2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. Crisnatol

Crisnatol  (Synonyms: BWA770U)

Cat. No.: HY-108999A Purity: 99.51%
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Crisnatol (BWA770U) is an orally active and anticancer agent, and a member of the arylmethylaminopropanediol class of DNA intercalators. Crisnatol shows in vitro cytotoxicity against human breast cancer cells, but not normal human skin fibroblasts.

For research use only. We do not sell to patients.

Crisnatol Chemical Structure

Crisnatol Chemical Structure

CAS No. : 96389-68-3

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Based on 1 publication(s) in Google Scholar

Other Forms of Crisnatol:

Crisnatol Related Antibodies

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  • Purity & Documentation

  • References

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Description

Crisnatol (BWA770U) is an orally active and anticancer agent, and a member of the arylmethylaminopropanediol class of DNA intercalators. Crisnatol shows in vitro cytotoxicity against human breast cancer cells, but not normal human skin fibroblasts[1][2][3].

In Vitro

Crisnatol (1.3 μg/mL; 24-72 h) inhibits the replication of HepG2 cells, decreases cell viability by 35%[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Crisnatol Related Antibodies

Cell Viability Assay[2]

Cell Line: HepG2 cells
Concentration: 1.3 μg/mL
Incubation Time: 24 hours, 48 hours, 72 hours, and 126 hours
Result: Inhibited cell viability at 48 hr.
In Vivo

Crisnatol (25 mg/kg; p.o.; single dose) shows oral activity and shows stable metabolite profile extract of rat feces by autoradiography[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

345.43

Formula

C23H23NO2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OCC(C)(NCC1=C2C=CC=CC2=C3C(C4=CC=CC=C4C=C3)=C1)CO
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (289.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8949 mL 14.4747 mL 28.9494 mL
5 mM 0.5790 mL 2.8949 mL 5.7899 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8949 mL 14.4747 mL 28.9494 mL 72.3736 mL
5 mM 0.5790 mL 2.8949 mL 5.7899 mL 14.4747 mL
10 mM 0.2895 mL 1.4475 mL 2.8949 mL 7.2374 mL
15 mM 0.1930 mL 0.9650 mL 1.9300 mL 4.8249 mL
20 mM 0.1447 mL 0.7237 mL 1.4475 mL 3.6187 mL
25 mM 0.1158 mL 0.5790 mL 1.1580 mL 2.8949 mL
30 mM 0.0965 mL 0.4825 mL 0.9650 mL 2.4125 mL
40 mM 0.0724 mL 0.3619 mL 0.7237 mL 1.8093 mL
50 mM 0.0579 mL 0.2895 mL 0.5790 mL 1.4475 mL
60 mM 0.0482 mL 0.2412 mL 0.4825 mL 1.2062 mL
80 mM 0.0362 mL 0.1809 mL 0.3619 mL 0.9047 mL
100 mM 0.0289 mL 0.1447 mL 0.2895 mL 0.7237 mL
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Crisnatol Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Crisnatol96389-68-3BWA770UDNA/RNA SynthesisMCF-7human breast cancer cellbreast cancer cell lineMDA-MB-231human skin fibroblastsInhibitorinhibitorinhibit

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