1. Cell Cycle/DNA Damage
    Anti-infection
  2. DNA/RNA Synthesis
    HCV
  3. Lomibuvir

Lomibuvir (Synonyms: VX-222)

Cat. No.: HY-75800 Purity: 99.90%
Handling Instructions

Lomibuvir (VX-222), a selective, non-nucleoside polymerase inhibitor, targets thumb pocket 2 of the HCV NS5B polymerase (RdRp) with a Kd of 17 nM. Lomibuvir inhibits the 1b/Con1 HCV subgenomic replicon with an EC50 of 5.2 nM. Lomibuvir preferentially inhibits elongative RNA synthesis rather than de novo-initiated RNA synthesis.

For research use only. We do not sell to patients.

Lomibuvir Chemical Structure

Lomibuvir Chemical Structure

CAS No. : 1026785-55-6

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1  mL in DMSO USD 132 In-stock
Estimated Time of Arrival: December 31
5 mg USD 120 In-stock
Estimated Time of Arrival: December 31
10 mg USD 210 In-stock
Estimated Time of Arrival: December 31
50 mg USD 630 In-stock
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Customer Review

Based on 2 publication(s) in Google Scholar

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Description

Lomibuvir (VX-222), a selective, non-nucleoside polymerase inhibitor, targets thumb pocket 2 of the HCV NS5B polymerase (RdRp) with a Kd of 17 nM. Lomibuvir inhibits the 1b/Con1 HCV subgenomic replicon with an EC50 of 5.2 nM. Lomibuvir preferentially inhibits elongative RNA synthesis rather than de novo-initiated RNA synthesis[1].

In Vitro

Lomibuvir (VX-222) inhibits WT HCV 1b/Con1 replicon with an EC50 of 5.2 nM. Lomibuvir inhibits M423T, L419M and I482L (mutant replicons) with EC50s of 79.8, 563.1, 45.3 nM, respectively. Lomibuvir reduces de novo initiation slightly but also shows strong inhibition of primer extension. The IC50 of Lomibuvir for primer-extended RNA synthesis is 31 nM[1].
Lomibuvir is a non-nucleoside, allosteric inhibitor of the hepatitis C virus NS5B polymerase[2].

Clinical Trial
Molecular Weight

445.61

Formula

C₂₅H₃₅NO₄S

CAS No.

1026785-55-6

SMILES

O=C(C1=C(N([[email protected]@H]2CC[[email protected]@H](O)CC2)C([[email protected]]3CC[[email protected]](C)CC3)=O)C=C(C#CC(C)(C)C)S1)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 32 mg/mL (71.81 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2441 mL 11.2206 mL 22.4411 mL
5 mM 0.4488 mL 2.2441 mL 4.4882 mL
10 mM 0.2244 mL 1.1221 mL 2.2441 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

LomibuvirVX-222VX222VX 222DNA/RNA SynthesisHCVHepatitis C virusnon-nucleosidepolymeraseNS5BsubgenomicrepliconRNAsynthesisInhibitorinhibitorinhibit

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Lomibuvir
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