1. Anti-infection
  2. Bacterial
    Antibiotic
  3. Cefmetazole sodium

Cefmetazole sodium (Synonyms: Sodium cefmetazole)

Cat. No.: HY-B1257 Purity: 98.12%
Handling Instructions

Cefmetazole sodium (Sodium cefmetazole) is a semisynthetic cephamycin antibiotic with broad-spectrum antibacterial activity, covering gram-positive, gram-negative, and anaerobic bacteria. Cefmetazole sodium binds to penicillin binding proteins (PBPs), resulting in interfering bacterial cell wall biosynthesis. Cefmetazole sodium is used for the research of gynecologic, intraabdominal, urinary tract, respiratory tract and skin and soft tissue infections.

For research use only. We do not sell to patients.

Cefmetazole sodium Chemical Structure

Cefmetazole sodium Chemical Structure

CAS No. : 56796-39-5

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Solution
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 66 In-stock
Estimated Time of Arrival: December 31
Solid
100 mg USD 60 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Cefmetazole sodium (Sodium cefmetazole) is a semisynthetic cephamycin antibiotic with broad-spectrum antibacterial activity, covering gram-positive, gram-negative, and anaerobic bacteria. Cefmetazole sodium binds to penicillin binding proteins (PBPs), resulting in interfering bacterial cell wall biosynthesis. Cefmetazole sodium is used for the research of gynecologic, intraabdominal, urinary tract, respiratory tract and skin and soft tissue infections[1][2][3].

In Vitro

Cefmetazole sodium (Sodium cefmetazole) has antibiotic affinity to S. aureus with a MIC value of 1.0 mg/L and has affinity for PBP1, PBP2 and PBP3 with IC50 values of ≤0.3, 0.109 and 0.494 mg/L[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Cefmetazole sodium (Sodium cefmetazole) (100 mg/kg; i.h.; twice a day, for 7 days; male ICR mice) alters gut bacterial flora[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male ICR mice[3]
Dosage: 100 mg/kg
Administration: Subcutaneous injection; twice a day, for 7 days
Result: Reduced Peyer's patch (PP) lymphocyte cell numbers while decreased bacterial numbers in the small intestine.
Clinical Trial
Molecular Weight

493.52

Formula

C15H16N7NaO5S3

CAS No.
SMILES

O=C(C(N12)=C(CSC3=NN=NN3C)CS[[email protected]]2([H])[[email protected]](OC)(NC(CSCC#N)=O)C1=O)O[Na]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (506.57 mM; Need ultrasonic)

H2O : 100 mg/mL (202.63 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0263 mL 10.1313 mL 20.2626 mL
5 mM 0.4053 mL 2.0263 mL 4.0525 mL
10 mM 0.2026 mL 1.0131 mL 2.0263 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.21 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.21 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.21 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 98.12%

References
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Product Name:
Cefmetazole sodium
Cat. No.:
HY-B1257
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