2. 疾患モデリングル製品 Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. Endocrine and Metabolic Disease Models Urinary System Disease Models DNA/RNA Synthesis Endogenous Metabolite
  4. High Uric Acid Models
  5. Adenine

アデニン  (Synonyms: Adenine; 6-Aminopurine; Vitamin B4; ビタミン B4)

製品番号: HY-B0152 純度: 99.99%
COA 取扱説明書 Technical Support

Adenine (6-Aminopurine), a purine, is one of the four nucleobases in the nucleic acid of DNA. Adenine acts as a chemical component of DNA and RNA. Adenine also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号 : 73-24-5

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 55 在庫あり
Solution
10 mM * 1 mL in DMSO USD 55 在庫あり
Solid
500 mg $50 在庫あり
1 g $60 在庫あり
25 g $144 在庫あり
50 g   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 22 publication(s) in Google Scholar

Other Forms of Adenine:

アデニン 関連抗体

Top Publications Citing Use of Products

    Adenine purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2022 Mar 21;100:154067.  [Abstract]

    Capsaicin (10 and 15mg/kg, i.p.,once per week for 8 weeks) treatment lessened the deposition of ECM proteins in the kidneys from Adenine (0.25% w/w)-fed mice. Representative images of MTS (blue color), Picrosirius Red staining (red color), and IF staining of fibronectin (red color) and COL1A1 (green color) for kidney sections from adenine-fed (Adenine) or normal-fed (Ctrl) mice. Scale bars are 50 μm.

    Adenine purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2022 Mar 21;100:154067.  [Abstract]

    Capsaicin (10 and 15 mg/kg, i.p., once per week for 8 weeks) treatment lessened the deposition of ECM proteins in the kidneys from Adenine (0.25% w/w)-fed mice. WB images of fibronectin and COL1A1 expressions in kidney lysates from mice.

    Adenine purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2022 Mar 21;100:154067.  [Abstract]

    Capsaicin(10 or 15 mg/kg, i.p., once per week for 8 weeks) improved survival rate of Adenine (0.25% w/w)-fed mice. (A) Relative weight curves of indicated mice as described in A (n = 6). Mouse weight is measured once per 3 days, the initial weight is set to 1, and day 0 means the time point starting Adenine-rich diet. (B) Kaplan-Meier survival analysis of indicated mice as described in A (n = 12). Data are means ± SEM. *p < 0.05; **p < 0.01; ***p < 0.001.

    Adenine purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2022 Mar 21;100:154067.  [Abstract]

    Capsaicin(10 or 15 mg/kg, i.p., once per week for 8 weeks) improved kidney function of Adenine (0.25% w/w)-fed mice. Concentrations of serum creatinine, urea, and albumin from mice (n = 8). Data are means ± SEM. *p < 0.05; **p < 0.01; ***p < 0.001.

    Adenine purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2022 Mar 21;100:154067.  [Abstract]

    Capsaicin(10 or 15 mg/kg, i.p., once per week for 8 weeks) treatment prevented phenotypic alteration of tubular epithelial cells in the kidneys from Adenine (ADE) (0.25% w/w)-fed mice. Representative IHC staining images of E-cadherin and vimentin kidney sections from mice. Scale bars are 25 μm.

    DNA/RNA Synthesis アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    RNASE L DNA Polymerases RNA Polymerases Helicases DNA Ligase

    Endogenous Metabolite アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    Human Endogenous Metabolite Microbial Metabolite

    • 生物活性

    • 純度とドキュメンテーション

    • 参考文献

    • カスタマーレビュー

    製品説明

    Adenine (6-Aminopurine), a purine, is one of the four nucleobases in the nucleic acid of DNA. Adenine acts as a chemical component of DNA and RNA. Adenine also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis[1][2][3].

    IC50 & Target

    Human Endogenous Metabolite

     

    Microbial Metabolite

     

    Cellular Effect
    Cell Line Type Value Description References
    A-431 IC50
    > 100 μg/mL
    Compound: adenine
    Inhibition of phosphatidylinositol 4-kinase in human A431 cell membrane by liquid scintillation counting
    Inhibition of phosphatidylinositol 4-kinase in human A431 cell membrane by liquid scintillation counting
    		[PMID: 1666120]
    MT4 IC50
    12 μM
    Compound: 2',3'-didehydro 2030-dideoxy adenine
    Potency against non nucleoside reverse transcriptor was determined in MT-4 cells
    Potency against non nucleoside reverse transcriptor was determined in MT-4 cells
    		[PMID: 15109677]
    Oocyte IC50
    200 μM
    Compound: 1
    Inhibitory activity against purified cdc2 p34/Cyclin B obtained from M phase oocytes of the starfish Marthasterias glacialis.
    Inhibitory activity against purified cdc2 p34/Cyclin B obtained from M phase oocytes of the starfish Marthasterias glacialis.
    		[PMID: 9046330]
    体内実験

    Note:
    Please do not refer to only one article to determine the experimental conditions. It is recommended to determine the optimal experimental conditions (animal strain, age, dosage, frequency and cycle, detection time and indicators, etc.) through preliminary experiments before the formal experiment.

    Adenine can be used to induce chronic kidney injury models. Pharmacokinetic data show that in adult male Sprague-Dawley rats, 20-30 minutes after administration (10 mg/kg, i.v.), the Adenine content in blood dialysate samples is 0.78 μg/mL[4].

    Induction of Chronic Kidney Disease (CKD)[4][5][6]
    Background
    Adenine is metabolized by the liver to form dihydroxyadenine, which is insoluble in water. The latter is deposited in the kidneys, which can cause post-renal obstruction, affect uric acid excretion, and cause kidney damage.
    Specific Modeling Methods
    Mice: C57BL/6J • 8 weeks of age
    Administration: 0.2% Adenine in diet; 3 weeks
    Rat: Sprague-Dawley (SD) • male • 8 weeks of age
    Administration: 0.5% Adenine in diet; 3 weeks
    Note
    Modeling Indicators
    Biochemical changs: KW-to-BW ratio increasing; Systolic and diastotic blood pressure increasing; Blood urea nitrogen increasing; serum creatinine levels increasing

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    臨床実験
    分子量

    135.13

    分子式

    C5H5N5
    CAS 番号
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    NC1=C2N=CNC2=NC=N1
    Structure Classification
    Initial Source
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    溶剤 & 溶解度
    体外: 

    DMSO : ≥ 10 mg/mL (74.00 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    H2O : 2 mg/mL (14.80 mM; ultrasonic and warming and heat to 60°C)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 7.4003 mL 37.0014 mL 74.0028 mL
    5 mM 1.4801 mL 7.4003 mL 14.8006 mL
    10 mM 0.7400 mL 3.7001 mL 7.4003 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

    C1

    ×
    体積 （開始）

    V1

    =
    濃度 （終了）

    C2

    ×
    体積 （終了）

    V2

    体内:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 1 mg/mL (7.40 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    純度とドキュメンテーション

    純度: 99.99%

    COA (254 KB) HNMR (129 KB) RP-HPLC (213 KB) LCMS (317 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O / DMSO 1 mM 7.4003 mL 37.0014 mL 74.0028 mL 185.0070 mL
    5 mM 1.4801 mL 7.4003 mL 14.8006 mL 37.0014 mL
    10 mM 0.7400 mL 3.7001 mL 7.4003 mL 18.5007 mL
    DMSO 15 mM 0.4934 mL 2.4668 mL 4.9335 mL 12.3338 mL
    20 mM 0.3700 mL 1.8501 mL 3.7001 mL 9.2504 mL
    25 mM 0.2960 mL 1.4801 mL 2.9601 mL 7.4003 mL
    30 mM 0.2467 mL 1.2334 mL 2.4668 mL 6.1669 mL
    40 mM 0.1850 mL 0.9250 mL 1.8501 mL 4.6252 mL
    50 mM 0.1480 mL 0.7400 mL 1.4801 mL 3.7001 mL
    60 mM 0.1233 mL 0.6167 mL 1.2334 mL 3.0835 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.

    Adenine Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Adenine73-24-5DNA/RNA SynthesisEndogenous MetabolitepurineDNAnucleobaseInhibitorinhibitorinhibit

    最近チェックした製品:

    オンラインお問い合わせ

    Your information is safe with us. * Required Fields.

    製品名

    		  

    カスタマ需要量 *

    お名前 *

    		 

    タイトル

    メールアドレス *

    		 

    電話番号 *

    デパートメント

    		 

    組纖名 *

    市区町村

    都道府県

    国或いは地域 *

    		      

    必ず会社名を記載ください。個人への返信は行いません。

    備考

    バルクお問い合わせ

    Inquiry Information

    製品名:
    Adenine
    製品番号:
    HY-B0152
    数量:
    MCE 日本正規代理店:

    カスタマーレビュー

    Thank You for Your Feedback!

    Request for HNMR Report

    Please fill out this form to request the QC report. We will send it to your Email address shortly.

    Your information is safe with us. * Required Fields.

    製品名

    		  

    Lot #

    お名前 *

    		 

    メールアドレス *

    電話番号 *

    		 

    部門 *

    組纖名 *

    		 

    国或いは地域 *

    備考

    Request for HNMR Report

    We have received your request and will respond to you as soon as possible.