96389-69-4
Chemical Structure
Crisnatol mesylate
Synonym(s): BWA770U mesylate
- CAS No.: 96389-69-4
- Formula:C24H27NO5S
- Molecular Weight:441.54
IUPAC Name: 2-((chrysen-6-ylmethyl)amino)-2-methylpropane-1,3-diol methanesulfonate
InChIKey: NJWBUDCAWGTQAS-UHFFFAOYSA-N
SMILES: OCC(C)(NCC1=C2C=CC=CC2=C3C(C4=CC=CC=C4C=C3)=C1)CO.OS(=O)(C)=O
Biological Activity: Crisnatol (BWA770U) mesylate is an orally active and anticancer agent, and a member of the arylmethylaminopropanediol class of DNA intercalators. Crisnatol mesylate shows in vitro cytotoxicity against human breast cancer cells, but not normal human skin fibroblasts[1][2][3].
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Crisnatol mesylate | Crisnatol (BWA770U) mesylate is an orally active and anticancer agent, and a member of the arylmethylaminopropanediol class of DNA intercalators. Crisnatol mesylate shows in vitro cytotoxicity against human breast cancer cells, but not normal human skin fibroblasts. | |||||||||||||||||||||
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- [1]. Adams DJ. In vitro pharmacodynamic assay for cancer drug development: application to crisnatol, a new DNA intercalator. Cancer Res. 1989 Dec 1;49(23):6615-20. [Content Brief]
- [2]. Patel DK, et al. Metabolism of a novel antitumor agent, crisnatol, by a human hepatoma cell line, Hep G2, and hepatic microsomes. Characterization of metabolites. Biochem Pharmacol. 1991 Jul 5;42(2):337-46. [Content Brief]
- [3]. Patel DK, et al. Disposition, metabolism, and excretion of the anticancer agent crisnatol in the rat. Drug Metab Dispos. 1991 Mar-Apr;19(2):491-7. [Content Brief]
Keywords
