-2 cells assessed as reduction in cell viability after 48 hrs
    Cytotoxicity against human Caco-2 cells assessed as reduction in cell viability after 48 hrs
    		[PMID: 34601029]
    Caco-2 IC50
    3 3
    Compound: Roscovitine
    Cytotoxicity against human Caco2 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst 3342 staining based assay
    Cytotoxicity against human Caco2 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst 3342 staining based assay
    		[PMID: 26142492]
    A549 IC50
    14.7 3
    Compound: Roscovitine
    Antiproliferative activity against human A549 cells after 3 days by SRB assay
    Antiproliferative activity against human A549 cells after 3 days by SRB assay
    		[PMID: 20361800]
    Caco-2 IC50
    5 3
    Compound: Roscovitine
    Antiproliferative activity against human Caco2 cells incubated for 48 hrs by Hoechst 3342 dye staining based assay
    Antiproliferative activity against human Caco2 cells incubated for 48 hrs by Hoechst 3342 dye staining based assay
    		[PMID: 23063566]
    Caco-2 IC50
    3 3
    Compound: Roscovitine
    Cytotoxicity against human Caco2 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst 3342 staining based assay
    Cytotoxicity against human Caco2 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst 3342 staining based assay
    		[PMID: 26142492]
    A549 IC50
    15.9 3
    Compound: Chemicel probe : R-CYC202
    Cytotoxicity against p53 wild-type human A549 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
    Cytotoxicity against p53 wild-type human A549 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
    		[PMID: 12432547]
    Caco-2 IC50
    6 3
    Compound: Roscovitine
    Antiproliferative activity against human Caco-2 cells after 72 hrs by imaging analysis
    Antiproliferative activity against human Caco-2 cells after 72 hrs by imaging analysis
    		[PMID: 19665384]
    A549 IC50
    2.18 3
    Compound: 1
    Cytotoxicity against human A549 cells after 48 hrs by MTT assay
    Cytotoxicity against human A549 cells after 48 hrs by MTT assay
    		[PMID: 23623491]
    Caco-2 IC50
    17 3
    Compound: Roscovitine
    Cytotoxicity against human CaCo-2 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst-33342 staining based cell counting method (Rvb > 25 microM)
    Cytotoxicity against human CaCo-2 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst-33342 staining based cell counting method (Rvb > 25 microM)
    		[PMID: 33422908]
    CAKI-1 GI50
    6.3 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human Caki1 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human Caki1 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    CAKI-1 GI50
    6.3 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human Caki1 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human Caki1 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    A549 IC50
    > 10 3
    Compound: Roscovitine
    Antiproliferative activity against human A549 cells measured after 72 hrs by CCK8 assay
    Antiproliferative activity against human A549 cells measured after 72 hrs by CCK8 assay
    		[PMID: 31272794]
    CAL-148 IC50
    > 10 3
    Compound: Roscovitine
    Antiproliferative activity against human CAL148 cells measured after 72 hrs by CCK8 assay
    Antiproliferative activity against human CAL148 cells measured after 72 hrs by CCK8 assay
    		[PMID: 31272794]
    CAL-148 IC50
    >10 3
    Compound: Roscovitine
    Antiproliferative activity against human CAL148 cells measured after 72 hrs by CCK8 assay
    Antiproliferative activity against human CAL148 cells measured after 72 hrs by CCK8 assay
    		[PMID: 31272794]
    A549 IC50
    > 100 3
    Compound: Roscovitine
    Antiproliferative activity against human A549 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
    Antiproliferative activity against human A549 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
    		[PMID: 37708799]
    CCRF-CEM GI50
    > 100 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human CCRF-CEM cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human CCRF-CEM cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    CCRF-CEM GI50
    >100 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human CCRF-CEM cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human CCRF-CEM cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    CCRF-CEM IC50
    16.3 3
    Compound: Roscovitine
    Cytotoxicity against human CEM cells assessed as reduction in number of viable cells after 72 hrs by fluorescence assay
    Cytotoxicity against human CEM cells assessed as reduction in number of viable cells after 72 hrs by fluorescence assay
    		[PMID: 22770608]
    CCRF-CEM IC50
    16.3 3
    Compound: Roscovitine
    Cytotoxicity against human CEM cells assessed as reduction in number of viable cells after 72 hrs by fluorescence assay
    Cytotoxicity against human CEM cells assessed as reduction in number of viable cells after 72 hrs by fluorescence assay
    		[PMID: 22770608]
    CH1 GI50
    3.25 3
    Compound: 1, alphaR-1, CYC202, Seliciclib, R-roscovitine
    Growth inhibition of doxorubicin-susceptible human CH1 cells after 96 hrs by sulforhodamine B assay
    Growth inhibition of doxorubicin-susceptible human CH1 cells after 96 hrs by sulforhodamine B assay
    		[PMID: 21982796]
    ACHN GI50
    12.6 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human ACHN cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human ACHN cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    CCRF-CEM IC50
    18.2 3
    Compound: Roscovitine
    In vitro cytotoxic effect on CEM cancer cell line
    In vitro cytotoxic effect on CEM cancer cell line
    		[PMID: 12392733]
    CH1 GI50
    5.4 3
    Compound: 1, alphaR-1, CYC202, Seliciclib, R-roscovitine
    Growth inhibition of doxorubicin-resistant human CH1 cells after 96 hrs by sulforhodamine B assay
    Growth inhibition of doxorubicin-resistant human CH1 cells after 96 hrs by sulforhodamine B assay
    		[PMID: 21982796]
    ACHN IC50
    11.9 3
    Compound: Chemicel probe : R-CYC202
    Cytotoxicity against p53 wild-type human ACHN cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
    Cytotoxicity against p53 wild-type human ACHN cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
    		[PMID: 12432547]
    CH1 GI50
    5.4 3
    Compound: 1, alphaR-1, CYC202, Seliciclib, R-roscovitine
    Growth inhibition of doxorubicin-resistant human CH1 cells after 96 hrs by sulforhodamine B assay
    Growth inhibition of doxorubicin-resistant human CH1 cells after 96 hrs by sulforhodamine B assay
    		[PMID: 21982796]
    COLO 205 GI50
    12.6 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human COLO205 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human COLO205 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    CH1 GI50
    3.25 3
    Compound: 1, alphaR-1, CYC202, Seliciclib, R-roscovitine
    Growth inhibition of doxorubicin-susceptible human CH1 cells after 96 hrs by sulforhodamine B assay
    Growth inhibition of doxorubicin-susceptible human CH1 cells after 96 hrs by sulforhodamine B assay
    		[PMID: 21982796]
    ACHN IC50
    2.88 3
    Compound: 1
    Cytotoxicity against human ACHN cells after 48 hrs by MTT assay
    Cytotoxicity against human ACHN cells after 48 hrs by MTT assay
    		[PMID: 23623491]
    COLO 205 GI50
    24.9 3
    Compound: Roscovitine
    Antiproliferative activity against human COLO205 cells after 72 hrs by sulforhodamine B assay
    Antiproliferative activity against human COLO205 cells after 72 hrs by sulforhodamine B assay
    		[PMID: 21080703]
    COLO 205 GI50
    24.9 3
    Compound: Roscovitine
    Antiproliferative activity against human COLO205 cells after 72 hrs by sulforhodamine B assay
    Antiproliferative activity against human COLO205 cells after 72 hrs by sulforhodamine B assay
    		[PMID: 21080703]
    DU-145 IC50
    1.9 3
    Compound: 1
    Cytotoxicity against human DU145 cells after 48 hrs by MTT assay
    Cytotoxicity against human DU145 cells after 48 hrs by MTT assay
    		[PMID: 23623491]
    COLO 205 GI50
    12.6 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human COLO205 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human COLO205 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    DU-145 GI50
    15.8 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human DU145 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human DU145 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    AN3-CA IC50
    14.1 3
    Compound: Chemicel probe : R-CYC202
    Cytotoxicity against human AN3-CA cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
    Cytotoxicity against human AN3-CA cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
    		[PMID: 12432547]
    DU-145 GI50
    15.8 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human DU145 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human DU145 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    EKVX GI50
    19.9 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human EKVX cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human EKVX cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    DU-145 IC50
    1.9 3
    Compound: 1
    Cytotoxicity against human DU145 cells after 48 hrs by MTT assay
    Cytotoxicity against human DU145 cells after 48 hrs by MTT assay
    		[PMID: 23623491]
    ASPC1 IC50
    17767 1
    Compound: Roscovitine
    Antiproliferative activity against human AsPC1 cells after 72 hrs by prestoblue assay
    Antiproliferative activity against human AsPC1 cells after 72 hrs by prestoblue assay
    		[PMID: 30343954]
    Epithelial cell IC50
    25 3
    Compound: K00020, roscovitine
    Growth inhibition of human renal epithelial cells after 72 hrs by TUNEL assay
    Growth inhibition of human renal epithelial cells after 72 hrs by TUNEL assay
    		[PMID: 18077363]
    EKVX GI50
    19.9 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human EKVX cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human EKVX cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    Fibroblast IC50
    > 20 3
    Compound: Rosco
    Cytotoxicity against human fibroblasts assessed as cell viability after 48 hrs by Hoechst 33342 staining based assay
    Cytotoxicity against human fibroblasts assessed as cell viability after 48 hrs by Hoechst 33342 staining based assay
    		[PMID: 28214231]
    Epithelial cell IC50
    25 3
    Compound: K00020, roscovitine
    Growth inhibition of human renal epithelial cells after 72 hrs by TUNEL assay
    Growth inhibition of human renal epithelial cells after 72 hrs by TUNEL assay
    		[PMID: 18077363]
    BXPC-3 IC50
    15284 1
    Compound: Roscovitine
    Antiproliferative activity against human BxPC3 cells after 72 hrs by prestoblue assay
    Antiproliferative activity against human BxPC3 cells after 72 hrs by prestoblue assay
    		[PMID: 30343954]
    Fibroblast IC50
    >25 3
    Compound: Roscovitine
    Antiproliferative activity against human fibroblast after 72 hrs by imaging analysis
    Antiproliferative activity against human fibroblast after 72 hrs by imaging analysis
    		[PMID: 19665384]
    Fibroblast IC50
    > 25 3
    Compound: Roscovitin
    Cytotoxicity against human fibroblast cells after 48 hrs by Hoechst-33342 staining-based imaging analysis
    Cytotoxicity against human fibroblast cells after 48 hrs by Hoechst-33342 staining-based imaging analysis
    		[PMID: 21944287]
    Fibroblast IC50
    > 25 3
    Compound: Roscovitine
    Antiproliferative activity against human fibroblast after 72 hrs by imaging analysis
    Antiproliferative activity against human fibroblast after 72 hrs by imaging analysis
    		[PMID: 19665384]
    Fibroblast IC50
    12 3
    Compound: Roscovitine
    Antiproliferative activity against human fibroblast cells after 48 hrs by Hoechst 33342 staining-based assay
    Antiproliferative activity against human fibroblast cells after 48 hrs by Hoechst 33342 staining-based assay
    		[PMID: 30655216]
    Fibroblast IC50
    12 3
    Compound: Roscovitine
    Antiproliferative activity against human fibroblast cells after 48 hrs by Hoechst 33342 staining-based assay
    Antiproliferative activity against human fibroblast cells after 48 hrs by Hoechst 33342 staining-based assay
    		[PMID: 30655216]
    Fibroblast IC50
    >25 3
    Compound: Roscovitin
    Cytotoxicity against human fibroblast cells after 48 hrs by Hoechst-33342 staining-based imaging analysis
    Cytotoxicity against human fibroblast cells after 48 hrs by Hoechst-33342 staining-based imaging analysis
    		[PMID: 21944287]
    CAKI-1 GI50
    6.3 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human Caki1 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human Caki1 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    Fibroblast IC50
    15 3
    Compound: Roscovitine
    Cytotoxicity against human skin fibroblast cells assessed as reduction in cell viability after 48 hrs
    Cytotoxicity against human skin fibroblast cells assessed as reduction in cell viability after 48 hrs
    		[PMID: 34601029]
    Fibroblast IC50
    6 3
    Compound: Roscovitine
    Cytotoxicity against human Fibroblast cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst-33342 staining based cell counting method (Rvb > 25 microM)
    Cytotoxicity against human Fibroblast cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst-33342 staining based cell counting method (Rvb > 25 microM)
    		[PMID: 33422908]
    Fibroblast IC50
    6 3
    Compound: Roscovitine
    Cytotoxicity against human Fibroblast cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst-33342 staining based cell counting method (Rvb > 25 microM)
    Cytotoxicity against human Fibroblast cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst-33342 staining based cell counting method (Rvb > 25 microM)
    		[PMID: 33422908]
    Fibroblast IC50
    7 3
    Compound: Roscovitin
    Cytotoxicity against human Fibroblasts assessed as cell growth inhibition
    Cytotoxicity against human Fibroblasts assessed as cell growth inhibition
    		[PMID: 26934105]
    G-361 IC50
    20.8 3
    Compound: Seliciclib; L2
    Cytotoxicity against human G361 cells assessed as cell viability after 72 hrs by fluorescence microplate reader method
    Cytotoxicity against human G361 cells assessed as cell viability after 72 hrs by fluorescence microplate reader method
    		[PMID: 26741853]
    CAL-148 IC50
    > 10 3
    Compound: Roscovitine
    Antiproliferative activity against human CAL148 cells measured after 72 hrs by CCK8 assay
    Antiproliferative activity against human CAL148 cells measured after 72 hrs by CCK8 assay
    		[PMID: 31272794]
    Fibroblast IC50
    >20 3
    Compound: Rosco
    Cytotoxicity against human fibroblasts assessed as cell viability after 48 hrs by Hoechst 33342 staining based assay
    Cytotoxicity against human fibroblasts assessed as cell viability after 48 hrs by Hoechst 33342 staining based assay
    		[PMID: 28214231]
    Fibroblast IC50
    15 3
    Compound: Roscovitine
    Cytotoxicity against human skin fibroblast cells assessed as reduction in cell viability after 48 hrs
    Cytotoxicity against human skin fibroblast cells assessed as reduction in cell viability after 48 hrs
    		[PMID: 34601029]
    G-361 IC50
    22.4 3
    Compound: Roscov
    Cytotoxicity against human G361 cells assessed as reduction in cell viability after 72 hrs by calcein AM staining based fluorescence assay
    Cytotoxicity against human G361 cells assessed as reduction in cell viability after 72 hrs by calcein AM staining based fluorescence assay
    		[PMID: 26851505]
    CCRF-CEM GI50
    > 100 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human CCRF-CEM cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human CCRF-CEM cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    G-361 IC50
    22.4 3
    Compound: Roscovitine
    Cytotoxicity against human G361 cells assessed as reduction in number of viable cells after 72 hrs by fluorescence assay
    Cytotoxicity against human G361 cells assessed as reduction in number of viable cells after 72 hrs by fluorescence assay
    		[PMID: 22770608]
    G-361 IC50
    20.8 3
    Compound: Seliciclib; L2
    Cytotoxicity against human G361 cells assessed as cell viability after 72 hrs by fluorescence microplate reader method
    Cytotoxicity against human G361 cells assessed as cell viability after 72 hrs by fluorescence microplate reader method
    		[PMID: 26741853]
    CCRF-CEM IC50
    16.3 3
    Compound: Roscovitine
    Cytotoxicity against human CEM cells assessed as reduction in number of viable cells after 72 hrs by fluorescence assay
    Cytotoxicity against human CEM cells assessed as reduction in number of viable cells after 72 hrs by fluorescence assay
    		[PMID: 22770608]
    G-361 IC50
    22.4 3
    Compound: roscovitine, CYC202, seliciclib
    Cytotoxicity against human G361 cells assessed as growth inhibition after 72 hrs by calcein AM staining-based fluoroscence assay
    Cytotoxicity against human G361 cells assessed as growth inhibition after 72 hrs by calcein AM staining-based fluoroscence assay
    		[PMID: 23829517]
    G-361 IC50
    22.4 3
    Compound: roscovitine, CYC202, seliciclib
    Cytotoxicity against human G361 cells assessed as growth inhibition after 72 hrs by calcein AM staining-based fluoroscence assay
    Cytotoxicity against human G361 cells assessed as growth inhibition after 72 hrs by calcein AM staining-based fluoroscence assay
    		[PMID: 23829517]
    CCRF-CEM IC50
    18.2 3
    Compound: Roscovitine
    In vitro cytotoxic effect on CEM cancer cell line
    In vitro cytotoxic effect on CEM cancer cell line
    		[PMID: 12392733]
    Granta-519 IC50
    25 3
    Compound: K00020, roscovitine
    Growth inhibition of human Granta519 cells after 72 hrs by TUNEL assay
    Growth inhibition of human Granta519 cells after 72 hrs by TUNEL assay
    		[PMID: 18077363]
    G-361 IC50
    22.4 3
    Compound: Roscov
    Cytotoxicity against human G361 cells assessed as reduction in cell viability after 72 hrs by calcein AM staining based fluorescence assay
    Cytotoxicity against human G361 cells assessed as reduction in cell viability after 72 hrs by calcein AM staining based fluorescence assay
    		[PMID: 26851505]
    G-361 IC50
    22.4 3
    Compound: Roscovitine
    Cytotoxicity against human G361 cells assessed as reduction in number of viable cells after 72 hrs by fluorescence assay
    Cytotoxicity against human G361 cells assessed as reduction in number of viable cells after 72 hrs by fluorescence assay
    		[PMID: 22770608]
    HaCaT IC50
    12 3
    Compound: Roscovitine
    Antiproliferative activity against human HaCaT cells after 48 hrs by Hoechst 33342 staining-based assay
    Antiproliferative activity against human HaCaT cells after 48 hrs by Hoechst 33342 staining-based assay
    		[PMID: 30655216]
    HaCaT IC50
    16.7 3
    Compound: Rosco
    Cytotoxicity against human HaCaT cells assessed as cell viability after 48 hrs by Hoechst 33342 staining based assay
    Cytotoxicity against human HaCaT cells assessed as cell viability after 48 hrs by Hoechst 33342 staining based assay
    		[PMID: 28214231]
    CH1 GI50
    3.25 3
    Compound: 1, alphaR-1, CYC202, Seliciclib, R-roscovitine
    Growth inhibition of doxorubicin-susceptible human CH1 cells after 96 hrs by sulforhodamine B assay
    Growth inhibition of doxorubicin-susceptible human CH1 cells after 96 hrs by sulforhodamine B assay
    		[PMID: 21982796]
    G-361 IC50
    34 3
    Compound: Roscovitine
    In vitro cytotoxic effect on G361 cancer cell line
    In vitro cytotoxic effect on G361 cancer cell line
    		[PMID: 12392733]
    HCC 2998 GI50
    31.6 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human HCC2998 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human HCC2998 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    CH1 GI50
    5.4 3
    Compound: 1, alphaR-1, CYC202, Seliciclib, R-roscovitine
    Growth inhibition of doxorubicin-resistant human CH1 cells after 96 hrs by sulforhodamine B assay
    Growth inhibition of doxorubicin-resistant human CH1 cells after 96 hrs by sulforhodamine B assay
    		[PMID: 21982796]
    Granta-519 IC50
    25 3
    Compound: K00020, roscovitine
    Growth inhibition of human Granta519 cells after 72 hrs by TUNEL assay
    Growth inhibition of human Granta519 cells after 72 hrs by TUNEL assay
    		[PMID: 18077363]
    HCT-116 IC50
    14.4 3
    Compound: Roscovitine
    Cytotoxicity against human HCT116 cells assessed as reduction in number of viable cells after 72 hrs by fluorescence assay
    Cytotoxicity against human HCT116 cells assessed as reduction in number of viable cells after 72 hrs by fluorescence assay
    		[PMID: 22770608]
    HaCaT IC50
    12 3
    Compound: Roscovitine
    Antiproliferative activity against human HaCaT cells after 48 hrs by Hoechst 33342 staining-based assay
    Antiproliferative activity against human HaCaT cells after 48 hrs by Hoechst 33342 staining-based assay
    		[PMID: 30655216]
    COLO 205 GI50
    12.6 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human COLO205 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human COLO205 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    HCT-116 IC50
    14.4 3
    Compound: roscovitine, CYC202, seliciclib
    Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by calcein AM staining-based fluoroscence assay
    Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by calcein AM staining-based fluoroscence assay
    		[PMID: 23829517]
    HaCaT IC50
    16.7 3
    Compound: Rosco
    Cytotoxicity against human HaCaT cells assessed as cell viability after 48 hrs by Hoechst 33342 staining based assay
    Cytotoxicity against human HaCaT cells assessed as cell viability after 48 hrs by Hoechst 33342 staining based assay
    		[PMID: 28214231]
    COLO 205 GI50
    24.9 3
    Compound: Roscovitine
    Antiproliferative activity against human COLO205 cells after 72 hrs by sulforhodamine B assay
    Antiproliferative activity against human COLO205 cells after 72 hrs by sulforhodamine B assay
    		[PMID: 21080703]
    HCT-116 IC50
    14.42 3
    Compound: Roscov
    Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by calcein AM staining based fluorescence assay
    Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by calcein AM staining based fluorescence assay
    		[PMID: 26851505]
    HCC 2998 GI50
    31.6 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human HCC2998 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human HCC2998 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    HCT-116 GI50
    15.5 3
    Compound: Roscovitine
    Antiproliferative activity against human HCT116 cells after 72 hrs by sulforhodamine B assay
    Antiproliferative activity against human HCT116 cells after 72 hrs by sulforhodamine B assay
    		[PMID: 21080703]
    HCT-116 GI50
    15.5 3
    Compound: Roscovitine
    Antiproliferative activity against human HCT116 cells after 72 hrs by sulforhodamine B assay
    Antiproliferative activity against human HCT116 cells after 72 hrs by sulforhodamine B assay
    		[PMID: 21080703]
    HCT-116 IC50
    15.54 3
    Compound: Roscovitine
    Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability after 48 hrs by MTT assay
    Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability after 48 hrs by MTT assay
    		[PMID: 32773088]
    HCT-116 GI50
    5.01 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human HCT116 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human HCT116 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    HCT-116 IC50
    16.38 3
    Compound: (R)-roscovitine
    Cytotoxicity against human HCT116 cells after 48 hrs by SRB assay
    Cytotoxicity against human HCT116 cells after 48 hrs by SRB assay
    		[PMID: 23036956]
    HCT-116 GI50
    5.05 3
    Compound: 1, alphaR-1, CYC202, Seliciclib, R-roscovitine
    Growth inhibition of human HCT116 cells after 96 hrs by sulforhodamine B assay
    Growth inhibition of human HCT116 cells after 96 hrs by sulforhodamine B assay
    		[PMID: 21982796]
    HCT-116 IC50
    2 3
    Compound: Roscovitine
    Antiproliferative activity against human HCT116 cells after 48 hrs by Hoechst 3342 staining analysis
    Antiproliferative activity against human HCT116 cells after 48 hrs by Hoechst 3342 staining analysis
    		[PMID: 27019296]
    HCT-116 IC50
    9 3
    Compound: Roscovitine
    Antiproliferative activity against human HCT116 cells after 48 hrs by Hoechst 33342 staining-based assay
    Antiproliferative activity against human HCT116 cells after 48 hrs by Hoechst 33342 staining-based assay
    		[PMID: 30655216]
    HCT-116 IC50
    2 3
    Compound: Roscovitine
    Antiproliferative activity against human HCT116 cells after 48 hrs by Hoechst 3342 staining analysis
    Antiproliferative activity against human HCT116 cells after 48 hrs by Hoechst 3342 staining analysis
    		[PMID: 27019296]
    HCT-116 IC50
    2 3
    Compound: Roscovitine
    Cytotoxicity against human HCT116 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst 3342 staining based assay
    Cytotoxicity against human HCT116 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst 3342 staining based assay
    		[PMID: 26142492]
    Caco-2 IC50
    10 3
    Compound: Roscovitin
    Cytotoxicity against human Caco2 cells after 48 hrs by Hoechst-33342 staining-based imaging analysis
    Cytotoxicity against human Caco2 cells after 48 hrs by Hoechst-33342 staining-based imaging analysis
    		[PMID: 21944287]
    HCT-116 IC50
    5 3
    Compound: Roscovitine
    Antiproliferative activity against human HCT116 cells after 72 hrs by imaging analysis
    Antiproliferative activity against human HCT116 cells after 72 hrs by imaging analysis
    		[PMID: 19665384]
    HCT-116 IC50
    5 3
    Compound: Roscovitine
    Antiproliferative activity against human HCT116 cells after 72 hrs by imaging analysis
    Antiproliferative activity against human HCT116 cells after 72 hrs by imaging analysis
    		[PMID: 19665384]
    Caco-2 IC50
    10 3
    Compound: Roscovitine
    Antiproliferative activity against human Caco2 cells after 48 hrs by Hoechst 33342 staining-based assay
    Antiproliferative activity against human Caco2 cells after 48 hrs by Hoechst 33342 staining-based assay
    		[PMID: 30655216]
    HCT-116 GI50
    5.01 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human HCT116 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human HCT116 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    HCT-116 IC50
    6.76 3
    Compound: Roscovitine
    Antiproliferative activity against human HCT-116 cells assessed as reduction in cell growth incubated for 72 hrs by CCK-8 assay
    Antiproliferative activity against human HCT-116 cells assessed as reduction in cell growth incubated for 72 hrs by CCK-8 assay
    		[PMID: 32361064]
    Caco-2 IC50
    12.9 3
    Compound: Rosco
    Cytotoxicity against human Caco2 cells assessed as cell viability after 48 hrs by Hoechst 33342 staining based assay
    Cytotoxicity against human Caco2 cells assessed as cell viability after 48 hrs by Hoechst 33342 staining based assay
    		[PMID: 28214231]
    HCT-116 GI50
    5.05 3
    Compound: 1, alphaR-1, CYC202, Seliciclib, R-roscovitine
    Growth inhibition of human HCT116 cells after 96 hrs by sulforhodamine B assay
    Growth inhibition of human HCT116 cells after 96 hrs by sulforhodamine B assay
    		[PMID: 21982796]
    Caco-2 IC50
    14 3
    Compound: Roscovitine
    Cytotoxicity against human Caco-2 cells assessed as reduction in cell viability after 48 hrs
    Cytotoxicity against human Caco-2 cells assessed as reduction in cell viability after 48 hrs
    		[PMID: 34601029]
    HCT-116 IC50
    7 3
    Compound: Roscovitine
    Antiproliferative activity against human HCT116 cells incubated for 48 hrs by Hoechst 3342 dye staining based assay
    Antiproliferative activity against human HCT116 cells incubated for 48 hrs by Hoechst 3342 dye staining based assay
    		[PMID: 23063566]
    HCT-116 IC50
    6.76 3
    Compound: Roscovitine
    Antiproliferative activity against human HCT-116 cells assessed as reduction in cell growth incubated for 72 hrs by CCK-8 assay
    Antiproliferative activity against human HCT-116 cells assessed as reduction in cell growth incubated for 72 hrs by CCK-8 assay
    		[PMID: 32361064]
    Caco-2 IC50
    16 3
    Compound: Roscovitin
    Cytotoxicity against human Caco2 cells assessed as cell growth inhibition
    Cytotoxicity against human Caco2 cells assessed as cell growth inhibition
    		[PMID: 26934105]
    HCT-116 IC50
    8 3
    Compound: Roscovitin
    Cytotoxicity against human HCT116 cells after 48 hrs by Hoechst-33342 staining-based imaging analysis
    Cytotoxicity against human HCT116 cells after 48 hrs by Hoechst-33342 staining-based imaging analysis
    		[PMID: 21944287]
    HCT-116 IC50
    16.38 3
    Compound: (R)-roscovitine
    Cytotoxicity against human HCT116 cells after 48 hrs by SRB assay
    Cytotoxicity against human HCT116 cells after 48 hrs by SRB assay
    		[PMID: 23036956]
    HCT-116 IC50
    7 3
    Compound: Roscovitine
    Antiproliferative activity against human HCT116 cells incubated for 48 hrs by Hoechst 3342 dye staining based assay
    Antiproliferative activity against human HCT116 cells incubated for 48 hrs by Hoechst 3342 dye staining based assay
    		[PMID: 23063566]
    Caco-2 IC50
    17 3
    Compound: Roscovitine
    Cytotoxicity against human CaCo-2 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst-33342 staining based cell counting method (Rvb > 25 microM)
    Cytotoxicity against human CaCo-2 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst-33342 staining based cell counting method (Rvb > 25 microM)
    		[PMID: 33422908]
    HCT-116 IC50
    8 3
    Compound: Rosco
    Cytotoxicity against human HCT116 cells assessed as cell viability after 48 hrs by Hoechst 33342 staining based assay
    Cytotoxicity against human HCT116 cells assessed as cell viability after 48 hrs by Hoechst 33342 staining based assay
    		[PMID: 28214231]
    HCT-116 IC50
    9 3
    Compound: Roscovitin
    Cytotoxicity against human HCT116 cells assessed as cell growth inhibition
    Cytotoxicity against human HCT116 cells assessed as cell growth inhibition
    		[PMID: 26934105]
    Caco-2 IC50
    3 3
    Compound: Roscovitine
    Cytotoxicity against human Caco2 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst 3342 staining based assay
    Cytotoxicity against human Caco2 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst 3342 staining based assay
    		[PMID: 26142492]
    HCT-116 IC50
    8 3
    Compound: Roscovitin
    Cytotoxicity against human HCT116 cells after 48 hrs by Hoechst-33342 staining-based imaging analysis
    Cytotoxicity against human HCT116 cells after 48 hrs by Hoechst-33342 staining-based imaging analysis
    		[PMID: 21944287]
    Caco-2 IC50
    3 3
    Compound: Roscovitine
    Antiproliferative activity against human Caco2 cells after 48 hrs by Hoechst 3342 staining analysis
    Antiproliferative activity against human Caco2 cells after 48 hrs by Hoechst 3342 staining analysis
    		[PMID: 27019296]
    HCT-116 IC50
    8 3
    Compound: Rosco
    Cytotoxicity against human HCT116 cells assessed as cell viability after 48 hrs by Hoechst 33342 staining based assay
    Cytotoxicity against human HCT116 cells assessed as cell viability after 48 hrs by Hoechst 33342 staining based assay
    		[PMID: 28214231]
    HCT-116 IC50
    9 3
    Compound: Roscovitine
    Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability after 48 hrs
    Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability after 48 hrs
    		[PMID: 34601029]
    Caco-2 IC50
    5 3
    Compound: Roscovitine
    Antiproliferative activity against human Caco2 cells incubated for 48 hrs by Hoechst 3342 dye staining based assay
    Antiproliferative activity against human Caco2 cells incubated for 48 hrs by Hoechst 3342 dye staining based assay
    		[PMID: 23063566]
    HCT-116 IC50
    14.4 3
    Compound: roscovitine, CYC202, seliciclib
    Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by calcein AM staining-based fluoroscence assay
    Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by calcein AM staining-based fluoroscence assay
    		[PMID: 23829517]
    HCT-116 IC50
    9 3
    Compound: Roscovitine
    Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst-33342 staining based cell counting method (Rvb > 25 microM)
    Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst-33342 staining based cell counting method (Rvb > 25 microM)
    		[PMID: 33422908]
    HCT-116 IC50
    9 3
    Compound: Roscovitine
    Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability after 48 hrs
    Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability after 48 hrs
    		[PMID: 34601029]
    Caco-2 IC50
    6 3
    Compound: Roscovitine
    Antiproliferative activity against human Caco-2 cells after 72 hrs by imaging analysis
    Antiproliferative activity against human Caco-2 cells after 72 hrs by imaging analysis
    		[PMID: 19665384]
    HCT-116 IC50
    9 3
    Compound: Roscovitine
    Antiproliferative activity against human HCT116 cells after 48 hrs by Hoechst 33342 staining-based assay
    Antiproliferative activity against human HCT116 cells after 48 hrs by Hoechst 33342 staining-based assay
    		[PMID: 30655216]
    HCT-116 IC50
    15.54 3
    Compound: Roscovitine
    Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability after 48 hrs by MTT assay
    Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability after 48 hrs by MTT assay
    		[PMID: 32773088]
    HCT-15 GI50
    19.9 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human HCT15 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human HCT15 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    ChaGo-K-1 IC50
    30.2 3
    Compound: Chemicel probe : R-CYC202
    Cytotoxicity against human ChaGo-K-1 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
    Cytotoxicity against human ChaGo-K-1 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
    		[PMID: 12432547]
    HCT-116 IC50
    14.42 3
    Compound: Roscov
    Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by calcein AM staining based fluorescence assay
    Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by calcein AM staining based fluorescence assay
    		[PMID: 26851505]
    HEK293 IC50
    23.4 3
    Compound: Roscovitine
    Inhibition of L-type calcium channel measured using 2-electrode voltage-clamp in human embryonic kidney cells heterologically expressing alpha-1C subunit
    Inhibition of L-type calcium channel measured using 2-electrode voltage-clamp in human embryonic kidney cells heterologically expressing alpha-1C subunit
    		[PMID: 22761000]
    HCT-116 IC50
    2 3
    Compound: Roscovitine
    Cytotoxicity against human HCT116 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst 3342 staining based assay
    Cytotoxicity against human HCT116 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst 3342 staining based assay
    		[PMID: 26142492]
    DU-145 GI50
    15.8 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human DU145 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human DU145 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    HEK293 IC50
    46.7 3
    Compound: 8a, (R)-roscovitine
    Antiproliferative activity against HEK293 cells assessed as survival after 48 hrs by MTS reduction assay
    Antiproliferative activity against HEK293 cells assessed as survival after 48 hrs by MTS reduction assay
    		[PMID: 18698753]
    DU-145 IC50
    1.9 3
    Compound: 1
    Cytotoxicity against human DU145 cells after 48 hrs by MTT assay
    Cytotoxicity against human DU145 cells after 48 hrs by MTT assay
    		[PMID: 23623491]
    HCT-116 IC50
    9 3
    Compound: Roscovitine
    Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst-33342 staining based cell counting method (Rvb > 25 microM)
    Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst-33342 staining based cell counting method (Rvb > 25 microM)
    		[PMID: 33422908]
    HEK293 IC50
    48.9 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human HEK293 cells after 48 hrs by MTS reduction assay
    Antiproliferative activity against human HEK293 cells after 48 hrs by MTS reduction assay
    		[PMID: 19128055]
    DU-145 IC50
    18.8 3
    Compound: Chemicel probe : R-CYC202
    Cytotoxicity against p53 mutant human DU-145 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
    Cytotoxicity against p53 mutant human DU-145 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
    		[PMID: 12432547]
    HCT-116 IC50
    14.4 3
    Compound: Roscovitine
    Cytotoxicity against human HCT116 cells assessed as reduction in number of viable cells after 72 hrs by fluorescence assay
    Cytotoxicity against human HCT116 cells assessed as reduction in number of viable cells after 72 hrs by fluorescence assay
    		[PMID: 22770608]
    HeLa IC50
    1.81 3
    Compound: 1
    Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
    Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
    		[PMID: 23623491]
    HCT-15 GI50
    19.9 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human HCT15 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human HCT15 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    HeLa IC50
    11.21 3
    Compound: Roscovitine
    Antiproliferative activity against human HeLa cells assessed as reduction in cell growth incubated for 72 hrs by CCK-8 assay
    Antiproliferative activity against human HeLa cells assessed as reduction in cell growth incubated for 72 hrs by CCK-8 assay
    		[PMID: 32361064]
    HEK293 IC50
    46.7 3
    Compound: 8a, (R)-roscovitine
    Antiproliferative activity against HEK293 cells assessed as survival after 48 hrs by MTS reduction assay
    Antiproliferative activity against HEK293 cells assessed as survival after 48 hrs by MTS reduction assay
    		[PMID: 18698753]
    HeLa IC50
    2.2 3
    Compound: Roscovitine
    Cytotoxicity against human HeLa cells by MTT assay
    Cytotoxicity against human HeLa cells by MTT assay
    		[PMID: 36325400]
    EKVX GI50
    19.9 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human EKVX cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human EKVX cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    HEK293 IC50
    48.9 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human HEK293 cells after 48 hrs by MTS reduction assay
    Antiproliferative activity against human HEK293 cells after 48 hrs by MTS reduction assay
    		[PMID: 19128055]
    HeLa IC50
    28.6 3
    Compound: roscovitine, CYC202, seliciclib
    Cytotoxicity against human HeLa cells assessed as growth inhibition after 72 hrs by calcein AM staining-based fluoroscence assay
    Cytotoxicity against human HeLa cells assessed as growth inhibition after 72 hrs by calcein AM staining-based fluoroscence assay
    		[PMID: 23829517]
    HEK293 IC50
    23.4 3
    Compound: Roscovitine
    Inhibition of L-type calcium channel measured using 2-electrode voltage-clamp in human embryonic kidney cells heterologically expressing alpha-1C subunit
    Inhibition of L-type calcium channel measured using 2-electrode voltage-clamp in human embryonic kidney cells heterologically expressing alpha-1C subunit
    		[PMID: 22761000]
    HEK293 IC50
    5 3
    Compound: roscovitine
    Inhibition of mouse Dyrk1A autophosphorylation in HEk293 cells
    Inhibition of mouse Dyrk1A autophosphorylation in HEk293 cells
    		[PMID: 16698266]
    HeLa S3 GI50
    20 3
    Compound: 2
    Antiproliferative activity against human HeLaS3 cells by sulforhodamine B assay
    Antiproliferative activity against human HeLaS3 cells by sulforhodamine B assay
    		[PMID: 19846305]
    HeLa IC50
    11.21 3
    Compound: Roscovitine
    Antiproliferative activity against human HeLa cells assessed as reduction in cell growth incubated for 72 hrs by CCK-8 assay
    Antiproliferative activity against human HeLa cells assessed as reduction in cell growth incubated for 72 hrs by CCK-8 assay
    		[PMID: 32361064]
    Hep 3B2 IC50
    9 3
    Compound: Roscovitine
    Growth inhibition of human Hep3B cells after 72 hrs by MTS/PMS system based colorimetric assay
    Growth inhibition of human Hep3B cells after 72 hrs by MTS/PMS system based colorimetric assay
    		[PMID: 25988923]
    Epithelial cell IC50
    25 3
    Compound: K00020, roscovitine
    Growth inhibition of human renal epithelial cells after 72 hrs by TUNEL assay
    Growth inhibition of human renal epithelial cells after 72 hrs by TUNEL assay
    		[PMID: 18077363]
    HepG2 IC50
    15.47 3
    Compound: (R)-roscovitine
    Cytotoxicity against human HepG2 cells after 48 hrs by SRB assay
    Cytotoxicity against human HepG2 cells after 48 hrs by SRB assay
    		[PMID: 23036956]
    HeLa IC50
    1.81 3
    Compound: 1
    Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
    Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
    		[PMID: 23623491]
    HepG2 IC50
    15.76 3
    Compound: Roscovitine
    Antiproliferative activity against human HepG2 cells measured after 72 hrs by CCK8 assay
    Antiproliferative activity against human HepG2 cells measured after 72 hrs by CCK8 assay
    		[PMID: 31272794]
    HeLa IC50
    28.6 3
    Compound: roscovitine, CYC202, seliciclib
    Cytotoxicity against human HeLa cells assessed as growth inhibition after 72 hrs by calcein AM staining-based fluoroscence assay
    Cytotoxicity against human HeLa cells assessed as growth inhibition after 72 hrs by calcein AM staining-based fluoroscence assay
    		[PMID: 23829517]
    Fibroblast IC50
    12 3
    Compound: Roscovitine
    Antiproliferative activity against human fibroblast cells after 48 hrs by Hoechst 33342 staining-based assay
    Antiproliferative activity against human fibroblast cells after 48 hrs by Hoechst 33342 staining-based assay
    		[PMID: 30655216]
    HepG2 GI50
    25.9 3
    Compound: Roscovitine
    Antiproliferative activity against human HepG2 cells after 72 hrs by sulforhodamine B assay
    Antiproliferative activity against human HepG2 cells after 72 hrs by sulforhodamine B assay
    		[PMID: 21080703]
    HeLa IC50
    2.2 3
    Compound: Roscovitine
    Cytotoxicity against human HeLa cells by MTT assay
    Cytotoxicity against human HeLa cells by MTT assay
    		[PMID: 36325400]
    Fibroblast IC50
    15 3
    Compound: Roscovitine
    Cytotoxicity against human skin fibroblast cells assessed as reduction in cell viability after 48 hrs
    Cytotoxicity against human skin fibroblast cells assessed as reduction in cell viability after 48 hrs
    		[PMID: 34601029]
    HepG2 IC50
    8.53 3
    Compound: Roscovitine
    Antiproliferative activity against human HepG2 cells assessed as reduction in cell growth incubated for 72 hrs by CCK-8 assay
    Antiproliferative activity against human HepG2 cells assessed as reduction in cell growth incubated for 72 hrs by CCK-8 assay
    		[PMID: 32361064]
    Fibroblast IC50
    6 3
    Compound: Roscovitine
    Cytotoxicity against human Fibroblast cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst-33342 staining based cell counting method (Rvb > 25 microM)
    Cytotoxicity against human Fibroblast cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst-33342 staining based cell counting method (Rvb > 25 microM)
    		[PMID: 33422908]
    HeLa S3 GI50
    20 3
    Compound: 2
    Antiproliferative activity against human HeLaS3 cells by sulforhodamine B assay
    Antiproliferative activity against human HeLaS3 cells by sulforhodamine B assay
    		[PMID: 19846305]
    HL-60(TB) GI50
    19.9 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human HL60(TB) cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human HL60(TB) cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    Fibroblast IC50
    7 3
    Compound: Roscovitin
    Cytotoxicity against human Fibroblasts assessed as cell growth inhibition
    Cytotoxicity against human Fibroblasts assessed as cell growth inhibition
    		[PMID: 26934105]
    HeLa S3 GI50
    20 3
    Compound: 1
    Growth inhibition of human HeLaS3 cells
    Growth inhibition of human HeLaS3 cells
    		[PMID: 19854650]
    HOP-62 GI50
    25.1 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human HOP62 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human HOP62 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    Hep 3B2 IC50
    9 3
    Compound: Roscovitine
    Growth inhibition of human Hep3B cells after 72 hrs by MTS/PMS system based colorimetric assay
    Growth inhibition of human Hep3B cells after 72 hrs by MTS/PMS system based colorimetric assay
    		[PMID: 25988923]
    Fibroblast IC50
    > 20 3
    Compound: Rosco
    Cytotoxicity against human fibroblasts assessed as cell viability after 48 hrs by Hoechst 33342 staining based assay
    Cytotoxicity against human fibroblasts assessed as cell viability after 48 hrs by Hoechst 33342 staining based assay
    		[PMID: 28214231]
    HOP-92 GI50
    50.1 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human HOP92 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human HOP92 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    HepG2 GI50
    25.9 3
    Compound: Roscovitine
    Antiproliferative activity against human HepG2 cells after 72 hrs by sulforhodamine B assay
    Antiproliferative activity against human HepG2 cells after 72 hrs by sulforhodamine B assay
    		[PMID: 21080703]
    Fibroblast IC50
    > 25 3
    Compound: Roscovitin
    Cytotoxicity against human fibroblast cells after 48 hrs by Hoechst-33342 staining-based imaging analysis
    Cytotoxicity against human fibroblast cells after 48 hrs by Hoechst-33342 staining-based imaging analysis
    		[PMID: 21944287]
    HepG2 IC50
    8.53 3
    Compound: Roscovitine
    Antiproliferative activity against human HepG2 cells assessed as reduction in cell growth incubated for 72 hrs by CCK-8 assay
    Antiproliferative activity against human HepG2 cells assessed as reduction in cell growth incubated for 72 hrs by CCK-8 assay
    		[PMID: 32361064]
    HOS IC50
    24.3 3
    Compound: Roscovitine
    Cytotoxicity against human HOS cells assessed as reduction in number of viable cells after 72 hrs by fluorescence assay
    Cytotoxicity against human HOS cells assessed as reduction in number of viable cells after 72 hrs by fluorescence assay
    		[PMID: 22770608]
    Fibroblast IC50
    > 25 3
    Compound: Roscovitine
    Antiproliferative activity against human fibroblast after 72 hrs by imaging analysis
    Antiproliferative activity against human fibroblast after 72 hrs by imaging analysis
    		[PMID: 19665384]
    HOS IC50
    24.3 3
    Compound: roscovitine, CYC202, seliciclib
    Cytotoxicity against human HOS cells assessed as growth inhibition after 72 hrs by calcein AM staining-based fluoroscence assay
    Cytotoxicity against human HOS cells assessed as growth inhibition after 72 hrs by calcein AM staining-based fluoroscence assay
    		[PMID: 23829517]
    HepG2 IC50
    15.76 3
    Compound: Roscovitine
    Antiproliferative activity against human HepG2 cells measured after 72 hrs by CCK8 assay
    Antiproliferative activity against human HepG2 cells measured after 72 hrs by CCK8 assay
    		[PMID: 31272794]
    G-361 IC50
    20.8 3
    Compound: Seliciclib; L2
    Cytotoxicity against human G361 cells assessed as cell viability after 72 hrs by fluorescence microplate reader method
    Cytotoxicity against human G361 cells assessed as cell viability after 72 hrs by fluorescence microplate reader method
    		[PMID: 26741853]
    Hs-578T GI50
    12.8 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human Hs 578T cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human Hs 578T cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    HepG2 IC50
    15.47 3
    Compound: (R)-roscovitine
    Cytotoxicity against human HepG2 cells after 48 hrs by SRB assay
    Cytotoxicity against human HepG2 cells after 48 hrs by SRB assay
    		[PMID: 23036956]
    G-361 IC50
    22.4 3
    Compound: Roscov
    Cytotoxicity against human G361 cells assessed as reduction in cell viability after 72 hrs by calcein AM staining based fluorescence assay
    Cytotoxicity against human G361 cells assessed as reduction in cell viability after 72 hrs by calcein AM staining based fluorescence assay
    		[PMID: 26851505]
    HL-60(TB) GI50
    19.9 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human HL60(TB) cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human HL60(TB) cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    HT-1080 IC50
    16.8 3
    Compound: Roscovitine
    Antiproliferative activity against human HT1080 cells after 3 days by SRB assay
    Antiproliferative activity against human HT1080 cells after 3 days by SRB assay
    		[PMID: 20361800]
    G-361 IC50
    22.4 3
    Compound: Roscovitine
    Cytotoxicity against human G361 cells assessed as reduction in number of viable cells after 72 hrs by fluorescence assay
    Cytotoxicity against human G361 cells assessed as reduction in number of viable cells after 72 hrs by fluorescence assay
    		[PMID: 22770608]
    HT-1080 IC50
    9.62 3
    Compound: (R)-roscovitine
    Cytotoxicity against human HT1080 cells after 48 hrs by SRB assay
    Cytotoxicity against human HT1080 cells after 48 hrs by SRB assay
    		[PMID: 23036956]
    G-361 IC50
    22.4 3
    Compound: roscovitine, CYC202, seliciclib
    Cytotoxicity against human G361 cells assessed as growth inhibition after 72 hrs by calcein AM staining-based fluoroscence assay
    Cytotoxicity against human G361 cells assessed as growth inhibition after 72 hrs by calcein AM staining-based fluoroscence assay
    		[PMID: 23829517]
    HOP-62 GI50
    25.1 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human HOP62 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human HOP62 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    HOP-92 GI50
    50.1 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human HOP92 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human HOP92 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    HT-29 IC50
    11.63 3
    Compound: (R)-roscovitine
    Cytotoxicity against human HT-29 cells after 48 hrs by SRB assay
    Cytotoxicity against human HT-29 cells after 48 hrs by SRB assay
    		[PMID: 23036956]
    G-361 IC50
    34 3
    Compound: Roscovitine
    In vitro cytotoxic effect on G361 cancer cell line
    In vitro cytotoxic effect on G361 cancer cell line
    		[PMID: 12392733]
    HT-29 GI50
    19.9 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human HT29 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human HT29 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    Granta-519 IC50
    25 3
    Compound: K00020, roscovitine
    Growth inhibition of human Granta519 cells after 72 hrs by TUNEL assay
    Growth inhibition of human Granta519 cells after 72 hrs by TUNEL assay
    		[PMID: 18077363]
    HOS IC50
    24.3 3
    Compound: roscovitine, CYC202, seliciclib
    Cytotoxicity against human HOS cells assessed as growth inhibition after 72 hrs by calcein AM staining-based fluoroscence assay
    Cytotoxicity against human HOS cells assessed as growth inhibition after 72 hrs by calcein AM staining-based fluoroscence assay
    		[PMID: 23829517]
    HOS IC50
    24.3 3
    Compound: Roscovitine
    Cytotoxicity against human HOS cells assessed as reduction in number of viable cells after 72 hrs by fluorescence assay
    Cytotoxicity against human HOS cells assessed as reduction in number of viable cells after 72 hrs by fluorescence assay
    		[PMID: 22770608]
    HT-29 GI50
    6.4 3
    Compound: 1, alphaR-1, CYC202, Seliciclib, R-roscovitine
    Growth inhibition of human HT-29 cells after 96 hrs by sulforhodamine B assay
    Growth inhibition of human HT-29 cells after 96 hrs by sulforhodamine B assay
    		[PMID: 21982796]
    HCC 2998 GI50
    31.6 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human HCC2998 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human HCC2998 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    Huh-7 IC50
    10 3
    Compound: Roscovitin
    Cytotoxicity against human HuH7 cells after 48 hrs by Hoechst-33342 staining-based imaging analysis
    Cytotoxicity against human HuH7 cells after 48 hrs by Hoechst-33342 staining-based imaging analysis
    		[PMID: 21944287]
    HOS IC50
    32 3
    Compound: Roscovitine
    In vitro cytotoxic effect on HOS cancer cell line
    In vitro cytotoxic effect on HOS cancer cell line
    		[PMID: 12392733]
    Huh-7 IC50
    12 3
    Compound: Roscovitine
    Antiproliferative activity against human HuH7 cells incubated for 48 hrs by Hoechst 3342 dye staining based assay
    Antiproliferative activity against human HuH7 cells incubated for 48 hrs by Hoechst 3342 dye staining based assay
    		[PMID: 23063566]
    Hs-578T GI50
    12.8 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human Hs 578T cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human Hs 578T cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    Huh-7 IC50
    14 3
    Compound: Roscovitine
    Cytotoxicity against human HuH-7 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst-33342 staining based cell counting method (Rvb > 25 microM)
    Cytotoxicity against human HuH-7 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst-33342 staining based cell counting method (Rvb > 25 microM)
    		[PMID: 33422908]
    HT-1080 IC50
    16.8 3
    Compound: Roscovitine
    Antiproliferative activity against human HT1080 cells after 3 days by SRB assay
    Antiproliferative activity against human HT1080 cells after 3 days by SRB assay
    		[PMID: 20361800]
    Huh-7 IC50
    15.4 3
    Compound: Rosco
    Cytotoxicity against human HuH7 cells assessed as cell viability after 48 hrs by Hoechst 33342 staining based assay
    Cytotoxicity against human HuH7 cells assessed as cell viability after 48 hrs by Hoechst 33342 staining based assay
    		[PMID: 28214231]
    HT-1080 IC50
    9.62 3
    Compound: (R)-roscovitine
    Cytotoxicity against human HT1080 cells after 48 hrs by SRB assay
    Cytotoxicity against human HT1080 cells after 48 hrs by SRB assay
    		[PMID: 23036956]
    HT-29 GI50
    19.9 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human HT29 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human HT29 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    Huh-7 IC50
    20 3
    Compound: Roscovitine
    Antiproliferative activity against human HuH7 cells after 48 hrs by Hoechst 33342 staining-based assay
    Antiproliferative activity against human HuH7 cells after 48 hrs by Hoechst 33342 staining-based assay
    		[PMID: 30655216]
    Huh-7 IC50
    5 3
    Compound: Roscovitine
    Antiproliferative activity against human HuH7 cells after 48 hrs by Hoechst 3342 staining analysis
    Antiproliferative activity against human HuH7 cells after 48 hrs by Hoechst 3342 staining analysis
    		[PMID: 27019296]
    HT-29 GI50
    6.4 3
    Compound: 1, alphaR-1, CYC202, Seliciclib, R-roscovitine
    Growth inhibition of human HT-29 cells after 96 hrs by sulforhodamine B assay
    Growth inhibition of human HT-29 cells after 96 hrs by sulforhodamine B assay
    		[PMID: 21982796]
    Huh-7 IC50
    5 3
    Compound: Roscovitine
    Cytotoxicity against human HuH7 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst 3342 staining based assay
    Cytotoxicity against human HuH7 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst 3342 staining based assay
    		[PMID: 26142492]
    HT-29 IC50
    11.63 3
    Compound: (R)-roscovitine
    Cytotoxicity against human HT-29 cells after 48 hrs by SRB assay
    Cytotoxicity against human HT-29 cells after 48 hrs by SRB assay
    		[PMID: 23036956]
    Huh-7 IC50
    5 3
    Compound: Roscovitine
    Antiproliferative activity against human HuH7 cells after 72 hrs by imaging analysis
    Antiproliferative activity against human HuH7 cells after 72 hrs by imaging analysis
    		[PMID: 19665384]
    Huh-7 IC50
    20 3
    Compound: Roscovitine
    Antiproliferative activity against human HuH7 cells after 48 hrs by Hoechst 33342 staining-based assay
    Antiproliferative activity against human HuH7 cells after 48 hrs by Hoechst 33342 staining-based assay
    		[PMID: 30655216]
    Huh-7 IC50
    9 3
    Compound: Roscovitine
    Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability after 48 hrs
    Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability after 48 hrs
    		[PMID: 34601029]
    Huh-7 IC50
    5 3
    Compound: Roscovitine
    Antiproliferative activity against human HuH7 cells after 48 hrs by Hoechst 3342 staining analysis
    Antiproliferative activity against human HuH7 cells after 48 hrs by Hoechst 3342 staining analysis
    		[PMID: 27019296]
    HUVEC GI50
    3.7 3
    Compound: Roscovitine
    Antiproliferative activity against human HUVEC cells after 72 hrs by sulforhodamine B assay
    Antiproliferative activity against human HUVEC cells after 72 hrs by sulforhodamine B assay
    		[PMID: 21080703]
    Huh-7 IC50
    5 3
    Compound: Roscovitine
    Antiproliferative activity against human HuH7 cells after 72 hrs by imaging analysis
    Antiproliferative activity against human HuH7 cells after 72 hrs by imaging analysis
    		[PMID: 19665384]
    IGROV-1 GI50
    6.3 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human IGROV1 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human IGROV1 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    Huh-7 IC50
    12 3
    Compound: Roscovitine
    Antiproliferative activity against human HuH7 cells incubated for 48 hrs by Hoechst 3342 dye staining based assay
    Antiproliferative activity against human HuH7 cells incubated for 48 hrs by Hoechst 3342 dye staining based assay
    		[PMID: 23063566]
    IMR-32 IC50
    17 3
    Compound: (R)-Roscovitine; Roscovitine
    Antiproliferative activity against human IMR32 cells after 2 days by XTT assay
    Antiproliferative activity against human IMR32 cells after 2 days by XTT assay
    		[PMID: 30199702]
    Huh-7 IC50
    10 3
    Compound: Roscovitin
    Cytotoxicity against human HuH7 cells after 48 hrs by Hoechst-33342 staining-based imaging analysis
    Cytotoxicity against human HuH7 cells after 48 hrs by Hoechst-33342 staining-based imaging analysis
    		[PMID: 21944287]
    K562 IC50
    > 20 3
    Compound: Roscovitine
    Antiproliferative activity against human K562 cells after 3 days by SRB assay
    Antiproliferative activity against human K562 cells after 3 days by SRB assay
    		[PMID: 20361800]
    Huh-7 IC50
    15.4 3
    Compound: Rosco
    Cytotoxicity against human HuH7 cells assessed as cell viability after 48 hrs by Hoechst 33342 staining based assay
    Cytotoxicity against human HuH7 cells assessed as cell viability after 48 hrs by Hoechst 33342 staining based assay
    		[PMID: 28214231]
    K562 IC50
    30.9 3
    Compound: Seliciclib; L2
    Cytotoxicity against human K562 cells assessed as cell viability after 72 hrs by fluorescence microplate reader method
    Cytotoxicity against human K562 cells assessed as cell viability after 72 hrs by fluorescence microplate reader method
    		[PMID: 26741853]
    HCT-116 GI50
    15.5 3
    Compound: Roscovitine
    Antiproliferative activity against human HCT116 cells after 72 hrs by sulforhodamine B assay
    Antiproliferative activity against human HCT116 cells after 72 hrs by sulforhodamine B assay
    		[PMID: 21080703]
    Huh-7 IC50
    9 3
    Compound: Roscovitine
    Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability after 48 hrs
    Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability after 48 hrs
    		[PMID: 34601029]
    K562 IC50
    42 3
    Compound: roscovitine
    Cytotoxicity against human K562 cells after 72 hrs using Calcein AM by fluorescence assay
    Cytotoxicity against human K562 cells after 72 hrs using Calcein AM by fluorescence assay
    		[PMID: 25757603]
    Huh-7 IC50
    5 3
    Compound: Roscovitine
    Cytotoxicity against human HuH7 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst 3342 staining based assay
    Cytotoxicity against human HuH7 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst 3342 staining based assay
    		[PMID: 26142492]
    HCT-116 GI50
    5.01 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human HCT116 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human HCT116 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    Huh-7 IC50
    14 3
    Compound: Roscovitine
    Cytotoxicity against human HuH-7 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst-33342 staining based cell counting method (Rvb > 25 microM)
    Cytotoxicity against human HuH-7 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst-33342 staining based cell counting method (Rvb > 25 microM)
    		[PMID: 33422908]
    K562 IC50
    45.5 3
    Compound: Roscov
    Cytotoxicity against human K562 cells assessed as reduction in cell viability after 72 hrs by calcein AM staining based fluorescence assay
    Cytotoxicity against human K562 cells assessed as reduction in cell viability after 72 hrs by calcein AM staining based fluorescence assay
    		[PMID: 26851505]
    HCT-116 GI50
    5.05 3
    Compound: 1, alphaR-1, CYC202, Seliciclib, R-roscovitine
    Growth inhibition of human HCT116 cells after 96 hrs by sulforhodamine B assay
    Growth inhibition of human HCT116 cells after 96 hrs by sulforhodamine B assay
    		[PMID: 21982796]
    HUVEC GI50
    3.7 3
    Compound: Roscovitine
    Antiproliferative activity against human HUVEC cells after 72 hrs by sulforhodamine B assay
    Antiproliferative activity against human HUVEC cells after 72 hrs by sulforhodamine B assay
    		[PMID: 21080703]
    K562 IC50
    45.5 3
    Compound: Roscovitine
    Cytotoxicity against human K562 cells assessed as reduction in number of viable cells after 72 hrs by fluorescence assay
    Cytotoxicity against human K562 cells assessed as reduction in number of viable cells after 72 hrs by fluorescence assay
    		[PMID: 22770608]
    HCT-116 IC50
    10.7 3
    Compound: Chemicel probe : R-CYC202
    Cytotoxicity against p53 wild-type human HCT-116 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
    Cytotoxicity against p53 wild-type human HCT-116 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
    		[PMID: 12432547]
    K562 IC50
    45.5 3
    Compound: Roscovitine
    Cytotoxicity against human K562 cells after 72 hrs by calcein-AM assay
    Cytotoxicity against human K562 cells after 72 hrs by calcein-AM assay
    		[PMID: 23981532]
    IGROV-1 GI50
    6.3 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human IGROV1 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human IGROV1 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    HCT-116 IC50
    14.4 3
    Compound: Roscovitine
    Cytotoxicity against human HCT116 cells assessed as reduction in number of viable cells after 72 hrs by fluorescence assay
    Cytotoxicity against human HCT116 cells assessed as reduction in number of viable cells after 72 hrs by fluorescence assay
    		[PMID: 22770608]
    K562 IC50
    45.5 3
    Compound: roscovitine, CYC202, seliciclib
    Cytotoxicity against human K562 cells assessed as growth inhibition after 72 hrs by calcein AM staining-based fluoroscence assay
    Cytotoxicity against human K562 cells assessed as growth inhibition after 72 hrs by calcein AM staining-based fluoroscence assay
    		[PMID: 23829517]
    IMR-32 IC50
    17 3
    Compound: (R)-Roscovitine; Roscovitine
    Antiproliferative activity against human IMR32 cells after 2 days by XTT assay
    Antiproliferative activity against human IMR32 cells after 2 days by XTT assay
    		[PMID: 30199702]
    HCT-116 IC50
    14.4 3
    Compound: roscovitine, CYC202, seliciclib
    Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by calcein AM staining-based fluoroscence assay
    Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by calcein AM staining-based fluoroscence assay
    		[PMID: 23829517]
    K562 GI50
    50.1 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human K562 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human K562 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    HCT-116 IC50
    14.42 3
    Compound: Roscov
    Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by calcein AM staining based fluorescence assay
    Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by calcein AM staining based fluorescence assay
    		[PMID: 26851505]
    K562 GI50
    50.1 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human K562 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human K562 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    KB IC50
    24.6 3
    Compound: Roscovitine
    Growth inhibition of human KB cells after 72 hrs by MTS/PMS system based colorimetric assay
    Growth inhibition of human KB cells after 72 hrs by MTS/PMS system based colorimetric assay
    		[PMID: 25988923]
    HCT-116 IC50
    15.54 3
    Compound: Roscovitine
    Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability after 48 hrs by MTT assay
    Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability after 48 hrs by MTT assay
    		[PMID: 32773088]
    K562 IC50
    42 3
    Compound: Roskovotin
    Antiproliferative activity against human K562 cells
    Antiproliferative activity against human K562 cells
    		[PMID: 23352483]
    KB IC50
    30.1 3
    Compound: Roscovitine
    Antiproliferative activity against human KB cells after 3 days by SRB assay
    Antiproliferative activity against human KB cells after 3 days by SRB assay
    		[PMID: 20361800]
    HCT-116 IC50
    16.38 3
    Compound: (R)-roscovitine
    Cytotoxicity against human HCT116 cells after 48 hrs by SRB assay
    Cytotoxicity against human HCT116 cells after 48 hrs by SRB assay
    		[PMID: 23036956]
    K562 IC50
    >20 3
    Compound: Roscovitine
    Antiproliferative activity against human K562 cells after 3 days by SRB assay
    Antiproliferative activity against human K562 cells after 3 days by SRB assay
    		[PMID: 20361800]
    KM12 GI50
    15 3
    Compound: 1, alphaR-1, CYC202, Seliciclib, R-roscovitine
    Growth inhibition of human KM12 cells after 96 hrs by sulforhodamine B assay
    Growth inhibition of human KM12 cells after 96 hrs by sulforhodamine B assay
    		[PMID: 21982796]
    K562 IC50
    40 3
    Compound: Roscovitine
    Cytotoxic property against K562 cell line was determined
    Cytotoxic property against K562 cell line was determined
    		[PMID: 12941319]
    HCT-116 IC50
    17.32 3
    Compound: Roscovitine
    Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
    Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
    		[PMID: 37708799]
    KM12 GI50
    5.01 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human KM12 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human KM12 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    K562 IC50
    45.5 3
    Compound: Roscovitine
    Cytotoxicity against human K562 cells
    Cytotoxicity against human K562 cells
    		[PMID: 27189674]
    HCT-116 IC50
    2 3
    Compound: Roscovitine
    Cytotoxicity against human HCT116 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst 3342 staining based assay
    Cytotoxicity against human HCT116 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst 3342 staining based assay
    		[PMID: 26142492]
    L02 IC50
    20.48 3
    Compound: (R)-roscovitine
    Cytotoxicity against human L02 cells after 48 hrs by SRB assay
    Cytotoxicity against human L02 cells after 48 hrs by SRB assay
    		[PMID: 23036956]
    HCT-116 IC50
    2 3
    Compound: Roscovitine
    Antiproliferative activity against human HCT116 cells after 48 hrs by Hoechst 3342 staining analysis
    Antiproliferative activity against human HCT116 cells after 48 hrs by Hoechst 3342 staining analysis
    		[PMID: 27019296]
    K562 IC50
    45.5 3
    Compound: Roscovitine
    Cytotoxicity against human K562 cells after 72 hrs by calcein-AM assay
    Cytotoxicity against human K562 cells after 72 hrs by calcein-AM assay
    		[PMID: 23981532]
    LOX IMVI GI50
    12.6 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human LOXIMVI cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human LOXIMVI cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    K562 IC50
    42 3
    Compound: roscovitine
    Cytotoxicity against human K562 cells after 72 hrs using Calcein AM by fluorescence assay
    Cytotoxicity against human K562 cells after 72 hrs using Calcein AM by fluorescence assay
    		[PMID: 25757603]
    HCT-116 IC50
    5 3
    Compound: Roscovitine
    Antiproliferative activity against human HCT116 cells after 72 hrs by imaging analysis
    Antiproliferative activity against human HCT116 cells after 72 hrs by imaging analysis
    		[PMID: 19665384]
    LP-1 IC50
    12.68 3
    Compound: CYC202, R-roscovitine
    Cytotoxicity against human LP-1 cells after 72 hrs by alamar blue assay
    Cytotoxicity against human LP-1 cells after 72 hrs by alamar blue assay
    		[PMID: 15958589]
    HCT-116 IC50
    6.76 3
    Compound: Roscovitine
    Antiproliferative activity against human HCT-116 cells assessed as reduction in cell growth incubated for 72 hrs by CCK-8 assay
    Antiproliferative activity against human HCT-116 cells assessed as reduction in cell growth incubated for 72 hrs by CCK-8 assay
    		[PMID: 32361064]
    K562 IC50
    30.9 3
    Compound: Seliciclib; L2
    Cytotoxicity against human K562 cells assessed as cell viability after 72 hrs by fluorescence microplate reader method
    Cytotoxicity against human K562 cells assessed as cell viability after 72 hrs by fluorescence microplate reader method
    		[PMID: 26741853]
    M14 GI50
    25.1 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human M14 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human M14 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    HCT-116 IC50
    7 3
    Compound: Roscovitine
    Antiproliferative activity against human HCT116 cells incubated for 48 hrs by Hoechst 3342 dye staining based assay
    Antiproliferative activity against human HCT116 cells incubated for 48 hrs by Hoechst 3342 dye staining based assay
    		[PMID: 23063566]
    K562 IC50
    45.5 3
    Compound: roscovitine, CYC202, seliciclib
    Cytotoxicity against human K562 cells assessed as growth inhibition after 72 hrs by calcein AM staining-based fluoroscence assay
    Cytotoxicity against human K562 cells assessed as growth inhibition after 72 hrs by calcein AM staining-based fluoroscence assay
    		[PMID: 23829517]
    Malme-3M GI50
    19.9 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human MALME-3M cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human MALME-3M cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    K562 IC50
    45.5 3
    Compound: Roscov
    Cytotoxicity against human K562 cells assessed as reduction in cell viability after 72 hrs by calcein AM staining based fluorescence assay
    Cytotoxicity against human K562 cells assessed as reduction in cell viability after 72 hrs by calcein AM staining based fluorescence assay
    		[PMID: 26851505]
    HCT-116 IC50
    8 3
    Compound: Rosco
    Cytotoxicity against human HCT116 cells assessed as cell viability after 48 hrs by Hoechst 33342 staining based assay
    Cytotoxicity against human HCT116 cells assessed as cell viability after 48 hrs by Hoechst 33342 staining based assay
    		[PMID: 28214231]
    MCF-10A GI50
    16.3 3
    Compound: Roscovitine
    Antiproliferative activity against human MCF10A cells after 72 hrs by sulforhodamine B assay
    Antiproliferative activity against human MCF10A cells after 72 hrs by sulforhodamine B assay
    		[PMID: 21080703]
    K562 IC50
    45.5 3
    Compound: Roscovitine
    Cytotoxicity against human K562 cells assessed as reduction in number of viable cells after 72 hrs by fluorescence assay
    Cytotoxicity against human K562 cells assessed as reduction in number of viable cells after 72 hrs by fluorescence assay
    		[PMID: 22770608]
    HCT-116 IC50
    8 3
    Compound: Roscovitin
    Cytotoxicity against human HCT116 cells after 48 hrs by Hoechst-33342 staining-based imaging analysis
    Cytotoxicity against human HCT116 cells after 48 hrs by Hoechst-33342 staining-based imaging analysis
    		[PMID: 21944287]
    MCF7 IC50
    10.2 3
    Compound: Rosco
    Cytotoxicity against human MCF7 assessed as cell viability after 48 hrs by Hoechst 33342 staining based assay
    Cytotoxicity against human MCF7 assessed as cell viability after 48 hrs by Hoechst 33342 staining based assay
    		[PMID: 28214231]
    HCT-116 IC50
    9 3
    Compound: Roscovitin
    Cytotoxicity against human HCT116 cells assessed as cell growth inhibition
    Cytotoxicity against human HCT116 cells assessed as cell growth inhibition
    		[PMID: 26934105]
    K562 IC50
    40 3
    Compound: Roscovitine
    In vitro cytotoxic effect on K562 cancer cell line
    In vitro cytotoxic effect on K562 cancer cell line
    		[PMID: 12392733]
    MCF7 IC50
    11 3
    Compound: roscovitine
    Cytotoxicity against human MCF7 cells after 72 hrs using Calcein AM by fluorescence assay
    Cytotoxicity against human MCF7 cells after 72 hrs using Calcein AM by fluorescence assay
    		[PMID: 25757603]
    KB IC50
    30.1 3
    Compound: Roscovitine
    Antiproliferative activity against human KB cells after 3 days by SRB assay
    Antiproliferative activity against human KB cells after 3 days by SRB assay
    		[PMID: 20361800]
    HCT-116 IC50
    9 3
    Compound: Roscovitine
    Antiproliferative activity against human HCT116 cells after 48 hrs by Hoechst 33342 staining-based assay
    Antiproliferative activity against human HCT116 cells after 48 hrs by Hoechst 33342 staining-based assay
    		[PMID: 30655216]
    MCF7 IC50
    12.22 3
    Compound: (R)-roscovitine
    Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
    Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
    		[PMID: 23036956]
    HCT-116 IC50
    9 3
    Compound: Roscovitine
    Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst-33342 staining based cell counting method (Rvb > 25 microM)
    Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst-33342 staining based cell counting method (Rvb > 25 microM)
    		[PMID: 33422908]
    KB IC50
    24.6 3
    Compound: Roscovitine
    Growth inhibition of human KB cells after 72 hrs by MTS/PMS system based colorimetric assay
    Growth inhibition of human KB cells after 72 hrs by MTS/PMS system based colorimetric assay
    		[PMID: 25988923]
    MCF7 IC50
    12.25 3
    Compound: Roscov
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by calcein AM staining based fluorescence assay
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by calcein AM staining based fluorescence assay
    		[PMID: 26851505]
    HCT-116 IC50
    9 3
    Compound: Roscovitine
    Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability after 48 hrs
    Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability after 48 hrs
    		[PMID: 34601029]
    SH-SY5Y IC50
    41 1
    Compound: 2
    Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability by MTS assay
    Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability by MTS assay
    		[PMID: 30639897]
    MCF7 IC50
    12.3 3
    Compound: Roscovitine
    Cytotoxicity against human MCF7 cells assessed as reduction in number of viable cells after 72 hrs by fluorescence assay
    Cytotoxicity against human MCF7 cells assessed as reduction in number of viable cells after 72 hrs by fluorescence assay
    		[PMID: 22770608]
    KM12 GI50
    5.01 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human KM12 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human KM12 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    MCF7 IC50
    12.3 3
    Compound: Roscovitine
    Cytotoxicity against human MCF7 cells after 72 hrs by calcein-AM assay
    Cytotoxicity against human MCF7 cells after 72 hrs by calcein-AM assay
    		[PMID: 23981532]
    KM12 GI50
    15 3
    Compound: 1, alphaR-1, CYC202, Seliciclib, R-roscovitine
    Growth inhibition of human KM12 cells after 96 hrs by sulforhodamine B assay
    Growth inhibition of human KM12 cells after 96 hrs by sulforhodamine B assay
    		[PMID: 21982796]
    L02 IC50
    20.48 3
    Compound: (R)-roscovitine
    Cytotoxicity against human L02 cells after 48 hrs by SRB assay
    Cytotoxicity against human L02 cells after 48 hrs by SRB assay
    		[PMID: 23036956]
    MCF7 IC50
    12.3 3
    Compound: roscovitine, CYC202, seliciclib
    Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by calcein AM staining-based fluoroscence assay
    Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by calcein AM staining-based fluoroscence assay
    		[PMID: 23829517]
    MCF7 GI50
    12.6 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human MCF7 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human MCF7 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    LOX IMVI GI50
    12.6 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human LOXIMVI cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human LOXIMVI cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    MCF7 IC50
    14.7 3
    Compound: Roscovitine
    Antiproliferative activity against human MCF7 cells after 3 days by SRB assay
    Antiproliferative activity against human MCF7 cells after 3 days by SRB assay
    		[PMID: 20361800]
    HCT-15 GI50
    19.9 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human HCT15 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human HCT15 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    LP-1 IC50
    12.68 3
    Compound: CYC202, R-roscovitine
    Cytotoxicity against human LP-1 cells after 72 hrs by alamar blue assay
    Cytotoxicity against human LP-1 cells after 72 hrs by alamar blue assay
    		[PMID: 15958589]
    MCF7 IC50
    19.6 3
    Compound: Roscovitine
    Growth inhibition of human MCF7 cells after 72 hrs by MTS/PMS system based colorimetric assay
    Growth inhibition of human MCF7 cells after 72 hrs by MTS/PMS system based colorimetric assay
    		[PMID: 25988923]
    M14 GI50
    25.1 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human M14 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human M14 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    HCT-15 IC50
    18.3 3
    Compound: Chemicel probe : R-CYC202
    Cytotoxicity against p53 mutant human HCT-15 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
    Cytotoxicity against p53 mutant human HCT-15 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
    		[PMID: 12432547]
    MCF7 IC50
    20.2 3
    Compound: Roscovitine
    Cytotoxicity against human MCF7 cells assessed as inhibition of cell viability after 72 hrs by calcien AM dye based fluorescence analysis
    Cytotoxicity against human MCF7 cells assessed as inhibition of cell viability after 72 hrs by calcien AM dye based fluorescence analysis
    		[PMID: 23399722]
    Malme-3M GI50
    19.9 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human MALME-3M cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human MALME-3M cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    MCF7 IC50
    27.2 3
    Compound: Seliciclib; L2
    Cytotoxicity against human MCF7 cells assessed as cell viability after 72 hrs by fluorescence microplate reader method
    Cytotoxicity against human MCF7 cells assessed as cell viability after 72 hrs by fluorescence microplate reader method
    		[PMID: 26741853]
    MCF-10A GI50
    16.3 3
    Compound: Roscovitine
    Antiproliferative activity against human MCF10A cells after 72 hrs by sulforhodamine B assay
    Antiproliferative activity against human MCF10A cells after 72 hrs by sulforhodamine B assay
    		[PMID: 21080703]
    MCF7 IC50
    3.98 3
    Compound: 1
    Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
    Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
    		[PMID: 23623491]
    MCF7 GI50
    7.8 3
    Compound: Roscovitine
    Antiproliferative activity against human MCF7 cells after 72 hrs by sulforhodamine B assay
    Antiproliferative activity against human MCF7 cells after 72 hrs by sulforhodamine B assay
    		[PMID: 21080703]
    HEK293 IC50
    23.4 3
    Compound: Roscovitine
    Inhibition of L-type calcium channel measured using 2-electrode voltage-clamp in human embryonic kidney cells heterologically expressing alpha-1C subunit
    Inhibition of L-type calcium channel measured using 2-electrode voltage-clamp in human embryonic kidney cells heterologically expressing alpha-1C subunit
    		[PMID: 22761000]
    MCF7 GI50
    12.6 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human MCF7 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human MCF7 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    MCF7 IC50
    55.01 3
    Compound: R-Roscovitine
    Antiproliferative activity against human MCF7 cells expressing estrogen receptor after 48 hrs by WST-1 assay
    Antiproliferative activity against human MCF7 cells expressing estrogen receptor after 48 hrs by WST-1 assay
    		[PMID: 21440449]
    HEK293 IC50
    46.7 3
    Compound: 8a, (R)-roscovitine
    Antiproliferative activity against HEK293 cells assessed as survival after 48 hrs by MTS reduction assay
    Antiproliferative activity against HEK293 cells assessed as survival after 48 hrs by MTS reduction assay
    		[PMID: 18698753]
    MCF7 GI50
    7.8 3
    Compound: Roscovitine
    Antiproliferative activity against human MCF7 cells after 72 hrs by sulforhodamine B assay
    Antiproliferative activity against human MCF7 cells after 72 hrs by sulforhodamine B assay
    		[PMID: 21080703]
    HEK293 IC50
    48.9 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human HEK293 cells after 48 hrs by MTS reduction assay
    Antiproliferative activity against human HEK293 cells after 48 hrs by MTS reduction assay
    		[PMID: 19128055]
    MCF7 IC50
    11 3
    Compound: Roskovotin
    Antiproliferative activity against human MCF7 cells
    Antiproliferative activity against human MCF7 cells
    		[PMID: 23352483]
    MCF7 IC50
    14.7 3
    Compound: Roscovitine
    Antiproliferative activity against human MCF7 cells after 3 days by SRB assay
    Antiproliferative activity against human MCF7 cells after 3 days by SRB assay
    		[PMID: 20361800]
    MCF7 IC50
    9 3
    Compound: Roscovitine
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs
    		[PMID: 34601029]
    HEK293 IC50
    5 3
    Compound: roscovitine
    Inhibition of mouse Dyrk1A autophosphorylation in HEk293 cells
    Inhibition of mouse Dyrk1A autophosphorylation in HEk293 cells
    		[PMID: 16698266]
    MCF7 IC50
    9 3
    Compound: Roscovitine
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst-33342 staining based cell counting method (Rvb > 25 microM)
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst-33342 staining based cell counting method (Rvb > 25 microM)
    		[PMID: 33422908]
    MCF7 IC50
    55.01 3
    Compound: R-Roscovitine
    Antiproliferative activity against human MCF7 cells expressing estrogen receptor after 48 hrs by WST-1 assay
    Antiproliferative activity against human MCF7 cells expressing estrogen receptor after 48 hrs by WST-1 assay
    		[PMID: 21440449]
    MCF7 IC50
    11.1 3
    Compound: Roscovitine
    Cytotoxic property against MCF-7 cell line was determined
    Cytotoxic property against MCF-7 cell line was determined
    		[PMID: 12941319]
    MDA-MB-231 IC50
    12 3
    Compound: Roscovitine
    Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by Hoechst 33342 staining-based assay
    Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by Hoechst 33342 staining-based assay
    		[PMID: 30655216]
    HL-60(TB) GI50
    19.9 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human HL60(TB) cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human HL60(TB) cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    MCF7 IC50
    10.2 3
    Compound: Rosco
    Cytotoxicity against human MCF7 assessed as cell viability after 48 hrs by Hoechst 33342 staining based assay
    Cytotoxicity against human MCF7 assessed as cell viability after 48 hrs by Hoechst 33342 staining based assay
    		[PMID: 28214231]
    MDA-MB-231 IC50
    12 3
    Compound: Roscovitine
    Antiproliferative activity against human MDA-MB-231 cells incubated for 48 hrs by Hoechst 3342 dye staining based assay
    Antiproliferative activity against human MDA-MB-231 cells incubated for 48 hrs by Hoechst 3342 dye staining based assay
    		[PMID: 23063566]
    MDA-MB-231 IC50
    15 3
    Compound: Roscovitine
    Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst-33342 staining based cell counting method (Rvb > 25 microM)
    Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst-33342 staining based cell counting method (Rvb > 25 microM)
    		[PMID: 33422908]
    MCF7 IC50
    12.3 3
    Compound: Roscovitine
    Cytotoxicity against human MCF7 cells
    Cytotoxicity against human MCF7 cells
    		[PMID: 27189674]
    MDA-MB-231 IC50
    15 3
    Compound: Roscovitin
    Cytotoxicity against human MDA-MB-231 cells after 48 hrs by Hoechst-33342 staining-based imaging analysis
    Cytotoxicity against human MDA-MB-231 cells after 48 hrs by Hoechst-33342 staining-based imaging analysis
    		[PMID: 21944287]
    HOP-62 GI50
    25.1 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human HOP62 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human HOP62 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    MCF7 IC50
    3.98 3
    Compound: 1
    Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
    Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
    		[PMID: 23623491]
    MDA-MB-231 IC50
    16.8 3
    Compound: Rosco
    Cytotoxicity against human MDA-MB-231 cells assessed as cell viability after 48 hrs by Hoechst 33342 staining based assay
    Cytotoxicity against human MDA-MB-231 cells assessed as cell viability after 48 hrs by Hoechst 33342 staining based assay
    		[PMID: 28214231]
    MCF7 IC50
    12.22 3
    Compound: (R)-roscovitine
    Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
    Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
    		[PMID: 23036956]
    MCF7 IC50
    12.3 3
    Compound: Roscovitine
    Cytotoxicity against human MCF7 cells after 72 hrs by calcein-AM assay
    Cytotoxicity against human MCF7 cells after 72 hrs by calcein-AM assay
    		[PMID: 23981532]
    MDA-MB-231 IC50
    17 3
    Compound: Roscovitine
    Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 48 hrs
    Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 48 hrs
    		[PMID: 34601029]
    MDA-MB-231 GI50
    22.6 3
    Compound: Roscovitine
    Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by sulforhodamine B assay
    Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by sulforhodamine B assay
    		[PMID: 21080703]
    MCF7 IC50
    11 3
    Compound: roscovitine
    Cytotoxicity against human MCF7 cells after 72 hrs using Calcein AM by fluorescence assay
    Cytotoxicity against human MCF7 cells after 72 hrs using Calcein AM by fluorescence assay
    		[PMID: 25757603]
    HOP-92 GI50
    50.1 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human HOP92 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human HOP92 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    MDA-MB-231 IC50
    3 3
    Compound: Roscovitine
    Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by Hoechst 3342 staining analysis
    Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by Hoechst 3342 staining analysis
    		[PMID: 27019296]
    MCF7 IC50
    27.2 3
    Compound: Seliciclib; L2
    Cytotoxicity against human MCF7 cells assessed as cell viability after 72 hrs by fluorescence microplate reader method
    Cytotoxicity against human MCF7 cells assessed as cell viability after 72 hrs by fluorescence microplate reader method
    		[PMID: 26741853]
    MDA-MB-231 IC50
    3 3
    Compound: Roscovitine
    Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst 3342 staining based assay
    Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst 3342 staining based assay
    		[PMID: 26142492]
    MCF7 IC50
    12.3 3
    Compound: roscovitine, CYC202, seliciclib
    Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by calcein AM staining-based fluoroscence assay
    Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by calcein AM staining-based fluoroscence assay
    		[PMID: 23829517]
    MCF7 IC50
    11 3
    Compound: Roscovitine
    Cytotoxicity against human MCF7 cells assessed as inhibition of cell proliferation
    Cytotoxicity against human MCF7 cells assessed as inhibition of cell proliferation
    		[PMID: 26698538]
    MDA-MB-231 GI50
    39.8 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    HOS IC50
    24.3 3
    Compound: Roscovitine
    Cytotoxicity against human HOS cells assessed as reduction in number of viable cells after 72 hrs by fluorescence assay
    Cytotoxicity against human HOS cells assessed as reduction in number of viable cells after 72 hrs by fluorescence assay
    		[PMID: 22770608]
    MDA-MB-231 IC50
    54.64 3
    Compound: R-Roscovitine
    Antiproliferative activity against estrogen receptor-deficient human MDA-MB-231 cells after 48 hrs by WST-1 assay
    Antiproliferative activity against estrogen receptor-deficient human MDA-MB-231 cells after 48 hrs by WST-1 assay
    		[PMID: 21440449]
    MCF7 IC50
    20.2 3
    Compound: Roscovitine
    Cytotoxicity against human MCF7 cells assessed as inhibition of cell viability after 72 hrs by calcien AM dye based fluorescence analysis
    Cytotoxicity against human MCF7 cells assessed as inhibition of cell viability after 72 hrs by calcien AM dye based fluorescence analysis
    		[PMID: 23399722]
    HOS IC50
    24.3 3
    Compound: roscovitine, CYC202, seliciclib
    Cytotoxicity against human HOS cells assessed as growth inhibition after 72 hrs by calcein AM staining-based fluoroscence assay
    Cytotoxicity against human HOS cells assessed as growth inhibition after 72 hrs by calcein AM staining-based fluoroscence assay
    		[PMID: 23829517]
    MDA-MB-435 GI50
    12.6 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human MDA-MB-435 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human MDA-MB-435 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    HOS IC50
    32 3
    Compound: Roscovitine
    In vitro cytotoxic effect on HOS cancer cell line
    In vitro cytotoxic effect on HOS cancer cell line
    		[PMID: 12392733]
    MCF7 IC50
    9 3
    Compound: Roscovitine
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs
    		[PMID: 34601029]
    MDA-MB-468 IC50
    18 3
    Compound: Roscovitine
    Cytotoxicity against human MDA-MB-468 cells assessed as reduction in cell viability after 48 hrs
    Cytotoxicity against human MDA-MB-468 cells assessed as reduction in cell viability after 48 hrs
    		[PMID: 34601029]
    HS27 IC50
    22.2 3
    Compound: Chemicel probe : R-CYC202
    Cytotoxicity against human HS27 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
    Cytotoxicity against human HS27 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
    		[PMID: 12432547]
    MCF7 IC50
    12.25 3
    Compound: Roscov
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by calcein AM staining based fluorescence assay
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by calcein AM staining based fluorescence assay
    		[PMID: 26851505]
    MIA PaCa-2 IC50
    18214 1
    Compound: Roscovitine
    Antiproliferative activity against human MIAPaCa2 cells after 72 hrs by prestoblue assay
    Antiproliferative activity against human MIAPaCa2 cells after 72 hrs by prestoblue assay
    		[PMID: 30343954]
    MCF7 IC50
    9 3
    Compound: Roscovitine
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst-33342 staining based cell counting method (Rvb > 25 microM)
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst-33342 staining based cell counting method (Rvb > 25 microM)
    		[PMID: 33422908]
    HT-1080 IC50
    16.8 3
    Compound: Roscovitine
    Antiproliferative activity against human HT1080 cells after 3 days by SRB assay
    Antiproliferative activity against human HT1080 cells after 3 days by SRB assay
    		[PMID: 20361800]
    MCF7 IC50
    12.3 3
    Compound: Roscovitine
    Cytotoxicity against human MCF7 cells assessed as reduction in number of viable cells after 72 hrs by fluorescence assay
    Cytotoxicity against human MCF7 cells assessed as reduction in number of viable cells after 72 hrs by fluorescence assay
    		[PMID: 22770608]
    MKN-45 IC50
    7.6 3
    Compound: Roscovitine
    Growth inhibition of human MKN45 cells after 72 hrs by MTS/PMS system based colorimetric assay
    Growth inhibition of human MKN45 cells after 72 hrs by MTS/PMS system based colorimetric assay
    		[PMID: 25988923]
    HT-1080 IC50
    9.62 3
    Compound: (R)-roscovitine
    Cytotoxicity against human HT1080 cells after 48 hrs by SRB assay
    Cytotoxicity against human HT1080 cells after 48 hrs by SRB assay
    		[PMID: 23036956]
    MOLT-4 GI50
    25.1 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human MOLT4 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human MOLT4 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    MCF7 IC50
    19.6 3
    Compound: Roscovitine
    Growth inhibition of human MCF7 cells after 72 hrs by MTS/PMS system based colorimetric assay
    Growth inhibition of human MCF7 cells after 72 hrs by MTS/PMS system based colorimetric assay
    		[PMID: 25988923]
    HT-1376 IC50
    18.4 3
    Compound: Chemicel probe : R-CYC202
    Cytotoxicity against p53 mutant human HT-1376 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
    Cytotoxicity against p53 mutant human HT-1376 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
    		[PMID: 12432547]
    NCI/ADR-RES GI50
    6.3 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human NCI/ADR-RES cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human NCI/ADR-RES cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    MCF7 IC50
    11.1 3
    Compound: Roscovitine
    In vitro cytotoxic effect on MCF-7 cancer cell line
    In vitro cytotoxic effect on MCF-7 cancer cell line
    		[PMID: 12392733]
    NCI-H226 GI50
    19.9 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human NCI-H226 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human NCI-H226 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    MDA-MB-231 GI50
    22.6 3
    Compound: Roscovitine
    Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by sulforhodamine B assay
    Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by sulforhodamine B assay
    		[PMID: 21080703]
    NCI-H23 GI50
    12.6 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human NCI-H23 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human NCI-H23 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    MDA-MB-231 GI50
    39.8 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    NCI-H322M GI50
    31.6 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human NCI-H322M cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human NCI-H322M cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    MDA-MB-231 IC50
    54.64 3
    Compound: R-Roscovitine
    Antiproliferative activity against estrogen receptor-deficient human MDA-MB-231 cells after 48 hrs by WST-1 assay
    Antiproliferative activity against estrogen receptor-deficient human MDA-MB-231 cells after 48 hrs by WST-1 assay
    		[PMID: 21440449]
    MDA-MB-231 IC50
    12 3
    Compound: Roscovitine
    Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by Hoechst 33342 staining-based assay
    Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by Hoechst 33342 staining-based assay
    		[PMID: 30655216]
    NCI-H460 IC50
    11.6 3
    Compound: Roscovitine
    Growth inhibition of human NCI-H460 cells after 72 hrs by MTS/PMS system based colorimetric assay
    Growth inhibition of human NCI-H460 cells after 72 hrs by MTS/PMS system based colorimetric assay
    		[PMID: 25988923]
    NCI-H460 IC50
    11.9 3
    Compound: Roscovitine
    Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell growth incubated for 72 hrs by CCK-8 assay
    Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell growth incubated for 72 hrs by CCK-8 assay
    		[PMID: 32361064]
    MDA-MB-231 IC50
    3 3
    Compound: Roscovitine
    Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by Hoechst 3342 staining analysis
    Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by Hoechst 3342 staining analysis
    		[PMID: 27019296]
    MDA-MB-231 IC50
    12 3
    Compound: Roscovitine
    Antiproliferative activity against human MDA-MB-231 cells incubated for 48 hrs by Hoechst 3342 dye staining based assay
    Antiproliferative activity against human MDA-MB-231 cells incubated for 48 hrs by Hoechst 3342 dye staining based assay
    		[PMID: 23063566]
    NCI-H460 GI50
    25.1 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human NCI-H460 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human NCI-H460 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    NCI-H522 GI50
    15.8 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human NCI-H522 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human NCI-H522 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    MDA-MB-231 IC50
    15 3
    Compound: Roscovitin
    Cytotoxicity against human MDA-MB-231 cells after 48 hrs by Hoechst-33342 staining-based imaging analysis
    Cytotoxicity against human MDA-MB-231 cells after 48 hrs by Hoechst-33342 staining-based imaging analysis
    		[PMID: 21944287]
    MDA-MB-231 IC50
    15 3
    Compound: Roscovitin
    Cytotoxicity against human MDA-MB-231 cells assessed as cell growth inhibition
    Cytotoxicity against human MDA-MB-231 cells assessed as cell growth inhibition
    		[PMID: 26934105]
    NCI-H727 IC50
    > 20 3
    Compound: Rosco
    Cytotoxicity against human NCI-H727 cells assessed as cell viability after 48 hrs by Hoechst 33342 staining based assay
    Cytotoxicity against human NCI-H727 cells assessed as cell viability after 48 hrs by Hoechst 33342 staining based assay
    		[PMID: 28214231]
    NCI-H727 IC50
    20 3
    Compound: Roscovitine
    Antiproliferative activity against human NCI-H727 cells after 48 hrs by Hoechst 33342 staining-based assay
    Antiproliferative activity against human NCI-H727 cells after 48 hrs by Hoechst 33342 staining-based assay
    		[PMID: 30655216]
    HT-29 GI50
    19.9 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human HT29 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human HT29 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    MDA-MB-231 IC50
    16.8 3
    Compound: Rosco
    Cytotoxicity against human MDA-MB-231 cells assessed as cell viability after 48 hrs by Hoechst 33342 staining based assay
    Cytotoxicity against human MDA-MB-231 cells assessed as cell viability after 48 hrs by Hoechst 33342 staining based assay
    		[PMID: 28214231]
    MDA-MB-231 IC50
    15 3
    Compound: 2
    Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability
    Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability
    		[PMID: 31514062]
    NCI-H727 IC50
    20 3
    Compound: Roscovitine
    Antiproliferative activity against human NCI-H727 cells incubated for 48 hrs by Hoechst 3342 dye staining based assay
    Antiproliferative activity against human NCI-H727 cells incubated for 48 hrs by Hoechst 3342 dye staining based assay
    		[PMID: 23063566]
    HT-29 GI50
    6.4 3
    Compound: 1, alphaR-1, CYC202, Seliciclib, R-roscovitine
    Growth inhibition of human HT-29 cells after 96 hrs by sulforhodamine B assay
    Growth inhibition of human HT-29 cells after 96 hrs by sulforhodamine B assay
    		[PMID: 21982796]
    NCI-H727 IC50
    28 3
    Compound: Roscovitine
    Cytotoxicity against human NCI-H727 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst-33342 staining based cell counting method (Rvb > 25 microM)
    Cytotoxicity against human NCI-H727 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst-33342 staining based cell counting method (Rvb > 25 microM)
    		[PMID: 33422908]
    MDA-MB-231 IC50
    17 3
    Compound: Roscovitine
    Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 48 hrs
    Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 48 hrs
    		[PMID: 34601029]
    HT-29 IC50
    11.63 3
    Compound: (R)-roscovitine
    Cytotoxicity against human HT-29 cells after 48 hrs by SRB assay
    Cytotoxicity against human HT-29 cells after 48 hrs by SRB assay
    		[PMID: 23036956]
    NCI-H727 IC50
    4 3
    Compound: Roscovitine
    Antiproliferative activity against human NCI-H727 cells after 48 hrs by Hoechst 3342 staining analysis
    Antiproliferative activity against human NCI-H727 cells after 48 hrs by Hoechst 3342 staining analysis
    		[PMID: 27019296]
    HT-29 IC50
    14.6 3
    Compound: Chemicel probe : R-CYC202
    Cytotoxicity against p53 mutant human HT-29 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
    Cytotoxicity against p53 mutant human HT-29 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
    		[PMID: 12432547]
    MDA-MB-231 IC50
    3 3
    Compound: Roscovitine
    Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst 3342 staining based assay
    Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst 3342 staining based assay
    		[PMID: 26142492]
    MDA-MB-231 IC50
    15 3
    Compound: Roscovitine
    Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst-33342 staining based cell counting method (Rvb > 25 microM)
    Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst-33342 staining based cell counting method (Rvb > 25 microM)
    		[PMID: 33422908]
    NCI-H727 IC50
    4 3
    Compound: Roscovitine
    Cytotoxicity against human NCI-H727 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst 3342 staining based assay
    Cytotoxicity against human NCI-H727 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst 3342 staining based assay
    		[PMID: 26142492]
    HT-29 IC50
    > 100 3
    Compound: Roscovitine
    Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
    Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
    		[PMID: 37708799]
    NCI-H929 IC50
    8.84 3
    Compound: CYC202, R-roscovitine
    Cytotoxicity against human NCI-H929 cells after 72 hrs by alamar blue assay
    Cytotoxicity against human NCI-H929 cells after 72 hrs by alamar blue assay
    		[PMID: 15958589]
    MDA-MB-435 GI50
    12.6 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human MDA-MB-435 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human MDA-MB-435 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    Non-small cell lung cancer cells GI50
    23.6 3
    Compound: Roscovitine
    Anticancer activity against human Non-small cell lung cancer cell line assessed as cell growth inhibition incubated for 48 hrs by Sulphorhodamine B assay
    Anticancer activity against human Non-small cell lung cancer cell line assessed as cell growth inhibition incubated for 48 hrs by Sulphorhodamine B assay
    		[PMID: 27744184]
    MDA-MB-468 IC50
    18 3
    Compound: Roscovitine
    Cytotoxicity against human MDA-MB-468 cells assessed as reduction in cell viability after 48 hrs
    Cytotoxicity against human MDA-MB-468 cells assessed as reduction in cell viability after 48 hrs
    		[PMID: 34601029]
    Oocyte IC50
    0.65 1
    Compound: 3; CYC202
    Inhibition of starfish oocyte CDK1/Cyclin B using histone H1 as substrate incubated for 10 mins in presence of [gamma-32P]ATP by scintillation counter analysis
    Inhibition of starfish oocyte CDK1/Cyclin B using histone H1 as substrate incubated for 10 mins in presence of [gamma-32P]ATP by scintillation counter analysis
    		[PMID: 35485642]
    Sf21 IC50
    100 1
    Compound: Roscovitine
    Inhibition of CDK2/cyclin E (unknown origin) expressed in baculovirus infected Sf21 insect cells in presence of [gamma33P]ATP
    Inhibition of CDK2/cyclin E (unknown origin) expressed in baculovirus infected Sf21 insect cells in presence of [gamma33P]ATP
    		[PMID: 32150405]
    HUVEC GI50
    3.7 3
    Compound: Roscovitine
    Antiproliferative activity against human HUVEC cells after 72 hrs by sulforhodamine B assay
    Antiproliferative activity against human HUVEC cells after 72 hrs by sulforhodamine B assay
    		[PMID: 21080703]
    Oocyte IC50
    650 1
    Compound: 2
    Inhibition of starfish oocyte CDK1 using histone H1 as substrate incubated for 10 mins in presence of [gamma-32P]ATP by radiometric scintillation assay
    Inhibition of starfish oocyte CDK1 using histone H1 as substrate incubated for 10 mins in presence of [gamma-32P]ATP by radiometric scintillation assay
    		[PMID: 35235745]
    MKN-45 IC50
    7.6 3
    Compound: Roscovitine
    Growth inhibition of human MKN45 cells after 72 hrs by MTS/PMS system based colorimetric assay
    Growth inhibition of human MKN45 cells after 72 hrs by MTS/PMS system based colorimetric assay
    		[PMID: 25988923]
    OPM-2 IC50
    18.46 3
    Compound: CYC202, R-roscovitine
    Cytotoxicity against human OPM2 cells after 72 hrs by alamar blue assay
    Cytotoxicity against human OPM2 cells after 72 hrs by alamar blue assay
    		[PMID: 15958589]
    MOLT-4 GI50
    25.1 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human MOLT4 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human MOLT4 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    OVCAR-3 GI50
    12.6 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human OVCAR-3 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human OVCAR-3 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    Sf9 IC50
    170 1
    Compound: roscovitine, CYC202, seliciclib
    Inhibition of human recombinant CDK2/Cyclin E expressed in baculovirus infected sf9 cells using histone H1 as substrate
    Inhibition of human recombinant CDK2/Cyclin E expressed in baculovirus infected sf9 cells using histone H1 as substrate
    		[PMID: 23829517]
    OVCAR-3 IC50
    37 3
    Compound: (R)-Roscovitine; Roscovitine
    Antiproliferative activity against human OVCAR3 cells after 2 days by XTT assay
    Antiproliferative activity against human OVCAR3 cells after 2 days by XTT assay
    		[PMID: 30199702]
    Sf9 IC50
    180 1
    Compound: Roscovitine
    Inhibition of CDK2/Cyclin E (unknown origin) expressed in Sf9 cells using histone H1 as substrate
    Inhibition of CDK2/Cyclin E (unknown origin) expressed in Sf9 cells using histone H1 as substrate
    		[PMID: 22770608]
    HaCaT IC50
    12 3
    Compound: Roscovitine
    Antiproliferative activity against human HaCaT cells after 48 hrs by Hoechst 33342 staining-based assay
    Antiproliferative activity against human HaCaT cells after 48 hrs by Hoechst 33342 staining-based assay
    		[PMID: 30655216]
    OVCAR-4 GI50
    31.6 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human OVCAR4 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human OVCAR4 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    Sf21 IC50
    193 1
    Compound: Roscovitine
    Inhibition of wild-type human N-terminal GST-tagged CDK2/cycA2 expressed in Sf21 insect cells using FAM-labelled substrate preincubated for 10 mins followed by substrate addition and measured after 30 mins by fluorescence assay
    Inhibition of wild-type human N-terminal GST-tagged CDK2/cycA2 expressed in Sf21 insect cells using FAM-labelled substrate preincubated for 10 mins followed by substrate addition and measured after 30 mins by fluorescence assay
    		[PMID: 31272794]
    HaCaT IC50
    16.7 3
    Compound: Rosco
    Cytotoxicity against human HaCaT cells assessed as cell viability after 48 hrs by Hoechst 33342 staining based assay
    Cytotoxicity against human HaCaT cells assessed as cell viability after 48 hrs by Hoechst 33342 staining based assay
    		[PMID: 28214231]
    OVCAR-5 GI50
    39.8 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human OVCAR5 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human OVCAR5 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    NCI/ADR-RES GI50
    6.3 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human NCI/ADR-RES cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human NCI/ADR-RES cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    Panel breast cells GI50
    22.7 3
    Compound: Roscovitine
    Anticancer activity against human Panel breast (Carcinoma cell lines) assessed as cell growth inhibition incubated for 48 hrs by Sulphorhodamine B assay
    Anticancer activity against human Panel breast (Carcinoma cell lines) assessed as cell growth inhibition incubated for 48 hrs by Sulphorhodamine B assay
    		[PMID: 27744184]
    NCI-H226 GI50
    19.9 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human NCI-H226 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human NCI-H226 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    NCI-H23 GI50
    12.6 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human NCI-H23 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human NCI-H23 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    Panel CNS (Carcinoma cell lines) GI50
    24.7 3
    Compound: Roscovitine
    Anticancer activity against human Panel CNS (Carcinoma cell lines) assessed as cell growth inhibition incubated for 48 hrs by Sulphorhodamine B assay
    Anticancer activity against human Panel CNS (Carcinoma cell lines) assessed as cell growth inhibition incubated for 48 hrs by Sulphorhodamine B assay
    		[PMID: 27744184]
    NCI-H322M GI50
    31.6 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human NCI-H322M cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human NCI-H322M cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    Panel colon cells GI50
    24.8 3
    Compound: Roscovitine
    Anticancer activity against human Panel colon (Carcinoma cell lines) assessed as cell growth inhibition incubated for 48 hrs by Sulphorhodamine B assay
    Anticancer activity against human Panel colon (Carcinoma cell lines) assessed as cell growth inhibition incubated for 48 hrs by Sulphorhodamine B assay
    		[PMID: 27744184]
    Panel leukemia cells GI50
    37.5 3
    Compound: Roscovitine
    Anticancer activity against human Panel leukemia (Carcinoma cell lines) assessed as cell growth inhibition incubated for 48 hrs by Sulphorhodamine B assay
    Anticancer activity against human Panel leukemia (Carcinoma cell lines) assessed as cell growth inhibition incubated for 48 hrs by Sulphorhodamine B assay
    		[PMID: 27744184]
    HeLa IC50
    1.81 3
    Compound: 1
    Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
    Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
    		[PMID: 23623491]
    NCI-H460 GI50
    25.1 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human NCI-H460 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human NCI-H460 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    NCI-H460 IC50
    11.9 3
    Compound: Roscovitine
    Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell growth incubated for 72 hrs by CCK-8 assay
    Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell growth incubated for 72 hrs by CCK-8 assay
    		[PMID: 32361064]
    Panel melanoma cells GI50
    14.8 3
    Compound: Roscovitine
    Anticancer activity against human Panel melanoma (Carcinoma cell lines) assessed as cell growth inhibition incubated for 48 hrs by Sulphorhodamine B assay
    Anticancer activity against human Panel melanoma (Carcinoma cell lines) assessed as cell growth inhibition incubated for 48 hrs by Sulphorhodamine B assay
    		[PMID: 27744184]
    HeLa IC50
    11.21 3
    Compound: Roscovitine
    Antiproliferative activity against human HeLa cells assessed as reduction in cell growth incubated for 72 hrs by CCK-8 assay
    Antiproliferative activity against human HeLa cells assessed as reduction in cell growth incubated for 72 hrs by CCK-8 assay
    		[PMID: 32361064]
    Panel ovarian cells GI50
    29.3 3
    Compound: Roscovitine
    Anticancer activity against human Panel ovarian (Carcinoma cell lines) assessed as cell growth inhibition incubated for 48 hrs by Sulphorhodamine B assay
    Anticancer activity against human Panel ovarian (Carcinoma cell lines) assessed as cell growth inhibition incubated for 48 hrs by Sulphorhodamine B assay
    		[PMID: 27744184]
    HeLa IC50
    2.2 3
    Compound: Roscovitine
    Cytotoxicity against human HeLa cells by MTT assay
    Cytotoxicity against human HeLa cells by MTT assay
    		[PMID: 36325400]
    NCI-H460 IC50
    11.6 3
    Compound: Roscovitine
    Growth inhibition of human NCI-H460 cells after 72 hrs by MTS/PMS system based colorimetric assay
    Growth inhibition of human NCI-H460 cells after 72 hrs by MTS/PMS system based colorimetric assay
    		[PMID: 25988923]
    Panel prostate cells GI50
    17.9 3
    Compound: Roscovitine
    Anticancer activity against human Panel prostate (Carcinoma cell lines) assessed as cell growth inhibition incubated for 48 hrs by Sulphorhodamine B assay
    Anticancer activity against human Panel prostate (Carcinoma cell lines) assessed as cell growth inhibition incubated for 48 hrs by Sulphorhodamine B assay
    		[PMID: 27744184]
    HeLa IC50
    28.6 3
    Compound: roscovitine, CYC202, seliciclib
    Cytotoxicity against human HeLa cells assessed as growth inhibition after 72 hrs by calcein AM staining-based fluoroscence assay
    Cytotoxicity against human HeLa cells assessed as growth inhibition after 72 hrs by calcein AM staining-based fluoroscence assay
    		[PMID: 23829517]
    NCI-H522 GI50
    15.8 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human NCI-H522 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human NCI-H522 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    Panel renal cells GI50
    24.9 3
    Compound: Roscovitine
    Anticancer activity against human Panel renal (Carcinoma cell lines) assessed as cell growth inhibition incubated for 48 hrs by Sulphorhodamine B assay
    Anticancer activity against human Panel renal (Carcinoma cell lines) assessed as cell growth inhibition incubated for 48 hrs by Sulphorhodamine B assay
    		[PMID: 27744184]
    NCI-H727 IC50
    20 3
    Compound: Roscovitine
    Antiproliferative activity against human NCI-H727 cells after 48 hrs by Hoechst 33342 staining-based assay
    Antiproliferative activity against human NCI-H727 cells after 48 hrs by Hoechst 33342 staining-based assay
    		[PMID: 30655216]
    HeLa S3 GI50
    20 3
    Compound: 1
    Growth inhibition of human HeLaS3 cells
    Growth inhibition of human HeLaS3 cells
    		[PMID: 19854650]
    PC-3 IC50
    10 3
    Compound: Roscovitine
    Cytotoxicity against human PC-3 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst-33342 staining based cell counting method (Rvb > 25 microM)
    Cytotoxicity against human PC-3 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst-33342 staining based cell counting method (Rvb > 25 microM)
    		[PMID: 33422908]
    NCI-H727 IC50
    4 3
    Compound: Roscovitine
    Antiproliferative activity against human NCI-H727 cells after 48 hrs by Hoechst 3342 staining analysis
    Antiproliferative activity against human NCI-H727 cells after 48 hrs by Hoechst 3342 staining analysis
    		[PMID: 27019296]
    HeLa S3 GI50
    20 3
    Compound: 2
    Antiproliferative activity against human HeLaS3 cells by sulforhodamine B assay
    Antiproliferative activity against human HeLaS3 cells by sulforhodamine B assay
    		[PMID: 19846305]
    NCI-H727 IC50
    20 3
    Compound: Roscovitine
    Antiproliferative activity against human NCI-H727 cells incubated for 48 hrs by Hoechst 3342 dye staining based assay
    Antiproliferative activity against human NCI-H727 cells incubated for 48 hrs by Hoechst 3342 dye staining based assay
    		[PMID: 23063566]
    PC-3 IC50
    10 3
    Compound: Roscovitine
    Antiproliferative activity against human PC3 cells incubated for 48 hrs by Hoechst 3342 dye staining based assay
    Antiproliferative activity against human PC3 cells incubated for 48 hrs by Hoechst 3342 dye staining based assay
    		[PMID: 23063566]
    Hep 3B2 IC50
    9 3
    Compound: Roscovitine
    Growth inhibition of human Hep3B cells after 72 hrs by MTS/PMS system based colorimetric assay
    Growth inhibition of human Hep3B cells after 72 hrs by MTS/PMS system based colorimetric assay
    		[PMID: 25988923]
    PC-3 IC50
    11 3
    Compound: Roscovitine
    Cytotoxicity against human PC-3 cells assessed as reduction in cell viability after 48 hrs
    Cytotoxicity against human PC-3 cells assessed as reduction in cell viability after 48 hrs
    		[PMID: 34601029]
    HepG2 GI50
    25.9 3
    Compound: Roscovitine
    Antiproliferative activity against human HepG2 cells after 72 hrs by sulforhodamine B assay
    Antiproliferative activity against human HepG2 cells after 72 hrs by sulforhodamine B assay
    		[PMID: 21080703]
    NCI-H727 IC50
    >20 3
    Compound: Rosco
    Cytotoxicity against human NCI-H727 cells assessed as cell viability after 48 hrs by Hoechst 33342 staining based assay
    Cytotoxicity against human NCI-H727 cells assessed as cell viability after 48 hrs by Hoechst 33342 staining based assay
    		[PMID: 28214231]
    PC-3 IC50
    12 3
    Compound: Roscovitine
    Antiproliferative activity against human PC3 cells after 48 hrs by Hoechst 33342 staining-based assay
    Antiproliferative activity against human PC3 cells after 48 hrs by Hoechst 33342 staining-based assay
    		[PMID: 30655216]
    HepG2 IC50
    11.3 3
    Compound: Chemicel probe : R-CYC202
    Cytotoxicity against p53 wild-type human HepG2 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
    Cytotoxicity against p53 wild-type human HepG2 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
    		[PMID: 12432547]
    NCI-H727 IC50
    4 3
    Compound: Roscovitine
    Cytotoxicity against human NCI-H727 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst 3342 staining based assay
    Cytotoxicity against human NCI-H727 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst 3342 staining based assay
    		[PMID: 26142492]
    PC-3 IC50
    16.5 3
    Compound: Rosco
    Cytotoxicity against human PC3 cells assessed as cell viability after 48 hrs by Hoechst 33342 staining based assay
    Cytotoxicity against human PC3 cells assessed as cell viability after 48 hrs by Hoechst 33342 staining based assay
    		[PMID: 28214231]
    NCI-H727 IC50
    28 3
    Compound: Roscovitine
    Cytotoxicity against human NCI-H727 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst-33342 staining based cell counting method (Rvb > 25 microM)
    Cytotoxicity against human NCI-H727 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst-33342 staining based cell counting method (Rvb > 25 microM)
    		[PMID: 33422908]
    HepG2 IC50
    15.47 3
    Compound: (R)-roscovitine
    Cytotoxicity against human HepG2 cells after 48 hrs by SRB assay
    Cytotoxicity against human HepG2 cells after 48 hrs by SRB assay
    		[PMID: 23036956]
    PC-3 GI50
    19.9 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human PC3 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human PC3 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    HepG2 IC50
    15.76 3
    Compound: Roscovitine
    Antiproliferative activity against human HepG2 cells measured after 72 hrs by CCK8 assay
    Antiproliferative activity against human HepG2 cells measured after 72 hrs by CCK8 assay
    		[PMID: 31272794]
    NCI-H929 IC50
    8.84 3
    Compound: CYC202, R-roscovitine
    Cytotoxicity against human NCI-H929 cells after 72 hrs by alamar blue assay
    Cytotoxicity against human NCI-H929 cells after 72 hrs by alamar blue assay
    		[PMID: 15958589]
    PC-3 IC50
    2 3
    Compound: Roscovitine
    Antiproliferative activity against human PC3 cells after 48 hrs by Hoechst 3342 staining analysis
    Antiproliferative activity against human PC3 cells after 48 hrs by Hoechst 3342 staining analysis
    		[PMID: 27019296]
    HepG2 IC50
    8.53 3
    Compound: Roscovitine
    Antiproliferative activity against human HepG2 cells assessed as reduction in cell growth incubated for 72 hrs by CCK-8 assay
    Antiproliferative activity against human HepG2 cells assessed as reduction in cell growth incubated for 72 hrs by CCK-8 assay
    		[PMID: 32361064]
    PC-3 IC50
    2 3
    Compound: Roscovitine
    Cytotoxicity against human PC3 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst 3342 staining based assay
    Cytotoxicity against human PC3 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst 3342 staining based assay
    		[PMID: 26142492]
    HepG2 IC50
    > 100 3
    Compound: Roscovitine
    Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
    Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
    		[PMID: 37708799]
    Oocyte IC50
    0.33 3
    Compound: (R)-roscovitine
    Inhibition of starfish oocytes CDK1/cyclin B
    Inhibition of starfish oocytes CDK1/cyclin B
    		[PMID: 19128055]
    PC-3 GI50
    25.2 3
    Compound: Roscovitine
    Antiproliferative activity against human PC3 cells after 72 hrs by sulforhodamine B assay
    Antiproliferative activity against human PC3 cells after 72 hrs by sulforhodamine B assay
    		[PMID: 21080703]
    Oocyte IC50
    0.2 3
    Compound: 26
    Inhibitory activity against purified cdc2 p34/Cyclin B obtained from M phase oocytes of the starfish Marthasterias glacialis.
    Inhibitory activity against purified cdc2 p34/Cyclin B obtained from M phase oocytes of the starfish Marthasterias glacialis.
    		[PMID: 9046330]
    OPM-2 IC50
    18.46 3
    Compound: CYC202, R-roscovitine
    Cytotoxicity against human OPM2 cells after 72 hrs by alamar blue assay
    Cytotoxicity against human OPM2 cells after 72 hrs by alamar blue assay
    		[PMID: 15958589]
    PC-3 IC50
    8 3
    Compound: Roscovitin
    Cytotoxicity against human PC3 cells after 48 hrs by Hoechst-33342 staining-based imaging analysis
    Cytotoxicity against human PC3 cells after 48 hrs by Hoechst-33342 staining-based imaging analysis
    		[PMID: 21944287]
    PC-3 IC50
    8 3
    Compound: Roscovitine
    Antiproliferative activity against human PC3 cells after 72 hrs by imaging analysis
    Antiproliferative activity against human PC3 cells after 72 hrs by imaging analysis
    		[PMID: 19665384]
    OVCAR-3 GI50
    12.6 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human OVCAR-3 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human OVCAR-3 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    RL IC50
    0.9 3
    Compound: Rosco
    Cytotoxicity against human RL assessed as cell viability after 48 hrs by Hoechst 33342 staining based assay
    Cytotoxicity against human RL assessed as cell viability after 48 hrs by Hoechst 33342 staining based assay
    		[PMID: 28214231]
    Hs-578T GI50
    12.8 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human Hs 578T cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human Hs 578T cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    OVCAR-3 IC50
    37 3
    Compound: (R)-Roscovitine; Roscovitine
    Antiproliferative activity against human OVCAR3 cells after 2 days by XTT assay
    Antiproliferative activity against human OVCAR3 cells after 2 days by XTT assay
    		[PMID: 30199702]
    RPMI-8226 IC50
    19.5 3
    Compound: CYC202, R-roscovitine
    Cytotoxicity against human RPM18226 cells after 72 hrs by alamar blue assay
    Cytotoxicity against human RPM18226 cells after 72 hrs by alamar blue assay
    		[PMID: 15958589]
    OVCAR-4 GI50
    31.6 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human OVCAR4 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human OVCAR4 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    RXF 393 GI50
    5 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human RFX393 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human RFX393 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    OVCAR-5 GI50
    39.8 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human OVCAR5 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human OVCAR5 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    SAOS-2 GI50
    13.9 3
    Compound: Roscovitine
    Antiproliferative activity against human Saos2 cells after 72 hrs by sulforhodamine B assay
    Antiproliferative activity against human Saos2 cells after 72 hrs by sulforhodamine B assay
    		[PMID: 21080703]
    Sf21 IC50
    0.5 3
    Compound: Roscovitine
    Inhibition of CDK2/cyclin A expressed in baculovirus infected insect Sf21 cells using [gamma-P32]ATP and histone H1 as substrate after 10 mins by radiometric assay
    Inhibition of CDK2/cyclin A expressed in baculovirus infected insect Sf21 cells using [gamma-P32]ATP and histone H1 as substrate after 10 mins by radiometric assay
    		[PMID: 22000924]
    Panel CNS (Carcinoma cell lines) GI50
    24.7 3
    Compound: Roscovitine
    Anticancer activity against human Panel CNS (Carcinoma cell lines) assessed as cell growth inhibition incubated for 48 hrs by Sulphorhodamine B assay
    Anticancer activity against human Panel CNS (Carcinoma cell lines) assessed as cell growth inhibition incubated for 48 hrs by Sulphorhodamine B assay
    		[PMID: 27744184]
    Sf21 IC50
    0.5 3
    Compound: Roscovitine
    Inhibition of human N-terminal hexahistidine-tagged CDK2 expressed in baculovirus infected Sf21 cells using histone H1 as substrate after 10 mins in presence of [gamma-32P]-ATP
    Inhibition of human N-terminal hexahistidine-tagged CDK2 expressed in baculovirus infected Sf21 cells using histone H1 as substrate after 10 mins in presence of [gamma-32P]-ATP
    		[PMID: 23933045]
    Sf21 IC50
    15 3
    Compound: Roscovitine
    Inhibition of CDK4/cyclin D expressed in baculovirus infected insect Sf21 cells using [gamma-P32]ATP and histone H1 as substrate after 10 mins by radiometric assay
    Inhibition of CDK4/cyclin D expressed in baculovirus infected insect Sf21 cells using [gamma-P32]ATP and histone H1 as substrate after 10 mins by radiometric assay
    		[PMID: 22000924]
    Huh-7 IC50
    10 3
    Compound: Roscovitin
    Cytotoxicity against human HuH7 cells after 48 hrs by Hoechst-33342 staining-based imaging analysis
    Cytotoxicity against human HuH7 cells after 48 hrs by Hoechst-33342 staining-based imaging analysis
    		[PMID: 21944287]
    Sf21 IC50
    193 1
    Compound: Roscovitine
    Inhibition of wild-type human N-terminal GST-tagged CDK2/cycA2 expressed in Sf21 insect cells using FAM-labelled substrate preincubated for 10 mins followed by substrate addition and measured after 30 mins by fluorescence assay
    Inhibition of wild-type human N-terminal GST-tagged CDK2/cycA2 expressed in Sf21 insect cells using FAM-labelled substrate preincubated for 10 mins followed by substrate addition and measured after 30 mins by fluorescence assay
    		[PMID: 31272794]
    Huh-7 IC50
    12 3
    Compound: Roscovitine
    Antiproliferative activity against human HuH7 cells incubated for 48 hrs by Hoechst 3342 dye staining based assay
    Antiproliferative activity against human HuH7 cells incubated for 48 hrs by Hoechst 3342 dye staining based assay
    		[PMID: 23063566]
    SF-268 GI50
    19.9 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human SF268 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human SF268 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    Huh-7 IC50
    14 3
    Compound: Roscovitine
    Cytotoxicity against human HuH-7 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst-33342 staining based cell counting method (Rvb > 25 microM)
    Cytotoxicity against human HuH-7 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst-33342 staining based cell counting method (Rvb > 25 microM)
    		[PMID: 33422908]
    SF-268 IC50
    8.8 3
    Compound: Roscovitine
    Growth inhibition of human SF268 cells after 72 hrs by MTS/PMS system based colorimetric assay
    Growth inhibition of human SF268 cells after 72 hrs by MTS/PMS system based colorimetric assay
    		[PMID: 25988923]
    Huh-7 IC50
    15.4 3
    Compound: Rosco
    Cytotoxicity against human HuH7 cells assessed as cell viability after 48 hrs by Hoechst 33342 staining based assay
    Cytotoxicity against human HuH7 cells assessed as cell viability after 48 hrs by Hoechst 33342 staining based assay
    		[PMID: 28214231]
    SF-295 GI50
    25.1 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human SF295 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human SF295 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    Huh-7 IC50
    20 3
    Compound: Roscovitine
    Antiproliferative activity against human HuH7 cells after 48 hrs by Hoechst 33342 staining-based assay
    Antiproliferative activity against human HuH7 cells after 48 hrs by Hoechst 33342 staining-based assay
    		[PMID: 30655216]
    SF-539 GI50
    15.8 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human SF539 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human SF539 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    Huh-7 IC50
    5 3
    Compound: Roscovitine
    Antiproliferative activity against human HuH7 cells after 72 hrs by imaging analysis
    Antiproliferative activity against human HuH7 cells after 72 hrs by imaging analysis
    		[PMID: 19665384]
    PC-3 GI50
    25.2 3
    Compound: Roscovitine
    Antiproliferative activity against human PC3 cells after 72 hrs by sulforhodamine B assay
    Antiproliferative activity against human PC3 cells after 72 hrs by sulforhodamine B assay
    		[PMID: 21080703]
    Sf9 IC50
    > 100 3
    Compound: Roscovitine
    Inhibition of recombinant Abl kinase (unknown origin) expressed in Sf9 cells using GGEAIYAAPFKK as substrate in presence of [gamma33P]ATP
    Inhibition of recombinant Abl kinase (unknown origin) expressed in Sf9 cells using GGEAIYAAPFKK as substrate in presence of [gamma33P]ATP
    		[PMID: 24681986]
    Huh-7 IC50
    5 3
    Compound: Roscovitine
    Cytotoxicity against human HuH7 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst 3342 staining based assay
    Cytotoxicity against human HuH7 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst 3342 staining based assay
    		[PMID: 26142492]
    Sf9 IC50
    0.1 3
    Compound: 24, CYC202, Seliciclib
    Inhibition of His-6-tagged recombinant human CDK2/cyclinE expressed in baculovirus-infected sf9 cells using histone H1 as substrate after 10 mins by liquid scintillation counting in presence of [gamma-32P]ATP
    Inhibition of His-6-tagged recombinant human CDK2/cyclinE expressed in baculovirus-infected sf9 cells using histone H1 as substrate after 10 mins by liquid scintillation counting in presence of [gamma-32P]ATP
    		[PMID: 24417566]
    Huh-7 IC50
    5 3
    Compound: Roscovitine
    Antiproliferative activity against human HuH7 cells after 48 hrs by Hoechst 3342 staining analysis
    Antiproliferative activity against human HuH7 cells after 48 hrs by Hoechst 3342 staining analysis
    		[PMID: 27019296]
    PC-3 GI50
    19.9 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human PC3 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human PC3 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    Sf9 IC50
    0.1 3
    Compound: Roscovitine
    Inhibition of CDK2/cyclin E (unknown origin) expressed in Sf9 cells using histone H1 as substrate in presence of [gamma33P]ATP
    Inhibition of CDK2/cyclin E (unknown origin) expressed in Sf9 cells using histone H1 as substrate in presence of [gamma33P]ATP
    		[PMID: 24681986]
    Huh-7 IC50
    9 3
    Compound: Roscovitine
    Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability after 48 hrs
    Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability after 48 hrs
    		[PMID: 34601029]
    PC-3 IC50
    12 3
    Compound: Roscovitine
    Antiproliferative activity against human PC3 cells after 48 hrs by Hoechst 33342 staining-based assay
    Antiproliferative activity against human PC3 cells after 48 hrs by Hoechst 33342 staining-based assay
    		[PMID: 30655216]
    Sf9 IC50
    0.158 3
    Compound: Roscov
    Inhibition of CDK2/Cyclin E (unknown origin) expressed in sf9 cells using histone H1 as substrate in presence of [gamma33P]-ATP
    Inhibition of CDK2/Cyclin E (unknown origin) expressed in sf9 cells using histone H1 as substrate in presence of [gamma33P]-ATP
    		[PMID: 26851505]
    PC-3 IC50
    2 3
    Compound: Roscovitine
    Antiproliferative activity against human PC3 cells after 48 hrs by Hoechst 3342 staining analysis
    Antiproliferative activity against human PC3 cells after 48 hrs by Hoechst 3342 staining analysis
    		[PMID: 27019296]
    IGROV-1 GI50
    6.3 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human IGROV1 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human IGROV1 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    PC-3 IC50
    8 3
    Compound: Roscovitine
    Antiproliferative activity against human PC3 cells after 72 hrs by imaging analysis
    Antiproliferative activity against human PC3 cells after 72 hrs by imaging analysis
    		[PMID: 19665384]
    Sf9 IC50
    0.2 3
    Compound: Seliciclib; L2
    Inhibition of CDK2/Cyclin E (unknown origin) expressed in baculoviral infected insect Sf9 cells using histone H1 as substrate in presence of [gamma-33P]ATP
    Inhibition of CDK2/Cyclin E (unknown origin) expressed in baculoviral infected insect Sf9 cells using histone H1 as substrate in presence of [gamma-33P]ATP
    		[PMID: 26741853]
    PC-3 IC50
    10 3
    Compound: Roscovitine
    Antiproliferative activity against human PC3 cells incubated for 48 hrs by Hoechst 3342 dye staining based assay
    Antiproliferative activity against human PC3 cells incubated for 48 hrs by Hoechst 3342 dye staining based assay
    		[PMID: 23063566]
    Sf9 IC50
    0.27 3
    Compound: Roscovitine
    Inhibition of recombinant full length N-terminal GST tagged human CDK5/p25 expressed in baculovirus infected sf9 cells using histone H1 as substrate measured after 60 mins in presence of ATP by ADP-Glo kinase assay
    Inhibition of recombinant full length N-terminal GST tagged human CDK5/p25 expressed in baculovirus infected sf9 cells using histone H1 as substrate measured after 60 mins in presence of ATP by ADP-Glo kinase assay
    		[PMID: 31098000]
    Sf9 IC50
    0.49 3
    Compound: 24, CYC202, Seliciclib
    Inhibition of His-6-tagged recombinant human CDK7/cyclinH expressed in baculovirus-infected sf9 cells using biotinyl-Ahx-(YSPTSPS)4 as substrate after 45 mins by liquid scintillation counting in presence of [gamma-32P]ATP
    Inhibition of His-6-tagged recombinant human CDK7/cyclinH expressed in baculovirus-infected sf9 cells using biotinyl-Ahx-(YSPTSPS)4 as substrate after 45 mins by liquid scintillation counting in presence of [gamma-32P]ATP
    		[PMID: 24417566]
    IMR-32 IC50
    17 3
    Compound: (R)-Roscovitine; Roscovitine
    Antiproliferative activity against human IMR32 cells after 2 days by XTT assay
    Antiproliferative activity against human IMR32 cells after 2 days by XTT assay
    		[PMID: 30199702]
    PC-3 IC50
    8 3
    Compound: Roscovitin
    Cytotoxicity against human PC3 cells after 48 hrs by Hoechst-33342 staining-based imaging analysis
    Cytotoxicity against human PC3 cells after 48 hrs by Hoechst-33342 staining-based imaging analysis
    		[PMID: 21944287]
    Sf9 IC50
    0.7 3
    Compound: Roscovitine
    Inhibition of GST-fused CDK2/cyclin A (unknown origin) expressed in baculovirus infected Sf9 cells after 10 min in presence of [gamma-32PP]ATP
    Inhibition of GST-fused CDK2/cyclin A (unknown origin) expressed in baculovirus infected Sf9 cells after 10 min in presence of [gamma-32PP]ATP
    		10.1007/s00044-009-9233-5
    IMR-90 IC50
    > 100 3
    Compound: Chemicel probe : R-CYC202
    Cytotoxicity against human IMR-90 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
    Cytotoxicity against human IMR-90 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
    		[PMID: 12432547]
    PC-3 IC50
    12 3
    Compound: Roscovitin
    Cytotoxicity against human PC3 cells assessed as cell growth inhibition
    Cytotoxicity against human PC3 cells assessed as cell growth inhibition
    		[PMID: 26934105]
    Sf9 IC50
    0.7 3
    Compound: Roscovitine
    Inhibition of GST-fused CDK2/cyclin E (unknown origin) expressed in baculovirus infected Sf9 cells after 10 min in presence of [gamma-32PP]ATP
    Inhibition of GST-fused CDK2/cyclin E (unknown origin) expressed in baculovirus infected Sf9 cells after 10 min in presence of [gamma-32PP]ATP
    		10.1007/s00044-009-9233-5
    PC-3 IC50
    16.5 3
    Compound: Rosco
    Cytotoxicity against human PC3 cells assessed as cell viability after 48 hrs by Hoechst 33342 staining based assay
    Cytotoxicity against human PC3 cells assessed as cell viability after 48 hrs by Hoechst 33342 staining based assay
    		[PMID: 28214231]
    K562 GI50
    50.1 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human K562 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human K562 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    PC-3 IC50
    11 3
    Compound: Roscovitine
    Cytotoxicity against human PC-3 cells assessed as reduction in cell viability after 48 hrs
    Cytotoxicity against human PC-3 cells assessed as reduction in cell viability after 48 hrs
    		[PMID: 34601029]
    Sf9 IC50
    170 1
    Compound: roscovitine, CYC202, seliciclib
    Inhibition of human recombinant CDK2/Cyclin E expressed in baculovirus infected sf9 cells using histone H1 as substrate
    Inhibition of human recombinant CDK2/Cyclin E expressed in baculovirus infected sf9 cells using histone H1 as substrate
    		[PMID: 23829517]
    K562 IC50
    30.9 3
    Compound: Seliciclib; L2
    Cytotoxicity against human K562 cells assessed as cell viability after 72 hrs by fluorescence microplate reader method
    Cytotoxicity against human K562 cells assessed as cell viability after 72 hrs by fluorescence microplate reader method
    		[PMID: 26741853]
    PC-3 IC50
    2 3
    Compound: Roscovitine
    Cytotoxicity against human PC3 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst 3342 staining based assay
    Cytotoxicity against human PC3 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst 3342 staining based assay
    		[PMID: 26142492]
    Sf9 IC50
    180 1
    Compound: Roscovitine
    Inhibition of CDK2/Cyclin E (unknown origin) expressed in Sf9 cells using histone H1 as substrate
    Inhibition of CDK2/Cyclin E (unknown origin) expressed in Sf9 cells using histone H1 as substrate
    		[PMID: 22770608]
    K562 IC50
    40 3
    Compound: Roscovitine
    In vitro cytotoxic effect on K562 cancer cell line
    In vitro cytotoxic effect on K562 cancer cell line
    		[PMID: 12392733]
    Sf9 IC50
    2.69 3
    Compound: 24, CYC202, Seliciclib
    Inhibition of His-6-tagged recombinant human CDK1/cyclinB1 expressed in baculovirus-infected sf9 cells by liquid scintillation counting in presence of [gamma-32P]ATP
    Inhibition of His-6-tagged recombinant human CDK1/cyclinB1 expressed in baculovirus-infected sf9 cells by liquid scintillation counting in presence of [gamma-32P]ATP
    		[PMID: 24417566]
    PC-3 IC50
    10 3
    Compound: Roscovitine
    Cytotoxicity against human PC-3 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst-33342 staining based cell counting method (Rvb > 25 microM)
    Cytotoxicity against human PC-3 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst-33342 staining based cell counting method (Rvb > 25 microM)
    		[PMID: 33422908]
    K562 IC50
    40 3
    Compound: Roscovitine
    Cytotoxic property against K562 cell line was determined
    Cytotoxic property against K562 cell line was determined
    		[PMID: 12941319]
    SH-SY5Y IC50
    16.1 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human SH-SY5Y cells after 48 hrs by MTS reduction assay
    Antiproliferative activity against human SH-SY5Y cells after 48 hrs by MTS reduction assay
    		[PMID: 19128055]
    Oocyte IC50
    650 1
    Compound: roscovitine
    In vitro inhibitory activity against Cyclin-dependent kinase 1-cyclin B complex from starfish oocytes
    In vitro inhibitory activity against Cyclin-dependent kinase 1-cyclin B complex from starfish oocytes
    		[PMID: 10753466]
    K562 IC50
    42 3
    Compound: Roskovotin
    Antiproliferative activity against human K562 cells
    Antiproliferative activity against human K562 cells
    		[PMID: 23352483]
    SH-SY5Y IC50
    17 3
    Compound: Ros, Seliciclib
    Cytotoxicity against human SH-SY5Y cells assessed as cell viability after 48 hrs by MTS reduction assay
    Cytotoxicity against human SH-SY5Y cells assessed as cell viability after 48 hrs by MTS reduction assay
    		[PMID: 22982525]
    Oocyte IC50
    650 1
    Compound: 2
    Inhibition of starfish oocyte CDK1 using histone H1 as substrate incubated for 10 mins in presence of [gamma-32P]ATP by radiometric scintillation assay
    Inhibition of starfish oocyte CDK1 using histone H1 as substrate incubated for 10 mins in presence of [gamma-32P]ATP by radiometric scintillation assay
    		[PMID: 35235745]
    K562 IC50
    42 3
    Compound: roscovitine
    Cytotoxicity against human K562 cells after 72 hrs using Calcein AM by fluorescence assay
    Cytotoxicity against human K562 cells after 72 hrs using Calcein AM by fluorescence assay
    		[PMID: 25757603]
    SH-SY5Y IC50
    17.4 3
    Compound: (R)-roscovitine
    Cytotoxicity against human SH-SY5Y cells after 48 hrs by MTS assay
    Cytotoxicity against human SH-SY5Y cells after 48 hrs by MTS assay
    		[PMID: 23218601]
    RL IC50
    0.9 3
    Compound: Rosco
    Cytotoxicity against human RL assessed as cell viability after 48 hrs by Hoechst 33342 staining based assay
    Cytotoxicity against human RL assessed as cell viability after 48 hrs by Hoechst 33342 staining based assay
    		[PMID: 28214231]
    K562 IC50
    45.5 3
    Compound: Roscov
    Cytotoxicity against human K562 cells assessed as reduction in cell viability after 72 hrs by calcein AM staining based fluorescence assay
    Cytotoxicity against human K562 cells assessed as reduction in cell viability after 72 hrs by calcein AM staining based fluorescence assay
    		[PMID: 26851505]
    RPMI-8226 IC50
    19.5 3
    Compound: CYC202, R-roscovitine
    Cytotoxicity against human RPM18226 cells after 72 hrs by alamar blue assay
    Cytotoxicity against human RPM18226 cells after 72 hrs by alamar blue assay
    		[PMID: 15958589]
    SH-SY5Y IC50
    17.5 3
    Compound: 8a, (R)-roscovitine
    Antiproliferative activity against human SH-SY5Y cells assessed as survival after 48 hrs by MTS reduction assay
    Antiproliferative activity against human SH-SY5Y cells assessed as survival after 48 hrs by MTS reduction assay
    		[PMID: 18698753]
    K562 IC50
    45.5 3
    Compound: Roscovitine
    Cytotoxicity against human K562 cells assessed as reduction in number of viable cells after 72 hrs by fluorescence assay
    Cytotoxicity against human K562 cells assessed as reduction in number of viable cells after 72 hrs by fluorescence assay
    		[PMID: 22770608]
    SH-SY5Y IC50
    21 3
    Compound: (R)-Roscovitine; Roscovitine
    Antiproliferative activity against human SH-SY5Y cells after 2 days by XTT assay
    Antiproliferative activity against human SH-SY5Y cells after 2 days by XTT assay
    		[PMID: 30199702]
    K562 IC50
    45.5 3
    Compound: Roscovitine
    Cytotoxicity against human K562 cells after 72 hrs by calcein-AM assay
    Cytotoxicity against human K562 cells after 72 hrs by calcein-AM assay
    		[PMID: 23981532]
    RXF 393 GI50
    5 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human RFX393 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human RFX393 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    SH-SY5Y IC50
    41 1
    Compound: 2
    Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability by MTS assay
    Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability by MTS assay
    		[PMID: 30639897]
    K562 IC50
    45.5 3
    Compound: Roscovitine
    Cytotoxicity against human K562 cells
    Cytotoxicity against human K562 cells
    		[PMID: 27189674]
    SAOS-2 GI50
    13.9 3
    Compound: Roscovitine
    Antiproliferative activity against human Saos2 cells after 72 hrs by sulforhodamine B assay
    Antiproliferative activity against human Saos2 cells after 72 hrs by sulforhodamine B assay
    		[PMID: 21080703]
    SiHa IC50
    2.69 3
    Compound: Roscovitine
    Cytotoxicity against human SiHa cells by MTT assay
    Cytotoxicity against human SiHa cells by MTT assay
    		[PMID: 36325400]
    Sf21 IC50
    0.5 3
    Compound: Roscovitine
    Inhibition of CDK2/cyclin A expressed in baculovirus infected insect Sf21 cells using [gamma-P32]ATP and histone H1 as substrate after 10 mins by radiometric assay
    Inhibition of CDK2/cyclin A expressed in baculovirus infected insect Sf21 cells using [gamma-P32]ATP and histone H1 as substrate after 10 mins by radiometric assay
    		[PMID: 22000924]
    K562 IC50
    45.5 3
    Compound: roscovitine, CYC202, seliciclib
    Cytotoxicity against human K562 cells assessed as growth inhibition after 72 hrs by calcein AM staining-based fluoroscence assay
    Cytotoxicity against human K562 cells assessed as growth inhibition after 72 hrs by calcein AM staining-based fluoroscence assay
    		[PMID: 23829517]
    SK-MEL-2 GI50
    15.8 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human SK-MEL-2 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human SK-MEL-2 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    Sf21 IC50
    15 3
    Compound: Roscovitine
    Inhibition of CDK4/cyclin D expressed in baculovirus infected insect Sf21 cells using [gamma-P32]ATP and histone H1 as substrate after 10 mins by radiometric assay
    Inhibition of CDK4/cyclin D expressed in baculovirus infected insect Sf21 cells using [gamma-P32]ATP and histone H1 as substrate after 10 mins by radiometric assay
    		[PMID: 22000924]
    K562 IC50
    > 100 3
    Compound: Roscovitine
    Antiproliferative activity against human K562 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
    Antiproliferative activity against human K562 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
    		[PMID: 37708799]
    Sf21 IC50
    0.5 3
    Compound: Roscovitine
    Inhibition of human N-terminal hexahistidine-tagged CDK2 expressed in baculovirus infected Sf21 cells using histone H1 as substrate after 10 mins in presence of [gamma-32P]-ATP
    Inhibition of human N-terminal hexahistidine-tagged CDK2 expressed in baculovirus infected Sf21 cells using histone H1 as substrate after 10 mins in presence of [gamma-32P]-ATP
    		[PMID: 23933045]
    SK-MEL-5 GI50
    10 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human SK-MEL-5 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human SK-MEL-5 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    K562 IC50
    > 20 3
    Compound: Roscovitine
    Antiproliferative activity against human K562 cells after 3 days by SRB assay
    Antiproliferative activity against human K562 cells after 3 days by SRB assay
    		[PMID: 20361800]
    SF-268 GI50
    19.9 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human SF268 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human SF268 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    SK-OV-3 GI50
    35.7 3
    Compound: Roscovitine
    Antiproliferative activity against human SKOV3 cells after 72 hrs by sulforhodamine B assay
    Antiproliferative activity against human SKOV3 cells after 72 hrs by sulforhodamine B assay
    		[PMID: 21080703]
    SK-OV-3 GI50
    79.4 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human SKOV3 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human SKOV3 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    SF-268 IC50
    8.8 3
    Compound: Roscovitine
    Growth inhibition of human SF268 cells after 72 hrs by MTS/PMS system based colorimetric assay
    Growth inhibition of human SF268 cells after 72 hrs by MTS/PMS system based colorimetric assay
    		[PMID: 25988923]
    SF-295 GI50
    25.1 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human SF295 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human SF295 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    SNB-75 GI50
    12.6 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human SNB75 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human SNB75 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    KB IC50
    24.6 3
    Compound: Roscovitine
    Growth inhibition of human KB cells after 72 hrs by MTS/PMS system based colorimetric assay
    Growth inhibition of human KB cells after 72 hrs by MTS/PMS system based colorimetric assay
    		[PMID: 25988923]
    SNU-638 IC50
    9.77 3
    Compound: Roscovitine
    Antiproliferative activity against human SNU638 cells after 3 days by SRB assay
    Antiproliferative activity against human SNU638 cells after 3 days by SRB assay
    		[PMID: 20361800]
    KB IC50
    30.1 3
    Compound: Roscovitine
    Antiproliferative activity against human KB cells after 3 days by SRB assay
    Antiproliferative activity against human KB cells after 3 days by SRB assay
    		[PMID: 20361800]
    SF-539 GI50
    15.8 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human SF539 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human SF539 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    SR GI50
    5.01 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human SR cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human SR cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    KM12 GI50
    15 3
    Compound: 1, alphaR-1, CYC202, Seliciclib, R-roscovitine
    Growth inhibition of human KM12 cells after 96 hrs by sulforhodamine B assay
    Growth inhibition of human KM12 cells after 96 hrs by sulforhodamine B assay
    		[PMID: 21982796]
    Sf9 IC50
    0.2 3
    Compound: Seliciclib; L2
    Inhibition of CDK2/Cyclin E (unknown origin) expressed in baculoviral infected insect Sf9 cells using histone H1 as substrate in presence of [gamma-33P]ATP
    Inhibition of CDK2/Cyclin E (unknown origin) expressed in baculoviral infected insect Sf9 cells using histone H1 as substrate in presence of [gamma-33P]ATP
    		[PMID: 26741853]
    SW-620 GI50
    79.4 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human SW620 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human SW620 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    Sf9 IC50
    0.1 3
    Compound: Roscovitine
    Inhibition of CDK2/cyclin E (unknown origin) expressed in Sf9 cells using histone H1 as substrate in presence of [gamma33P]ATP
    Inhibition of CDK2/cyclin E (unknown origin) expressed in Sf9 cells using histone H1 as substrate in presence of [gamma33P]ATP
    		[PMID: 24681986]
    KM12 GI50
    5.01 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human KM12 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human KM12 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    T47D GI50
    16.8 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human T47D cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human T47D cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    Sf9 IC50
    0.158 3
    Compound: Roscov
    Inhibition of CDK2/Cyclin E (unknown origin) expressed in sf9 cells using histone H1 as substrate in presence of [gamma33P]-ATP
    Inhibition of CDK2/Cyclin E (unknown origin) expressed in sf9 cells using histone H1 as substrate in presence of [gamma33P]-ATP
    		[PMID: 26851505]
    TK-10 GI50
    63.1 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human TK10 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human TK10 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    Sf9 IC50
    0.7 3
    Compound: Roscovitine
    Inhibition of GST-fused CDK2/cyclin A (unknown origin) expressed in baculovirus infected Sf9 cells after 10 min in presence of [gamma-32PP]ATP
    Inhibition of GST-fused CDK2/cyclin A (unknown origin) expressed in baculovirus infected Sf9 cells after 10 min in presence of [gamma-32PP]ATP
    		10.1007/s00044-009-9233-5
    U-251 GI50
    50.1 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human U251 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human U251 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    L02 IC50
    20.48 3
    Compound: (R)-roscovitine
    Cytotoxicity against human L02 cells after 48 hrs by SRB assay
    Cytotoxicity against human L02 cells after 48 hrs by SRB assay
    		[PMID: 23036956]
    Sf9 IC50
    2.69 3
    Compound: 24, CYC202, Seliciclib
    Inhibition of His-6-tagged recombinant human CDK1/cyclinB1 expressed in baculovirus-infected sf9 cells by liquid scintillation counting in presence of [gamma-32P]ATP
    Inhibition of His-6-tagged recombinant human CDK1/cyclinB1 expressed in baculovirus-infected sf9 cells by liquid scintillation counting in presence of [gamma-32P]ATP
    		[PMID: 24417566]
    U-266 IC50
    17.93 3
    Compound: CYC202, R-roscovitine
    Cytotoxicity against human U266 cells after 72 hrs by alamar blue assay
    Cytotoxicity against human U266 cells after 72 hrs by alamar blue assay
    		[PMID: 15958589]
    Sf9 IC50
    0.1 3
    Compound: 24, CYC202, Seliciclib
    Inhibition of His-6-tagged recombinant human CDK2/cyclinE expressed in baculovirus-infected sf9 cells using histone H1 as substrate after 10 mins by liquid scintillation counting in presence of [gamma-32P]ATP
    Inhibition of His-6-tagged recombinant human CDK2/cyclinE expressed in baculovirus-infected sf9 cells using histone H1 as substrate after 10 mins by liquid scintillation counting in presence of [gamma-32P]ATP
    		[PMID: 24417566]
    LOX IMVI GI50
    12.6 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human LOXIMVI cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human LOXIMVI cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    UACC-62 GI50
    7.9 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human UACC62 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human UACC62 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    Sf9 IC50
    0.49 3
    Compound: 24, CYC202, Seliciclib
    Inhibition of His-6-tagged recombinant human CDK7/cyclinH expressed in baculovirus-infected sf9 cells using biotinyl-Ahx-(YSPTSPS)4 as substrate after 45 mins by liquid scintillation counting in presence of [gamma-32P]ATP
    Inhibition of His-6-tagged recombinant human CDK7/cyclinH expressed in baculovirus-infected sf9 cells using biotinyl-Ahx-(YSPTSPS)4 as substrate after 45 mins by liquid scintillation counting in presence of [gamma-32P]ATP
    		[PMID: 24417566]
    UO-31 GI50
    12.6 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human UO31 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human UO31 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    Sf9 IC50
    >100 3
    Compound: Roscovitine
    Inhibition of recombinant Abl kinase (unknown origin) expressed in Sf9 cells using GGEAIYAAPFKK as substrate in presence of [gamma33P]ATP
    Inhibition of recombinant Abl kinase (unknown origin) expressed in Sf9 cells using GGEAIYAAPFKK as substrate in presence of [gamma33P]ATP
    		[PMID: 24681986]
    WI-38 IC50
    24.12 3
    Compound: Roscovitine
    Cytotoxicity against human WI-38 cells assessed as reduction in cell viability after 48 hrs by MTT assay
    Cytotoxicity against human WI-38 cells assessed as reduction in cell viability after 48 hrs by MTT assay
    		[PMID: 32773088]
    Sf9 IC50
    0.27 3
    Compound: Roscovitine
    Inhibition of recombinant full length N-terminal GST tagged human CDK5/p25 expressed in baculovirus infected sf9 cells using histone H1 as substrate measured after 60 mins in presence of ATP by ADP-Glo kinase assay
    Inhibition of recombinant full length N-terminal GST tagged human CDK5/p25 expressed in baculovirus infected sf9 cells using histone H1 as substrate measured after 60 mins in presence of ATP by ADP-Glo kinase assay
    		[PMID: 31098000]
    SH-SY5Y IC50
    21 3
    Compound: (R)-Roscovitine; Roscovitine
    Antiproliferative activity against human SH-SY5Y cells after 2 days by XTT assay
    Antiproliferative activity against human SH-SY5Y cells after 2 days by XTT assay
    		[PMID: 30199702]
    LP-1 IC50
    12.68 3
    Compound: CYC202, R-roscovitine
    Cytotoxicity against human LP-1 cells after 72 hrs by alamar blue assay
    Cytotoxicity against human LP-1 cells after 72 hrs by alamar blue assay
    		[PMID: 15958589]
    SH-SY5Y IC50
    16.1 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human SH-SY5Y cells after 48 hrs by MTS reduction assay
    Antiproliferative activity against human SH-SY5Y cells after 48 hrs by MTS reduction assay
    		[PMID: 19128055]
    SH-SY5Y IC50
    17.5 3
    Compound: 8a, (R)-roscovitine
    Antiproliferative activity against human SH-SY5Y cells assessed as survival after 48 hrs by MTS reduction assay
    Antiproliferative activity against human SH-SY5Y cells assessed as survival after 48 hrs by MTS reduction assay
    		[PMID: 18698753]
    SH-SY5Y IC50
    17.4 3
    Compound: (R)-roscovitine
    Cytotoxicity against human SH-SY5Y cells after 48 hrs by MTS assay
    Cytotoxicity against human SH-SY5Y cells after 48 hrs by MTS assay
    		[PMID: 23218601]
    LoVo IC50
    9.3 3
    Compound: Chemicel probe : R-CYC202
    Cytotoxicity against p53 wild-type human LoVo cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
    Cytotoxicity against p53 wild-type human LoVo cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
    		[PMID: 12432547]
    SH-SY5Y IC50
    17 3
    Compound: Ros, Seliciclib
    Cytotoxicity against human SH-SY5Y cells assessed as cell viability after 48 hrs by MTS reduction assay
    Cytotoxicity against human SH-SY5Y cells assessed as cell viability after 48 hrs by MTS reduction assay
    		[PMID: 22982525]
    SiHa IC50
    2.69 3
    Compound: Roscovitine
    Cytotoxicity against human SiHa cells by MTT assay
    Cytotoxicity against human SiHa cells by MTT assay
    		[PMID: 36325400]
    M14 GI50
    25.1 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human M14 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human M14 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    SK-MEL-2 GI50
    15.8 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human SK-MEL-2 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human SK-MEL-2 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    SK-MEL-5 GI50
    10 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human SK-MEL-5 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human SK-MEL-5 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    SK-OV-3 GI50
    35.7 3
    Compound: Roscovitine
    Antiproliferative activity against human SKOV3 cells after 72 hrs by sulforhodamine B assay
    Antiproliferative activity against human SKOV3 cells after 72 hrs by sulforhodamine B assay
    		[PMID: 21080703]
    SK-OV-3 GI50
    79.4 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human SKOV3 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human SKOV3 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    MCF-10A GI50
    16.3 3
    Compound: Roscovitine
    Antiproliferative activity against human MCF10A cells after 72 hrs by sulforhodamine B assay
    Antiproliferative activity against human MCF10A cells after 72 hrs by sulforhodamine B assay
    		[PMID: 21080703]
    SNB-75 GI50
    12.6 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human SNB75 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human SNB75 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    SNU-638 IC50
    9.77 3
    Compound: Roscovitine
    Antiproliferative activity against human SNU638 cells after 3 days by SRB assay
    Antiproliferative activity against human SNU638 cells after 3 days by SRB assay
    		[PMID: 20361800]
    SR GI50
    5.01 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human SR cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human SR cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    SW-620 GI50
    79.4 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human SW620 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human SW620 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    MCF7 GI50
    12.6 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human MCF7 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human MCF7 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    T47D GI50
    16.8 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human T47D cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human T47D cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    MCF7 GI50
    7.8 3
    Compound: Roscovitine
    Antiproliferative activity against human MCF7 cells after 72 hrs by sulforhodamine B assay
    Antiproliferative activity against human MCF7 cells after 72 hrs by sulforhodamine B assay
    		[PMID: 21080703]
    BXPC-3 IC50
    15284 1
    Compound: Roscovitine
    Antiproliferative activity against human BxPC3 cells after 72 hrs by prestoblue assay
    Antiproliferative activity against human BxPC3 cells after 72 hrs by prestoblue assay
    		[PMID: 30343954]
    ASPC1 IC50
    17767 1
    Compound: Roscovitine
    Antiproliferative activity against human AsPC1 cells after 72 hrs by prestoblue assay
    Antiproliferative activity against human AsPC1 cells after 72 hrs by prestoblue assay
    		[PMID: 30343954]
    MCF7 IC50
    10.2 3
    Compound: Rosco
    Cytotoxicity against human MCF7 assessed as cell viability after 48 hrs by Hoechst 33342 staining based assay
    Cytotoxicity against human MCF7 assessed as cell viability after 48 hrs by Hoechst 33342 staining based assay
    		[PMID: 28214231]
    MCF7 IC50
    10.9 3
    Compound: Chemicel probe : R-CYC202
    Cytotoxicity against p53 wild-type human MCF7 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
    Cytotoxicity against p53 wild-type human MCF7 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
    		[PMID: 12432547]
    MIA PaCa-2 IC50
    18214 1
    Compound: Roscovitine
    Antiproliferative activity against human MIAPaCa2 cells after 72 hrs by prestoblue assay
    Antiproliferative activity against human MIAPaCa2 cells after 72 hrs by prestoblue assay
    		[PMID: 30343954]
    TK-10 GI50
    63.1 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human TK10 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human TK10 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    MCF7 IC50
    11 3
    Compound: Roscovitine
    Cytotoxicity against human MCF7 cells assessed as inhibition of cell proliferation
    Cytotoxicity against human MCF7 cells assessed as inhibition of cell proliferation
    		[PMID: 26698538]
    U-251 GI50
    50.1 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human U251 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human U251 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    MCF7 IC50
    11 3
    Compound: Roskovotin
    Antiproliferative activity against human MCF7 cells
    Antiproliferative activity against human MCF7 cells
    		[PMID: 23352483]
    U-266 IC50
    17.93 3
    Compound: CYC202, R-roscovitine
    Cytotoxicity against human U266 cells after 72 hrs by alamar blue assay
    Cytotoxicity against human U266 cells after 72 hrs by alamar blue assay
    		[PMID: 15958589]
    MCF7 IC50
    11 3
    Compound: roscovitine
    Cytotoxicity against human MCF7 cells after 72 hrs using Calcein AM by fluorescence assay
    Cytotoxicity against human MCF7 cells after 72 hrs using Calcein AM by fluorescence assay
    		[PMID: 25757603]
    UACC-62 GI50
    7.9 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human UACC62 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human UACC62 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    MCF7 IC50
    11.1 3
    Compound: Roscovitine
    In vitro cytotoxic effect on MCF-7 cancer cell line
    In vitro cytotoxic effect on MCF-7 cancer cell line
    		[PMID: 12392733]
    UO-31 GI50
    12.6 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human UO31 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human UO31 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    MCF7 IC50
    11.1 3
    Compound: Roscovitine
    Cytotoxic property against MCF-7 cell line was determined
    Cytotoxic property against MCF-7 cell line was determined
    		[PMID: 12941319]
    WI-38 IC50
    24.12 3
    Compound: Roscovitine
    Cytotoxicity against human WI-38 cells assessed as reduction in cell viability after 48 hrs by MTT assay
    Cytotoxicity against human WI-38 cells assessed as reduction in cell viability after 48 hrs by MTT assay
    		[PMID: 32773088]
    MCF7 IC50
    12.22 3
    Compound: (R)-roscovitine
    Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
    Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
    		[PMID: 23036956]
    MCF7 IC50
    12.25 3
    Compound: Roscov
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by calcein AM staining based fluorescence assay
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by calcein AM staining based fluorescence assay
    		[PMID: 26851505]
    MCF7 IC50
    12.3 3
    Compound: Roscovitine
    Cytotoxicity against human MCF7 cells assessed as reduction in number of viable cells after 72 hrs by fluorescence assay
    Cytotoxicity against human MCF7 cells assessed as reduction in number of viable cells after 72 hrs by fluorescence assay
    		[PMID: 22770608]
    MCF7 IC50
    12.3 3
    Compound: Roscovitine
    Cytotoxicity against human MCF7 cells after 72 hrs by calcein-AM assay
    Cytotoxicity against human MCF7 cells after 72 hrs by calcein-AM assay
    		[PMID: 23981532]
    MCF7 IC50
    12.3 3
    Compound: Roscovitine
    Cytotoxicity against human MCF7 cells
    Cytotoxicity against human MCF7 cells
    		[PMID: 27189674]
    MCF7 IC50
    12.3 3
    Compound: roscovitine, CYC202, seliciclib
    Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by calcein AM staining-based fluoroscence assay
    Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by calcein AM staining-based fluoroscence assay
    		[PMID: 23829517]
    MCF7 IC50
    14.7 3
    Compound: Roscovitine
    Antiproliferative activity against human MCF7 cells after 3 days by SRB assay
    Antiproliferative activity against human MCF7 cells after 3 days by SRB assay
    		[PMID: 20361800]
    MCF7 IC50
    19.6 3
    Compound: Roscovitine
    Growth inhibition of human MCF7 cells after 72 hrs by MTS/PMS system based colorimetric assay
    Growth inhibition of human MCF7 cells after 72 hrs by MTS/PMS system based colorimetric assay
    		[PMID: 25988923]
    MCF7 IC50
    20.2 3
    Compound: Roscovitine
    Cytotoxicity against human MCF7 cells assessed as inhibition of cell viability after 72 hrs by calcien AM dye based fluorescence analysis
    Cytotoxicity against human MCF7 cells assessed as inhibition of cell viability after 72 hrs by calcien AM dye based fluorescence analysis
    		[PMID: 23399722]
    MCF7 IC50
    27.2 3
    Compound: Seliciclib; L2
    Cytotoxicity against human MCF7 cells assessed as cell viability after 72 hrs by fluorescence microplate reader method
    Cytotoxicity against human MCF7 cells assessed as cell viability after 72 hrs by fluorescence microplate reader method
    		[PMID: 26741853]
    MCF7 IC50
    3.98 3
    Compound: 1
    Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
    Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
    		[PMID: 23623491]
    MCF7 IC50
    55.01 3
    Compound: R-Roscovitine
    Antiproliferative activity against human MCF7 cells expressing estrogen receptor after 48 hrs by WST-1 assay
    Antiproliferative activity against human MCF7 cells expressing estrogen receptor after 48 hrs by WST-1 assay
    		[PMID: 21440449]
    MCF7 IC50
    9 3
    Compound: Roscovitine
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst-33342 staining based cell counting method (Rvb > 25 microM)
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst-33342 staining based cell counting method (Rvb > 25 microM)
    		[PMID: 33422908]
    MCF7 IC50
    9 3
    Compound: Roscovitine
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs
    		[PMID: 34601029]
    MCF7 IC50
    > 100 3
    Compound: Roscovitine
    Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
    		[PMID: 37708799]
    MDA-MB-231 GI50
    22.6 3
    Compound: Roscovitine
    Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by sulforhodamine B assay
    Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by sulforhodamine B assay
    		[PMID: 21080703]
    MDA-MB-231 GI50
    39.8 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    MDA-MB-231 IC50
    12 3
    Compound: Roscovitine
    Antiproliferative activity against human MDA-MB-231 cells incubated for 48 hrs by Hoechst 3342 dye staining based assay
    Antiproliferative activity against human MDA-MB-231 cells incubated for 48 hrs by Hoechst 3342 dye staining based assay
    		[PMID: 23063566]
    MDA-MB-231 IC50
    12 3
    Compound: Roscovitine
    Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by Hoechst 33342 staining-based assay
    Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by Hoechst 33342 staining-based assay
    		[PMID: 30655216]
    MDA-MB-231 IC50
    15 3
    Compound: 2
    Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability
    Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability
    		[PMID: 31514062]
    MDA-MB-231 IC50
    15 3
    Compound: Roscovitin
    Cytotoxicity against human MDA-MB-231 cells after 48 hrs by Hoechst-33342 staining-based imaging analysis
    Cytotoxicity against human MDA-MB-231 cells after 48 hrs by Hoechst-33342 staining-based imaging analysis
    		[PMID: 21944287]
    MDA-MB-231 IC50
    15 3
    Compound: Roscovitin
    Cytotoxicity against human MDA-MB-231 cells assessed as cell growth inhibition
    Cytotoxicity against human MDA-MB-231 cells assessed as cell growth inhibition
    		[PMID: 26934105]
    MDA-MB-231 IC50
    15 3
    Compound: Roscovitine
    Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst-33342 staining based cell counting method (Rvb > 25 microM)
    Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst-33342 staining based cell counting method (Rvb > 25 microM)
    		[PMID: 33422908]
    MDA-MB-231 IC50
    16.8 3
    Compound: Rosco
    Cytotoxicity against human MDA-MB-231 cells assessed as cell viability after 48 hrs by Hoechst 33342 staining based assay
    Cytotoxicity against human MDA-MB-231 cells assessed as cell viability after 48 hrs by Hoechst 33342 staining based assay
    		[PMID: 28214231]
    MDA-MB-231 IC50
    17 3
    Compound: Roscovitine
    Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 48 hrs
    Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 48 hrs
    		[PMID: 34601029]
    MDA-MB-231 IC50
    3 3
    Compound: Roscovitine
    Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst 3342 staining based assay
    Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst 3342 staining based assay
    		[PMID: 26142492]
    MDA-MB-231 IC50
    3 3
    Compound: Roscovitine
    Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by Hoechst 3342 staining analysis
    Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by Hoechst 3342 staining analysis
    		[PMID: 27019296]
    MDA-MB-231 IC50
    54.64 3
    Compound: R-Roscovitine
    Antiproliferative activity against estrogen receptor-deficient human MDA-MB-231 cells after 48 hrs by WST-1 assay
    Antiproliferative activity against estrogen receptor-deficient human MDA-MB-231 cells after 48 hrs by WST-1 assay
    		[PMID: 21440449]
    MDA-MB-435 GI50
    12.6 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human MDA-MB-435 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human MDA-MB-435 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    MDA-MB-435S IC50
    17.5 3
    Compound: Chemicel probe : R-CYC202
    Cytotoxicity against p53 mutant human MDA-MB-435S cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
    Cytotoxicity against p53 mutant human MDA-MB-435S cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
    		[PMID: 12432547]
    MDA-MB-468 IC50
    18 3
    Compound: Roscovitine
    Cytotoxicity against human MDA-MB-468 cells assessed as reduction in cell viability after 48 hrs
    Cytotoxicity against human MDA-MB-468 cells assessed as reduction in cell viability after 48 hrs
    		[PMID: 34601029]
    MES-SA IC50
    11.9 3
    Compound: Chemicel probe : R-CYC202
    Cytotoxicity against human MES-SA cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
    Cytotoxicity against human MES-SA cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
    		[PMID: 12432547]
    MES-SA/Dx5 IC50
    7.9 3
    Compound: Chemicel probe : R-CYC202
    Cytotoxicity against human MES-SA/Dx5 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
    Cytotoxicity against human MES-SA/Dx5 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
    		[PMID: 12432547]
    MGC-803 IC50
    > 100 3
    Compound: Roscovitine
    Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
    Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
    		[PMID: 37708799]
    MIA PaCa-2 IC50
    12 3
    Compound: Chemicel probe : R-CYC202
    Cytotoxicity against p53 wild-type human MIA PaCa-2 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
    Cytotoxicity against p53 wild-type human MIA PaCa-2 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
    		[PMID: 12432547]
    MIA PaCa-2 IC50
    13.9 3
    Compound: Chemicel probe : R-CYC202
    Cytotoxicity against p53 mutant human MIA PaCa-2 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
    Cytotoxicity against p53 mutant human MIA PaCa-2 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
    		[PMID: 12432547]
    MIA PaCa-2 IC50
    15.2 3
    Compound: Chemicel probe : R-CYC202
    Cytotoxicity against human MIA PaCa-2 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
    Cytotoxicity against human MIA PaCa-2 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
    		[PMID: 12432547]
    MIA PaCa-2 IC50
    18214 1
    Compound: Roscovitine
    Antiproliferative activity against human MIAPaCa2 cells after 72 hrs by prestoblue assay
    Antiproliferative activity against human MIAPaCa2 cells after 72 hrs by prestoblue assay
    		[PMID: 30343954]
    MKN-45 IC50
    7.6 3
    Compound: Roscovitine
    Growth inhibition of human MKN45 cells after 72 hrs by MTS/PMS system based colorimetric assay
    Growth inhibition of human MKN45 cells after 72 hrs by MTS/PMS system based colorimetric assay
    		[PMID: 25988923]
    MOLT-4 GI50
    25.1 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human MOLT4 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human MOLT4 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    Malme-3M GI50
    19.9 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human MALME-3M cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human MALME-3M cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    NCI-H1299 IC50
    83.02 3
    Compound: Roscovitine
    Antiproliferative activity against human NCI-H1299 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
    Antiproliferative activity against human NCI-H1299 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
    		[PMID: 37708799]
    NCI-H226 GI50
    19.9 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human NCI-H226 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human NCI-H226 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    NCI-H23 GI50
    12.6 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human NCI-H23 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human NCI-H23 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    NCI-H322M GI50
    31.6 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human NCI-H322M cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human NCI-H322M cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    NCI-H460 GI50
    25.1 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human NCI-H460 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human NCI-H460 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    NCI-H460 IC50
    11.6 3
    Compound: Roscovitine
    Growth inhibition of human NCI-H460 cells after 72 hrs by MTS/PMS system based colorimetric assay
    Growth inhibition of human NCI-H460 cells after 72 hrs by MTS/PMS system based colorimetric assay
    		[PMID: 25988923]
    NCI-H460 IC50
    11.9 3
    Compound: Roscovitine
    Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell growth incubated for 72 hrs by CCK-8 assay
    Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell growth incubated for 72 hrs by CCK-8 assay
    		[PMID: 32361064]
    NCI-H460 IC50
    13.1 3
    Compound: Chemicel probe : R-CYC202
    Cytotoxicity against p53 wild-type human NCI-H460 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
    Cytotoxicity against p53 wild-type human NCI-H460 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
    		[PMID: 12432547]
    NCI-H522 GI50
    15.8 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human NCI-H522 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human NCI-H522 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    NCI-H69 IC50
    26 3
    Compound: Chemicel probe : R-CYC202
    Cytotoxicity against p53 mutant human NCI-H69 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
    Cytotoxicity against p53 mutant human NCI-H69 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
    		[PMID: 12432547]
    NCI-H727 IC50
    20 3
    Compound: Roscovitine
    Antiproliferative activity against human NCI-H727 cells incubated for 48 hrs by Hoechst 3342 dye staining based assay
    Antiproliferative activity against human NCI-H727 cells incubated for 48 hrs by Hoechst 3342 dye staining based assay
    		[PMID: 23063566]
    NCI-H727 IC50
    20 3
    Compound: Roscovitine
    Antiproliferative activity against human NCI-H727 cells after 48 hrs by Hoechst 33342 staining-based assay
    Antiproliferative activity against human NCI-H727 cells after 48 hrs by Hoechst 33342 staining-based assay
    		[PMID: 30655216]
    NCI-H727 IC50
    28 3
    Compound: Roscovitine
    Cytotoxicity against human NCI-H727 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst-33342 staining based cell counting method (Rvb > 25 microM)
    Cytotoxicity against human NCI-H727 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst-33342 staining based cell counting method (Rvb > 25 microM)
    		[PMID: 33422908]
    NCI-H727 IC50
    4 3
    Compound: Roscovitine
    Cytotoxicity against human NCI-H727 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst 3342 staining based assay
    Cytotoxicity against human NCI-H727 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst 3342 staining based assay
    		[PMID: 26142492]
    NCI-H727 IC50
    4 3
    Compound: Roscovitine
    Antiproliferative activity against human NCI-H727 cells after 48 hrs by Hoechst 3342 staining analysis
    Antiproliferative activity against human NCI-H727 cells after 48 hrs by Hoechst 3342 staining analysis
    		[PMID: 27019296]
    NCI-H727 IC50
    > 20 3
    Compound: Rosco
    Cytotoxicity against human NCI-H727 cells assessed as cell viability after 48 hrs by Hoechst 33342 staining based assay
    Cytotoxicity against human NCI-H727 cells assessed as cell viability after 48 hrs by Hoechst 33342 staining based assay
    		[PMID: 28214231]
    NCI-H929 IC50
    8.84 3
    Compound: CYC202, R-roscovitine
    Cytotoxicity against human NCI-H929 cells after 72 hrs by alamar blue assay
    Cytotoxicity against human NCI-H929 cells after 72 hrs by alamar blue assay
    		[PMID: 15958589]
    NCI/ADR-RES GI50
    6.3 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human NCI/ADR-RES cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human NCI/ADR-RES cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    Non-small cell lung cancer cell line GI50
    23.6 3
    Compound: Roscovitine
    Anticancer activity against human Non-small cell lung cancer cell line assessed as cell growth inhibition incubated for 48 hrs by Sulphorhodamine B assay
    Anticancer activity against human Non-small cell lung cancer cell line assessed as cell growth inhibition incubated for 48 hrs by Sulphorhodamine B assay
    		[PMID: 27744184]
    OPM-2 IC50
    18.46 3
    Compound: CYC202, R-roscovitine
    Cytotoxicity against human OPM2 cells after 72 hrs by alamar blue assay
    Cytotoxicity against human OPM2 cells after 72 hrs by alamar blue assay
    		[PMID: 15958589]
    OVCAR-3 GI50
    12.6 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human OVCAR-3 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human OVCAR-3 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    OVCAR-3 IC50
    37 3
    Compound: (R)-Roscovitine; Roscovitine
    Antiproliferative activity against human OVCAR3 cells after 2 days by XTT assay
    Antiproliferative activity against human OVCAR3 cells after 2 days by XTT assay
    		[PMID: 30199702]
    OVCAR-4 GI50
    31.6 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human OVCAR4 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human OVCAR4 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    OVCAR-5 GI50
    39.8 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human OVCAR5 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human OVCAR5 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    Oocyte IC50
    0.2 3
    Compound: 26
    Inhibitory activity against purified cdc2 p34/Cyclin B obtained from M phase oocytes of the starfish Marthasterias glacialis.
    Inhibitory activity against purified cdc2 p34/Cyclin B obtained from M phase oocytes of the starfish Marthasterias glacialis.
    		[PMID: 9046330]
    Oocyte IC50
    0.33 3
    Compound: (R)-roscovitine
    Inhibition of starfish oocytes CDK1/cyclin B
    Inhibition of starfish oocytes CDK1/cyclin B
    		[PMID: 19128055]
    Oocyte IC50
    0.65 1
    Compound: 3; CYC202
    Inhibition of starfish oocyte CDK1/Cyclin B using histone H1 as substrate incubated for 10 mins in presence of [gamma-32P]ATP by scintillation counter analysis
    Inhibition of starfish oocyte CDK1/Cyclin B using histone H1 as substrate incubated for 10 mins in presence of [gamma-32P]ATP by scintillation counter analysis
    		[PMID: 35485642]
    Oocyte IC50
    650 1
    Compound: 2
    Inhibition of starfish oocyte CDK1 using histone H1 as substrate incubated for 10 mins in presence of [gamma-32P]ATP by radiometric scintillation assay
    Inhibition of starfish oocyte CDK1 using histone H1 as substrate incubated for 10 mins in presence of [gamma-32P]ATP by radiometric scintillation assay
    		[PMID: 35235745]
    Oocyte IC50
    650 1
    Compound: roscovitine
    In vitro inhibitory activity against Cyclin-dependent kinase 1-cyclin B complex from starfish oocytes
    In vitro inhibitory activity against Cyclin-dependent kinase 1-cyclin B complex from starfish oocytes
    		[PMID: 10753466]
    PBMC CC50
    22 3
    Compound: 48; CYC202, aSbR-21
    Cytotoxicity against human PBMC
    Cytotoxicity against human PBMC
    		[PMID: 33539089]
    PC-3 GI50
    19.9 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human PC3 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human PC3 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    PC-3 GI50
    25.2 3
    Compound: Roscovitine
    Antiproliferative activity against human PC3 cells after 72 hrs by sulforhodamine B assay
    Antiproliferative activity against human PC3 cells after 72 hrs by sulforhodamine B assay
    		[PMID: 21080703]
    PC-3 IC50
    10 3
    Compound: Roscovitine
    Antiproliferative activity against human PC3 cells incubated for 48 hrs by Hoechst 3342 dye staining based assay
    Antiproliferative activity against human PC3 cells incubated for 48 hrs by Hoechst 3342 dye staining based assay
    		[PMID: 23063566]
    PC-3 IC50
    10 3
    Compound: Roscovitine
    Cytotoxicity against human PC-3 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst-33342 staining based cell counting method (Rvb > 25 microM)
    Cytotoxicity against human PC-3 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst-33342 staining based cell counting method (Rvb > 25 microM)
    		[PMID: 33422908]
    PC-3 IC50
    11 3
    Compound: Roscovitine
    Cytotoxicity against human PC-3 cells assessed as reduction in cell viability after 48 hrs
    Cytotoxicity against human PC-3 cells assessed as reduction in cell viability after 48 hrs
    		[PMID: 34601029]
    PC-3 IC50
    12 3
    Compound: Roscovitin
    Cytotoxicity against human PC3 cells assessed as cell growth inhibition
    Cytotoxicity against human PC3 cells assessed as cell growth inhibition
    		[PMID: 26934105]
    PC-3 IC50
    12 3
    Compound: Roscovitine
    Antiproliferative activity against human PC3 cells after 48 hrs by Hoechst 33342 staining-based assay
    Antiproliferative activity against human PC3 cells after 48 hrs by Hoechst 33342 staining-based assay
    		[PMID: 30655216]
    PC-3 IC50
    16.5 3
    Compound: Rosco
    Cytotoxicity against human PC3 cells assessed as cell viability after 48 hrs by Hoechst 33342 staining based assay
    Cytotoxicity against human PC3 cells assessed as cell viability after 48 hrs by Hoechst 33342 staining based assay
    		[PMID: 28214231]
    PC-3 IC50
    2 3
    Compound: Roscovitine
    Cytotoxicity against human PC3 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst 3342 staining based assay
    Cytotoxicity against human PC3 cells assessed as reduction in cell viability incubated for 48 hrs by Hoechst 3342 staining based assay
    		[PMID: 26142492]
    PC-3 IC50
    2 3
    Compound: Roscovitine
    Antiproliferative activity against human PC3 cells after 48 hrs by Hoechst 3342 staining analysis
    Antiproliferative activity against human PC3 cells after 48 hrs by Hoechst 3342 staining analysis
    		[PMID: 27019296]
    PC-3 IC50
    8 3
    Compound: Roscovitin
    Cytotoxicity against human PC3 cells after 48 hrs by Hoechst-33342 staining-based imaging analysis
    Cytotoxicity against human PC3 cells after 48 hrs by Hoechst-33342 staining-based imaging analysis
    		[PMID: 21944287]
    PC-3 IC50
    8 3
    Compound: Roscovitine
    Antiproliferative activity against human PC3 cells after 72 hrs by imaging analysis
    Antiproliferative activity against human PC3 cells after 72 hrs by imaging analysis
    		[PMID: 19665384]
    PC-3 IC50
    > 100 3
    Compound: Roscovitine
    Antiproliferative activity against human PC-3 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
    Antiproliferative activity against human PC-3 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
    		[PMID: 37708799]
    Panel CNS (Carcinoma cell lines) GI50
    24.7 3
    Compound: Roscovitine
    Anticancer activity against human Panel CNS (Carcinoma cell lines) assessed as cell growth inhibition incubated for 48 hrs by Sulphorhodamine B assay
    Anticancer activity against human Panel CNS (Carcinoma cell lines) assessed as cell growth inhibition incubated for 48 hrs by Sulphorhodamine B assay
    		[PMID: 27744184]
    Panel breast (Carcinoma cell lines) GI50
    22.7 3
    Compound: Roscovitine
    Anticancer activity against human Panel breast (Carcinoma cell lines) assessed as cell growth inhibition incubated for 48 hrs by Sulphorhodamine B assay
    Anticancer activity against human Panel breast (Carcinoma cell lines) assessed as cell growth inhibition incubated for 48 hrs by Sulphorhodamine B assay
    		[PMID: 27744184]
    Panel colon (Carcinoma cell lines) GI50
    24.8 3
    Compound: Roscovitine
    Anticancer activity against human Panel colon (Carcinoma cell lines) assessed as cell growth inhibition incubated for 48 hrs by Sulphorhodamine B assay
    Anticancer activity against human Panel colon (Carcinoma cell lines) assessed as cell growth inhibition incubated for 48 hrs by Sulphorhodamine B assay
    		[PMID: 27744184]
    Panel leukemia (Carcinoma cell lines) GI50
    37.5 3
    Compound: Roscovitine
    Anticancer activity against human Panel leukemia (Carcinoma cell lines) assessed as cell growth inhibition incubated for 48 hrs by Sulphorhodamine B assay
    Anticancer activity against human Panel leukemia (Carcinoma cell lines) assessed as cell growth inhibition incubated for 48 hrs by Sulphorhodamine B assay
    		[PMID: 27744184]
    Panel melanoma (Carcinoma cell lines) GI50
    14.8 3
    Compound: Roscovitine
    Anticancer activity against human Panel melanoma (Carcinoma cell lines) assessed as cell growth inhibition incubated for 48 hrs by Sulphorhodamine B assay
    Anticancer activity against human Panel melanoma (Carcinoma cell lines) assessed as cell growth inhibition incubated for 48 hrs by Sulphorhodamine B assay
    		[PMID: 27744184]
    Panel ovarian (Carcinoma cell lines) GI50
    29.3 3
    Compound: Roscovitine
    Anticancer activity against human Panel ovarian (Carcinoma cell lines) assessed as cell growth inhibition incubated for 48 hrs by Sulphorhodamine B assay
    Anticancer activity against human Panel ovarian (Carcinoma cell lines) assessed as cell growth inhibition incubated for 48 hrs by Sulphorhodamine B assay
    		[PMID: 27744184]
    Panel prostate (Carcinoma cell lines) GI50
    17.9 3
    Compound: Roscovitine
    Anticancer activity against human Panel prostate (Carcinoma cell lines) assessed as cell growth inhibition incubated for 48 hrs by Sulphorhodamine B assay
    Anticancer activity against human Panel prostate (Carcinoma cell lines) assessed as cell growth inhibition incubated for 48 hrs by Sulphorhodamine B assay
    		[PMID: 27744184]
    Panel renal (Carcinoma cell lines) GI50
    24.9 3
    Compound: Roscovitine
    Anticancer activity against human Panel renal (Carcinoma cell lines) assessed as cell growth inhibition incubated for 48 hrs by Sulphorhodamine B assay
    Anticancer activity against human Panel renal (Carcinoma cell lines) assessed as cell growth inhibition incubated for 48 hrs by Sulphorhodamine B assay
    		[PMID: 27744184]
    RL IC50
    0.9 3
    Compound: Rosco
    Cytotoxicity against human RL assessed as cell viability after 48 hrs by Hoechst 33342 staining based assay
    Cytotoxicity against human RL assessed as cell viability after 48 hrs by Hoechst 33342 staining based assay
    		[PMID: 28214231]
    RPMI-8226 IC50
    19.5 3
    Compound: CYC202, R-roscovitine
    Cytotoxicity against human RPM18226 cells after 72 hrs by alamar blue assay
    Cytotoxicity against human RPM18226 cells after 72 hrs by alamar blue assay
    		[PMID: 15958589]
    RXF 393 GI50
    5 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human RFX393 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human RFX393 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    SAOS-2 GI50
    13.9 3
    Compound: Roscovitine
    Antiproliferative activity against human Saos2 cells after 72 hrs by sulforhodamine B assay
    Antiproliferative activity against human Saos2 cells after 72 hrs by sulforhodamine B assay
    		[PMID: 21080703]
    SF-268 GI50
    19.9 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human SF268 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human SF268 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    SF-268 IC50
    8.8 3
    Compound: Roscovitine
    Growth inhibition of human SF268 cells after 72 hrs by MTS/PMS system based colorimetric assay
    Growth inhibition of human SF268 cells after 72 hrs by MTS/PMS system based colorimetric assay
    		[PMID: 25988923]
    SF-295 GI50
    25.1 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human SF295 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human SF295 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    SF-539 GI50
    15.8 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human SF539 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human SF539 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    SH-SY5Y IC50
    16.1 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human SH-SY5Y cells after 48 hrs by MTS reduction assay
    Antiproliferative activity against human SH-SY5Y cells after 48 hrs by MTS reduction assay
    		[PMID: 19128055]
    SH-SY5Y IC50
    17 3
    Compound: Ros, Seliciclib
    Cytotoxicity against human SH-SY5Y cells assessed as cell viability after 48 hrs by MTS reduction assay
    Cytotoxicity against human SH-SY5Y cells assessed as cell viability after 48 hrs by MTS reduction assay
    		[PMID: 22982525]
    SH-SY5Y IC50
    17.4 3
    Compound: (R)-roscovitine
    Cytotoxicity against human SH-SY5Y cells after 48 hrs by MTS assay
    Cytotoxicity against human SH-SY5Y cells after 48 hrs by MTS assay
    		[PMID: 23218601]
    SH-SY5Y IC50
    17.5 3
    Compound: 8a, (R)-roscovitine
    Antiproliferative activity against human SH-SY5Y cells assessed as survival after 48 hrs by MTS reduction assay
    Antiproliferative activity against human SH-SY5Y cells assessed as survival after 48 hrs by MTS reduction assay
    		[PMID: 18698753]
    SH-SY5Y IC50
    21 3
    Compound: (R)-Roscovitine; Roscovitine
    Antiproliferative activity against human SH-SY5Y cells after 2 days by XTT assay
    Antiproliferative activity against human SH-SY5Y cells after 2 days by XTT assay
    		[PMID: 30199702]
    SH-SY5Y IC50
    41 1
    Compound: 2
    Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability by MTS assay
    Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability by MTS assay
    		[PMID: 30639897]
    SK-MEL-2 GI50
    15.8 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human SK-MEL-2 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human SK-MEL-2 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    SK-MEL-5 GI50
    10 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human SK-MEL-5 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human SK-MEL-5 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    SK-OV-3 GI50
    35.7 3
    Compound: Roscovitine
    Antiproliferative activity against human SKOV3 cells after 72 hrs by sulforhodamine B assay
    Antiproliferative activity against human SKOV3 cells after 72 hrs by sulforhodamine B assay
    		[PMID: 21080703]
    SK-OV-3 GI50
    79.4 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human SKOV3 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human SKOV3 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    SNB-75 GI50
    12.6 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human SNB75 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human SNB75 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    SNU-638 IC50
    9.77 3
    Compound: Roscovitine
    Antiproliferative activity against human SNU638 cells after 3 days by SRB assay
    Antiproliferative activity against human SNU638 cells after 3 days by SRB assay
    		[PMID: 20361800]
    SR GI50
    5.01 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human SR cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human SR cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    SW-620 GI50
    79.4 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human SW620 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human SW620 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    Sf21 IC50
    0.5 3
    Compound: Roscovitine
    Inhibition of CDK2/cyclin A expressed in baculovirus infected insect Sf21 cells using [gamma-P32]ATP and histone H1 as substrate after 10 mins by radiometric assay
    Inhibition of CDK2/cyclin A expressed in baculovirus infected insect Sf21 cells using [gamma-P32]ATP and histone H1 as substrate after 10 mins by radiometric assay
    		[PMID: 22000924]
    Sf21 IC50
    0.5 3
    Compound: Roscovitine
    Inhibition of human N-terminal hexahistidine-tagged CDK2 expressed in baculovirus infected Sf21 cells using histone H1 as substrate after 10 mins in presence of [gamma-32P]-ATP
    Inhibition of human N-terminal hexahistidine-tagged CDK2 expressed in baculovirus infected Sf21 cells using histone H1 as substrate after 10 mins in presence of [gamma-32P]-ATP
    		[PMID: 23933045]
    Sf21 IC50
    100 1
    Compound: Roscovitine
    Inhibition of CDK2/cyclin E (unknown origin) expressed in baculovirus infected Sf21 insect cells in presence of [gamma33P]ATP
    Inhibition of CDK2/cyclin E (unknown origin) expressed in baculovirus infected Sf21 insect cells in presence of [gamma33P]ATP
    		[PMID: 32150405]
    Sf21 IC50
    15 3
    Compound: Roscovitine
    Inhibition of CDK4/cyclin D expressed in baculovirus infected insect Sf21 cells using [gamma-P32]ATP and histone H1 as substrate after 10 mins by radiometric assay
    Inhibition of CDK4/cyclin D expressed in baculovirus infected insect Sf21 cells using [gamma-P32]ATP and histone H1 as substrate after 10 mins by radiometric assay
    		[PMID: 22000924]
    Sf21 IC50
    193 1
    Compound: Roscovitine
    Inhibition of wild-type human N-terminal GST-tagged CDK2/cycA2 expressed in Sf21 insect cells using FAM-labelled substrate preincubated for 10 mins followed by substrate addition and measured after 30 mins by fluorescence assay
    Inhibition of wild-type human N-terminal GST-tagged CDK2/cycA2 expressed in Sf21 insect cells using FAM-labelled substrate preincubated for 10 mins followed by substrate addition and measured after 30 mins by fluorescence assay
    		[PMID: 31272794]
    Sf9 IC50
    0.1 3
    Compound: 24, CYC202, Seliciclib
    Inhibition of His-6-tagged recombinant human CDK2/cyclinE expressed in baculovirus-infected sf9 cells using histone H1 as substrate after 10 mins by liquid scintillation counting in presence of [gamma-32P]ATP
    Inhibition of His-6-tagged recombinant human CDK2/cyclinE expressed in baculovirus-infected sf9 cells using histone H1 as substrate after 10 mins by liquid scintillation counting in presence of [gamma-32P]ATP
    		[PMID: 24417566]
    Sf9 IC50
    0.1 3
    Compound: Roscovitine
    Inhibition of CDK2/cyclin E (unknown origin) expressed in Sf9 cells using histone H1 as substrate in presence of [gamma33P]ATP
    Inhibition of CDK2/cyclin E (unknown origin) expressed in Sf9 cells using histone H1 as substrate in presence of [gamma33P]ATP
    		[PMID: 24681986]
    Sf9 IC50
    0.158 3
    Compound: Roscov
    Inhibition of CDK2/Cyclin E (unknown origin) expressed in sf9 cells using histone H1 as substrate in presence of [gamma33P]-ATP
    Inhibition of CDK2/Cyclin E (unknown origin) expressed in sf9 cells using histone H1 as substrate in presence of [gamma33P]-ATP
    		[PMID: 26851505]
    Sf9 IC50
    0.2 3
    Compound: Seliciclib; L2
    Inhibition of CDK2/Cyclin E (unknown origin) expressed in baculoviral infected insect Sf9 cells using histone H1 as substrate in presence of [gamma-33P]ATP
    Inhibition of CDK2/Cyclin E (unknown origin) expressed in baculoviral infected insect Sf9 cells using histone H1 as substrate in presence of [gamma-33P]ATP
    		[PMID: 26741853]
    Sf9 IC50
    0.27 3
    Compound: Roscovitine
    Inhibition of recombinant full length N-terminal GST tagged human CDK5/p25 expressed in baculovirus infected sf9 cells using histone H1 as substrate measured after 60 mins in presence of ATP by ADP-Glo kinase assay
    Inhibition of recombinant full length N-terminal GST tagged human CDK5/p25 expressed in baculovirus infected sf9 cells using histone H1 as substrate measured after 60 mins in presence of ATP by ADP-Glo kinase assay
    		[PMID: 31098000]
    Sf9 IC50
    0.49 3
    Compound: 24, CYC202, Seliciclib
    Inhibition of His-6-tagged recombinant human CDK7/cyclinH expressed in baculovirus-infected sf9 cells using biotinyl-Ahx-(YSPTSPS)4 as substrate after 45 mins by liquid scintillation counting in presence of [gamma-32P]ATP
    Inhibition of His-6-tagged recombinant human CDK7/cyclinH expressed in baculovirus-infected sf9 cells using biotinyl-Ahx-(YSPTSPS)4 as substrate after 45 mins by liquid scintillation counting in presence of [gamma-32P]ATP
    		[PMID: 24417566]
    Sf9 IC50
    0.7 3
    Compound: Roscovitine
    Inhibition of GST-fused CDK2/cyclin A (unknown origin) expressed in baculovirus infected Sf9 cells after 10 min in presence of [gamma-32PP]ATP
    Inhibition of GST-fused CDK2/cyclin A (unknown origin) expressed in baculovirus infected Sf9 cells after 10 min in presence of [gamma-32PP]ATP
    		10.1007/s00044-009-9233-5
    Sf9 IC50
    0.7 3
    Compound: Roscovitine
    Inhibition of GST-fused CDK2/cyclin E (unknown origin) expressed in baculovirus infected Sf9 cells after 10 min in presence of [gamma-32PP]ATP
    Inhibition of GST-fused CDK2/cyclin E (unknown origin) expressed in baculovirus infected Sf9 cells after 10 min in presence of [gamma-32PP]ATP
    		10.1007/s00044-009-9233-5
    Sf9 IC50
    170 1
    Compound: roscovitine, CYC202, seliciclib
    Inhibition of human recombinant CDK2/Cyclin E expressed in baculovirus infected sf9 cells using histone H1 as substrate
    Inhibition of human recombinant CDK2/Cyclin E expressed in baculovirus infected sf9 cells using histone H1 as substrate
    		[PMID: 23829517]
    Sf9 IC50
    180 1
    Compound: Roscovitine
    Inhibition of CDK2/Cyclin E (unknown origin) expressed in Sf9 cells using histone H1 as substrate
    Inhibition of CDK2/Cyclin E (unknown origin) expressed in Sf9 cells using histone H1 as substrate
    		[PMID: 22770608]
    Sf9 IC50
    2.69 3
    Compound: 24, CYC202, Seliciclib
    Inhibition of His-6-tagged recombinant human CDK1/cyclinB1 expressed in baculovirus-infected sf9 cells by liquid scintillation counting in presence of [gamma-32P]ATP
    Inhibition of His-6-tagged recombinant human CDK1/cyclinB1 expressed in baculovirus-infected sf9 cells by liquid scintillation counting in presence of [gamma-32P]ATP
    		[PMID: 24417566]
    Sf9 IC50
    > 100 3
    Compound: Roscovitine
    Inhibition of recombinant Abl kinase (unknown origin) expressed in Sf9 cells using GGEAIYAAPFKK as substrate in presence of [gamma33P]ATP
    Inhibition of recombinant Abl kinase (unknown origin) expressed in Sf9 cells using GGEAIYAAPFKK as substrate in presence of [gamma33P]ATP
    		[PMID: 24681986]
    SiHa IC50
    2.69 3
    Compound: Roscovitine
    Cytotoxicity against human SiHa cells by MTT assay
    Cytotoxicity against human SiHa cells by MTT assay
    		[PMID: 36325400]
    T-cell IC50
    600 1
    Compound: Seliciclib
    Inhibition of CDK9/Cyclin T (unknown origin)
    Inhibition of CDK9/Cyclin T (unknown origin)
    		[PMID: 19169685]
    T47D GI50
    16.8 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human T47D cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human T47D cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    TK-10 GI50
    63.1 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human TK10 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human TK10 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    U-251 GI50
    50.1 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human U251 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human U251 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    U-266 IC50
    17.93 3
    Compound: CYC202, R-roscovitine
    Cytotoxicity against human U266 cells after 72 hrs by alamar blue assay
    Cytotoxicity against human U266 cells after 72 hrs by alamar blue assay
    		[PMID: 15958589]
    UACC-62 GI50
    7.9 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human UACC62 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human UACC62 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    UO-31 GI50
    12.6 3
    Compound: (R)-roscovitine
    Antiproliferative activity against human UO31 cells after 72 hrs by ViaLight assay
    Antiproliferative activity against human UO31 cells after 72 hrs by ViaLight assay
    		[PMID: 19128055]
    WI-38 IC50
    24 3
    Compound: Chemicel probe : R-CYC202
    Cytotoxicity against human WI-38 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
    Cytotoxicity against human WI-38 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
    		[PMID: 12432547]
    WI-38 IC50
    24.12 3
    Compound: Roscovitine
    Cytotoxicity against human WI-38 cells assessed as reduction in cell viability after 48 hrs by MTT assay
    Cytotoxicity against human WI-38 cells assessed as reduction in cell viability after 48 hrs by MTT assay
    		[PMID: 32773088]
    In Vitro

    (R)-Roscovitine (Seliciclib) displays high efficiency and high selectivity towards some cyclin-dependent kinases. The kinase specificity of Seliciclib is investigated with 25 highly purified kinases (including protein kinase A, G and C isoforms, myosin light-chain kinase, casein kinase 2, IR tyrosine kinase, c-src, v-abl). Most kinases are not significantly inhibited by (R)-Roscovitine. Cdc2, Cdk2, and Cdk5 only are substantially inhibited (IC50 values of 0.65, 0.7, and 0.2 μM, respectively). Cdk4k and Cdk6 are very poorly inhibited by (R)-Roscovitine (IC50>100 μM). Extracellular regulated kinases erk1 and erk2 are inhibited with an IC50 of 34 μM and 14 μM, respectively. (R)-Roscovitine inhibits the proliferation of mammalian cell lines with an average IC50 of 16 μM[1]. (R)-Roscovitine (Seliciclib) decreases the level of CDK5 and p35 with upregulation of E-cadherin, but downregulation of Vimentin and Collagen IV. Moreover, (R)-Roscovitine inhibits the ability of high glucose cultured NRK52E cells to migrate and invade[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    (R)-Roscovitine Related Antibodies
    In Vivo

    Compare with normal controls, (R)-Roscovitine (Seliciclib) downregulates phosphorylated ERK1/2 and PPARγ with concomitant increase in E-cadherin, but decrease in Vimentin and Collagen IV. Correspondingly, (R)-Roscovitine decreases renal tubulointerstitial fibrosis of diabetic rats. (R)-Roscovitine is effective in decreasing tubulointerstitial fibrosis via the ERK1/2/PPARγ pathway in diabetic rats[2]. (R)-Roscovitine (Seliciclib) (16.5 mg/kg) significantly reduces the rate of tumor growth and increases survival of treated mice. Strikingly, (R)-Roscovitine treatment leads to complete tumor disappearance in one mouse (25%); moreover, no tumor regrowth in this mouse is found 5 months after completion of the treatment. Mouse weights do not differ significantly between mice treated with (R)-Roscovitine and control mice, and behavioral differences between the two groups are also negligible. These results suggest that (R)-Roscovitine can be used effectively as a selective tumor growth inhibitor in HPV+ head and neck cancer[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Essai clinique
    Masse moléculaire

    354.45

    Formule

    C19H26N6O
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    OC[C@H](NC1=NC(NCC2=CC=CC=C2)=C3C(N(C=N3)C(C)C)=N1)CC
    Livraison

    Room temperature in continental US; may vary elsewhere.
    Stockage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 1 year
    -20°C 6 months
    Solvant et solubilité
    In Vitro: 

    DMSO : ≥ 100 mg/mL (282.13 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.8213 mL 14.1064 mL 28.2127 mL
    5 mM 0.5643 mL 2.8213 mL 5.6425 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

    • Calculateur de molarité

    • Calculateur de dilution

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.5 mg/mL (7.05 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.5 mg/mL (7.05 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    Pureté et documentation

    Purity: 99.53%

    SDS (393 KB)

    COA (252 KB) LCMS (108 KB)

    Instruction de manipulation (2659 KB)
    Références
    Test cellulaire
    [2]

    Rat kidney tubular epithelial cells (NRK52E) are used. CDK5 inhibitor (R)-Roscovitine (Seliciclib) (Ros.; 10 μM) and activator p35 (15 μM), PPARγ agonist BRL 49653 (Rosi.; 50 nM), and ERK1/2 inhibitor U0126 (50 nM) are used to treat NRK52E cells. Cells in each group are treated for 72 hours and then harvested for further analyses[2].

    MCE n'a pas confirmé de manière indépendante l'exactitude de ces méthodes. Ils sont pour référence seulement.
    Administration animale
    [2][3]

    Rats[2]
    Male Sprague Dawley rats (6-8 weeks of age) are given intraperitoneally a single injection of either Streptozotocin (65 mg/kg) diluted in 0.1 M citrate buffer pH 4.5 (diabetic) or citrate buffer (non-diabetic). Plasma glucose concentrations are determined using the glucose oxidase method on a glucose analyzer three days after the injection. Rats with a glucose level over 16.7 mM are considered diabetic and thus included in the study. Plasma glucose level is measured once every week. To investigate the effect of CDK5 inhibition on renal tubulointerstitial fibrosis, Seliciclib (25 mg/kg) is injected peritoneally to diabetic rats every day till sacrifice. DMSO is included as controls.
    Mice[3]
    Exponentially growing UMSCC47 cells are injected subcutaneously into the sacral area of female NUDE mice. Each mouse is inoculated with 2×105 cells in 50% matrigel and 50% PBS at a volume of 100 μL. After tumors reach a measurable size, the mice are given 16.5 mg/kg doses of intraperitoneal Seliciclib or vehicle injections. Body weight, tumor growth, and general behavior are monitored. Tumor volumes are measured every 3 days. Mice are sacrificed when the tumor exceeded a size of 0.5cm3.

    MCE n'a pas confirmé de manière indépendante l'exactitude de ces méthodes. Ils sont pour référence seulement.
    Références

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.8213 mL 14.1064 mL 28.2127 mL 70.5318 mL
    5 mM 0.5643 mL 2.8213 mL 5.6425 mL 14.1064 mL
    10 mM 0.2821 mL 1.4106 mL 2.8213 mL 7.0532 mL
    15 mM 0.1881 mL 0.9404 mL 1.8808 mL 4.7021 mL
    20 mM 0.1411 mL 0.7053 mL 1.4106 mL 3.5266 mL
    25 mM 0.1129 mL 0.5643 mL 1.1285 mL 2.8213 mL
    30 mM 0.0940 mL 0.4702 mL 0.9404 mL 2.3511 mL
    40 mM 0.0705 mL 0.3527 mL 0.7053 mL 1.7633 mL
    50 mM 0.0564 mL 0.2821 mL 0.5643 mL 1.4106 mL
    60 mM 0.0470 mL 0.2351 mL 0.4702 mL 1.1755 mL
    80 mM 0.0353 mL 0.1763 mL 0.3527 mL 0.8816 mL
    100 mM 0.0282 mL 0.1411 mL 0.2821 mL 0.7053 mL
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    (R)-Roscovitine Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    (R)-Roscovitine186692-46-6Seliciclib CYC202CYC202CYC 202CYC-202CDKCyclin dependent kinaseInhibitorinhibitorinhibit

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