IMG-008 

IMG-008 is a fully human antagonistic antibody targeting IL-36R, acting as a high-affinity IL-36R inhibitor (K_d = 6.23 pM). IMG-008 competitively blocks the pro-inflammatory signaling pathway mediated by human IL-36R, inhibiting receptor activation and the production of inflammatory cytokines. IMG-008 suppresses Imiquimod (HY-B0180)-induced skin inflammation in humanized mice, and Fc modification increases its serum exposure and prolongs its half-life. IMG-008 can be used in studies related to IL-36R-mediated inflammatory diseases such as psoriasis^[1].

Human

IMG-008 binds to human IL-36R with an affinity of 6.23 pM, as determined by SPR^[1].
IMG-008 inhibits the activation of IL-36R reporter cells and suppresses the production of inflammatory cytokines in primary human epidermal keratinocytes and dermal fibroblasts^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

IMG-008 potently suppresses Imiquimod (HY-B0180) skin inflammation in IL-36R humanized mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

8808  [NCBI]

Q9HB29

IL-1RL2/IL-36R

ELISA, FACS, Functional assay

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

Please refer to the lot-specific COA for specific buffer information.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Lei R, et al. 1060 IMG-008, a potent anti-human IL-36R antagonistic antibody, inhibits IL-36R-mediated inflammation. J Invest Dermatol. 2023 May;143(5 Suppl):S182.