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Cat. No.: HY-N16677

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Abiesadine I

Abiesadine I is a diterpenoid inhibitor targeting LPS-induced NO production (IC₅₀>100 μg/mL) that can be isolated from Abies georgei. Abiesadine I inhibits LPS-induced nitric oxide (NO) production in RAW264.7 macrophages, exhibiting anti-inflammatory activity.

For research use only. We do not sell to patients.

CAS No.: 1210347-50-4
Formula: C₂₄H₃₄O₅
Molecular Weight:402.52

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

Abiesadine I Chemical Structure

CAS No.: 1210347-50-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All NO Synthase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	100 μg/mL Compound: 9, Abiesadine I	Inhibition of TNF-alpha-induced NF-kappaB activity in human pNF-kappaB-luc-293 cells Inhibition of TNF-alpha-induced NF-kappaB activity in human pNF-kappaB-luc-293 cells	[PMID: 20022253]

Chemical Information

CAS No. 1210347-50-4
Molecular Weight 402.52
Formula C₂₄H₃₄O₅
SMILES

C[C@@]12[C@](CCC3=CC(C(C)(O)C)=CC=C32)([H])[C@@](C)(CCC1)COC(CCC(O)=O)=O
Structure Classification
- Terpenoids
- Diterpenoids
Initial Source
- Plants
- Pinaceae
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yang XW, et al. Isolation, structure, and bioactivities of abiesadines A-Y, 25 new diterpenes from Abies georgei Orr. Bioorg Med Chem. 2010 Jan 15;18(2):744-54. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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Abiesadine I

All NO Synthase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Abiesadine I Related Classifications

HY-N16677 Related Classifications