1. Cell Cycle/DNA Damage
    Anti-infection
  2. DNA/RNA Synthesis
    HCV
  3. cis-Lomibuvir

cis-Lomibuvir (Synonyms: cis-VX-222)

Cat. No.: HY-114571
Handling Instructions

cis-Lomibuvir (cis-VX-222) is the cis-isomer of Lomibuvir. Lomibuvir (VX-222), a selective, non-nucleoside polymerase inhibitor, targets thumb pocket 2 of the HCV NS5B polymerase (RdRp) with a Kd of 17 nM. Lomibuvir inhibits the 1b/Con1 HCV subgenomic replicon with an EC50 of 5.2 nM. Lomibuvir preferentially inhibits elongative RNA synthesis rather than de novo-initiated RNA synthesis.

For research use only. We do not sell to patients.

cis-Lomibuvir Chemical Structure

cis-Lomibuvir Chemical Structure

CAS No. : 1026785-59-0

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Description

cis-Lomibuvir (cis-VX-222) is the cis-isomer of Lomibuvir. Lomibuvir (VX-222), a selective, non-nucleoside polymerase inhibitor, targets thumb pocket 2 of the HCV NS5B polymerase (RdRp) with a Kd of 17 nM. Lomibuvir inhibits the 1b/Con1 HCV subgenomic replicon with an EC50 of 5.2 nM. Lomibuvir preferentially inhibits elongative RNA synthesis rather than de novo-initiated RNA synthesis[1].

Molecular Weight

445.61

Formula

C25H35NO4S

CAS No.
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cis-Lomibuvir
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