Crisnatol mesylate
Based on 1 publication(s) in Google Scholar
Crisnatol (BWA770U) mesylate is an orally active and anticancer agent, and a member of the arylmethylaminopropanediol class of DNA intercalators. Crisnatol mesylate shows in vitro cytotoxicity against human breast cancer cells, but not normal human skin fibroblasts.
For research use only. We do not sell to patients.
- CAS No.: 96389-69-4
- Formula: C24H27NO5S
- Molecular Weight:441.54
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) Crisnatol mesylate
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Biological Activity
Crisnatol (1.3 μg/mL; 24-72 h) mesylate inhibits the replication of HepG2 cells, decreases cell viability by 35%[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HepG2 cells
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Concentration:1.3 μg/mL
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Incubation Time:24 hours, 48 hours, 72 hours, and 126 hours
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Result:Inhibited cell viability at 48 hr.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 96389-69-4
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Molecular Weight 441.54
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Formula C24H27NO5S
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SMILES
OCC(C)(NCC1=C2C=CC=CC2=C3C(C4=CC=CC=C4C=C3)=C1)CO.OS(=O)(C)=O
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Synonyms
BWA770U mesylate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Nat Commun
Integrative residue-intuitive machine learning and MD Approach to Unveil Allosteric Site and Mechanism for β2AR. [Abstract]2024 Sep 16;15(1):8130. PMID: 39285201
Purity & Documentation
References
[1]. Adams DJ. In vitro pharmacodynamic assay for cancer drug development: application to crisnatol, a new DNA intercalator. Cancer Res. 1989 Dec 1;49(23):6615-20. [Content Brief]
[2]. Patel DK, et al. Metabolism of a novel antitumor agent, crisnatol, by a human hepatoma cell line, Hep G2, and hepatic microsomes. Characterization of metabolites. Biochem Pharmacol. 1991 Jul 5;42(2):337-46. [Content Brief]
[3]. Patel DK, et al. Disposition, metabolism, and excretion of the anticancer agent crisnatol in the rat. Drug Metab Dispos. 1991 Mar-Apr;19(2):491-7. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Crisnatol mesylate Related Classifications
HY-108999 Related Classifications
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