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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
79 Results for "
fatty acid derivative
" in MedChemExpress (MCE) Product Catalog:
Products (79)
79 Results for "fatty acid derivative" in MCE Product Catalog:
20
20 Publications Verification
Cat. No.: HY-W127378
CAS No.: 144189-73-1
Synonyms: 1,2-Dioleoyl-3-trimethylammonium-propane methylsulfate
DOTAP methylsulfat is a cationic lipid reagent, a cationic derivative of trimethylammonium, linked to two 18-carbon fatty acid tails, each with a single olefin group. DOTAP methylsulfat can self-assemble with negatively charged ions (such as DNA) to form complexes, which can be adsorbed to the cell membrane surface and enter the cell by electrostatic interaction and endocytosis, respectively. DOTAP methylsulfat promotes endosomal membrane fusion with its own hydrophobic domain, releases DNA into the cytoplasm, and exerts gene delivery function. DOTAP methylsulfat can be widely used in research fields such as gene therapy, cell transfection, and non-viral vector design .
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2 Cited Publications
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FATP1-IN-2 (compound 12a), an arylpiperazine derivative, is an orally active fatty acid transport protein 1 (FATP1) inhibitor (human IC50=0.43 μM, mouse IC50=0.39 μM) .
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1 Cited Publications
Cat. No.: HY-N0853A
CAS No.: 18674-16-3
Synonyms: Alisol A 24-monoacetate; Alisol A monoacetate
Cat. No.: HY-B0766
CAS No.: 118159-48-1
Synonyms: SY801
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Autophagy Apoptosis HBV HCV HSP Reactive Oxygen Species (ROS) Bcl-2 Family Glutathione S-transferase p38 MAPK NF-κB Microtubule/Tubulin ERK JNK TNF Receptor Interleukin Related CDK Cyclin G-associated Kinase (GAK) mTOR P-glycoprotein Ferroptosis
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Bicyclol (SY801) is an orally active derivative of the traditional Chinese medicine Schisandra chinensis, which has antiviral, anti-inflammatory, immunomodulatory, antioxidant, anti-steatosis, anti-fibrotic and anti-tumor activities. Bicyclol regulates the expression of heat shock proteins and plays an anti-apoptosis role in hepatocytes. Bicyclol reduces the activation of NF-κB and the levels of inflammatory factors in hepatocytes infected with hepatitis C virus (HCV) by inhibiting the activation of the ROS-MAPK-NF-κB pathway, and prevents ferroptosis in acute liver injury. Bicyclol can change the expression of Mdr-1, GSH/GST and Bcl-2, increase the intracellular concentration of anticancer drugs, and sensitize drug-resistant cells to anticancer drugs. Bicyclol inhibits the proliferation of human malignant hepatoma cells by regulating the PI3K/AKT pathway and the Ras/Raf/MEK/ERK pathway. Bicyclol can be used in the study of chronic hepatitis, acute liver injury, nonalcoholic fatty liver disease, liver fibrosis and hepatocellular carcinoma .
Cat. No.: HY-W004290
CAS No.: 1731-92-6
Synonyms: Methyl margarate
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Cat. No.: HY-N16308
CAS No.: 3091879-77-2
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Cat. No.: HY-121457
CAS No.: 875685-44-2
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9-Nitrooleate, a nitro fatty acid, is a nitro derivative of Oleic acid (HY-N1446). 9-Nitrooleate has potential for use in vascular disease research.
Cat. No.: HY-W018004
CAS No.: 1190-49-4
Cat. No.: HY-W011311
CAS No.: 2734-47-6
Category:
Ketones, Aldehydes, Acids Other Diseases Balsaminaceae Plants Seeds of Impatiens balsamina L. Disease Research Fields
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Cat. No.: HY-D1336
CAS No.: 2183440-42-6
Cat. No.: HY-W004290S
CAS No.: 1219804-81-5
Synonyms: Methyl trans-9-Octadecenoate; (E)-Methyl octadec-9-enoate
Synonyms: AC 223; DL-N-(α-Methylbenzyl)linoleamide
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Melinamide, an amide derivative of an unsaturated long-chain fatty acid, is an inhibitor of cholesterol absorption with an IC50 of 20.9 μM.
Cat. No.: HY-W009118
CAS No.: 123622-48-0
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Cat. No.: HY-113434B
CAS No.: 71030-39-2
Synonyms: (±)-5-HETE
Category:
Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Inflammation/Immunology
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Phosphatidylcholine transfer protein inhibitor-1 is a derivative of phosphatidylcholine transfer protein (PC-TP) inhibitor. Phosphatidylcholine transfer protein inhibitor-1 can be used for the research of obesity, type 2 diabetes, non-alcoholic fatty liver disease .
NITD-916, a 4-hydroxy-2-pyridone derivative, is an orally active mycobacterial enoyl reductase InhA inhibitor with an IC50 of 570 nM. NITD-916 forms a ternary complex with InhA and NADH to block access to the fatty acyl substrate binding pocket. NITD-916 inhibition of InhA reduces the synthesis of mycolic acids and results in cell death. NITD-916 has potent anti-tuberculosis effects .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
