Search Result

Results for "

LPS-induced RAW264.7 macrophages

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (4) Bcl-2 Family (1) Caspase (1) COX (5) Dengue Virus (1) Drug Derivative (2) Flavivirus (1) Fungal (1) HDAC (1) IKK (1) Interleukin Related (6) JAK (2) JNK (1) Keap1-Nrf2 (2) Lipoxygenase (1) nAChR (2) NF-κB (7) NO Synthase (10) NOD-like Receptor (NLR) (1) p38 MAPK (2) Parasite (1) Reactive Oxygen Species (ROS) (1) Reference Standards (2) STAT (2) TNF Receptor (7) Toll-like Receptor (TLR) (1)
By Research Areas:	Cancer (2) Infection (2) Inflammation/Immunology (20) Metabolic Disease (1) Neurological Disease (1)

By Targets:

Apoptosis (4)

Bcl-2 Family (1)

Caspase (1)

COX (5)

Dengue Virus (1)

Drug Derivative (2)

Flavivirus (1)

Fungal (1)

HDAC (1)

IKK (1)

Interleukin Related (6)

JAK (2)

JNK (1)

Keap1-Nrf2 (2)

Lipoxygenase (1)

nAChR (2)

NF-κB (7)

NO Synthase (10)

NOD-like Receptor (NLR) (1)

p38 MAPK (2)

Parasite (1)

Reactive Oxygen Species (ROS) (1)

Reference Standards (2)

STAT (2)

TNF Receptor (7)

Toll-like Receptor (TLR) (1)

By Research Areas:

Cancer (2)

Infection (2)

Inflammation/Immunology (20)

Metabolic Disease (1)

Neurological Disease (1)

Inhibitors & Agonists

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-129113

α-Chaconine	COX	Inflammation/Immunology
α-Chaconine inhibits the expressions of COX-2, IL-1β, IL-6, and TNF-α at the transcriptional level. α-Chaconine inhibits the LPS-induced expressions of iNOS and COX-2 at the protein and mRNA levels and their promoter activities in RAW 264.7 macrophages. Anti-inflammatory effects .

HY-N2535

Coniferaldehyde 1 Publications Verification 4-Hydroxy-3-methoxycinnamaldehyde	Keap1-Nrf2 Apoptosis	Inflammation/Immunology
Coniferaldehyde (4-Hydroxy-3-methoxycinnamaldehyde) is an effective inducer of heme oxygenase-1 (HO-1). Coniferaldehyde inhibits LPS-induced apoptosis through the PKCα/β II/Nrf-2/HO-1 dependent pathway in RAW264.7 macrophage cells. Coniferaldehyde has antioxidant and anti-inflammatory activities .

HY-W082785A

L6H21 1 Publications Verification	TNF Receptor Interleukin Related Toll-like Receptor (TLR) NF-κB NOD-like Receptor (NLR) Apoptosis Caspase Bcl-2 Family Reactive Oxygen Species (ROS)	Neurological Disease Metabolic Disease Inflammation/Immunology
L6H21, a Chalcone (HY-121054) derivative, is an orally active, potent and specific myeloid differentiation 2 (MD-2) inhibitor. L6H21 directly binds to MD-2 protein with a high affinity and low K_D value of 33.3 μM, blocking the formation of the LPS-TLR4/MD-2 complex. L6H21 inhibits LPS-induced expression of TNF-α and IL-6 in RAW264.7 macrophages, with IC₅₀ values of 6.58 and 8.59 μM, respectively. L6H21 can be used for alcoholic liver disease, metabolic disturbance and neuroinflammation research .

HY-146066

α7 nAchR-JAK2-STAT3 agonist 1	nAChR JAK STAT NO Synthase Interleukin Related	Inflammation/Immunology
α7 nAchR-JAK2-STAT3 agonist 1 is a potent α7 nAchR-JAK2-STAT3 agonist, with an IC₅₀ value of 0.32 μM for nitric oxide (NO). α7 nAchR-JAK2-STAT3 agonist 1 effectively suppresses the expression of iNOS, IL-1β, and IL-6 in murine RAW264.7 macrophages. α7 nAchR-JAK2-STAT3 agonist 1 can inhibit LPS-induced NO release, NF-κB activation and cytokine production. α7 nAchR-JAK2-STAT3 can be used for researching sepsis .

HY-N7012

7,3',4'-Tri-O-methylluteolin 1 Publications Verification 5-Hydroxy-3',4',7-trimethoxyflavone	Lipoxygenase TNF Receptor Interleukin Related COX Fungal Parasite Apoptosis	Infection Inflammation/Immunology Cancer
7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone) is a flavonoid with multiple biological activities. 7,3',4'-Tri-O-methylluteolin inhibits soybean lipoxygenase (LOX), with an IC₅₀ value of 23.97 µg/mL. 7,3',4'-Tri-O-methylluteolin possesses anti-inflammatory effects in Lipopolysaccharides (HY-D1056) (LPS)-induced RAW 264.7 macrophages. 7,3',4'-Tri-O-methylluteolin inhibits the binding of MDM2 with p53 and induces apoptosis in MCF-7 breast cancer cells. 7,3',4'-Tri-O-methylluteolin also has antioxidant, antifungal and antitrypanosomal activities sup>[4]sup>[5].

HY-N3364

Lucidone	Flavivirus Dengue Virus TNF Receptor NF-κB NO Synthase COX JNK p38 MAPK IKK	Infection Inflammation/Immunology
Lucidone, an anti-inflammatory agent that can be isolated from the fruit of Lindera erythrocarpa Makino. Lucidone inhibits LPS-induced NO and PGE₂ production in RAW 264.7 mouse macrophages. Lucidone also decreases TNF-α secretion, iNOS and COX-2 expression. Lucidone prevents NF-κB translocation and inhibits JNK and p38MAPK signals. Lucidone also has inhibitory activity against Dengue virus (DENV) (EC₅₀=25 μM) .

HY-N12188

Stigmasta-3,5-dien-7-one	NF-κB TNF Receptor Interleukin Related p38 MAPK	Inflammation/Immunology
Stigmasta-3,5-dien-7-one is a steroid compound that can be isolated from Harrisonia abyssinica. Stigmasta-3,5-dien-7-one blocks the NF-κB signaling pathway via down-regulation of phospho-p38 mitogen-activated protein kinase and phosphorylation and degradation of inhibitor of NF-κB α. Stigmasta-3,5-dien-7-one reduces LPS (HY-D1056)-induced nitric oxide, PGE₂, and pro-inflammatory cytokine levels in macrophages. Stigmasta-3,5-dien-7-one can be used for inflammation diseases .

HY-N12283

NF-κB-IN-13	NF-κB	Inflammation/Immunology
NF-κB-IN-13 (compound 12) can significantly inhibit LPS-induced NF-κB activation and NO production in RAW264.7 macrophages. NF-κB-IN-13 has anti-inflammatory effects .

HY-146066A

(R)-α7 nAchR-JAK2-STAT3 agonist 1	nAChR JAK STAT NO Synthase	Others
(R)-α7 nAchR-JAK2-STAT3 agonist 1 is the R-enantiomer of α7 nAchR-JAK2-STAT3 agonist 1 (HY-146066). α7 nAchR-JAK2-STAT3 agonist 1 is a potent α7 nAchR-JAK2-STAT3 agonist, with an IC₅₀ value of 0.32 μM for nitric oxide (NO). α7 nAchR-JAK2-STAT3 agonist 1 effectively suppresses the expression of iNOS, IL-1β, and IL-6 in murine RAW264.7 macrophages. α7 nAchR-JAK2-STAT3 agonist 1 can inhibit LPS-induced NO release, NF-κB activation and cytokine production. α7 nAchR-JAK2-STAT3 can be used for researching sepsis .

HY-129113R

α-?Chaconine (Standard)	Reference Standards COX	Inflammation/Immunology
α-Chaconine (Standard) is the analytical standard of α-Chaconine. This product is intended for research and analytical applications. α-Chaconine inhibits the expressions of COX-2, IL-1β, IL-6, and TNF-α at the transcriptional level. α-Chaconine inhibits the LPS-induced expressions of iNOS and COX-2 at the protein and mRNA levels and their promoter activities in RAW 264.7 macrophages. Anti-inflammatory effects .

HY-N9000

Loganic acid 6′-O-β-D-glucoside	TNF Receptor	Inflammation/Immunology
Loganic acid 6′-O-β-D-glucoside, a iridoidal glucoside, is isolated from the whole plant of Gentiana rhodantha (Gentianaceae). Loganic acid 6′-O-β-D-glucoside inhibits LPS-induced NO and TNF-α production in macrophage RAW264.7 cells .

HY-153762

COX-2-IN-32	NO Synthase NF-κB COX	Inflammation/Immunology
COX-2-IN-32 (Compound 2f) is an iNOS and COX-2 inhibitor. COX-2-IN-32 decreases the expression of NF-κB. COX-2-IN-32 has anti-inflammatory activity by inhibits NO production in LPS-induced RAW264.7 macrophages (IC₅₀: 11.2 μM) .

HY-N10297

Curindolizine	Others	Inflammation/Immunology
Curindolizine, indolizine alkaloid , displays an anti-inflammatory action in lipopolyssacharide (LPS)-induced RAW 264.7 macrophages with an IC₅₀ value of 5.31 μM .

HY-N2535R

Coniferaldehyde (Standard) 4-Hydroxy-3-methoxycinnamaldehyde (Standard)	Reference Standards Keap1-Nrf2 Apoptosis	Inflammation/Immunology
Coniferaldehyde (Standard) is the analytical standard of Coniferaldehyde. This product is intended for research and analytical applications. Coniferaldehyde (4-Hydroxy-3-methoxycinnamaldehyde) is an effective inducer of heme oxygenase-1 (HO-1). Coniferaldehyde inhibits LPS-induced apoptosis through the PKCα/β II/Nrf-2/HO-1 dependent pathway in RAW264.7 macrophage cells. Coniferaldehyde has antioxidant and anti-inflammatory activities .

HY-155821

Anti-inflammatory agent 55	NF-κB NO Synthase TNF Receptor Interleukin Related	Inflammation/Immunology
Anti-inflammatory agent 55 (compound 9j) is a derivative of Coixol and has anti-inflammatory activity. Anti-inflammatory agent 54 inhibits the NF-κB pathway and downregulates the expression of iNOS, TNF-α, IL-6 and IL-1β. Anti-inflammatory agent 54 inhibits LPS-induced nitric oxide (NO) production in RAW264.7 macrophages (IC₅₀: 0.8 μM) and exerts in vivo anti-inflammatory activity in a mouse auricular edema model .

HY-155820

Anti-inflammatory agent 54	NF-κB NO Synthase TNF Receptor Interleukin Related	Inflammation/Immunology
Anti-inflammatory agent 54 (compound 9c) is a derivative of Coixol and has anti-inflammatory activity. Anti-inflammatory agent 54 inhibits the NF-κB pathway and downregulates the expression of iNOS, TNF-α, IL-6 and IL-1β. Anti-inflammatory agent 54 inhibits LPS-induced nitric oxide (NO) production in RAW264.7 macrophages (IC₅₀: 2.4 μM) and exerts in vivo anti-inflammatory activity in a mouse auricular edema model .

HY-126211

KBH-A42	HDAC	Inflammation/Immunology
KBH-A42 is a novel histone deacetylase (HDAC) inhibitor with significant anti-inflammatory properties. KBH-A42 against TNF-α and NO production with IC₅₀ values of 1.10 and 2.71 µM, respectively, in the LPS-induced murine macrophage RAW 264.7 cells .

HY-N16677

Abiesadine I	NO Synthase	Inflammation/Immunology
Abiesadine I is a diterpenoid inhibitor targeting LPS-induced NO production (IC₅₀>100 μg/mL) that can be isolated from Abies georgei. Abiesadine I inhibits LPS-induced nitric oxide (NO) production in RAW264.7 macrophages, exhibiting anti-inflammatory activity .

HY-N16774

Balanophonin B	NO Synthase	Inflammation/Immunology
Balanophonin B is a selective inhibitor (IC₅₀=1.46 μg/mL) that targets the lipopolysaccharide (LPS)-induced nitric oxide (NO) production pathway and can be isolated from Lithocarpus pachylepis. Balanophonin B inhibits the production of NO in LPS-stimulated RAW264.7 macrophages and exerts anti-inflammatory activity to reduce the inflammatory response. Balanophonin B can be used for anti-inflammatory drug development and biological activity research of natural lignan compounds .

HY-N16817

Rabdoternin E	NO Synthase	Inflammation/Immunology Cancer
Rabdoternin E is a potential anti-inflammatory and antitumor agent. 2α-Acetoxy-14,15-cyclopimara-7β,16-diol only inhibits nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW264.7 macrophages (IC₅₀=2.3 μM) and exhibits cytotoxicity against human tumor cells such as HL-60 and SW-480 (IC₅₀ values ??of 2.6 μM and 4.1 μM, respectively). Rabdoternin E is an ent-kaurane-type diterpenoid compound that can be naturally extracted from the 70% acetone aqueous extract of the aerial parts of Isodon rosthornii (Diels) Hara (a plant of the Lamiaceae family, Isodon genus) .

HY-N13821

2α-Acetoxy-14,15-cyclopimara-7β,16-diol	NO Synthase	Inflammation/Immunology
2α-Acetoxy-14,15-cyclopimara-7β,16-diol (compound 2) is a potential anti-inflammatory agent, exhibiting weak anti-inflammatory activity by inhibiting inflammation-related NO production. 2α-Acetoxy-14,15-cyclopimara-7β,16-diol only inhibits nitric oxide (NO) production in LPS-induced RAW264.7 macrophages, with an inhibition rate of 28.1%. 2α-Acetoxy-14,15-cyclopimara-7β,16-diol can be naturally extracted from the 70% ethanol extract of the seeds of Caesalpinia minax Hance (a plant of the Caesalpinia genus in the Fabaceae family) .

HY-N16877

N-(2-Hydroxy-3-methylbutyl)-adenosine	Drug Derivative	Others
N-(2-Hydroxy-3-methylbutyl)-adenosine is a natural alkaloid.

HY-N3691

Daturataturin A aglycone	Drug Derivative	Others
Daturataturin A aglycone is a natural steroid.

α-Chaconine	Alkaloids Piperidine Alkaloids Zea mays L. Pyrrole Alkaloids Classification of Application Fields Gramineae Plants Inflammation/Immunology Disease Research Fields Source Classification	COX
α-Chaconine inhibits the expressions of COX-2, IL-1β, IL-6, and TNF-α at the transcriptional level. α-Chaconine inhibits the LPS-induced expressions of iNOS and COX-2 at the protein and mRNA levels and their promoter activities in RAW 264.7 macrophages. Anti-inflammatory effects .

Coniferaldehyde 1 Publications Verification 4-Hydroxy-3-methoxycinnamaldehyde	Monophenols other families Classification of Application Fields Simple Phenylpropanols Phenols Phenylpropanoids Plants Inflammation/Immunology Disease Research Fields Source Classification	Keap1-Nrf2 Apoptosis
Coniferaldehyde (4-Hydroxy-3-methoxycinnamaldehyde) is an effective inducer of heme oxygenase-1 (HO-1). Coniferaldehyde inhibits LPS-induced apoptosis through the PKCα/β II/Nrf-2/HO-1 dependent pathway in RAW264.7 macrophage cells. Coniferaldehyde has antioxidant and anti-inflammatory activities .

7,3',4'-Tri-O-methylluteolin 1 Publications Verification 5-Hydroxy-3',4',7-trimethoxyflavone	Monophenols Flavonoids Classification of Application Fields Flavones Labiatae Phenols Plants Swartzia polyphylla DC. Inflammation/Immunology Disease Research Fields Source Classification	Lipoxygenase TNF Receptor Interleukin Related COX Fungal Parasite Apoptosis
7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone) is a flavonoid with multiple biological activities. 7,3',4'-Tri-O-methylluteolin inhibits soybean lipoxygenase (LOX), with an IC₅₀ value of 23.97 µg/mL. 7,3',4'-Tri-O-methylluteolin possesses anti-inflammatory effects in Lipopolysaccharides (HY-D1056) (LPS)-induced RAW 264.7 macrophages. 7,3',4'-Tri-O-methylluteolin inhibits the binding of MDM2 with p53 and induces apoptosis in MCF-7 breast cancer cells. 7,3',4'-Tri-O-methylluteolin also has antioxidant, antifungal and antitrypanosomal activities sup>[4]sup>[5].

Lucidone	Natural Products Lindera lucida (Blume) Boerl. Plants Lauraceae Source Classification	Flavivirus Dengue Virus TNF Receptor NF-κB NO Synthase COX JNK p38 MAPK IKK
Lucidone, an anti-inflammatory agent that can be isolated from the fruit of Lindera erythrocarpa Makino. Lucidone inhibits LPS-induced NO and PGE₂ production in RAW 264.7 mouse macrophages. Lucidone also decreases TNF-α secretion, iNOS and COX-2 expression. Lucidone prevents NF-κB translocation and inhibits JNK and p38MAPK signals. Lucidone also has inhibitory activity against Dengue virus (DENV) (EC₅₀=25 μM) .

Stigmasta-3,5-dien-7-one	Structural Classification Harrisonia abyssinica Oliv. Cardiacglycosides Rutaceae Plants Steroids Source Classification	NF-κB TNF Receptor Interleukin Related p38 MAPK
Stigmasta-3,5-dien-7-one is a steroid compound that can be isolated from Harrisonia abyssinica. Stigmasta-3,5-dien-7-one blocks the NF-κB signaling pathway via down-regulation of phospho-p38 mitogen-activated protein kinase and phosphorylation and degradation of inhibitor of NF-κB α. Stigmasta-3,5-dien-7-one reduces LPS (HY-D1056)-induced nitric oxide, PGE₂, and pro-inflammatory cytokine levels in macrophages. Stigmasta-3,5-dien-7-one can be used for inflammation diseases .

NF-κB-IN-13	Natural Products Thymelaeaceae Plants Aquilaria sinensis (Lour.) Spreng. Source Classification	NF-κB
NF-κB-IN-13 (compound 12) can significantly inhibit LPS-induced NF-κB activation and NO production in RAW264.7 macrophages. NF-κB-IN-13 has anti-inflammatory effects .

α-?Chaconine (Standard)	Alkaloids Piperidine Alkaloids Structural Classification Zea mays L. Pyrrole Alkaloids Gramineae Plants Source Classification	Reference Standards COX
α-Chaconine (Standard) is the analytical standard of α-Chaconine. This product is intended for research and analytical applications. α-Chaconine inhibits the expressions of COX-2, IL-1β, IL-6, and TNF-α at the transcriptional level. α-Chaconine inhibits the LPS-induced expressions of iNOS and COX-2 at the protein and mRNA levels and their promoter activities in RAW 264.7 macrophages. Anti-inflammatory effects .

Loganic acid 6′-O-β-D-glucoside	Classification of Application Fields Ketones, Aldehydes, Acids Gentianaceae Plants Inflammation/Immunology Disease Research Fields Gentiana rhodantha Franch. ex Hemsl. Source Classification	TNF Receptor
Loganic acid 6′-O-β-D-glucoside, a iridoidal glucoside, is isolated from the whole plant of Gentiana rhodantha (Gentianaceae). Loganic acid 6′-O-β-D-glucoside inhibits LPS-induced NO and TNF-α production in macrophage RAW264.7 cells .

Curindolizine	Alkaloids Microorganisms Classification of Application Fields Disease Research Fields Inflammation/Immunology Source Classification	Others
Curindolizine, indolizine alkaloid , displays an anti-inflammatory action in lipopolyssacharide (LPS)-induced RAW 264.7 macrophages with an IC₅₀ value of 5.31 μM .

Coniferaldehyde (Standard) 4-Hydroxy-3-methoxycinnamaldehyde (Standard)	Structural Classification Monophenols other families Simple Phenylpropanols Phenols Phenylpropanoids Plants Source Classification	Reference Standards Keap1-Nrf2 Apoptosis
Coniferaldehyde (Standard) is the analytical standard of Coniferaldehyde. This product is intended for research and analytical applications. Coniferaldehyde (4-Hydroxy-3-methoxycinnamaldehyde) is an effective inducer of heme oxygenase-1 (HO-1). Coniferaldehyde inhibits LPS-induced apoptosis through the PKCα/β II/Nrf-2/HO-1 dependent pathway in RAW264.7 macrophage cells. Coniferaldehyde has antioxidant and anti-inflammatory activities .

Abiesadine I	Structural Classification Pinaceae Terpenoids Pityrogramma triangularis Diterpenoids Plants Source Classification	NO Synthase
Abiesadine I is a diterpenoid inhibitor targeting LPS-induced NO production (IC₅₀>100 μg/mL) that can be isolated from Abies georgei. Abiesadine I inhibits LPS-induced nitric oxide (NO) production in RAW264.7 macrophages, exhibiting anti-inflammatory activity .

Balanophonin B	Structural Classification Lignans Phenylpropanoids Plants Fagaceae Lithocarpus pachylepis A. Camus Source Classification	NO Synthase
Balanophonin B is a selective inhibitor (IC₅₀=1.46 μg/mL) that targets the lipopolysaccharide (LPS)-induced nitric oxide (NO) production pathway and can be isolated from Lithocarpus pachylepis. Balanophonin B inhibits the production of NO in LPS-stimulated RAW264.7 macrophages and exerts anti-inflammatory activity to reduce the inflammatory response. Balanophonin B can be used for anti-inflammatory drug development and biological activity research of natural lignan compounds .

Rabdoternin E	Structural Classification Terpenoids Labiatae Erythrina arborescensRoxb. Diterpenoids Plants Source Classification	NO Synthase
Rabdoternin E is a potential anti-inflammatory and antitumor agent. 2α-Acetoxy-14,15-cyclopimara-7β,16-diol only inhibits nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW264.7 macrophages (IC₅₀=2.3 μM) and exhibits cytotoxicity against human tumor cells such as HL-60 and SW-480 (IC₅₀ values ??of 2.6 μM and 4.1 μM, respectively). Rabdoternin E is an ent-kaurane-type diterpenoid compound that can be naturally extracted from the 70% acetone aqueous extract of the aerial parts of Isodon rosthornii (Diels) Hara (a plant of the Lamiaceae family, Isodon genus) .

2α-Acetoxy-14,15-cyclopimara-7β,16-diol	Triterpenes Structural Classification Terpenoids Plants Guilandina minax (Hance) G. P. Lewis Fabaceae Source Classification	NO Synthase
2α-Acetoxy-14,15-cyclopimara-7β,16-diol (compound 2) is a potential anti-inflammatory agent, exhibiting weak anti-inflammatory activity by inhibiting inflammation-related NO production. 2α-Acetoxy-14,15-cyclopimara-7β,16-diol only inhibits nitric oxide (NO) production in LPS-induced RAW264.7 macrophages, with an inhibition rate of 28.1%. 2α-Acetoxy-14,15-cyclopimara-7β,16-diol can be naturally extracted from the 70% ethanol extract of the seeds of Caesalpinia minax Hance (a plant of the Caesalpinia genus in the Fabaceae family) .

N-(2-Hydroxy-3-methylbutyl)-adenosine	Structural Classification Natural Products Hippocastanaceae Plants Aesculus chinensis var. wilsonii (Rehder) Turland & N. H. Xia Source Classification	Drug Derivative
N-(2-Hydroxy-3-methylbutyl)-adenosine is a natural alkaloid.

Daturataturin A aglycone	Structural Classification Datura metel L. Solanaceae Plants Steroids Source Classification	Drug Derivative
Daturataturin A aglycone is a natural steroid.

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

LPS-induced RAW264.7 macrophages

Inhibitors & Agonists

NaturalProducts

Natural
Products