プロスタグランジン F2α (Synonyms: PGF2α; Dinoprost; Prostaglandin F2α)

Name: Dinoprost
Brand: MedChemExpress
SKU: HY-12956
Rating: 5.0 (9 reviews)

製品番号: HY-12956 純度: 99.84%: Data Sheet SDS COA 取扱説明書
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Technical Support

Dinoprost (Prostaglandin F2α) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist. Dinoprost is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost plays a key role in the onset and progression of labour.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号 : 551-11-1

容量	価格（税別）	在庫状況	数量
Solid or liquid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 66	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 66	在庫あり	Estimated Time of Arrival: December 31
Solid or liquid
5 mg	$60	在庫あり	Estimated Time of Arrival: December 31
10 mg	$90	在庫あり	Estimated Time of Arrival: December 31
25 mg	$180	在庫あり	Estimated Time of Arrival: December 31
50 mg	$280	在庫あり	Estimated Time of Arrival: December 31
100 mg	$440	在庫あり	Estimated Time of Arrival: December 31
200 mg		お問い合わせ
500 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

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Based on 9 publication(s) in Google Scholar

Other Forms of Dinoprost:

Dinoprost-d₄ 在庫あり
Dinoprost tromethamine salt 在庫あり
(5R)-Dinoprost お問い合わせ
Dinoprost-d₉ お問い合わせ
Dinoprost-¹³C₅ お問い合わせ
Dinoprost (methoxyamine) お問い合わせ
Dinoprost (Standard) お問い合わせ

顧客検証

Histological Imaging/Staining

RT-PCR

Cell Imaging/Staining

: Dinoprost purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 May 14:143:156866. [Abstract]; Dinoprost (20 mg/kg/d for 10 days, intraperitoneally injected). Representative images of MBP and LFB staining (scale bar, 500 μm) (n = 6), and transmission electron microscopy (scale bar, 1 μm) (n = 6) in the corpus callosum region of different groups of mice.

: Dinoprost purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 May 14:143:156866. [Abstract]; Dinoprost (20 mg/kg/d for 10 days, intraperitoneally injected). Expression of SLC2A4 and MBP in the mouse corpus callosum determined and statistically analyzed by protein immunoblotting.

: Dinoprost purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 May 14:143:156866. [Abstract]; Dinoprost (20 mg/kg/d for 10 days, intraperitoneally injected). Expression of SLC2A4 and MBP in the mouse corpus callosum determined and statistically analyzed by real-time PCR.

: Dinoprost purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 May 14:143:156866. [Abstract]; LPS+ATP-induced pyroptosis treated with EVO (at different concentrations) and SLC2A4 inhibitor Dinoprost (PGF2α, 1 μM, 24 h) followed by eGFP-mCherry probe detection of autophagic flux (scale bar, 20 μm) and fluorescence detection of SLC2A4 (scale bar, 50 μm): LAMP1 (green), LC3B (red), and DAPI (blue) (scale bar, 50 μm).

: Dinoprost purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 May 14:143:156866. [Abstract]; Western blot analysis of pyroptotic proteins GSDMD, GSDMD-N, and NLRP3 inflammasome expression after LPS+ATP induced-pyroptosis, and EVO and SLC2A4 inhibitor Dinoprost (PGF2α, 1 μM, 24 h) treatment.

: Dinoprost purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 May 14:143:156866. [Abstract]; Expressions of autophagy-related proteins P62, Beclin1, and LC3B detected by western blot after LPS+ATP induced-pyroptosis, and EVO and SLC2A4 inhibitor PGF2α treatment.

Prostaglandin Receptor アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

DP EP FP IP TXA₂/TP TXB₂

Endogenous Metabolite アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

Human Endogenous Metabolite Microbial Metabolite

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

IC₅₀ & Target^[1]^[2]

FP Receptor

Human Endogenous Metabolite

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	322 nM Compound: PGF2	Affinity for Prostanoid EP3 receptor expressed in CHO cell line Affinity for Prostanoid EP3 receptor expressed in CHO cell line	[PMID: 10715159]
CHO	IC₅₀	4200 nM Compound: PGF2	Affinity for Prostanoid EP4 receptor expressed in CHO cells Affinity for Prostanoid EP4 receptor expressed in CHO cells	[PMID: 10715159]
CHO	IC₅₀	> 10000 nM Compound: PGF2	Affinity for Prostaglandin I2 receptor expressed in CHO cells Affinity for Prostaglandin I2 receptor expressed in CHO cells	[PMID: 10715159]
CHO	IC₅₀	> 10000 nM Compound: PGF2	Affinity for Prostanoid EP2 receptor expressed in CHO cells Affinity for Prostanoid EP2 receptor expressed in CHO cells	[PMID: 10715159]
CHO	IC₅₀	> 10000 nM Compound: PGF2	Affinity for Prostanoid TP receptor expressed in CHO cells Affinity for Prostanoid TP receptor expressed in CHO cells	[PMID: 10715159]
COS-7	IC₅₀	380 nM Compound: PGF2	Affinity for Prostanoid EP1 receptor expressed in COS-7 cells. Affinity for Prostanoid EP1 receptor expressed in COS-7 cells.	[PMID: 10715159]
COS-7	IC₅₀	7 nM Compound: PGF2	Affinity for human Prostanoid FP receptor expressed in COS-7 cells Affinity for human Prostanoid FP receptor expressed in COS-7 cells	[PMID: 10715159]
HEK293	IC₅₀	4500 nM Compound: PGF2	Affinity for human Prostaglandin D2 receptor expressed in HEK293 cells Affinity for human Prostaglandin D2 receptor expressed in HEK293 cells	[PMID: 10715159]
K562	IC₅₀	> 700 μM Compound: 1	In vitro antiproliferative activity was measured on human leukemia K562 cells In vitro antiproliferative activity was measured on human leukemia K562 cells	10.1016/S0960-894X(00)80372-8
NIH3T3	EC₅₀	24.5 nM Compound: PGF2 alpha	Efficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cells Efficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cells	[PMID: 15357985]
NIH3T3	EC₅₀	24.5 nM Compound: PGF2alpha	Agonist activity at FP receptor in Swiss mouse 3T3 cells assessed as [3H]-IP accumulation by scintillation counting Agonist activity at FP receptor in Swiss mouse 3T3 cells assessed as [3H]-IP accumulation by scintillation counting	[PMID: 19101156]
Oocyte	IC₅₀	0.287 μM Compound: Prostaglandin F2alpha	TP_TRANSPORTER: inhibition of PGD2 uptake in Xenopus laevis oocytes TP_TRANSPORTER: inhibition of PGD2 uptake in Xenopus laevis oocytes	[PMID: 10973807]

体外実験

Dinoprost (Prostaglandin F2α; 1 μM; for 24 hours) induces ER stress, autophagy, and apoptosis in goat luteal cells^[1].
Dinoprost (1 μM; for 24 hours) significantly increases the expression of GRP78 and UPR sensors^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]

Cell Line:	Goat luteal cells
Concentration:	1 μM
Incubation Time:	For 24 hours
Result:	Significantly increased the apoptotic rate (15.62±3.12%).

Cell Autophagy Assay^[1]

Cell Line:	Goat luteal cells
Concentration:	1 μM
Incubation Time:	For 24 hours
Result:	There was extensive overlap between LC3 and LAMP1 in luteal cells and autophagolysosomes were formed in goat luteal cells.

Western Blot Analysis^[1]

Cell Line:	Goat luteal cells
Concentration:	1 μM
Incubation Time:	For 24 hours
Result:	The expression of GRP78 and UPR sensors including cleaved ATF6, phosphorylated-EIF2S1, EIF2S1, ATF4, phosphorylated-IRE1, autophagy-related protein LC3-II, and pro-apoptosis factor cleaved Caspase3 increased significantly in the cells.

臨床実験

分子量

354.48

分子式

C₂₀H₃₄O₅

CAS 番号

551-11-1

Appearance

<25°C Solid,>35°C Liquid

Color

White to light brown

SMILES

CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C[C@H](O)[C@@H]1C/C=C\CCCC(O)=O

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Endogenous metabolite

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

DMSO : 100 mg/mL (282.10 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.8210 mL	14.1052 mL	28.2103 mL
5 mM	0.5642 mL	2.8210 mL	5.6421 mL
10 mM	0.2821 mL	1.4105 mL	2.8210 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (7.05 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (7.05 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

純度とドキュメンテーション

純度: 99.84%

Select Batch:

データシート (280 KB) SDS (396 KB)

COA (252 KB) HNMR (453 KB) RP-HPLC (257 KB) MS (73 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Hagen Thieme, et al. Endothelin antagonism: effects of FP receptor agonists prostaglandin F2alpha and fluprostenol on trabecular meshwork contractility. Invest Ophthalmol Vis Sci. 2006 Mar;47(3):938-45. [Content Brief]

[2]. Xin Wen, et al. Prostaglandin F2α Induces Goat Corpus Luteum Regression via Endoplasmic Reticulum Stress and Autophagy. Front Physiol. 2020 Sep 11;11:868. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.8210 mL	14.1052 mL	28.2103 mL	70.5258 mL
	5 mM	0.5642 mL	2.8210 mL	5.6421 mL	14.1052 mL
	10 mM	0.2821 mL	1.4105 mL	2.8210 mL	7.0526 mL
	15 mM	0.1881 mL	0.9403 mL	1.8807 mL	4.7017 mL
	20 mM	0.1411 mL	0.7053 mL	1.4105 mL	3.5263 mL
	25 mM	0.1128 mL	0.5642 mL	1.1284 mL	2.8210 mL
	30 mM	0.0940 mL	0.4702 mL	0.9403 mL	2.3509 mL
	40 mM	0.0705 mL	0.3526 mL	0.7053 mL	1.7631 mL
	50 mM	0.0564 mL	0.2821 mL	0.5642 mL	1.4105 mL
	60 mM	0.0470 mL	0.2351 mL	0.4702 mL	1.1754 mL
	80 mM	0.0353 mL	0.1763 mL	0.3526 mL	0.8816 mL
	100 mM	0.0282 mL	0.1411 mL	0.2821 mL	0.7053 mL

Dinoprost Related Classifications

Endocrinology

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量		濃度		体積		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）	×	体積 _（開始）	=	濃度 _（終了）	×	体積 _（終了）
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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プロスタグランジン F2α (Synonyms: PGF2α; Dinoprost; Prostaglandin F2α)

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Prostaglandin Receptor アイソフォーム固有の製品をすべて表示:

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生物活性

純度とドキュメンテーション

参考文献

カスタマーレビュー

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Dinoprost Related Classifications

Molarity Calculator

Dilution Calculator

The molarity calculator equation

The dilution calculator equation

Keywords:

最近チェックした製品:

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プロスタグランジン F2α (Synonyms: PGF2α; Dinoprost; Prostaglandin F2α)

カスタマーレビュー

Other Forms of Dinoprost:

プロスタグランジン F2α 関連抗体

顧客検証

おすすめ

•関連スクリーニングライブラリ:

•関連小分子:

•関連タンパク質:

Prostaglandin Receptor アイソフォーム固有の製品をすべて表示:

Endogenous Metabolite アイソフォーム固有の製品をすべて表示:

生物活性

純度とドキュメンテーション

参考文献

カスタマーレビュー

プロスタグランジン F2α 関連抗体

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Dinoprost Related Classifications

Molarity Calculator

Dilution Calculator

The molarity calculator equation

The dilution calculator equation

Keywords:

最近チェックした製品:

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