22601-59-8
Chemical Structure
Bacitracin A
- CAS. Nr.: 22601-59-8
- Formula:C66H103N17O16S
- Molecular Weight:1422.69
IUPAC Name: 4-nitro-1H-pyrazol-3-amine hydrochloride
InChIKey: CLKOFPXJLQSYAH-ABRJDSQDSA-N
SMILES: O=C(N[C@@H](C(N[C@@](C(N[C@@H](C(N[C@H](C(N[C@@H](C(N[C@H](C(NCCCC1)=O)CC(N)=O)=O)CC(O)=O)=O)CC2=CN=CN2)=O)CC3=CC=CC=C3)=O)([H])[C@@H](C)CC)=O)CCCN)[C@H]1NC([C@H]([C@@H](C)CC)NC([C@@H](CCC(O)=O)NC([C@H](CC(C)C)NC([C@H]4N=C(SC4)[C@@H](N)[C@@H](C)CC)=O)=O)=O)=O
Biological Activity: Bacitracin A is an antibiotic with antibacterial activity against Gram-positive bacteria. Bacitracin A forms a ternary complex with divalent metal ions and C55-isopentenyl pyrophosphate, thereby inhibiting peptidoglycan biosynthesis and cell wall synthesis. Bacitracin A induces the formation of protoplasts and L-form bacteria, alters membrane permeability, regulates metal ion transport, inhibits in vitro enzyme biosynthesis, disrupts the cytoplasmic membrane and exerts bactericidal activity. Bacitracin A can be used in studies related to bacterial infections, fungal infections and amoebic infections[1][2][3].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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Bacitracin A | 97.3% | Bacitracin A is an antibiotic with antibacterial activity against Gram-positive bacteria. Bacitracin A forms a ternary complex with divalent metal ions and C55-isopentenyl pyrophosphate, thereby inhibiting peptidoglycan biosynthesis and cell wall synthesis. Bacitracin A induces the formation of protoplasts and L-form bacteria, alters membrane permeability, regulates metal ion transport, inhibits in vitro enzyme biosynthesis, disrupts the cytoplasmic membrane and exerts bactericidal activity. Bacitracin A can be used in studies related to bacterial infections, fungal infections and amoebic infections. | ||||||||||||||||||||
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[1]. Toscano W A Jr. Bacitracin. Pharmac. Ther, 1982, 16: 199-210.
[Content Brief] - [2]. Hong W, et al. Synthesis, construction, and evaluation of self-assembled nano-bacitracin A as an efficient antibacterial agent in vitro and in vivo. International journal of nanomedicine. 2017;12:4691-4708. [Content Brief]
- [3]. Ming LJ, et al. Metal binding and structure-activity relationship of the metalloantibiotic peptide bacitracin. Journal of inorganic biochemistry. 2002 Jul 25;91(1):46-58. [Content Brief]
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