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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
25 Results for "
human skin fibroblasts
" in MedChemExpress (MCE) Product Catalog:
Products (25)
25 Results for "human skin fibroblasts" in MCE Product Catalog:
67
67 Publications Verification
Synonyms: GM6001; Galardin
Ilomastat (GM6001) is a potent and broad spectrum matrix metalloprotease (MMP) inhibitor, inhibits MMPs (IC50s, 1.5 nM for MMP-1; 1.1 nM for MMP-2; 1.9 nM for MMP-3; 0.5 nM for MMP-9), with a Ki of 0.4 nM for human skin fibroblast collagenase (MMP-1).
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Category:
Duchesnea indica (Andr.) Focke Monophenols Other Diseases Rosaceae Extract Phenols Plants Disease Research Fields
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Environmental Pollutants PPAR Estrogen Receptor/ERR Biochemical Assay Reagents Cytochrome P450
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Octocrylene is an organic ultraviolet (UV) filter that absorbs mainly UVB radiation and shorter UVA wavelengths. Octocrylene acts as a partial agonist of PPARγ, which alters the gene transcription profile of lipid metabolism enzymes. In addition, Octocrylene is cytotoxic and genotoxic to human skin fibroblasts and mediates the biosynthesis of estrogens such as estriol in zebrafish larvae, while affecting antioxidant pathways including glutathione transferase and peroxisomes .
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Crisnatol (BWA770U) is an orally active and anticancer agent, and a member of the arylmethylaminopropanediol class of DNA intercalators. Crisnatol shows in vitro cytotoxicity against human breast cancer cells, but not normal human skin fibroblasts .
Cat. No.: HY-164159
CAS No.: 130603-71-3
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α-Glucosylrutin, a flavonoid, is a potent antioxidant with free radical scavenging activity. α-Glucosylrutin reduces MMP-1 gene expression, protein expression, and enzyme activity, and reduces MMP-2 protein expression and enzyme activity in UVA-irradiated human dermal fibroblasts. α-Glucosylrutin prevents oxidative stress-induced intracellular tyrosine residue phosphorylation and counteracts intracellular thiol level depletion in human skin cells. α-Glucosylrutin is effective in the prevention of dermatologic diseases in which oxidative stress is of pathogenetic relevance, e.g. in polymorphous light eruption (PLE). α-Glucosylrutin can be used for the research of UV-induced skin photodamage/photoaging .
Cat. No.: HY-P5232
CAS No.: 960608-17-7
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Cat. No.: HY-P5237
CAS No.: 960608-16-6
Cat. No.: HY-W020044R
CAS No.: 10191-41-0
Synonyms: DL-α-Tocopherol (Standard)
Cat. No.: HY-119358R
CAS No.: 6402-36-4
Cat. No.: HY-15768R
CAS No.: 142880-36-2
Synonyms: GM6001 (Standard); Galardin (Standard)
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Ilomastat (Standard) is the analytical standard of Ilomastat. This product is intended for research and analytical applications. Ilomastat (GM6001) is a potent and broad spectrum matrix metalloprotease (MMP) inhibitor, inhibits MMPs (IC50s, 1.5 nM for MMP-1; 1.1 nM for MMP-2; 1.9 nM for MMP-3; 0.5 nM for MMP-9), with a Ki of 0.4 nM for human skin fibroblast collagenase (MMP-1).
Cat. No.: HY-118518
CAS No.: 85247-77-4
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Ronipamil is a calcium ion antagonist. Ronipamil increases the specific binding and internalization of human 125I-LDL in human skin fibroblasts (HSF) and the human hepatoma cell line Hep G2 .
Cat. No.: HY-108999
CAS No.: 96389-69-4
Synonyms: BWA770U mesylate
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Crisnatol (BWA770U) mesylate is an orally active and anticancer agent, and a member of the arylmethylaminopropanediol class of DNA intercalators. Crisnatol mesylate shows in vitro cytotoxicity against human breast cancer cells, but not normal human skin fibroblasts .
Cat. No.: HY-W020044S1
CAS No.: 131230-17-6
Cat. No.: HY-W020044S
Cat. No.: HY-108999AR
CAS No.: 96389-68-3
Synonyms: BWA770U (Standard)
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Crisnatol (Standard) is the analytical standard of Crisnatol. This product is intended for research and analytical applications. Crisnatol (BWA770U) is an orally active and anticancer agent, and a member of the arylmethylaminopropanediol class of DNA intercalators. Crisnatol shows in vitro cytotoxicity against human breast cancer cells, but not normal human skin fibroblasts .
Cat. No.: HY-106818A
CAS No.: 103379-03-9
Synonyms: AJ-2615
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Monatepil (AJ-2615 free base) maleate is a calcium antagonist with potent α1-adrenoceptor blocking activity. Monatepil maleate inhibits vasopressin- or methacholine-induced ischemic electrocardiographic changes in a rat model of vasospastic angina and reduces the mean arterial pressure in anesthetized rats. Monatepil maleate also enhances low-density lipoprotein (LDL) receptor activity in human skin fibroblasts . Monatepil maleate can be used in research related to hypertension, atherosclerosis, hyperlipidemia and vasospastic angina .
Cat. No.: HY-W654296
Cat. No.: HY-P11638A
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
