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Cat. No.: HY-182641

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SAG analog (cis-isomer)

(Synonyms: SAG-Cl (cis-isomer))

SAG analog (cis-isomer) (SAG-Cl (cis-isomer)) (Compound 10b) is a Gli1 activator with an EC₅₀ of 7.6 nM. SAG analog (cis-isomer) is non-toxic.

For research use only. We do not sell to patients.

CAS No.: 1401532-77-1
Formula: C₂₈H₂₇Cl₂N₃OS
Molecular Weight:524.50

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

SAG analog (cis-isomer) Chemical Structure

CAS No.: 1401532-77-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

SAG analog (cis-isomer) (SAG-Cl (cis-isomer)) (Compound 10b) is a Gli1 activator with an EC₅₀ of 7.6 nM. SAG analog (cis-isomer) is non-toxic^[1].

IC₅₀ & Target^[1]

Gli1

7.6
nM (EC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
Shh Light II	EC₅₀	7.6 nM Compound: 10b	Activation of Shh pathway in mouse Shh-Light II cells assessed as induction of gli1 expression after 48 hrs by renilla luminescence assay Activation of Shh pathway in mouse Shh-Light II cells assessed as induction of gli1 expression after 48 hrs by renilla luminescence assay	[PMID: 22985958]

In Vitro

SAG analog (cis-isomer) (1000 nM; 48 h) potently activates Gli1 reporter gene expression in Shh-Light II cells with an EC₅₀ of 7.6 nM^[1].
SAG analog (cis-isomer) (10 μM; 24 h) shows no cytotoxicity in HUVE cells at concentrations up to 10 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1401532-77-1
Molecular Weight 524.50
Formula C₂₈H₂₇Cl₂N₃OS
SMILES

ClC1=C(C(N([C@H]2CC[C@H](CC2)NC)CC3=CC(C4=CC=NC=C4)=CC=C3)=O)SC5=CC=CC(Cl)=C15
Synonyms

SAG-Cl (cis-isomer)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Seifert K, et al. Potent small molecule Hedgehog agonists induce VEGF expression in vitro. Bioorg Med Chem. 2012;20(21):6465-6481. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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