cis-MZ 1 hydrate
cis-MZ 1 hydrate serves as a negative control for BRD4-targeted PROTAC MZ 1 (HY-107425). cis-MZ 1 hydrate can be used in colorectal cancer-related research.
(Pink: BRD4 ligand (HY-13030); Blue: VHL ligand (HY-120217A); Black: linker (HY-42637)).
For research use only. We do not sell to patients.
- Purity: 99.0%
- Formula: C49H60ClN9O8S2.1/4H2O
- Molecular Weight:1007.15
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All PROTACs Isoforms
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Biological Activity
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BRD4 |
VHL |
cis-MZ 1 hydrate shows no detectable binding affinity to the VHL-ElonginB-ElonginC complex in in vitro ITC experiments[1].
cis-MZ 1 (1 μM; 24-36 h) hydrate does not induce the degradation of BRD2, BRD3, or BRD4 in HeLa cells[1].
cis-MZ 1 (5 μM; up to 4 h) hydrate does not induce degradation of GFP-tagged BRD4 in U2OS cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HeLa cells
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Concentration:1 μM
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Incubation Time:24-36 h
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Result:Showed no degradation of BRD2, BRD3, or BRD4 after 24 h of treatment.
Showed no degradation of BRD2, BRD3, or BRD4 over the 36 h time course.
Chemical Information
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Appearance Solid
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Molecular Weight 1007.15
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Formula C49H60ClN9O8S2.1/4H2O
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Color White to off-white
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SMILES
CC1=C(C)SC2=C1C(C3=CC=C(C=C3)Cl)=N[C@@H](CC(NCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N4[C@@H](C[C@@H](C4)O)C(NCC5=CC=C(C6=C(N=CS6)C)C=C5)=O)=O)=O)=O)C7=NN=C(C)N27.[0.25].O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Zengerle M, et al. Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4. ACS Chem Biol. 2015;10(8):1770-1777. [Content Brief]
[2]. Gadd MS, et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat Chem Biol. 2017;13(5):514-521. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
cis-MZ 1 hydrate Related Classifications
HY-107425B Related Classifications
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