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Results for "

bacterial+cell+wall

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amino Acid Derivatives (1) Antibiotic (52) Bacterial (77) Beta-lactamase (5) Biochemical Assay Reagents (3) EAAT (5) Endogenous Metabolite (6) Fluorescent Dye (5) iGluR (2) Interleukin Related (8) Isotope-Labeled Compounds (7) NF-κB (8) p38 MAPK (8) Penicillin-binding protein (PBP) (15) Phosphomannose Isomerase (PMI) (1) Reference Standards (15) TGF-β Receptor (1) TNF Receptor (8)
By Research Areas:	Cancer (14) Cardiovascular Disease (5) Infection (74) Inflammation/Immunology (3) Metabolic Disease (4) Neurological Disease (7)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0030

D-Cycloserine 5+ Cited Publications	iGluR Bacterial Antibiotic	Infection Neurological Disease Cancer
D-Cycloserine is an antibiotic which targets sequential bacterial cell wall peptidoglycan biosynthesis enzymes, with blood-brain barrier permeability. D-Cycloserine is a partial NMDA agonist that can improve cognitive functions. D-Cycloserine can be used for multidrug-resistant tuberculosis research .

HY-B0200

Cephalexin Maximum Cited Publications 9 Publications Verification Cefalexin; Cephacillin	Penicillin-binding protein (PBP) Antibiotic Bacterial	Infection Cancer
Cephalexin (Cefalexin) is a potent, orally active semisynthetic cephalosporin antibiotic with a broad antibacterial spectrum. Cephalexin has antibacterial activity against a wide variety of gram-positive and gram-negative bacteria. Cephalexin targets penicillin-binding proteins (PBPs) to inhibit bacterial cell wall assembly. Cephalexin is used for the research of pneumonia, strep throat, and bacterial endocarditis, et al .

HY-W009274

N-Acetylmuramic acid MurNAc; NAMA	p38 MAPK NF-κB Bacterial	Infection Inflammation/Immunology
N-acetylmuramic acid is a component of the bacterial cell wall peptidoglycan, essential for maintaining cell shape and integrity . N-acetylmuramic acid inhibits spore germination by inhibiting a coat-associated hexosaminidase and a core enzyme . N-acetylmuramic acid is required by Bacteroides forsythus for proliferation and the maintenance of its cell shape . N-Acetylmuramic acid inhibits the p38 MAPK/NF-κB signaling pathway, and exhibits anti-inflammatory activity. N-Acetylmuramic acid is orally active .

HY-B0200B

Cephalexin monohydrate Maximum Cited Publications 9 Publications Verification Cefalexin hydrate; Cephacillin hydrate	Penicillin-binding protein (PBP) Antibiotic Bacterial	Infection Cancer
Cephalexin (Cefalexin) monohydrate is a potent, orally active new semisynthetic cephalosporin antibiotic with a broad antibacterial spectrum. Cephalexin (Cefalexin) monohydrate has antibacterial activity against a wide variety of gram-positive and gram-negative bacteria. Cephalexin (Cefalexin) monohydrate targets penicillin-binding proteins (PBPs) to inhibit bacterial cell wall assembly. Cephalexin (Cefalexin) monohydrate is used for the research of pneumonia, strep throat, and bacterial endocarditis, et al .

HY-B1190

Cefadroxil 5 Publications Verification BL-S 578	Bacterial Antibiotic EAAT	Infection Neurological Disease
Cefadroxil is an orally active broad-spectrum cephalosporin antibiotic. Cefadroxil inhibits *bacterial* cell wall synthesis and enhances the expression of glutamate transporter-1. Cefadroxil is dependent on the intestinal peptide transporter PepT1 for small intestinal absorption. Cefadroxil has inhibitory and bactericidal activity against a variety of Gram-positive and Gram-negative bacteria and has analgesic effects on neuropathic pain .

HY-147063

N-Acetyl-α-D-glucosamine 1-phosphate disodium	Endogenous Metabolite	Others
N-acetyl-α-d-glucosamine 1-phosphate disodium (GlcNAc-1-P) is an ectopic sugar phosphate and a key intermediate in N-glycoprotein biosynthesis. N-acetyl-α-d-glucosamine 1-phosphate disodium serves as a metabolic precursor of teichoic acid and muramic acid, which are components of bacterial cell walls .

HY-P1068

Lysozyme 5+ Cited Publications Muramidase	Bacterial TNF Receptor Interleukin Related TGF-β Receptor	Infection Inflammation/Immunology
Lysozyme (Muramidase) is a conserved antimicrobial protein. Lysozyme exerts its bactericidal effect by hydrolyzing bacterial cell wall peptidoglycan (PG). Lysozyme plays an important role in limiting bacterial growth on mucosal surfaces and other sites, not only controlling potential pathogens but also limiting overgrowth of microbiota to prevent dysbiosis. Extracellular lysozyme can also degrade polymeric PG into soluble fragments, activate NOD receptors in mucosal epithelial cells, and lead to the secretion of chemokines and activating factors by neutrophils and macrophages .

HY-131150

Ristomycin sulfate	Antibiotic Bacterial	Cardiovascular Disease Infection
Ristomycin sulfate is an antibacterial antibiotic and platelet aggregation inducer. Ristomycin sulfate interacts with the D-alanyl-D-alanine terminus of bacterial cell wall precursors to regulate bacterial cell wall synthesis. Ristomycin sulfate induces platelet aggregation in vitro and inhibits the growth of Gram-positive bacteria. Ristomycin sulfate serves as an in vitro diagnostic compound for detecting von Willebrand factor activity. Ristomycin sulfate is applicable to research related to von Willebrand disease and Bernard-Soulier syndrome .

HY-B0200A

Cephalexin hydrochloride Maximum Cited Publications 9 Publications Verification Cefalexin hydrochloride; Cephacillin hydrochloride	Penicillin-binding protein (PBP) Bacterial Antibiotic	Infection Cancer
Cephalexin (Cefalexin) hydrochloride is a potent, orally active new semisynthetic cephalosporin antibiotic with a broad antibacterial spectrum. Cephalexin (Cefalexin) hydrochloride has antibacterial activity against a wide variety of gram-positive and gram-negative bacteria. Cephalexin (Cefalexin) hydrochloride targets penicillin-binding proteins (PBPs) to inhibit bacterial cell wall assembly. Cephalexin (Cefalexin) hydrochloride is used for the research of pneumonia, strep throat, and bacterial endocarditis, et al .

HY-P1068A

Recombinant human lysozyme (plant expression)	Bacterial	Infection
Recombinant human lysozyme (plant expression) is a conserved anti-bacterial protein that causes bacterial lysis and death by hydrolyzing bacterial cell wall peptidoglycan (PG). Recombinant human lysozyme (plant expression) can be used to study bacterial infections .

HY-B1257

Cefmetazole sodium Sodium cefmetazole	Bacterial Antibiotic	Infection Cancer
Cefmetazole sodium (Sodium cefmetazole) is a semisynthetic cephamycin antibiotic with broad-spectrum antibacterial activity, covering gram-positive, gram-negative, and anaerobic bacteria. Cefmetazole sodium binds to penicillin binding proteins (PBPs), resulting in interfering bacterial cell wall biosynthesis. Cefmetazole sodium is used for the research of gynecologic, intraabdominal, urinary tract, respiratory tract and skin and soft tissue infections .

HY-B1824

Cefpirome sulfate 1 Publications Verification HR-810 sulfate	Bacterial Antibiotic	Infection
Cefpirome (HR-810) sulfate is a cephalosporin antibiotic that can cross cell membranes and the blood-brain barrier. Cefpirome sulfate binds to penicillin-binding proteins with high affinity, thereby inhibiting bacterial cell wall synthesis. Cefpirome sulfate exhibits bactericidal and growth-inhibitory activities against Gram-negative bacteria, Gram-positive bacteria, and susceptible anaerobic bacteria (including some β-lactamase-producing strains) .

HY-N7102

Ceftiofur 4 Publications Verification	Antibiotic Bacterial NF-κB p38 MAPK TNF Receptor Interleukin Related	Infection
Ceftiofur is a cell wall synthesis inhibitor that targets bacterial penicillin-binding proteins (PBPs) and has anti-inflammatory effects in endotoxemia. Ceftiofur exerts bactericidal effects by inhibiting the synthesis of bacterial cell wall peptidoglycan, leading to bacterial cell lysis. Ceftiofur also inhibits the activation of NF-κB and MAPKs, thereby reducing the secretion of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6 .

HY-B0898

Ceftiofur sodium 4 Publications Verification sodium ceftiofur	Antibiotic Bacterial NF-κB p38 MAPK TNF Receptor Interleukin Related	Infection
Ceftiofur sodium is a cell wall synthesis inhibitor that targets bacterial penicillin-binding proteins (PBPs) and has anti-inflammatory effects in endotoxemia. Ceftiofur sodium exerts bactericidal effects by inhibiting the synthesis of bacterial cell wall peptidoglycan, leading to bacterial cell lysis. Ceftiofur sodium also inhibits the activation of NF-κB and MAPKs, thereby reducing the secretion of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6 .

HY-B1275

Cephalothin sodium 3 Publications Verification Cefalotin sodium	Beta-lactamase Bacterial Antibiotic	Infection
Cephalothin (Cephalotin) sodium is a semi-synthetic cephalosporin antibiotic and beta-lactam antibiotic. Cephalothin inhibits class C β-lactamase AmpC, with an K_i of 0.32 µM. Cephalothin sodium binds to penicillin-binding proteins, interfering with the cross-linking of peptidoglycan in the cell wall and thus hindering the normal synthesis of the bacterial cell wall. Cephalothin sodium shows antibacterial activity against a variety of bacteria. Cephalothin sodium can be used in hematological and nephrotoxicity studies .

HY-B1275A

Cephalothin 3 Publications Verification Cephalotin	Beta-lactamase Bacterial Antibiotic	Infection Cardiovascular Disease
Cephalothin (Cephalotin) is a semi-synthetic cephalosporin antibiotic and beta-lactam antibiotic. Cephalothin inhibits class C β-lactamase AmpC, with an K_i of 0.32 µM. Cephalothin binds to penicillin-binding proteins, interfering with the cross-linking of peptidoglycan in the cell wall and thus hindering the normal synthesis of the bacterial cell wall. Cephalothin shows antibacterial activity against a variety of bacteria. Cephalothin can be used in hematological and nephrotoxicity studies .

HY-19750

TBA-7371 1 Publications Verification	Bacterial	Infection
TBA-7371 is an orally active and non-covalent inhibitor of Decaprenylphosphoryl-β-D-ribose oxidase (DprE1) of Mycobacterium tuberculosis (MIC=0.64 μg/mL). TBA-7371 can block the synthesis of arabinose in the bacterial cell wall, resulting in cell wall structural defects, thereby exerting an anti-tuberculosis effect. TBA-7371 can be used in the research of anti-tuberculosis drugs and has a synergistic bactericidal effect with Bedaquiline (HY-14881) and other drugs .

HY-B1924

Norvancomycin monohydrochloride 1 Publications Verification N-Demethylvancomycin monohydrochloride; NVCM monohydrochloride	Bacterial	Infection
Norvancomycin hydrochloride is a cell wall synthesis inhibitor targeting peptidoglycan precursors of Gram-positive bacteria and cannot pass the blood-brain barrier. Norvancomycin hydrochloride can competitively bind to peptidoglycan precursors, irreversibly inhibit bacterial cell wall synthesis, and exert antibacterial activity. Norvancomycin hydrochloride is mainly used in the study of Gram-positive bacterial infections, especially infections caused by methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-resistant Staphylococcus epidermidis (MRSE). Norvancomycin hydrochloride can also be incorporated into the bionic calcium phosphate coating of titanium implants to enhance antibacterial activity and inhibit postoperative orthopedic infections .

HY-138053

Ristocetin A sulfate Ristomycin III	Antibiotic	Cardiovascular Disease Infection
Ristocetin A sulfate (Ristomycin III) is a glycopeptide antibiotic that binds to von Willebrand factor (VWF) and bacterial cell wall components. Ristocetin A sulfate interferes with the biosynthesis of bacterial peptidoglycan by inhibiting transpeptidation. As an inducer of platelet adhesion and aggregation, Ristocetin A sulfate drives conformational changes by binding to the A1 domain of VWF, thereby activating downstream signaling pathways and promoting cytoskeletal rearrangement. Ristocetin A sulfate not only enhances platelet adhesion and spreading on immobilized VWF, but also induces the formation of asymmetric dimers with anticooperativity between platelets and plasma VWF. Ristocetin A sulfate is widely used in studies related to thromboembolic diseases and bacterial infections .

HY-N7101

Cefpodoxime Proxetil U-76,252; CS-807	Bacterial Antibiotic Penicillin-binding protein (PBP)	Infection
Cefpodoxime Proxetil is an orally active broad spectrum third-generation cephalosporin with potent antibacterial activity against both Gram-positive and Gram-negative bacteria including staphylococci, streptococci, Haemophilus influenzae, Neisseria gonorrhoeae, Escherichia coli, Klebsiella pnuemoniae, Citrobacter spp, and Proteus spp. Cefpodoxime Proxetil binds to penicillin binding proteins (PBPs), which inhibits peptidoglycan synthesis, finally results in interfering bacterial cell wall biosynthesis. Cefpodoxime Proxetil can be used against skin structure infections, acute otitis media, pharyngitis, tonsillitis, upper respiratory tract infection, urinary tract infections and sexually transmitted diseases .

HY-B1596

Ceftizoxime 1 Publications Verification	Bacterial Antibiotic	Infection
Ceftizoxime is a *bacterial* inhibitor which acts by interfering with bacterial cell wall synthesis and inhibiting cross-linking of the peptidoglycan.

HY-34516

D-Ornithine hydrochloride (R)-Ornithine hydrochloride	Endogenous Metabolite Bacterial	Metabolic Disease
D-Ornithine ((R)-Ornithine) hydrochloride is a constituent of *bacterial* cell wall. D-Ornithine hydrochloride promotes the production of L-arginine (HY-N0455). D-Ornithine hydrochloride enhances the expression of pyrrolysine-containing proteins .

HY-B1190A

Cefadroxil hydrate 5 Publications Verification BL-S 578 hydrate	Bacterial Antibiotic EAAT	Infection Neurological Disease
Cefadroxil hydrate is an orally active broad-spectrum cephalosporin antibiotic. Cefadroxil hydrate inhibits *bacterial* cell wall synthesis and enhances the expression of glutamate transporter-1. Cefadroxil hydrate is dependent on the intestinal peptide transporter PepT1 for small intestinal absorption. Cefadroxil hydrate has inhibitory and bactericidal activity against a variety of Gram-positive and Gram-negative bacteria and has analgesic effects on neuropathic pain .

HY-B1596A

Ceftizoxime sodium 1 Publications Verification SKF-88373	Penicillin-binding protein (PBP) Bacterial Antibiotic	Infection
Ceftizoxime sodium (SKF-88373) is third generation cephalosporin effective against Gram-negative and Gram-positive bacteria. It binds penicillin-binding proteins (PBPs) and inhibits the bacterial cell wall synthesis.

HY-W587753

Bacitracin A	Antibiotic Bacterial	Infection
Bacitracin A is an antibiotic, which exhibits antibacterial activity against gram-positive bacteria. Bacitracin A forms complex with long-chain polyisoprenyl pyrophosphates in presence of metal ions, dephosphorylates the lipid carrier intermediate Css-bactoprenyl pyrophosphate, inhibits thus the bacterial cell wall biosynthesis .

HY-107833

A40926	Antibiotic Bacterial	Infection
A40926 is a glycopeptide antibiotic that targets the bacterial cell wall peptidoglycan precursor D-alanyl-D-alanine (D-Ala-D-Ala). A40926 irreversibly inhibits cell wall synthesis by competitively binding to this target, and has high bactericidal activity against Gram-positive bacteria (such as Staphylococcus, Streptococcus) and Neisseria gonorrhoeae, with MIC=0.06-2 μg/mL, and is also effective against penicillin-resistant strains. A40926 blocks peptidoglycan cross-linking, destroys cell wall integrity, and causes bacterial lysis and death. A40926 has a fat-soluble fatty acid structure, which can increase serum concentrations and prolong the duration of action (e.g., the terminal half-life in rats is 61.22 h) .

HY-D1690A

sBADA	Fluorescent Dye	Others
sBADA is a potent green fluorescent dye. sBADA is a sulfonated BODIPY-FL 3-amino-D-alanine. sBADA is used to label peptidoglycans in bacterial cell walls in situ. (λ_ex=490 nm, λ_em=510 nm) .

HY-B0030R

D-Cycloserine (Standard) 5+ Cited Publications	Reference Standards iGluR Bacterial Antibiotic	Infection Neurological Disease Cancer
D-Cycloserine (Standard) is the analytical standard of D-Cycloserine. This product is intended for research and analytical applications. D-Cycloserine is an antibiotic which targets sequential bacterial cell wall peptidoglycan biosynthesis enzymes. D-Cycloserine is a partial NMDA agonist that can improve cognitive functions. D-Cycloserine can be used for multidrug-resistant tuberculosis research .

HY-B1595

Cefmetazole CS 1170	Antibiotic Bacterial	Infection Cancer
Cefmetazole (CS 1170) is a semisynthetic cephamycin antibiotic with broad-spectrum antibacterial activity, covering gram-positive, gram-negative and anaerobic bacteria. Cefmetazole binds to penicillin binding proteins (PBPs), resulting in interfering bacterial cell wall biosynthesis. Cefmetazole is used for the research of gynecologic, intraabdominal, urinary tract, respiratory tract and skin and soft tissue infections .

HY-B0200R

Cephalexin (Standard) Cefalexin (Standard); Cephacillin (Standard)	Penicillin-binding protein (PBP) Reference Standards Antibiotic Bacterial	Infection Cancer
Cephalexin (Standard) is the analytical standard of Cephalexin. This product is intended for research and analytical applications. Cephalexin (Cefalexin) is a potent, orally active semisynthetic cephalosporin antibiotic with a broad antibacterial spectrum. Cephalexin has antibacterial activity against a wide variety of gram-positive and gram-negative bacteria. Cephalexin targets penicillin-binding proteins (PBPs) to inhibit bacterial cell wall assembly. Cephalexin is used for the research of pneumonia, strep throat, and bacterial endocarditis, et al .

HY-135113

DL/meso-Lanthionine	Amino Acid Derivatives	Others
DL/meso-Lanthionine is a mixture of the racemic mixture (DL-) and meso- isomers of Lanthionine. Lanthionine is a non-protein amino acid composed of two alanine residues cross-linked by a thioether bond and is a structural component of the bacterial cell wall.

HY-B0200S

Cephalexin-d5 Cefalexin-d₅; Cephacillin-d₅	Antibiotic Bacterial	Infection
Cephalexin-d₅ is deuterium labeled Cephalexin. Cephalexin (Cefalexin; Cephacillin) is a potent, orally active and the first-generation?cephalosporin antibiotic. Cephalexin kills?gram-positive?and some?gram-negative bacteria?by disrupting the growth of the bacterial cell wall. Cephalexin monohydrate is used for the research of?pneumonia,?strep throat, and bacterial endocarditis, et al .

HY-B0026

Ceftiofur hydrochloride 4 Publications Verification	Antibiotic Bacterial NF-κB p38 MAPK TNF Receptor Interleukin Related	Infection
Ceftiofur hydrochloride is a cell wall synthesis inhibitor that targets bacterial penicillin-binding proteins (PBPs) and has anti-inflammatory effects in endotoxemia. Ceftiofur hydrochloride exerts bactericidal effects by inhibiting the synthesis of bacterial cell wall peptidoglycan, leading to bacterial cell lysis. Ceftiofur hydrochloride also inhibits the activation of NF-κB and MAPKs, thereby reducing the secretion of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6 .

HY-W653936

Cephalexin-d5 hydrate	Isotope-Labeled Compounds Bacterial Antibiotic Penicillin-binding protein (PBP)	Cancer
Cephalexin-d₅ (hydrate) is deuterium labeled Cephalexin (monohydrate). Cephalexin (Cefalexin) monohydrate is a potent, orally active new semisynthetic cephalosporin antibiotic with a broad antibacterial spectrum. Cephalexin (Cefalexin) monohydrate has antibacterial activity against a wide variety of gram-positive and gram-negative bacteria. Cephalexin (Cefalexin) monohydrate targets penicillin-binding proteins (PBPs) to inhibit bacterial cell wall assembly. Cephalexin (Cefalexin) monohydrate is used for the research of pneumonia, strep throat, and bacterial endocarditis, et al .

HY-B1190R

Cefadroxil (Standard) BL-S 578 (Standard)	Reference Standards Bacterial Antibiotic EAAT	Infection Neurological Disease
Cefadroxil (Standard) is the analytical standard of Cefadroxil (HY-B1190). This product is intended for research and analytical applications. Cefadroxil is an orally active broad-spectrum cephalosporin antibiotic. Cefadroxil inhibits *bacterial* cell wall synthesis and enhances the expression of glutamate transporter-1. Cefadroxil is dependent on the intestinal peptide transporter PepT1 for small intestinal absorption. Cefadroxil has inhibitory and bactericidal activity against a variety of Gram-positive and Gram-negative bacteria and has analgesic effects on neuropathic pain .

HY-B0898R

Ceftiofur sodium (Standard) sodium ceftiofur (Standard)	Reference Standards Antibiotic Bacterial NF-κB p38 MAPK TNF Receptor Interleukin Related	Infection
Ceftiofur sodium (Standard) is the analytical standard of Ceftiofur sodium (HY-B0898). This product is intended for research and analytical applications. Ceftiofur sodium is a cell wall synthesis inhibitor that targets bacterial penicillin-binding proteins (PBPs) and has anti-inflammatory effects in endotoxemia. Ceftiofur sodium exerts bactericidal effects by inhibiting the synthesis of bacterial cell wall peptidoglycan, leading to bacterial cell lysis. Ceftiofur sodium also inhibits the activation of NF-κB and MAPKs, thereby reducing the secretion of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6 .

HY-N11102

Thymidine-5'-diphosphate-L-rhamnose dTDP-L-Rhamnose	Endogenous Metabolite Bacterial	Infection
Thymidine-5'-diphosphate-L-rhamnose (dTDP-L-Rhamnose) is a key activated nucleotide sugar in bacteria, with a K_D value of 13 μM for Listeria monocytogenes RmlT. Thymidine-5'-diphosphate-L-rhamnose acts as a high-energy donor for L-Rhamnose (HY-N1420), and is specifically used for the synthesis of bacterial cell wall polysaccharides, capsules and virulence factors .

HY-B0200C

Cephalexin hydrochloride monohydrate Cefalexin hydrochloride monohydrate; Cephacillin hydrochloride monohydrate	Penicillin-binding protein (PBP) Antibiotic Bacterial	Infection Cancer
Cephalexin (Cefalexin) hydrochloride monohydrate is a potent, orally active new semisynthetic cephalosporin antibiotic with a broad antibacterial spectrum. Cephalexin (Cefalexin) hydrochloride monohydrate has antibacterial activity against a wide variety of gram-positive and gram-negative bacteria. Cephalexin (Cefalexin) hydrochloride monohydrate targets penicillin-binding proteins (PBPs) to inhibit bacterial cell wall assembly. Cephalexin (Cefalexin) hydrochloride monohydrate is used for the research of pneumonia, strep throat, and bacterial endocarditis, et al .

HY-B0200D

Cephalexin (lysine) Cefalexin (lysine); Cephacillin (lysine)	Penicillin-binding protein (PBP) Bacterial Antibiotic	Infection Cancer
Cephalexin (Cefalexin) lysine is a potent, orally active new semisynthetic cephalosporin antibiotic with a broad antibacterial spectrum. Cephalexin lysine has antibacterial activity against a wide variety of gram-positive and gram-negative bacteria. Cephalexin lysine targets penicillin-binding proteins (PBPs) to inhibit bacterial cell wall assembly. Cephalexin lysine is used for the research of pneumonia, strep throat, and bacterial endocarditis, et al .

HY-B1824R

Cefpirome sulfate (Standard) HR-810 sulfate (Standard)	Reference Standards Antibiotic Bacterial	Infection
Cefpirome (HR-810) sulfate (Standard) is the analytical standard of Cefpirome sulfate. This product is intended for research and analytical applications. Cefpirome sulfate is a cephalosporin antibiotic that can cross cell membranes and the blood-brain barrier. Cefpirome sulfate binds to penicillin-binding proteins with high affinity, thereby inhibiting bacterial cell wall synthesis. Cefpirome sulfate exhibits bactericidal and growth-inhibitory activities against Gram-negative bacteria, Gram-positive bacteria, and susceptible anaerobic bacteria (including some β-lactamase-producing strains).

HY-U00380

Tigemonam	Antibiotic Beta-lactamase Bacterial	Infection
Tigemonam is an orally active monobactam antibiotic with a K_i of 0.86 μM against Enterobacter cloacae P99 β-lactamase and 50.8 μM against Escherichia coli TEM-1 β-lactamase. Tigemonam binds to penicillin-binding proteins 1a, 3, and 4, inhibits bacterial cell wall synthesis, and exhibits bactericidal activity against aerobic gram-negative bacteria including Enterobacteriaceae, Haemophilus influenzae, and Neisseria gonorrhoeae. Tigemonam resists hydrolysis by multiple β-lactamase enzymes, reduces bacterial load in systemic, pyelonephritic, lung, and thigh muscle infections in rodents, and shows minimal difference between minimum inhibitory and bactericidal concentrations. Tigemonam can be used for the research of gram-negative bacterial infections, acute pyelonephritis, lung infection, and thigh muscle infection .

HY-E70602

T4 lysozyme	Bacterial	Others
T4 lysozyme is derived from a recombinant E.coli strain and can lyse bacterial cell walls. T4 lysozyme acts on the peptidoglycan of bacterial cell walls and hydrolyzes the β-1,4 bond between N-acetylmuramic acid and N-acetylglucosamine .

HY-W012267

2-Bromo-2'-methoxyacetophenone 2-Bromo-1-(2-methoxyphenyl)ethanone	Bacterial	Infection
2-Bromo-2'-methoxyacetophenone is an irreversible inhibitor for MurA, that inhibits MurA in E. coli with an IC₅₀ of 0.38 μM. 2-Bromo-2'-methoxyacetophenone can be used in antibacterial research for blocking bacterial cell wall synthesis .

HY-B0200BS

Cephalexin-d5 monohydrate Cefalexin hydrate-d₅; Cephacillin hydrate-d₅	Isotope-Labeled Compounds Antibiotic Bacterial	Infection
Cephalexin-d₅ (monohydrate) is the deuterium labeled Cephalexin monohydrate. Cephalexin monohydrate is a potent, orally active and the first-generation?cephalosporin antibiotic. Cephalexin monohydrate kills?gram-positive?and some?gram-negative bacteria?by disrupting the growth of the bacterial cell wall. Cephalexin monohydrate is used for the research of?pneumonia,?strep throat, and bacterial endocarditis, et al .

HY-N11102A

Thymidine-5'-diphosphate-L-rhamnose disodium dTDP-L-Rhamnose disodium	Endogenous Metabolite Bacterial	Infection
Thymidine-5'-diphosphate-L-rhamnose (dTDP-L-Rhamnose) disodium is a key activated nucleotide sugar in bacteria, with a K_D value of 13 μM for Listeria monocytogenes RmlT. Thymidine-5'-diphosphate-L-rhamnose disodium acts as a high-energy donor for L-Rhamnose (HY-N1420), and is specifically used for the synthesis of bacterial cell wall polysaccharides, capsules and virulence factors .

HY-130337

Teicoplanin A2-2	Antibiotic Bacterial	Infection
Teicoplanin A2-2 is a glycopeptide antibiotic. Teicoplanin A2-2 exhibits antibacterial activity, particularly against coagulase-negative staphylococci (CNS). Teicoplanin A2-2 inhibits bacterial cell wall synthesis by competitively binding to the terminal D-Ala-D-Ala peptide bonds in the cell wall synthesis process, leading to bacterial death. Teicoplanin A2-2 can be used for research into bacterial resistance mechanisms and the development of new antibiotics .

HY-B1190S

Cefadroxil-d4 hydrate BL-S 578-d4 hydrate	Isotope-Labeled Compounds Bacterial Antibiotic EAAT	Infection Neurological Disease
Cefadroxil-d₄ (hydrate) is the deuterium labeled Cefadroxil hydrate (HY-B1190A). Cefadroxil hydrate is an orally active broad-spectrum cephalosporin antibiotic. Cefadroxil hydrate inhibits *bacterial* cell wall synthesis and enhances the expression of glutamate transporter-1. Cefadroxil hydrate is dependent on the intestinal peptide transporter PepT1 for small intestinal absorption. Cefadroxil hydrate has inhibitory and bactericidal activity against a variety of Gram-positive and Gram-negative bacteria and has analgesic effects on neuropathic pain .

HY-B0898S

Ceftiofur-d3 sodium	Isotope-Labeled Compounds Antibiotic Bacterial NF-κB p38 MAPK TNF Receptor Interleukin Related	Infection
Ceftiofur-d₃ sodium is deuterium labeled Ceftiofur sodium (HY-B0898). Ceftiofur sodium is a cell wall synthesis inhibitor that targets bacterial penicillin-binding proteins (PBPs) and has anti-inflammatory effects in endotoxemia. Ceftiofur sodium exerts bactericidal effects by inhibiting the synthesis of bacterial cell wall peptidoglycan, leading to bacterial cell lysis. Ceftiofur sodium also inhibits the activation of NF-κB and MAPKs, thereby reducing the secretion of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6 .

HY-166113

Undecaprenyl-mpda monophosphate	Biochemical Assay Reagents	Others
Undecaprenyl-mpda monophosphate is an ester compounds that closely related to bacterial cell wall synthesis .

HY-167812

Trimethylsilyl-L-(+)-rhamnose	Bacterial
Trimethylsilyl-L-(+)-rhamnose is a chemically modified version of the natural sugar rhamnose that has activity in studying the role of rhamnose in bacterial cell walls. Trimethylsilyl-L-(+)-rhamnose can be used to explore the composition of bacterial cell walls and their biological functions. Trimethylsilyl-L-(+)-rhamnose can help scientists gain insight into bacterial growth and resistance mechanisms.

Cat. No.	Product Name

HY-L049

Antibacterial Compound Library

1,904 compounds

Antibacterial agents are a group of materials that fight against pathogenic bacteria. Thus, by killing or reducing the metabolic activity of bacteria, their pathogenic effect in the biological environments will be minimized. The most widely used antibacterial agents exert their effects on bacterial cell wall synthesis, protein synthesis, DNA replication and metabolic pathways. However, resistance to antimicrobial agents has become a major source of morbidity and mortality worldwide. The main mechanisms of resistance are limiting uptake of a drug, modification of a drug target, inactivation of a drug, and active efflux of a drug. Therefore, it is an urgent need to develop new drugs targeted at resistant organisms.

MCE offers a unique collection of 1,904 compounds with validated antibacterial activities. MCE antibacterial compound library is an effective tool for drug repurposing screening, combination screening and biological investigation.

HY-L914

Serine/Threonine Focused Covalent Fragment Library

3,208 compounds

In the research of covalent inhibitors targeting serine and threonine, scientists have found that the nucleophilicity of these hydroxyl groups is significantly enhanced due to the influence of their surrounding environment. This results in higher activity during catalytic reactions. Aspirin, which targets the non-catalytic domain serine (Ser529 in human COX1) of cyclooxygenase, exerts its anti-inflammatory effect through covalent binding. β-lactam antibiotics, which targets the catalytic domain serine of penicillin-binding proteins, interferes with bacterial cell wall synthesis.

Through careful selection, we constructed a structural filter containing over 110 electrophilic groups. By analyzing the electrophilic fragments selected by the structural filter, we removed any molecules with trivial or undesirable structural features. Ultimately, we obtained 3,300 fragment molecules which can target serine and threonine residues and can be used for fragment-based covalent drug discovery.

Cat. No.	Product Name	Type

HY-D0011A

Bromophenol red (sultone form)	Fluorescent Dyes
Bromophenol red (sultone form) is a chemical indicator. Bromophenol red (sultone form) binds to lysozyme and inhibits its activity against the bacterial cell wall, but not the polysaccharide component of peptidoglycan .

HY-D1690

sBADA TFA	Fluorescent Dyes
sBADA TFA is a potent green fluorescent dye. sBADA TFA is a sulfonated BODIPY-FL 3-amino-D-alanine. sBADA TFA is used to label peptidoglycans in bacterial cell walls in situ. (λ_ex=490 nm, λ_em=510 nm) .

HY-D3390

sCy5DA	Fluorescent Dyes
sCy5DA is a is a fluorescent D-amino acid . sCy5DA incorporates into bacterial peptidoglycan layers and cross-links via transpeptidase action, replacing peptidoglycan stem peptide D-amino acids. sCy5DA labels live bacterial cell walls, nascent peptidoglycan biosynthesis sites, and diverse bacterial species including Gram-negative, Gram-positive, and mycobacteria (Ex/Em = 646/665 nm) .

HY-D1737

RADA

Fluorescent Dyes

RADA is a fluorescent D-amino acid (FDAA) with high photostability and thermostability, which emits yellow-to-orange fluorescence. RADA shows low outer membrane permeability in wild-type Gram-negative Escherichia coli, but it targets penicillin-binding proteins and L,D-transpeptidases, mimics the interaction between acyl acceptors and enzyme intermediates, and integrates into peptidoglycan during biosynthesis. As a peptidoglycan labeling reagent, RADA metabolically integrates into the nascent peptidoglycan of live bacterial cells, labels the peptidoglycan at the poles and lateral walls of mycobacteria, and enables visualization of peptidoglycan synthesis and remodeling processes. RADA serves as a non-specific stain for fixed cells, is non-toxic to bacterial cells, and its red-shifted excitation/emission spectra reduce phototoxicity. RADA also supports virtual pulse-chase labeling experiments and stochastic optical reconstruction microscopy for sub-diffraction-limited imaging of bacterial cell walls .

Cat. No.	Product Name	Type

HY-W009274

N-Acetylmuramic acid

MurNAc; NAMA

Biochemical Assay Reagents

N-acetylmuramic acid is a component of the bacterial cell wall peptidoglycan, essential for maintaining cell shape and integrity . N-acetylmuramic acid inhibits spore germination by inhibiting a coat-associated hexosaminidase and a core enzyme . N-acetylmuramic acid is required by Bacteroides forsythus for proliferation and the maintenance of its cell shape . N-Acetylmuramic acid inhibits the p38 MAPK/NF-κB signaling pathway, and exhibits anti-inflammatory activity. N-Acetylmuramic acid is orally active .

HY-167812

Trimethylsilyl-L-(+)-rhamnose

Biochemical Assay Reagents

Trimethylsilyl-L-(+)-rhamnose is a chemically modified version of the natural sugar rhamnose that has activity in studying the role of rhamnose in bacterial cell walls. Trimethylsilyl-L-(+)-rhamnose can be used to explore the composition of bacterial cell walls and their biological functions. Trimethylsilyl-L-(+)-rhamnose can help scientists gain insight into bacterial growth and resistance mechanisms.

HY-W926978

Bromophenol red sodium	Biochemical Assay Reagents
Bromophenol red sodium is a chemical indicator. Bromophenol red sodium binds to lysozyme and inhibits its activity against the bacterial cell wall, but not the polysaccharide component of peptidoglycan .

Cat. No.	Product Name	Target	Research Area

HY-W587753

Bacitracin A	Antibiotic Bacterial	Infection
Bacitracin A is an antibiotic, which exhibits antibacterial activity against gram-positive bacteria. Bacitracin A forms complex with long-chain polyisoprenyl pyrophosphates in presence of metal ions, dephosphorylates the lipid carrier intermediate Css-bactoprenyl pyrophosphate, inhibits thus the bacterial cell wall biosynthesis .

HY-135113

DL/meso-Lanthionine	Amino Acid Derivatives	Others
DL/meso-Lanthionine is a mixture of the racemic mixture (DL-) and meso- isomers of Lanthionine. Lanthionine is a non-protein amino acid composed of two alanine residues cross-linked by a thioether bond and is a structural component of the bacterial cell wall.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0030

D-Cycloserine 5+ Cited Publications	Structural Classification Microorganisms Antibiotics Resistance Selection Antibacterial Disease Research Other Antibiotics Source Classification	iGluR Bacterial Antibiotic
D-Cycloserine is an antibiotic which targets sequential bacterial cell wall peptidoglycan biosynthesis enzymes, with blood-brain barrier permeability. D-Cycloserine is a partial NMDA agonist that can improve cognitive functions. D-Cycloserine can be used for multidrug-resistant tuberculosis research .

HY-W009274

N-Acetylmuramic acid MurNAc; NAMA	Natural Products Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	p38 MAPK NF-κB Bacterial
N-acetylmuramic acid is a component of the bacterial cell wall peptidoglycan, essential for maintaining cell shape and integrity . N-acetylmuramic acid inhibits spore germination by inhibiting a coat-associated hexosaminidase and a core enzyme . N-acetylmuramic acid is required by Bacteroides forsythus for proliferation and the maintenance of its cell shape . N-Acetylmuramic acid inhibits the p38 MAPK/NF-κB signaling pathway, and exhibits anti-inflammatory activity. N-Acetylmuramic acid is orally active .

HY-147063

N-Acetyl-α-D-glucosamine 1-phosphate disodium	Structural Classification Natural Products Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
N-acetyl-α-d-glucosamine 1-phosphate disodium (GlcNAc-1-P) is an ectopic sugar phosphate and a key intermediate in N-glycoprotein biosynthesis. N-acetyl-α-d-glucosamine 1-phosphate disodium serves as a metabolic precursor of teichoic acid and muramic acid, which are components of bacterial cell walls .

HY-131150

Ristomycin sulfate	Structural Classification Microorganisms Classification of Application Fields Antibiotics Antibacterial Disease Research Inflammation/Immunology Disease Research Fields Other Antibiotics Source Classification	Antibiotic Bacterial
Ristomycin sulfate is an antibacterial antibiotic and platelet aggregation inducer. Ristomycin sulfate interacts with the D-alanyl-D-alanine terminus of bacterial cell wall precursors to regulate bacterial cell wall synthesis. Ristomycin sulfate induces platelet aggregation in vitro and inhibits the growth of Gram-positive bacteria. Ristomycin sulfate serves as an in vitro diagnostic compound for detecting von Willebrand factor activity. Ristomycin sulfate is applicable to research related to von Willebrand disease and Bernard-Soulier syndrome .

HY-34516

D-Ornithine hydrochloride (R)-Ornithine hydrochloride	Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Bacterial
D-Ornithine ((R)-Ornithine) hydrochloride is a constituent of *bacterial* cell wall. D-Ornithine hydrochloride promotes the production of L-arginine (HY-N0455). D-Ornithine hydrochloride enhances the expression of pyrrolysine-containing proteins .

HY-B0030R

D-Cycloserine (Standard) 5+ Cited Publications	Infection Microorganisms Neurological Disease Classification of Application Fields Antibiotics Endogenous metabolite Disease Research Fields Beta-lactam Antibiotics Source Classification	Reference Standards iGluR Bacterial Antibiotic
D-Cycloserine (Standard) is the analytical standard of D-Cycloserine. This product is intended for research and analytical applications. D-Cycloserine is an antibiotic which targets sequential bacterial cell wall peptidoglycan biosynthesis enzymes. D-Cycloserine is a partial NMDA agonist that can improve cognitive functions. D-Cycloserine can be used for multidrug-resistant tuberculosis research .

HY-N11102

Thymidine-5'-diphosphate-L-rhamnose dTDP-L-Rhamnose	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Leguminosae Vigna radiata (L.) Wilczek Plants Endogenous metabolite Source Classification	Endogenous Metabolite Bacterial
Thymidine-5'-diphosphate-L-rhamnose (dTDP-L-Rhamnose) is a key activated nucleotide sugar in bacteria, with a K_D value of 13 μM for Listeria monocytogenes RmlT. Thymidine-5'-diphosphate-L-rhamnose acts as a high-energy donor for L-Rhamnose (HY-N1420), and is specifically used for the synthesis of bacterial cell wall polysaccharides, capsules and virulence factors .

HY-118797

Malioxamycin	Microorganisms Antibiotics Other Antibiotics Source Classification	Antibiotic Bacterial
Malioxamycin is an antibiotic that inhibits Gram-negative bacteria by inhibiting peptidoglycan synthesis in bacterial cell walls and promoting the formation of spheroplasts .

HY-N14420

Parvodicin B2	Microorganisms Antibiotics Other Antibiotics Source Classification	Antibiotic Bacterial
Parvodicin B2 is a glycopeptide antibiotic. Parvodicin B2 has inhibitory effect on Staphylococcus aureus, Staphylococcus furfur, Staphylococcus hemolyticus and Enterococcus faecalis. Parvodicin B2 acts by inhibiting the synthesis of bacterial cell wall .

HY-N14418

Parvodicin B1	Microorganisms Antibiotics Other Antibiotics Source Classification	Antibiotic Bacterial
Parvodicin B1 is a glycopeptide antibiotic. Parvodicin B1 has inhibitory effect on Staphylococcus aureus, Staphylococcus furfur, Staphylococcus hemolyticus and Enterococcus faecalis. Parvodicin B1 acts by inhibiting the synthesis of bacterial cell wall .

HY-34516R

D-Ornithine hydrochloride (Standard) (R)-Ornithine hydrochloride (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Endogenous Metabolite Bacterial Reference Standards
D-Ornithine (hydrochloride) (Standard) is the analytical standard of D-Ornithine (hydrochloride). This product is intended for research and analytical applications. D-Ornithine ((R)-Ornithine) hydrochloride is a constituent of bacterial cell wall. D-Ornithine hydrochloride promotes the production of L-arginine (HY-N0455). D-Ornithine hydrochloride enhances the expression of pyrrolysine-containing proteins .

Cat. No.	Product Name	Chemical Structure

HY-B0200S

Cephalexin-d5
Cephalexin-d₅ is deuterium labeled Cephalexin. Cephalexin (Cefalexin; Cephacillin) is a potent, orally active and the first-generation?cephalosporin antibiotic. Cephalexin kills?gram-positive?and some?gram-negative bacteria?by disrupting the growth of the bacterial cell wall. Cephalexin monohydrate is used for the research of?pneumonia,?strep throat, and bacterial endocarditis, et al .

HY-W653936

Cephalexin-d5 hydrate

Cephalexin-d₅ (hydrate) is deuterium labeled Cephalexin (monohydrate). Cephalexin (Cefalexin) monohydrate is a potent, orally active new semisynthetic cephalosporin antibiotic with a broad antibacterial spectrum. Cephalexin (Cefalexin) monohydrate has antibacterial activity against a wide variety of gram-positive and gram-negative bacteria. Cephalexin (Cefalexin) monohydrate targets penicillin-binding proteins (PBPs) to inhibit bacterial cell wall assembly. Cephalexin (Cefalexin) monohydrate is used for the research of pneumonia, strep throat, and bacterial endocarditis, et al .

HY-B0200BS

Cephalexin-d5 monohydrate

Cephalexin-d₅ (monohydrate) is the deuterium labeled Cephalexin monohydrate. Cephalexin monohydrate is a potent, orally active and the first-generation?cephalosporin antibiotic. Cephalexin monohydrate kills?gram-positive?and some?gram-negative bacteria?by disrupting the growth of the bacterial cell wall. Cephalexin monohydrate is used for the research of?pneumonia,?strep throat, and bacterial endocarditis, et al .

HY-B1190S

Cefadroxil-d4 hydrate

Cefadroxil-d₄ (hydrate) is the deuterium labeled Cefadroxil hydrate (HY-B1190A). Cefadroxil hydrate is an orally active broad-spectrum cephalosporin antibiotic. Cefadroxil hydrate inhibits bacterial cell wall synthesis and enhances the expression of glutamate transporter-1. Cefadroxil hydrate is dependent on the intestinal peptide transporter PepT1 for small intestinal absorption. Cefadroxil hydrate has inhibitory and bactericidal activity against a variety of Gram-positive and Gram-negative bacteria and has analgesic effects on neuropathic pain .

HY-B0898S

Ceftiofur-d3 sodium

Ceftiofur-d₃ sodium is deuterium labeled Ceftiofur sodium (HY-B0898). Ceftiofur sodium is a cell wall synthesis inhibitor that targets bacterial penicillin-binding proteins (PBPs) and has anti-inflammatory effects in endotoxemia. Ceftiofur sodium exerts bactericidal effects by inhibiting the synthesis of bacterial cell wall peptidoglycan, leading to bacterial cell lysis. Ceftiofur sodium also inhibits the activation of NF-κB and MAPKs, thereby reducing the secretion of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6 .

HY-N7101S1

Cefpodoxime Proxetil-d6

Cefpodoxime Proxetil-d₆ (U-76,252-d₆) is deuterium labeled Cefpodoxime Proxetil. Cefpodoxime proxetil is an orally administered broad spectrum third-generation cephalosporin. Cefpodoxime proxetil has anti-bacterial activity. Cefpodoxime proxetil binds to penicillin binding proteins (PBPs) which inhibits peptidoglycan synthesis, finally results in interfering bacterial cell wall biosynthesis .

HY-B1190S2

Cefadroxil-13C6

Cefadroxil- ¹³C₆ (BL-S 578- ¹³C₆) is ¹³C labeled Cefadroxil (HY-B1190). Cefadroxil is an orally active broad-spectrum cephalosporin antibiotic. Cefadroxil inhibits bacterial cell wall synthesis and enhances the expression of glutamate transporter-1. Cefadroxil is dependent on the intestinal peptide transporter PepT1 for small intestinal absorption. Cefadroxil has inhibitory and bactericidal activity against a variety of Gram-positive and Gram-negative bacteria and has analgesic effects on neuropathic pain .

HY-N7101S

Cefpodoxime proxetil-d7

Cefpodoxime proxetil-d7 (U-76-d7,252-d7; CS-807-d7) is the deuterium labeled Cefpodoxime Proxetil (HY-N7101). Cefpodoxime Proxetil is an orally active broad spectrum third-generation cephalosporin with potent antibacterial activity against both Gram-positive and Gram-negative bacteria including staphylococci, streptococci, Haemophilus influenzae, Neisseria gonorrhoeae, Escherichia coli, Klebsiella pnuemoniae, Citrobacter spp, and Proteus spp. Cefpodoxime Proxetil binds to penicillin binding proteins (PBPs), which inhibits peptidoglycan synthesis, finally results in interfering bacterial cell wall biosynthesis. Cefpodoxime Proxetil can be used against skin structure infections, acute otitis media, pharyngitis, tonsillitis, upper respiratory tract infection, urinary tract infections and sexually transmitted diseases .

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