2. Cell Cycle/DNA Damage Epigenetics
  3. HDAC Histone Methyltransferase
  4. cis-BG47

cis-BG47 is an cis-isomer of BG47, BG47 is a prototypical histone deacetylases HDAC1 and HDAC2 selective, optoepigenetic probe. BG47 can bind to and competitively inhibits the deacetylase activity of HDAC targets upon a light-induced trans-to-cis isomerization, and increases Histone Methyltransferase H3K9 acetylation. cis-BG47 can be used for neurological disease research.

For research use only. We do not sell to patients.

cis-BG47 Chemical Structure

cis-BG47 Chemical Structure

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Based on 1 publication(s) in Google Scholar

cis-BG47 Related Antibodies

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Description

cis-BG47 is an cis-isomer of BG47, BG47 is a prototypical histone deacetylases HDAC1 and HDAC2 selective, optoepigenetic probe. BG47 can bind to and competitively inhibits the deacetylase activity of HDAC targets upon a light-induced trans-to-cis isomerization, and increases Histone Methyltransferase H3K9 acetylation. cis-BG47 can be used for neurological disease research[1].

IC50 & Target[1]

HDAC1

 

HDAC2

 

In Vitro

cis-BG47 is an cis-isomer of BG47, BG47 is activated to the active cis isomer by 470 nm light[1].
cis-BG47 (BG47) (10 μM, 16 hours) elevates H3K9 acetylation only in the presence of light and also significantly upregulates the expression of haploinsufficiency of progranulin (PGRN) only in the presence of light (25 ms on/75 ms off) in human neural progenitor cells (NPCs)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

cis-BG47 Related Antibodies

Immunofluorescence[1]

Cell Line: Human neural progenitor cells (NPCs)
Concentration: 10 μM
Incubation Time: 16 hours
Result: Elevated H3K9 acetylation and significantly upregulated PGRN expression only in the presence of light (25 ms on/75 ms off).
Molecular Weight

442.53

Formula

C25H22N4O2S
Appearance

Solid

Color

Yellow to orange

SMILES

O=C(C1=CC=C(C=C1)/N=N\C2=CC=C(C=C2)N(C)C)NC3=CC(C4=CC=CS4)=CC=C3O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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cis-BG47 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

cis-BG47HDACHistone MethyltransferaseHistone deacetylasesHDAC1 inhibitorHDAC2 inhibitorHuman NPCsNeurological DiseaseInhibitorinhibitorinhibit

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