Antibacterial agent 138
Antibacterial agent 138 has excellent antibacterial activity to multi-drug resistant bacteria. Antibacterial agent 138 inhibits bacterial protein synthesis but bacterial cell walls.
For research use only. We do not sell to patients.
- CAS No.: 2971788-27-7
- Formula: C34H52INO4S
- Molecular Weight:697.75
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Antibacterial agent 138 (compound e4) (0.063 μg/mL, 24 h) shows excellent inhibition against MRSA and MRSE[1].
Antibacterial agent 138 has antimicrobial activity against multi-drug resistant bacteria, with MICs ( 0.063-32μg/mL) 16-64 times lower than that of Tiamulin[1].
Antibacterial agent 138 (60 μg/mL, 24 h) shows no signs of cytotoxicity in HEPG2 and HEK293 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:S. aureus, MRSA, S. pneumonia, MRSE, B. subtilis, VRE, K. peneumoniae.
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Concentration:0-50 μg/mL approximately.
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Incubation Time:24 h
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Result:MICs: 0.063, 0.063, <0.031, 0.063, 4, 4, 2 μg/mL
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mice model of systemic multi-drug resistant S. aureus infection[1]
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Dosage:2.5, 5, 10, 20, 40 mg/kg
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Administration:i.p.
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Result:Prolonged survival rate.
Reduced bacterial loads in the lungs and liver of infected mice.
Chemical Information
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CAS No. 2971788-27-7
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Molecular Weight 697.75
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Formula C34H52INO4S
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SMILES
C[C@@H]1[C@]23[C@](C(CC3)=O)([H])[C@]([C@@H](C[C@](C)([C@H]1O)C=C)OC(CSC4=CC=[N+](CCCCCCC)C=C4)=O)([C@@H](CC2)C)C.[I-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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