Bacitracin A
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Bacitracin A is an antibiotic with antibacterial activity against Gram-positive bacteria. Bacitracin A forms a ternary complex with divalent metal ions and C55-isopentenyl pyrophosphate, thereby inhibiting peptidoglycan biosynthesis and cell wall synthesis. Bacitracin A induces the formation of protoplasts and L-form bacteria, alters membrane permeability, regulates metal ion transport, inhibits in vitro enzyme biosynthesis, disrupts the cytoplasmic membrane and exerts bactericidal activity. Bacitracin A can be used in studies related to bacterial infections, fungal infections and amoebic infections.
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- Pureza : 97.3%
- No. CAS: 22601-59-8
- Fòrmula: C66H103N17O16S
- Peso molecular:1422.69
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Almacenamiento:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Actividad biológica
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Chemical Information
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Actividad biológica
Descripciòn
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | IC50 |
254.6 μM
Compound: BAC
|
Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay
Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay
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[PMID: 25593095] |
In Vitro
Bacitracin A exhibits cytotoxicity against human renal tubular epithelial HK-2 cells, with an IC50 of 4.22 μM after 48 h of in vitro incubation[2].
Bacitracin A forms stable Co2+ and Zn2+ complexes: the cobalt complex binds undecaprenyl pyrophosphate (with a binding constant of 1.05×106 M-1), while the zinc complex binds phosphate and pyrophosphate derivatives[3].
Bacitracin A binds to Micrococcus lysodeikticus cells with a Km value of 3.7 × 10-6 M, which is consistent with its interaction targeting C55-isoprenyl pyrophosphate[1].
Bacitracin A (20-200 μg/mL; 14 h) completely inhibits the growth of Escherichia coli SC 9251 when the outer membrane of the bacterium is disrupted by polymyxin-agarose[1].
Bacitracin A (4-8 μM; 2 h) kills Gram-positive bacteria Staphylococcus aureus ATCC 29213 (MBC 4 μM), Streptococcus pneumoniae ATCC 49619 (MBC 8 μM), and Trueperella pyogenes ATCC 19411 (MBC 8 μM)[2].
Bacitracin A (BA) (2-4 μM; 18-24 h) inhibits the growth of Gram-positive bacteria Staphylococcus aureus ATCC 29213 (MIC 2 μM), Streptococcus pneumoniae ATCC 49619 (MIC 4 μM), and Trueperella pyogenes ATCC 19411 (MIC 4 μM); it potently inhibits the growth of Micrococcus luteus ATCC 9341 (MIC 0.39 μg/mL), Staphylococcus aureus IFO 12732 (MIC 3.13 μg/mL), Bacillus cereus ATCC 11778 (MIC 6.25 μg/mL), and Micrococcus lysodeikticus (MIC 1×10-7 M)[2][3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 22601-59-8
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Appearance Solid
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Peso molecular 1422.69
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Fòrmula C66H103N17O16S
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Color White to off-white
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Pureza y Documentación
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Ficha de datos (263 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1].
Toscano W A Jr. Bacitracin. Pharmac. Ther, 1982, 16: 199-210.
[Content Brief]
[2]. Hong W, et al. Synthesis, construction, and evaluation of self-assembled nano-bacitracin A as an efficient antibacterial agent in vitro and in vivo. International journal of nanomedicine. 2017;12:4691-4708. [Content Brief]
[3]. Ming LJ, et al. Metal binding and structure-activity relationship of the metalloantibiotic peptide bacitracin. Journal of inorganic biochemistry. 2002 Jul 25;91(1):46-58. [Content Brief]
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Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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