Cat. No.: HY-W020044

DL-alpha-Tocopherol

(Synonyms: DL-α-Tocopherol)

7 Cited Publications

Customer Review

Based on 7 publication(s) in Google Scholar

DL-alpha-Tocopherol is a synthetic vitamin E, with antioxidation effect. DL-alpha-Tocopherol protects human skin fibroblasts against the cytotoxic effect of UVB.

For research use only. We do not sell to patients.

Purity: 99.57%
CAS No.: 10191-41-0
Formula: C₂₉H₅₀O₂
Molecular Weight:430.71

Storage:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

DL-alpha-Tocopherol Chemical Structure

CAS No.: 10191-41-0

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (7)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

DL-alpha-Tocopherol is a synthetic vitamin E, with antioxidation effect. DL-alpha-Tocopherol protects human skin fibroblasts against the cytotoxic effect of UVB^[1].

All DNA/RNA Synthesis Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	EC₅₀	>100 μM Compound: 10b	Modulation of human gamma-secretase presenilin-1 subunit expressed in CHO cells coexpressing human APP assessed as increase in amyloid beta 38 generation after 24 hrs by ELISA Modulation of human gamma-secretase presenilin-1 subunit expressed in CHO cells coexpressing human APP assessed as increase in amyloid beta 38 generation after 24 hrs by ELISA	[PMID: 23707256]
CHO	IC₅₀	>100 μM Compound: 10b	Modulation of human gamma-secretase presenilin-1 subunit expressed in CHO cells coexpressing human APP assessed as decrease in amyloid beta 40 generation after 24 hrs by ELISA Modulation of human gamma-secretase presenilin-1 subunit expressed in CHO cells coexpressing human APP assessed as decrease in amyloid beta 40 generation after 24 hrs by ELISA	[PMID: 23707256]
CHO	IC₅₀	>100 μM Compound: 10b	Modulation of human gamma-secretase presenilin-1 subunit expressed in CHO cells coexpressing human APP assessed as decrease in amyloid beta 42 generation after 24 hrs by ELISA Modulation of human gamma-secretase presenilin-1 subunit expressed in CHO cells coexpressing human APP assessed as decrease in amyloid beta 42 generation after 24 hrs by ELISA	[PMID: 23707256]

In Vitro

DL-alpha-Tocopherol (0.1-1 mM, 0-12 days) inhibits the proliferation of cancer cell OCIM-1, HEL and MCF-7, inhibits the DNA synthesis and induces apoptosis^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[3]

Cell Line:

OCIM-1, HEL and MCF-7
Concentration:

0.1-1 mM
Incubation Time:

0-12 days
Result:

Inhibited the proliferation.

In Vivo

DL-alpha-Tocopherol (100 mg/kg, iv, single dose) inhibit iron-induced lipid peroxidation in amygdala, limits brain injury response in Sprague-Dawley rats models^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague-Dawley rats models^[2]
Dosage:

100 mg/kg
Administration:

iv, single dose
Result:

Inhibited iron-induced lipid peroxidation in amygdala.

Chemical Information

CAS No. 10191-41-0
Appearance Liquid (Density: 0.950 g/cm³ )
Molecular Weight 430.71
Formula C₂₉H₅₀O₂
Color Light yellow to brown
SMILES

CC1=C2C(CCC(CCCC(C)CCCC(C)CCCC(C)C)(C)O2)=C(C)C(O)=C1C
Synonyms

DL-α-Tocopherol
Structure Classification
- Phenols
- Monophenols
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (7)

All Cell Proliferation/Viability AssayWBRT-PCRBio/Physico-chemical Assay

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Journal Impact Factor

Nature

Lithocholic acid phenocopies anti-ageing effects of calorie restriction. [Abstract]

2025 Jul;643(8070):192-200. PMID: 39695227
Acta Pharm Sin B

High intensity forced ultrasound-driven ferroptosis as a strategy for anti-tumor immune priming. [Abstract]

2025 Jul;15(7):3788-3804. PMID: 40698150

DL-alpha-Tocopherol purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2025 Jul;15(7):3788-3804. [Abstract]

DL-alpha-Tocopherol (VE; 20 μM; 24 h) demonstrated a significant attenuation of cytotoxicity in the HIFU, NP + H, and NP-PF-H groups in 4T1 cells.
Cell Death Dis

Overexpression of homeodomain-interacting protein kinase 2 (HIPK2) attenuates sepsis-mediated liver injury by restoring autophagy. [Abstract]

2018 Aug 28;9(9):847. PMID: 30154452

DL-alpha-Tocopherol purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2018 Aug 28;9(9):847. [Abstract]

HIPK2 expression is upregulated by treatments with 5 μM Resveratrol, 30 μM Aspirin, 10 μM DL-alpha-Tocopherol (vitamin E), and 15 μM Ursolic acid for another 16 h after the LPS treatment, as analysed by western blotting.

DL-alpha-Tocopherol purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2018 Aug 28;9(9):847. [Abstract]

HIPK2 expression was upregulated by treatments with 5 μM resveratrol, 30 μM aspirin, 10 μM DL-alpha-Tocopherol (vitamin E), and 15 μM ursolic acid for another 16 h after the LPS treatment, as analysed by Q-PCR.

DL-alpha-Tocopherol purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2018 Aug 28;9(9):847. [Abstract]

DL-alpha-Tocopherol (vitamin E; 10 μM) activated the promoter of the HIPK2 gene and by maintaining the stability of the 3′-UTR.
J Agric Food Chem

A Novel Anti-Osteoporosis Mechanism of VK2: Interfering with Ferroptosis via AMPK/SIRT1 Pathway in Type 2 Diabetic Osteoporosis. [Abstract]

2023 Feb 15;71(6):2745-2761. PMID: 36719855
Int J Mol Sci

Synergistic Effects of a Novel Combination of Natural Compounds Prevent H2O2-Induced Oxidative Stress in Red Blood Cells. [Abstract]

2025 Feb 5;26(3):1334. PMID: 39941102

DL-alpha-Tocopherol purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2025 Feb 5;26(3):1334. [Abstract]

DL-alpha-Tocopherol (Vit E; 1-100 μM; 1 h and 30 min) combined with Curc and Vit C, showed Anti-Oxidant Effects in RBCs.
SSRN

2025 Mar 31.
Res Sq

BMP receptor 2 inhibition regulates mitochondrial bioenergetics to induce synergistic cell death with BCL-2 inhibitors in leukemia and NSLC cells. [Abstract]

2024 Sep 12:rs.3.rs-5065904. PMID: 39315260

Solvent & Solubility

In Vitro:

Ethanol : ≥ 100 mg/mL (232.17 mM)

DMSO : 20 mg/mL (46.43 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.3217 mL

11.6087 mL

23.2175 mL

5 mM

0.4643 mL

2.3217 mL

4.6435 mL

10 mM

0.2322 mL

1.1609 mL

2.3217 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (5.80 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: 2.5 mg/mL (5.80 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (5.80 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kondo S, et al. Protective effect of dl-alpha-tocopherol on the cytotoxicity of ultraviolet B against human skin fibroblasts in vitro. Photodermatol Photoimmunol Photomed. 1990 Aug;7(4):173-7. [Content Brief]

[2]. Triggs WJ, et al., Effect of [dl]-alpha-tocopherol on FeCl2-induced lipid peroxidation in rat amygdala. Neurosci Lett. 1994 Oct 10;180(1):33-6. [Content Brief]

[3]. Sigounas G, et al., dl-alpha-tocopherol induces apoptosis in erythroleukemia, prostate, and breast cancer cells. Nutr Cancer. 1997;28(1):30-5. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO / Ethanol	1 mM	2.3217 mL	11.6087 mL	23.2175 mL	58.0437 mL
	5 mM	0.4643 mL	2.3217 mL	4.6435 mL	11.6087 mL
	10 mM	0.2322 mL	1.1609 mL	2.3217 mL	5.8044 mL
	15 mM	0.1548 mL	0.7739 mL	1.5478 mL	3.8696 mL
	20 mM	0.1161 mL	0.5804 mL	1.1609 mL	2.9022 mL
	25 mM	0.0929 mL	0.4643 mL	0.9287 mL	2.3217 mL
	30 mM	0.0774 mL	0.3870 mL	0.7739 mL	1.9348 mL
	40 mM	0.0580 mL	0.2902 mL	0.5804 mL	1.4511 mL
Ethanol	50 mM	0.0464 mL	0.2322 mL	0.4643 mL	1.1609 mL
	60 mM	0.0387 mL	0.1935 mL	0.3870 mL	0.9674 mL
	80 mM	0.0290 mL	0.1451 mL	0.2902 mL	0.7255 mL
	100 mM	0.0232 mL	0.1161 mL	0.2322 mL	0.5804 mL

Keywords

DL-alpha-Tocopherol

7 Cited Publications

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DL-alpha-Tocopherol

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Publications Citing Use of MedChemExpress (MCE) DL-alpha-Tocopherol

All DNA/RNA Synthesis Isoforms

Biological Activity

Chemical Information

Publications (7)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

DL-alpha-Tocopherol Related Classifications

HY-W020044 Related Classifications