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Cat. No.: HY-117583A

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BG47

BG47 is a prototypical histone deacetylases HDAC1 and HDAC2 selective, optoepigenetic probe. BG47 can bind to and competitively inhibits the deacetylase activity of HDAC targets upon a light-induced trans-to-cis isomerization, and increases Histone Methyltransferase H3K9 acetylation. BG47 can be used for neurological disease research.

For research use only. We do not sell to patients.

CAS No.: 1628784-54-2
Formula: C₂₅H₂₂N₄O₂S
Molecular Weight:442.53

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

BG47 Chemical Structure

CAS No.: 1628784-54-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

HDAC1

HDAC2

All HDAC Isoforms :

All Histone Methyltransferase Isoforms :

In Vitro

BG47 (10 μM, 16 hours) elevates H3K9 acetylation only in the presence of light and also significantly upregulates the expression of haploinsufficiency of progranulin (PGRN) only in the presence of light (25 ms on/75 ms off) in human neural progenitor cells (NPCs)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Immunofluorescence^[1]

Cell Line:

Human neural progenitor cells (NPCs)
Concentration:

10 μM
Incubation Time:

16 hours
Result:

Elevated H3K9 acetylation and significantly upregulated PGRN expression only in the presence of light (25 ms on/75 ms off).

Chemical Information

CAS No. 1628784-54-2
Molecular Weight 442.53
Formula C₂₅H₂₂N₄O₂S
SMILES

O=C(C1=CC=C(C=C1)/N=N/C2=CC=C(N(C)C)C=C2)NC3=C(O)C=CC(C4=CC=CS4)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Reis SA, et al. Light-controlled modulation of gene expression by chemical optoepigenetic probes. Nat Chem Biol. 2016 May;12(5):317-23. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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BG47

All HDAC Isoforms

All Histone Methyltransferase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

BG47 Related Classifications

HY-117583A Related Classifications