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Results for "

cis isomers

" in MedChemExpress (MCE) Product Catalog:

52

Inhibitors & Agonists

2

Biochemical Assay Reagents

14

Natural
Products

4

Isotope-Labeled Compounds

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B1583
    (Z)-Capsaicin

    Zucapsaicin; Civamide; cis-Capsaicin

    		 TRP Channel HSV Neurological Disease
    (Z)-Capsaicin is the cis isomer of capsaicin, acts as an orally active TRPV1 agonist, and is used in the research of neuropathic pain.
    (Z)-Capsaicin
  • HY-117215
    β-Ocimene

    		Environmental Pollutants Biochemical Assay Reagents Others
    Beta-Ocimene is a naturally occurring organic compound that belongs to the terpene family. It exists as a mixture of three isomers: cis β-Ocimene, trans β-Ocimene and myrcene-like β-Ocimene. It has a pleasant, sweet herbaceous scent and is found in many plants, including mint, basil, parsley, and kumquat. β-Ocimene is widely used in the flavor and fragrance industry due to its characteristic aroma and taste. It also has potential applications in agriculture as natural insect repellants and pheromones that attract beneficial insects. β-Ocimene has potential anti-inflammatory and anticancer activities.
    β-Ocimene
  • HY-107425A
    cis-MZ 1

    		PROTACs Epigenetic Reader Domain Cancer
    cis-MZ 1 is a cis isomer of meso-zeaxanthin, a xanthophyll carotenoid component of total zeaxanthin measured in serum and egg yolks.cis-MZ 1 is a triphenyltin benzoate that adopts either a tetrahedral monomeric structure (I) or a trans-SnR3O2 polymeric structure (III), with structure determined by a balance of steric and electronic factors .
    cis-MZ 1
  • HY-B1617A
    Zuclomiphene citrate
    1 Publications Verification

    		 Estrogen Receptor/ERR Metabolic Disease Endocrinology
    Zuclomiphene citrate is a cis isomer of Clomiphene citrate (HY-B0463). Zuclomiphene citrate is orally active and has an antiestrogenic effect. Zuclomiphene can reduce cholesterol levels. Zuclomiphene citrate can be for the researches of endocrinology and metabolic disease .
    Zuclomiphene citrate
  • HY-N7864
    Osbond acid

    all-cis-4,7,10,13,16-Docosapentaenoic acid

    		 Biochemical Assay Reagents Others
    Docosapentaenoic acid (DPA) is a 22-carbon fatty acid found in fish oil. It is a minor component of total serum unsaturated fatty acids in humans, ranging from 0.1% to 1%, and increasing with dietary supplementation. all-cis-4,7,10,13,16-DPA, also known as Austrian acid, is an isomer of DPA. It is an omega-6 fatty acid formed by the extension and desaturation of arachidonic acid. During fatty acid desaturase syndrome, levels of this fatty acid may be reduced, which may affect development. Upregulated hepatic elongate expression of very long fatty acid protein 6 and elevated levels of very long chain fatty acids, including all-cis 4,7,10,13,16-DPA, are characteristic of nonalcoholic steatohepatitis, a precancerous disease of hepatocellular carcinoma.
    Osbond acid
  • HY-151232
    (E/Z)-Rilzabrutinib

    (E/Z)-PRN1008

    		 Btk Inflammation/Immunology
    (E/Z)-Rilzabrutinib ((E/Z)-PRN1008) is a cis-trans isomer of Rilzabrutinib (HY-112166). Rilzabrutinib is a BTK inhibitor .
    (E/Z)-Rilzabrutinib
  • HY-N1952A
    cis-Isoeugenol

    		Drug Isomer Infection
    cis-Isoeugenol is the cis isomer of Isoeugenol (HY-N1952) .
    cis-Isoeugenol
  • HY-N0684A
    cis-Vitamin K1

    cis-Phylloquinone; cis-Phytomenadione

    		 Drug Isomer Cardiovascular Disease
    cis-Vitamin K1 (cis-Phylloquinone; cis-Phytomenadione) is an isomer of Vitamin K1 (HY-N0684) that can be used for the synthesis of Vitamin K1 (HY-N0684) .
    cis-Vitamin K1
  • HY-N0351A
    cis-p-Coumaric acid

    cis-4-Hydroxycinnamic acid

    		 Apoptosis Metabolic Disease
    cis-p-Coumaric acid (cis-4-Hydroxycinnamic acid) is the cis-form of p-Coumaric acid (HY-N0351), which is higher in viable seeds of groundnuts than in non-viable ones. p-Coumaric acid is an isomer of cinnamic acid with oral activity. p-Coumaric acid inhibits cell proliferation and promotes Apoptosis .
    cis-p-Coumaric acid
  • HY-B1342A
    13-cis-Vitamin A

    13-cis-Vitamin A1; 13-cis-Retinol

    		 Drug Isomer Drug Metabolite Metabolic Disease
    13-cis-Vitamin A (13-cis-Vitamin A1) is the 13-cis-isomer of Vitamin A (HY-B1342), which is an active metabolite found in butter .
    13-cis-Vitamin A
  • HY-145670
    cis,trans-Germacrone

    		Akt MDM-2/p53 Cancer
    cis,trans-Germacrone is a isomer of Germacrone (HY-N0440). Germacrone exhibits a wide range of antitumor, antioxidant and anti-inflammatory effects. Germacrone inhibits lung cancer cell proliferation and alters the Akt/MDM2/p53. Germacrone also arrests cell cycle at G1/S phase .
    cis,trans-Germacrone
  • HY-77111
    cis-INCB3344
    1 Publications Verification

    		 CCR Drug Isomer Inflammation/Immunology Endocrinology
    cis-INCB3344 is the isomer of INCB3344 (HY-50674), and can be used as an experimental control. INCB3344 is a potent, selective and orally bioavailable CCR2 antagonist with IC50 values of 5.1 nM (hCCR2) and 9.5 nM (mCCR2) in binding antagonism and 3.8 nM (hCCR2) and 7.8 nM (mCCR2) in antagonism of chemotaxis activity.
    cis-INCB3344
  • HY-W740803
    15-cis-Phytofluene

    (15Z)-Phytofluene

    		 Drug Intermediate Drug Isomer Others
    15-cis-Phytofluene is a cis-isomer of Phytofluene. 15-cis-Phytofluene is an acyclic carotenoid. 15-cis-Phytofluene acts as a biosynthetic intermediate in carotenoid biosynthesis .
    15-cis-Phytofluene
  • HY-N8356A
    9-cis-Vitamin A palmitate

    9-cis-Retinyl palmitate

    		 Endogenous Metabolite Others
    9-cis-Vitamin A palmitate (9-cis-Retinyl palmitate) is a 9-cis isomer formed by vitamin A palmitate in corn flakes. 9-cis-Vitamin A palmitate has a biological activity of 26% of all-trans-vitamin A palmitate, the most biologically ac-tive form of vitamin A .
    9-cis-Vitamin A palmitate
  • HY-10252A
    cis-NVP-ADW742

    cis-ADW742; cis-GSK 552602A; cis-ADW

    		 IGF-1R Insulin Receptor Apoptosis Inflammation/Immunology
    cis-NVP-ADW742 (cis-ADW742) is a cis isomer of NVP-ADW742 (HY-10252). NVP-ADW742 is an orally active, selective IGF-1R tyrosine kinase inhibitor with an IC50 of 0.17 μM. NVP-ADW742 inhibits insulin receptor (InsR) with an IC50 of 2.8 μM. NVP-ADW742 induces pleiotropic antiproliferative/proapoptotic biologic sequelae in tumor cells .
    cis-NVP-ADW742
  • HY-114571
    cis-Lomibuvir

    cis-VX-222

    		 DNA/RNA Synthesis HCV Infection
    cis-Lomibuvir (cis-VX-222) is the cis-isomer of Lomibuvir. Lomibuvir (VX-222), a selective, non-nucleoside polymerase inhibitor, targets thumb pocket 2 of the HCV NS5B polymerase (RdRp) with a Kd of 17 nM. Lomibuvir inhibits the 1b/Con1 HCV subgenomic replicon with an EC50 of 5.2 nM. Lomibuvir preferentially inhibits elongative RNA synthesis rather than de novo-initiated RNA synthesis . cis-Lomibuvir is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    cis-Lomibuvir
  • HY-118105
    RK-20448

    		Src VEGFR Tie Infection Cancer
    RK-20448 is an ATP-competitive inhibitor of Lck, Src, KDR/VEGF2R and Tie-2 with IC50 values of 0.24, 1.19, 10.74 and 5.85 µM, respectively. RK-20448 also inhibits BLK, Csk, Fyn and Lyn with IC50 values of 0.37, 4.27, 2.03 and 0.43 µM, respectively. RK-20448 is the cis isomer of A-419259 (HY-15764) .
    RK-20448
  • HY-145806
    13-cis-Retinyl acetate

    13-cis-Retinol acetate; 13-cis-Vitamin A acetate

    		 Endogenous Metabolite Endocrinology
    13-cis-Retinyl acetate (13-cis-Retinol acetate; 13-cis-Vitamin A acetate) is a 13-cis isomer formed by Retinyl acetate. 13-cis-Retinyl acetate is an active metabolite of vitamin A .
    13-cis-Retinyl acetate
  • HY-15805A
    cis-KIN-8194

    		Drug Isomer Others
    cis-KIN-8194 is the cis-isomer of KIN-8194 (HY-15805)
    cis-KIN-8194
  • HY-W700726
    cis-Atovaquone-d5 (contains 10% trans isomer)

    		Isotope-Labeled Compounds Others
    cis-Atovaquone-d5 (contains 10% trans isomer) is the deuterium labeled cis-Atovaquone.
    cis-Atovaquone-d5 (contains 10% trans isomer)
  • HY-101648
    ACAT-IN-1 cis isomer

    		Acyltransferase Metabolic Disease
    ACAT-IN-1 cis isomer is a potent ACAT inhibitor with an IC50 of 100 nM.
    ACAT-IN-1 cis isomer
  • HY-N16225
    12(Z)-Octadecenoic acid

    cis-12-Octadecenoic acid

    		 Biochemical Assay Reagents Others
    12(Z)-Octadecenoic acid (cis-12-Octadecenoic acid) is the 12(Z)-isomer of Octadecenoic acid. 12(Z)-Octadecenoic acid is an unsaturated fatty acid .
    12(Z)-Octadecenoic acid
  • HY-N8356
    13-cis-Vitamin A palmitate

    13-cis-Retinyl palmitate

    		 Endogenous Metabolite Others
    13-cis-Vitamin A palmitate (13-cis-Retinyl palmitate) is a 13-cis isomer formed by vitamin A palmitate in corn flakes. 13-cis-Vitamin A palmitate has a biological activity of 75% of all-trans-vitamin A palmitate, the most biologically ac-tive form of vitamin A .
    13-cis-Vitamin A palmitate
  • HY-W718351
    (Z)-Octadec-8-enoic acid

    C18:1(8Z); cis-8-Octadecenoate; Δ8-cis-Octadecenoic acid

    		 Endogenous Metabolite Metabolic Disease
    cis-8-Octadecenoic acid is a monounsaturated fatty acid and an isomer of oleic acid (HY-N1446), trans-vaccenic acid (HY-113427), trans-petroselinic acid, and cis-petroselinic acid. It has been found in partially hydrogenated vegetable oil and milk fat.
    (Z)-Octadec-8-enoic acid
  • HY-173419
    5-cis-15(R)-Iloprost

    5-cis-15(R)-Ciloprost; 5-cis-15(R)-ZK 36374

    		 Drug Isomer Prostaglandin Receptor Endocrinology Cancer
    5-cis-15(R)-Iloprost (5-cis-15(R)-Ciloprost) is the C-5 cis-isomer and 15(R)-epimer of Iloprost (HY-A0096). Iloprost is a prostacyclin (PGI2) analogue, involves in embryo development and inflammation improvement, and inhibits tumor metastasis. Iloprost can be used for peripheral vascular research .
    5-cis-15(R)-Iloprost
  • HY-130317
    trans-11-Methyl-2-dodecenic acid

    trans-δ2-11-Methyl-dodecenoic acid

    		 Fungal Infection
    trans-11-Methyl-2-dodecenic acid is a isomer of cis-11-Methyl-2-dodecenoic acid (HY-134215). cis-11-Methyl-2-dodecenoic acid is a quorum sensing (QS) signal that acts as a diffusion signaling factor (DSF) in extracellular microbial and fungal communication systems .
    trans-11-Methyl-2-dodecenic acid
  • HY-155516A
    cis-KV1.3-IN-1

    		Potassium Channel Inflammation/Immunology
    cis-KV1.3-IN-1 (Compound cis-18) is a cis-isomer of KV1.3-IN-1 (HY-155516). cis-KV1.3-IN-1 is an inhibitor of the KV1.3 channel. cis-KV1.3-IN-1 (10 μM) inhibits KV1.3 by 25.53% in Xenopus oocytes expressing human hKV1.3 .
    cis-KV1.3-IN-1
  • HY-169234
    BChE-IN-35

    		Cholinesterase (ChE) Neurological Disease
    BChE-IN-35 (Azo-9) is a BChE inhibitor. BChE-IN-35 has a dynamic cis/trans conformational change, where the cis isomer preferentially binds to BChE. BChE-IN-35 can be used in Alzheimer's disease (AD) research .
    BChE-IN-35
  • HY-117583
    cis-BG47

    		HDAC Histone Methyltransferase Neurological Disease
    cis-BG47 is an cis-isomer of BG47, BG47 is a prototypical histone deacetylases HDAC1 and HDAC2 selective, optoepigenetic probe. BG47 can bind to and competitively inhibits the deacetylase activity of HDAC targets upon a light-induced trans-to-cis isomerization, and increases Histone Methyltransferase H3K9 acetylation. cis-BG47 can be used for neurological disease research .
    cis-BG47
  • HY-155295
    Z-CITCO

    		Constitutive Androstane Receptor Drug Isomer Metabolic Disease
    Z-CITCO is the cis isomer of CITCO (HY-103244). Z-CITCO is an agonist of constitutive androstane receptor (CAR) with an EC50 value of 3.9 µM .
    Z-CITCO
  • HY-B1583R
    (Z)-Capsaicin (Standard)

    Zucapsaicin (Standard); Civamide (Standard); cis-Capsaicin (Standard)

    		 Reference Standards TRP Channel HSV Neurological Disease
    (Z)-Capsaicin (Standard) is the analytical standard of (Z)-Capsaicin. This product is intended for research and analytical applications. (Z)-Capsaicin is the cis isomer of capsaicin, acts as an orally active TRPV1 agonist, and is used in the research of neuropathic pain.
    (Z)-Capsaicin (Standard)
  • HY-B1617
    Zuclomiphene

    		Estrogen Receptor/ERR Metabolic Disease Endocrinology
    Zuclomiphene is a cis isomer of Clomiphene citrate (HY-B0463). Zuclomiphene is orally active and has an antiestrogenic effect. Zuclomiphene can reduce cholesterol levels. Zuclomiphene can be for the researches of endocrinology and metabolic disease .
    Zuclomiphene
  • HY-161414
    trans-VUF25471

    		CXCR Others
    trans-VUF25471 (Compound trans-3e) is a photoswitchable ACKR3 agonist. trans-VUF25471 binds and activates ACKR3 at 10-fold lower concentrations compared to its cis-isomer .
    trans-VUF25471
  • HY-N0619A
    cis-Mulberroside A

    Mulberroside D

    		 TNF Receptor Interleukin Related Tyrosinase Inflammation/Immunology
    cis-Mulberroside A (Mulberroside D) is the cis-isomer of Mulberroside A. Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.) . Mulberroside A decreases the expressions of TNF-α, IL-1β, and IL-6 and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory and anti-apoptotic effects . Mulberroside A shows inhibitory activity against mushroom tyrosinase with an IC50 of 53.6 μM .
    cis-Mulberroside A
  • HY-119316A
    CM-545

    		HDAC Phosphodiesterase (PDE) Neurological Disease
    CM-545, the cis-isomer of CM-414 (HY-119316), is a dual inhibitor of PDE5, HDAC1, HDAC2, HDAC3, and HDAC6 with pIC50 values of 7.47, 6.65, 6.14, 6.55, and 6.84, repectively .
    CM-545
  • HY-171002
    PAD2-IN-2

    		Protein Arginine Deiminase Cancer
    PAD2-IN-2 (cis-isomer of 1) is a protein arginine deiminase 2 (PAD2) inhibitor. PAD2-IN-2 possess an azobenzene photoswitch to optically control PAD activity. PAD2-IN-2 inhibits histone H3-citrullination .
    PAD2-IN-2
  • HY-171002A
    PAD2-IN-2 TFA

    		Protein Arginine Deiminase Cancer
    PAD2-IN-2 (cis-isomer of 1) TFA is a protein arginine deiminase 2 (PAD2) inhibitor. PAD2-IN-2 TFA possess an azobenzene photoswitch to optically control PAD activity. PAD2-IN-2 TFA inhibits histone H3-citrullination .
    PAD2-IN-2 TFA
  • HY-B1617AS2
    Zuclomiphene d10 Citrate salt

    		Isotope-Labeled Compounds Estrogen Receptor/ERR Metabolic Disease Endocrinology
    Zuclomiphene d10 Citrate salt is deuterium labeled Zuclomiphene citrate (HY-B1617A). Zuclomiphene citrate is a cis isomer of Clomiphene citrate (HY-B0463). Zuclomiphene citrate is orally active and has an antiestrogenic effect. Zuclomiphene can reduce cholesterol levels. Zuclomiphene citrate can be for the researches of endocrinology and metabolic disease .
    Zuclomiphene d10 Citrate salt
  • HY-B1617AS
    Zuclomiphene-d4 citrate

    		Isotope-Labeled Compounds Estrogen Receptor/ERR Metabolic Disease Endocrinology
    Zuclomiphene-d4 citrate is a deuterium labeled Zuclomiphene citrate (HY-B1617A). Zuclomiphene citrate is a cis isomer of Clomiphene citrate (HY-B0463). Zuclomiphene citrate is orally active and has an antiestrogenic effect. Zuclomiphene can reduce cholesterol levels. Zuclomiphene citrate can be for the researches of endocrinology and metabolic disease .
    Zuclomiphene-d4 citrate
  • HY-B1617AS1
    Zuclomiphene-d5 citrate

    		Isotope-Labeled Compounds Estrogen Receptor/ERR Metabolic Disease Endocrinology
    Zuclomiphene-d5 citrate is the deuterium labeled Zuclomiphene citrate (HY-B1617A). Zuclomiphene citrate is a cis isomer of Clomiphene citrate (HY-B0463). Zuclomiphene citrate is orally active and has an antiestrogenic effect. Zuclomiphene can reduce cholesterol levels. Zuclomiphene citrate can be for the researches of endocrinology and metabolic disease .
    Zuclomiphene-d5 citrate
  • HY-129133
    cis-Miyabenol C

    		Drug Isomer Others
    cis-Miyabenol C is an isomer of the resveratrol trimer Miyabenol C, which can be isolated from grape herbs. Miyabenol C is an inhibitor of β-amyloid (Aβ) and amyloid β precursor protein (APP) in Alzheimer's disease model mice, and inhibit β-secretase activity without changing the protein level of β-secretase BACE1 .
    cis-Miyabenol C
  • HY-182641
    SAG analog (cis-isomer)

    SAG-Cl (cis-isomer)

    		 Gli Cardiovascular Disease
    SAG analog (cis-isomer) (SAG-Cl (cis-isomer)) (Compound 10b) is a Gli1 activator with an EC50 of 7.6 nM. SAG analog (cis-isomer) is non-toxic .
    SAG analog (cis-isomer)
  • HY-N15682
    13-cis-β-Carotene

    (7Z)-Provitamin A; (7Z)-beta-Carotene

    		 Drug Isomer Inflammation/Immunology
    13-cis-β-Carotene ((7Z)-Provitamin A; (7Z)-beta-Carotene) is a provitamin A carotenoid isomer found in leaves, flowers, stems, and fruit of Momordica charantia. 13-cis-β-Carotene undergoes nonenzymatic isomerization to other β-carotene isomers during aerobic incubation, extraction, and analysis. 13-cis-β-Carotene can be used for the research of chronic diseases .
    13-cis-β-Carotene
  • HY-N17724
    Cimicifugic acid N

    		Drug Isomer Others
    Cimicifugic acid N is the cis-isomer of Cimicifugic acid G, can be found in the aerial parts of Cimicifuga simplex and Cimicifuga japonica .
    Cimicifugic acid N
  • HY-141176B
    cis-Cyclooctene-amine

    		Drug Isomer Others
    cis-Cyclooctene-amine is the cis isomer of TCO-amine (HY-141176). TCO-amine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. TCO-amine is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
    cis-Cyclooctene-amine
  • HY-141176C
    cis-Cyclooctene-amine hydrochloride

    		Drug Isomer Others
    cis-Cyclooctene-amine hydrochloride is the cis isomer of TCO-amine hydrochloride (HY-141176A). TCO-amine hydrochloride is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. TCO-amine hydrochloride is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
    cis-Cyclooctene-amine hydrochloride
  • HY-136175B
    cis-Revumenib

    cis-SNDX-5613

    		 Epigenetic Reader Domain Cancer
    cis-Revumenib (cis-SNDX-5613) is an isomer of Revumenib (HY-136175). Revumenib (SNDX-5613) is a potent and specific Menin-MLL inhibitor with a binding Ki of 0.149 nM and a cell based IC50 of 10-20 nM. Revumenib can be used for the research of MLL-rearranged (MLL-r) acute leukemias, including acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) .
    cis-Revumenib
  • HY-180985
    Azo-PROTAC-4C-cis

    		PROTACs Bcr-Abl Cancer
    Azo-PROTAC-4C-cis is a BCR-ABL PROTAC degrader, and its degradation efficiency of BCR-ABL is much lower than that of its trans isomer Azo-PROTAC-4C-trans (HY-180983). Azo-PROTAC-4C-cis is the product of the conformational transformation of Azo-PROTAC-4C-trans under ultraviolet (UV) light irradiation. Azo-PROTAC-4C-cis can be converted into highly active Azo-PROTAC-4C-trans under visible light, thereby initiating protein degradation. Azo-PROTAC-4C-cis can be used for the study of myeloid leukemia .
    Azo-PROTAC-4C-cis
  • HY-182334
    azo-Q2a

    		Sodium Channel Cardiovascular Disease
    azo-Q2a is a photoswitchable NaV1.5 inhibitor. azo-Q2a exists as the trans isomer with low activity in the dark or under 480 nm illumination, and exists as the cis isomer with higher inhibitory potency under 365 nm illumination. azo-Q2a reduces the heart rate of living zebrafish larvae in a light-dependent manner. azo-Q2a can be used for the study of arrhythmias .
    azo-Q2a
  • HY-151871A
    cis-ICeD-2

    		HIV Dipeptidyl Peptidase Drug Isomer Infection
    cis-ICeD-2 is the cis isomer of ICeD-2 (HY-151871). ICeD-2 is a cell death inducer that induces cell death in HIV-1-infected cells. ICeD-2-mediated killing of HIV-1-infected cells is dependent on HIV-1 protease activity. ICeD-2 effectively blocks the hydrolysis of Gly-Pro-AMC by the dipeptidyl peptidases DPP8 and DPP9. ICeD-2 demonstrates strong stability against DPP9 in PBMCs. .
    cis-ICeD-2

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