2. Epigenetics
  3. Epigenetic Reader Domain
  4. cis-Revumenib

cis-Revumenib (cis-SNDX-5613) is an isomer of Revumenib (HY-136175). Revumenib (SNDX-5613) is a potent and specific Menin-MLL inhibitor with a binding Ki of 0.149 nM and a cell based IC50 of 10-20 nM. Revumenib can be used for the research of MLL-rearranged (MLL-r) acute leukemias, including acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML).

For research use only. We do not sell to patients.

cis-Revumenib

cis-Revumenib Chemical Structure

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Based on 1 publication(s) in Google Scholar

Other Forms of cis-Revumenib:

cis-Revumenib Related Antibodies

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Description

cis-Revumenib (cis-SNDX-5613) is an isomer of Revumenib (HY-136175). Revumenib (SNDX-5613) is a potent and specific Menin-MLL inhibitor with a binding Ki of 0.149 nM and a cell based IC50 of 10-20 nM. Revumenib can be used for the research of MLL-rearranged (MLL-r) acute leukemias, including acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML)[1].

In Vivo

Revumenib (HY-136175) shows in vivo plasma IC50 of 53 nM. Revumenib treatment provides significant survival benefit and leukemic control in aggressive MOLM-13 disseminated xenografts[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

630.82

Formula

C32H47FN6O4S
Appearance

Solid

SMILES

O=C(N(CC)C(C)C)C1=CC(F)=CC=C1OC2=CN=CN=C2N3CC4(CCN(C[C@H]5CC[C@@H](NS(=O)(CC)=O)CC5)CC4)C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (158.52 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5852 mL 7.9262 mL 15.8524 mL
5 mM 0.3170 mL 1.5852 mL 3.1705 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5852 mL 7.9262 mL 15.8524 mL 39.6310 mL
5 mM 0.3170 mL 1.5852 mL 3.1705 mL 7.9262 mL
10 mM 0.1585 mL 0.7926 mL 1.5852 mL 3.9631 mL
15 mM 0.1057 mL 0.5284 mL 1.0568 mL 2.6421 mL
20 mM 0.0793 mL 0.3963 mL 0.7926 mL 1.9815 mL
25 mM 0.0634 mL 0.3170 mL 0.6341 mL 1.5852 mL
30 mM 0.0528 mL 0.2642 mL 0.5284 mL 1.3210 mL
40 mM 0.0396 mL 0.1982 mL 0.3963 mL 0.9908 mL
50 mM 0.0317 mL 0.1585 mL 0.3170 mL 0.7926 mL
60 mM 0.0264 mL 0.1321 mL 0.2642 mL 0.6605 mL
80 mM 0.0198 mL 0.0991 mL 0.1982 mL 0.4954 mL
100 mM 0.0159 mL 0.0793 mL 0.1585 mL 0.3963 mL
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cis-Revumenib Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

cis-Revumenibcis-SNDX-5613Epigenetic Reader DomainInhibitorinhibitorinhibit

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