cis-MZ 1
Based on 1 Customer Validation
cis-MZ 1 (MZP-42) serves as a negative control for BRD4-targeted PROTAC MZ 1 (HY-107425). cis-MZ 1 can be used in colorectal cancer-related research.
(Pink: BRD4 ligand (HY-13030); Blue: VHL ligand (HY-120217A); Black: linker (HY-42637)).
For research use only. We do not sell to patients.
- Purity: 98.72%
- CAS No.: 1797406-72-4
- Formula: C49H60ClN9O8S2
- Molecular Weight:1002.64
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Epigenetics Compound Library
HY-L005
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Histone Modification Research Compound Library
HY-L024
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Anti-Cancer Compound Library
HY-L025
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Anti-Blood Cancer Compound Library
HY-L079
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Anti-Colorectal Cancer Compound Library
HY-L103
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PROTAC Library
HY-L151
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Anti-Hematopathy Compound Library
HY-L171
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Multi-Target Compound Library
HY-L176
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Bioactive Compound Library Max
HY-L181
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
All PROTACs Isoforms
More
Biological Activity
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BRD4 |
VHL |
cis-MZ 1 shows no detectable binding affinity to the VHL-ElonginB-ElonginC complex in in vitro ITC experiments[1].
cis-MZ 1 (1 μM; 24-36 h) does not induce the degradation of BRD2, BRD3, or BRD4 in HeLa cells[1].
cis-MZ 1 (5 μM; up to 4 h) does not induce degradation of GFP-tagged BRD4 in U2OS cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HeLa cells
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Concentration:1 μM
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Incubation Time:24-36 h
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Result:Showed no degradation of BRD2, BRD3, or BRD4 after 24 h of treatment.
Showed no degradation of BRD2, BRD3, or BRD4 over the 36 h time course.
Chemical Information
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CAS No. 1797406-72-4
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Appearance Solid
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Molecular Weight 1002.64
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Formula C49H60ClN9O8S2
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Color White to off-white
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SMILES
CC1=C(C)SC2=C1C(C3=CC=C(C=C3)Cl)=N[C@@H](CC(NCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N4[C@@H](C[C@@H](C4)O)C(NCC5=CC=C(C6=C(N=CS6)C)C=C5)=O)=O)=O)=O)C7=NN=C(C)N27
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Synonyms
MZP-42
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (99.74 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
[1]. Zengerle M, et al. Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4. ACS Chem Biol. 2015;10(8):1770-1777. [Content Brief]
[2]. Gadd MS, et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat Chem Biol. 2017;13(5):514-521. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.9974 mL | 4.9868 mL | 9.9737 mL | 24.9342 mL |
| 5 mM | 0.1995 mL | 0.9974 mL | 1.9947 mL | 4.9868 mL | |
| 10 mM | 0.0997 mL | 0.4987 mL | 0.9974 mL | 2.4934 mL | |
| 15 mM | 0.0665 mL | 0.3325 mL | 0.6649 mL | 1.6623 mL | |
| 20 mM | 0.0499 mL | 0.2493 mL | 0.4987 mL | 1.2467 mL | |
| 25 mM | 0.0399 mL | 0.1995 mL | 0.3989 mL | 0.9974 mL | |
| 30 mM | 0.0332 mL | 0.1662 mL | 0.3325 mL | 0.8311 mL | |
| 40 mM | 0.0249 mL | 0.1247 mL | 0.2493 mL | 0.6234 mL | |
| 50 mM | 0.0199 mL | 0.0997 mL | 0.1995 mL | 0.4987 mL | |
| 60 mM | 0.0166 mL | 0.0831 mL | 0.1662 mL | 0.4156 mL | |
| 80 mM | 0.0125 mL | 0.0623 mL | 0.1247 mL | 0.3117 mL |
cis-MZ 1 Related Classifications
HY-107425A Related Classifications
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