13-Hydroxy-alpha-tocopherol
13-Hydroxy-alpha-tocopherol is a fat-soluble vitamin E derivative and anticancer agent with antioxidant and antiproliferative activities. 13-Hydroxy-alpha-tocopherol scavenges peroxyl free radicals and protects polyunsaturated fatty acids from oxidative damage. 13-Hydroxy-alpha-tocopherol not only inhibits the growth of glioma cancer cells, but its deficiency is also closely associated with recurrent miscarriage, embryonic growth retardation and death. Clinical observations show that the expression of 13-Hydroxy-alpha-tocopherol is downregulated in the follicular fluid of patients with recurrent miscarriage. 13-Hydroxy-alpha-tocopherol has important application potential in the research of recurrent miscarriage and glioma.
For research use only. We do not sell to patients.
- CAS No.: 1160974-39-9
- Formula: C29H50O3
- Molecular Weight:446.71
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
13-Hydroxy-alpha-tocopherol (Compound 7) (10 μM; 24 h) potently inhibits the proliferation of murine glioma C6 cells, reducing cell number to ~50% of untreated controls[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:murine glioma C6 cancer cells
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Concentration:10 μM
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Incubation Time:24 h
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Result:Reduced cell proliferation to approximately 50% of the untreated control level.
Chemical Information
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CAS No. 1160974-39-9
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Molecular Weight 446.71
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Formula C29H50O3
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SMILES
CC1=C2C(O[C@@](C)(CC2)CCCC(C)CCCC(C)CCCC(C)CO)=C(C(C)=C1O)C
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Song J, et al. Novel high-coverage targeted metabolomics method (SWATHtoMRM) for exploring follicular fluid metabolome alterations in women with recurrent spontaneous abortion undergoing in vitro fertilization. Sci Rep. 2019;9(1):10873. Published 2019 Jul 26. [Content Brief]
[2]. Mazzini F, et al. Configuration of the vitamin E analogue garcinoic acid extracted from Garcinia Kola seeds. Chirality. 2009;21(5):519-524. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
13-Hydroxy-alpha-tocopherol Related Classifications
HY-Z11709 Related Classifications
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