13-Hydroxy-alpha-tocopherol 

13-Hydroxy-alpha-tocopherol is a fat-soluble vitamin E derivative and anticancer agent with antioxidant and antiproliferative activities. 13-Hydroxy-alpha-tocopherol scavenges peroxyl free radicals and protects polyunsaturated fatty acids from oxidative damage. 13-Hydroxy-alpha-tocopherol not only inhibits the growth of glioma cancer cells, but its deficiency is also closely associated with recurrent miscarriage, embryonic growth retardation and death. Clinical observations show that the expression of 13-Hydroxy-alpha-tocopherol is downregulated in the follicular fluid of patients with recurrent miscarriage. 13-Hydroxy-alpha-tocopherol has important application potential in the research of recurrent miscarriage and glioma^[1][2].

¹³-Hydroxy-alpha-tocopherol (Compound 7) (10 μM; 24 h) potently inhibits the proliferation of murine glioma C6 cells, reducing cell number to ~50% of untreated controls^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

446.71

C₂₉H₅₀O₃

1160974-39-9

CC1=C2C(O[C@@](C)(CC2)CCCC(C)CCCC(C)CCCC(C)CO)=C(C(C)=C1O)C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Song J, et al. Novel high-coverage targeted metabolomics method (SWATHtoMRM) for exploring follicular fluid metabolome alterations in women with recurrent spontaneous abortion undergoing in vitro fertilization. Sci Rep. 2019;9(1):10873. Published 2019 Jul 26.  [Content Brief]

  [2]. Mazzini F, et al. Configuration of the vitamin E analogue garcinoic acid extracted from Garcinia Kola seeds. Chirality. 2009;21(5):519-524.  [Content Brief]