1. Anti-infection
  2. HCV
  3. VX-222

VX-222 (Synonyms: VCH-222)

Cat. No.: HY-75800 Purity: 99.90%
Handling Instructions

VX-222 (VCH-222) is a novel, potent and selective inhibitor of HCV polymerase with IC50 of 0.94-1.2 μM, 15.3-fold less effective for mutant M423T, and 108-fold less effective for mutant I482L.

For research use only. We do not sell to patients.

VX-222 Chemical Structure

VX-222 Chemical Structure

CAS No. : 1026785-59-0

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 132 In-stock
Estimated Time of Arrival: December 31
5 mg USD 120 In-stock
Estimated Time of Arrival: December 31
10 mg USD 210 In-stock
Estimated Time of Arrival: December 31
50 mg USD 630 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 2 publication(s) in Google Scholar

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Description

VX-222 (VCH-222) is a novel, potent and selective inhibitor of HCV polymerase with IC50 of 0.94-1.2 μM, 15.3-fold less effective for mutant M423T, and 108-fold less effective for mutant I482L. IC50 Value: 0.94 μM (HCV NS5B 1a); 1.2 μM (HCV NS5B 1b) Target: HCV VX-222 is a small molecule non-nucleoside inhibitor of HCV NS5B polymerase that is being investigated for the treatment of hepatitis C virus infection. VX-222 exhibits non-competitive and selective inhibition in HCV NS5B of genotype 1a and 1b, with IC50 of 0.94 and 1.2 μM, respectively. VX-222 selectively inhibits the replication of subgenomic HCV genotype 1a and 1b with an EC50 of 22.3 and 11.2 nM, respectively. [1] Similarly, a recent study shows that VX-222 inhibits the 1b/Con1 HCV subgenomic replicon, with an EC50 of 5 nM. In rats and dogs, VCH-222 displays fine pharmacokinetic pro le, including low total body clearance and excellent oral bioavailability (greater than 30%) and good ADME properties. VCH-222 is biotransformed by several enzymes (CYP1A1, 2A6, 2B6, 2C8, CYP 3A4, UGT1A3) and is predicted to be actively transported in liver and excreted mainly intact in bile or as glucuronide adducts.

Clinical Trial
Molecular Weight

445.61

Formula

C₂₅H₃₅NO₄S

CAS No.

1026785-59-0

SMILES

O=C(C1=C(N([[email protected]@H]2CC[[email protected]](O)CC2)C([[email protected]]3CC[[email protected]](C)CC3)=O)C=C(C#CC(C)(C)C)S1)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 32 mg/mL (71.81 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2441 mL 11.2206 mL 22.4411 mL
5 mM 0.4488 mL 2.2441 mL 4.4882 mL
10 mM 0.2244 mL 1.1221 mL 2.2441 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 99.90%

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Keywords:

VX-222VCH-222VX222VX 222VCH222VCH 222HCVHepatitis C virusInhibitorinhibitorinhibit

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VX-222
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HY-75800
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