SAG analog (cis-isomer)  (Synonyms: SAG-Cl (cis-isomer))

SAG analog (cis-isomer) (SAG-Cl (cis-isomer)) (Compound 10b) is a Gli1 activator with an EC₅₀ of 7.6 nM. SAG analog (cis-isomer) is non-toxic^[1].

SAG analog (cis-isomer) (1000 nM; 48 h) potently activates Gli1 reporter gene expression in Shh-Light II cells with an EC₅₀ of 7.6 nM^[1].
SAG analog (cis-isomer) (10 μM; 24 h) shows no cytotoxicity in HUVE cells at concentrations up to 10 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

524.50

C₂₈H₂₇Cl₂N₃OS

1401532-77-1

ClC1=C(C(N([C@H]2CC[C@H](CC2)NC)CC3=CC(C4=CC=NC=C4)=CC=C3)=O)SC5=CC=CC(Cl)=C15

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Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Seifert K, et al. Potent small molecule Hedgehog agonists induce VEGF expression in vitro. Bioorg Med Chem. 2012;20(21):6465-6481.  [Content Brief]