2. PROTAC Epigenetics
  3. PROTACs Epigenetic Reader Domain
  4. cis-MZ 1

cis-MZ 1 is a cis isomer of meso-zeaxanthin, a xanthophyll carotenoid component of total zeaxanthin measured in serum and egg yolks.cis-MZ 1 is a triphenyltin benzoate that adopts either a tetrahedral monomeric structure (I) or a trans-SnR3O2 polymeric structure (III), with structure determined by a balance of steric and electronic factors.

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cis-MZ 1

cis-MZ 1 Chemical Structure

CAS No. : 1797406-72-4

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
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Based on 1 publication(s) in Google Scholar

Other Forms of cis-MZ 1:

cis-MZ 1 Related Antibodies

Top Publications Citing Use of Products

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

cis-MZ 1 is a cis isomer of meso-zeaxanthin, a xanthophyll carotenoid component of total zeaxanthin measured in serum and egg yolks.cis-MZ 1 is a triphenyltin benzoate that adopts either a tetrahedral monomeric structure (I) or a trans-SnR3O2 polymeric structure (III), with structure determined by a balance of steric and electronic factors[1].

IC50 & Target

BRD4(BD1BD2)

 

In Vitro

cis-MZ 1 is structurally identical to MZ1 (HY-107425), with the only difference being the inverted C-4 stereocenter of the hydroxyl group carried by cis-MZ 1. cis-MZ 1 shows no measurable binding affinity to VHL in ITC assays, so it is selected as a negative control compound for cellular level assays[1].
cis-MZ 1 (1 μM; 24 h) fails to induce BRD4 protein degradation in HeLa cells pretreated with siRNA targeting specific BET proteins for 24 h[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

cis-MZ 1 Related Antibodies
Molecular Weight

1002.64

Formula

C49H60ClN9O8S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC1=C(C)SC2=C1C(C3=CC=C(C=C3)Cl)=N[C@@H](CC(NCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N4[C@@H](C[C@@H](C4)O)C(NCC5=CC=C(C6=C(N=CS6)C)C=C5)=O)=O)=O)=O)C7=NN=C(C)N27
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (99.74 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9974 mL 4.9868 mL 9.9737 mL
5 mM 0.1995 mL 0.9974 mL 1.9947 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9974 mL 4.9868 mL 9.9737 mL 24.9342 mL
5 mM 0.1995 mL 0.9974 mL 1.9947 mL 4.9868 mL
10 mM 0.0997 mL 0.4987 mL 0.9974 mL 2.4934 mL
15 mM 0.0665 mL 0.3325 mL 0.6649 mL 1.6623 mL
20 mM 0.0499 mL 0.2493 mL 0.4987 mL 1.2467 mL
25 mM 0.0399 mL 0.1995 mL 0.3989 mL 0.9974 mL
30 mM 0.0332 mL 0.1662 mL 0.3325 mL 0.8311 mL
40 mM 0.0249 mL 0.1247 mL 0.2493 mL 0.6234 mL
50 mM 0.0199 mL 0.0997 mL 0.1995 mL 0.4987 mL
60 mM 0.0166 mL 0.0831 mL 0.1662 mL 0.4156 mL
80 mM 0.0125 mL 0.0623 mL 0.1247 mL 0.3117 mL
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cis-MZ 1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

cis-MZ 11797406-72-4PROTACsEpigenetic Reader Domaintrans-SnR 3 O 2 polymeric structureserumtetrahedral monomeric structuretriphenyltin benzoatemeso-zeaxanthinxanthophyll carotenoidtotal zeaxanthinegg yolks
Inhibitorinhibitorinhibit

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