2. Anti-infection
  3. Bacterial
  4. Antibacterial agent 138

Antibacterial agent 138 has excellent antibacterial activity to multi-drug resistant bacteria. Antibacterial agent 138 inhibits bacterial protein synthesis but bacterial cell walls.

For research use only. We do not sell to patients.

Antibacterial agent 138 Chemical Structure

Antibacterial agent 138 Chemical Structure

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Antibacterial agent 138 Related Antibodies

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Description

Antibacterial agent 138 has excellent antibacterial activity to multi-drug resistant bacteria. Antibacterial agent 138 inhibits bacterial protein synthesis but bacterial cell walls[1].

In Vitro

Antibacterial agent 138 (compound e4) (0.063 μg/mL, 24 h) shows excellent inhibition against MRSA and MRSE[1].
Antibacterial agent 138 has antimicrobial activity against multi-drug resistant bacteria, with MICs ( 0.063-32μg/mL) 16-64 times lower than that of Tiamulin[1].
Antibacterial agent 138 (60 μg/mL, 24 h) shows no signs of cytotoxicity in HEPG2 and HEK293 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antibacterial agent 138 Related Antibodies

Cell Viability Assay[1]

Cell Line: S. aureus, MRSA, S. pneumonia, MRSE, B. subtilis, VRE, K. peneumoniae.
Concentration: 0-50 μg/mL approximately.
Incubation Time: 24 h
Result: MICs: 0.063, 0.063, <0.031, 0.063, 4, 4, 2 μg/mL
In Vivo

Antibacterial agent 138 (compound e4) (2.5-40 mg/kg, i.p.) shows antibacterial activity in a mice model of systemic multi-drug resistant S. aureus infection [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice model of systemic multi-drug resistant S. aureus infection[1]
Dosage: 2.5, 5, 10, 20, 40 mg/kg
Administration: i.p.
Result: Prolonged survival rate.
Reduced bacterial loads in the lungs and liver of infected mice.
Molecular Weight

697.75

Formula

C34H52INO4S
SMILES

[H][C@@]12C(CC[C@]13CC[C@H]([C@]2([C@@H](C[C@@](C=C)([C@H]([C@@H]3C)O)C)OC(CSC4=CC=[N+](C=C4)CCCCCCC)=O)C)C)=O.[I-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Antibacterial agent 138 Related Classifications

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The dilution calculator equation

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antibacterial agent 138Antibacterial agent138Antibacterial agent-138BacterialAntibacterialmulti-drug resistantMRSAS. aureusInhibitorinhibitorinhibit

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Antibacterial agent 138
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