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Carbonic+anhydrase+inhibitors

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amyloid-β (2) Antibiotic (4) Apoptosis (10) Bacterial (11) Carbonic Anhydrase (90) Caspase (2) CDK (2) Drug Derivative (1) Endogenous Metabolite (2) Environmental Pollutants (1) HBV (2) Isotope-Labeled Compounds (5) Molecular Glues (2) mTOR (1) NKCC (1) Parasite (2) Phosphodiesterase (PDE) (2) Pyroptosis (2) Reactive Oxygen Species (ROS) (4) Reference Standards (12)
By Research Areas:	Cancer (35) Cardiovascular Disease (5) Endocrinology (8) Infection (20) Inflammation/Immunology (15) Metabolic Disease (4) Neurological Disease (25)

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13650

Indisulam Maximum Cited Publications 15 Publications Verification E 7070	Molecular Glues Carbonic Anhydrase	Cancer
Indisulam (E 7070) is a *carbonic anhydrase* inhibitor with anticancer activity. Indisulam (E 7070) is a sulfonamide agent that targets the G1 phase of the cell cycle. Indisulam (E 7070) causes a blockade in the G1/S transition through inhibition of the activation of both CDK2 and cyclin E. Indisulam (E 7070) targets splicing by inducing RBM39 degradation via recruitment to DCAF15 .

HY-B0242

Sulfanilamide 5 Publications Verification Sulphanilamide	Environmental Pollutants Antibiotic Bacterial	Infection
ulfanilamide (Sulphanilamide) is a potent and orally active sulfonamide antibiotic and can be a major intermediate of sulfamethoxazole biodegradation. Sulfanilamide also is a *carbonic anhydrase* inhibitor. Sulfanilamide shows inhibition on virus of lymphogranuloma venereum .

HY-N0639

Punicalin 2 Publications Verification	HBV Pyroptosis Carbonic Anhydrase	Infection Inflammation/Immunology
Punicalin is a species that can be isolated from the leaves of Punica granatum. Punicalin is an active molecule against hepatitis b virus (HBV). Punicalin can induce pyroptosis. Punicalin is a *Carbonic anhydrase* inhibitor. Punicalin blocks the binding of S-glycoprotein and ACE2 receptors. Pnuicalin has anti-inflammatory, antioxidant and antiviral activity .

HY-B0553

Methazolamide 4 Publications Verification L584601	Carbonic Anhydrase Apoptosis Reactive Oxygen Species (ROS) Caspase	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Methazolamide (L584601) is a BBB-penetrable and orally active *carbonic anhydrase* inhibitor, with a K_i of 14 nM for human carbonic anhydrase II. Methazolamide can reduce intraocular pressure and has a neuroprotective effect, being able to inhibit neuronal apoptosis. Methazolamide can be used in the research of ophthalmic diseases such as glaucoma and cerebrovascular diseases such as subarachnoid hemorrhage .

HY-B0124

Zonisamide 3 Publications Verification AD 810; CI 912	Carbonic Anhydrase Apoptosis	Neurological Disease
Zonisamide (AD 810) is an orally active *carbonic anhydrase* inhibitor, with K_is of 35.2 and 20.6 nM for hCA II and hCA V, respectively. Zonisamide exerts neuroprotective effects through anti-apoptosis and upregulating MnSOD levels. Zonisamide also increases the expression of Hrd1, thereby improving cardiac function in AAC rats. Zonisamide can be used in studies of seizure, parkinson’s disease and cardiac hypertrophy .

HY-B1480

Ethoxzolamide 3 Publications Verification Redupresin; L-643786; PNU-4191	Carbonic Anhydrase Bacterial	Infection Inflammation/Immunology
Ethoxzolamide is a *carbonic anhydrase* inhibitor with K_i of 1 nM.

HY-B0397

Dichlorphenamide 2 Publications Verification Diclofenamide	Carbonic Anhydrase	Neurological Disease
Dichlorphenamide (Diclofenamide) is an orally active, specific, carbonic anhydrase inhibitor. Dichlorphenamide can reduce intraocular pressure by inhibiting the secretion of water from the eye. Dichlorphenamide can be used for glaucoma research .

HY-101087

Benzenesulphonamide	Carbonic Anhydrase Amyloid-β Reactive Oxygen Species (ROS)	Neurological Disease Inflammation/Immunology Cancer
Benzenesulphonamide (Compound 1) is a *carbonic anhydrase* inhibitor. Benzenesulphonamide exhibits CA II inhibitory activity. Benzenesulphonamide reduces ROS and improves the gene expression of amyloid-β40 and 42. Benzenesulphonamide is beneficial for Alzheimer's disease. Benzenesulphonamide derivatives have anticancer, anti-inflammatory, and anticonvulsant activities. Benzenesulphonamide can be used in the research of Alzheimer's disease, epilepsy, inflammatory diseases, leukemia, melanoma, lung cancer, and colon cancer .

HY-108316

Sultiame 2 Publications Verification	Carbonic Anhydrase	Neurological Disease
Sultiame is a *carbonic anhydrase* inhibitor, widely used as an antiepileptic agent.

HY-B1056

Procodazole Propazol; 2-Benzimidazolepropionic acid	Bacterial Parasite Antibiotic Carbonic Anhydrase	Infection Cancer
Procodazole is an orally active enhancer and a non-specific active immune protector against viral and bacterial infections. Procodazole also exhibits antiparasitic activity. In addition, Procodazole is a carbonic anhydrase inhibitor with antitumor activity .

HY-W013316

Lasamide	Carbonic Anhydrase	Endocrinology
Lasamide is a potent human *Carbonic Anhydrase* inhibitor with K_i values of 7.54 and 2.76 nM for hCAXII and hCAIX, respectively .

HY-163109

Carbonic anhydrase inhibitor 16	Carbonic Anhydrase	Infection
Carbonic anhydrase inhibitor 16 (compound 1) is a dengue protease inhibitor with inhibitory activity against **carbonic anhydrase hCA I and hCA II** (K_i: 28.5 nM, 2.2 nM) .

HY-69085

4-Bromo-1H-indazole	Carbonic Anhydrase	Others
4-Bromo-1H-indazole is a *carbonic anhydrase* inhibitor, with an IC₅₀ of 0.403 mM and a K_i of 0.383 mM against hCA-I, as well as an IC₅₀ of 0.700 mM and a K_i of 0.935 mM against hCA-II. 4-Bromo-1H-indazole reduces the catalytic activity of human I and II isoforms of carbonic anhydrase .

HY-151917

*Enpp/Carbonic* anhydrase-IN-2**	Apoptosis Carbonic Anhydrase Phosphodiesterase (PDE)	Cancer
Enpp/Carbonic anhydrase-IN-2 (compound 1i) is a potent Enpp and *carbonic anhydrase* inhibitor with IC₅₀s of 1.13, 1.07, 0.74, 0.33, 0.68 for NPP1, NPP2, NPP3, CA-IX, CA-XII respectively. Enpp/Carbonic anhydrase-IN-2 shows antiproliferative activity for cancer cells and low cytotoxic against normal cells. Enpp/Carbonic anhydrase-IN-2 induces Apoptosis .

HY-W012168

4-Chloro-3-sulfamoylbenzoic acid	Carbonic Anhydrase	Metabolic Disease
4-Chloro-3-sulfamoylbenzoic acid is a weak inhibitor of human **carbonic anhydrase isoforms hCA I, hCA II, hCA IV, and hCA IX*, and a synthesis intermediate for carbonic anhydrase inhibitors. 4-Chloro-3-sulfamoylbenzoic acid is the major metabolite of tripamide detected in tissues, urine, and feces of rats* and rabbits following Tripamide (HY-106570) administration. 4-Chloro-3-sulfamoylbenzoic acid can be used for the study of carbonic anhydrase inhibition and species differences in drug metabolism .

HY-W044762

5,6-Dihydro-2H-pyran-2-one	Carbonic Anhydrase	Cancer
5,6-Dihydro-2H-pyran-2-one (Compound 1) is a prodrug-type *carbonic anhydrase* inhibitor. 5,6-Dihydro-2H-pyran-2-one can specifically inhibit the tumor-associated subtype hCA IX and the cytoplasmic subtype hCA I with K_i values of 1.35 and 8.03 μM. 5,6-Dihydro-2H-pyran-2-one can be used for the research on hypoxia-related cancer .

HY-142849

Carbonic anhydrase inhibitor 2	Carbonic Anhydrase	Endocrinology
Carbonic anhydrase inhibitor 1 (compound 7c) is a carbonic anhydrase II inhibitor. Carbonic anhydrase inhibitor 3 reduces the intraocular pressure in glaucomatous rabbits .

HY-N0085

Dimethylfraxetin 6,7,8-Trimethoxycoumarin; Fraxetin dimethyl ether	Carbonic Anhydrase	Cancer
Dimethylfraxetin is a *Carbonic anhydrase* inhibitor, with a K_i value of 0.0097 μM.

HY-B0242R

Sulfanilamide (Standard) Sulphanilamide (Standard)	Reference Standards Bacterial Antibiotic	Infection
Sulfanilamide (Standard) is the analytical standard of Sulfanilamide. This product is intended for research and analytical applications. ulfanilamide (Sulphanilamide) is a potent and orally active sulfonamide antibiotic and can be a major intermediate of sulfamethoxazole biodegradation. Sulfanilamide also is a *carbonic anhydrase* inhibitor. Sulfanilamide shows inhibition on virus of lymphogranuloma venereum .

HY-B0124A

Zonisamide sodium AD 810 sodium; CI 912 sodium	Carbonic Anhydrase Apoptosis	Cardiovascular Disease Neurological Disease
Zonisamide (AD 810) sodium is an orally active *carbonic anhydrase* inhibitor, with K_is of 35.2 and 20.6 nM for hCA II and hCA V, respectively. Zonisamide sodium exerts neuroprotective effects through anti-apoptosis and upregulating MnSOD levels. Zonisamide sodium also increases the expression of Hrd1, thereby improving cardiac function in AAC rats. Zonisamide sodium can be used in studies of seizure, parkinson’s disease and cardiac hypertrophy .

HY-142853

Carbonic anhydrase inhibitor 3	Carbonic Anhydrase	Endocrinology
Carbonic anhydrase inhibitor 3 (compound 11g) is a carbonic anhydrase II inhibitor. Carbonic anhydrase inhibitor 3 reduces the intraocular pressure in glaucomatous rabbits .

HY-144376

Carbonic anhydrase inhibitor 4	Carbonic Anhydrase	Cancer
Carbonic anhydrase inhibitor 4 is **carbonic anhydrase** photoprobe/inhibitor. Carbonic anhydrase inhibitor 4 is against human carbonic anhydrases (hCA I-XIV) with K_i values of 640-1166 nM .

HY-150570

Carbonic anhydrase inhibitor 14	Carbonic Anhydrase CDK	Cancer
Carbonic anhydrase inhibitor 14 (Compound 8b) is a carbonic anhydrase (CA) inhibitor with K_i values of 1203, 99.7, 9.4 and 27.7 nM against hCA I, hCA II, hCA IX and hCA XII, respectively. Carbonic anhydrase inhibitor 14 can also inhibit CDK2 with an IC₅₀ of 20.3 μM. Carbonic anhydrase inhibitor 14 shows antitumor activity .

HY-108316S

Sulthiame-d4	Isotope-Labeled Compounds Carbonic Anhydrase	Neurological Disease
Sulthiame-d₄ is the deuterium labeled Sultiame. Sultiame is a carbonic anhydrase inhibitor, widely used as an antiepileptic agent .

HY-W031519

Chloraminophenamide	Carbonic Anhydrase	Cardiovascular Disease
Chloraminophenamide (Compound 14) is a *carbonic anhydrase* inhibitor, with K_is of 75, 160 and 8400 nM for hCA II, bCA IV and hCA I, respectively. Chloraminophenamide has the potential for antiglaucoma research .

HY-106331A

(Rac)-Sezolamide hydrochloride MK-927; (Rac)-MK 417	Carbonic Anhydrase	Neurological Disease
(Rac)-Sezolamide hydrochloride (MK-927; (Rac)-MK 417) is a *carbonic anhydrase* inhibitor (CAI) (K_i: 12.0 nM). (Rac)-Sezolamide hydrochloride has a topical intraocular pressure (IOP) lowering effect. (Rac)-Sezolamide hydrochloride can be used in glaucoma research .

HY-129781

L-650719	Carbonic Anhydrase	Endocrinology
L-650719 is a topical carbonic anhydrase inhibitor (CAI) with a K_i of 10 nM for CA II. L-650719 has shown good intraocular pressure-lowering effects in a rabbit model. L-650719 may be used in glaucoma research .

HY-B0553S

Methazolamide-d6 L584601-d₆	Isotope-Labeled Compounds Carbonic Anhydrase	Inflammation/Immunology
Methazolamide-d₆ is the deuterium labeled Methazolamide. Methazolamide (L584601) is a sulfonamide derivative used as a carbonic anhydrase inhibitor with a K_i of 14 nM for human carbonic anhydrase II. Methazolamide, an intraocular pressure-lowering agent, reduces intraocular pressure elevations associated with glaucoma and other ocular disorders .

HY-151916

*Enpp/Carbonic* anhydrase-IN-1**	Apoptosis Carbonic Anhydrase Phosphodiesterase (PDE)	Cancer
Enpp/Carbonic anhydrase-IN-1 (compound 1e) is a potent Enpp and *carbonic anhydrase* inhibitor with IC₅₀s of 1.36, 1.35, 3.00, 0.88, 1.02 μM for NPP1, NPP2, NPP3, CA-II, CA-IX respectively. Enpp/Carbonic anhydrase-IN-1 shows antiproliferative activity for cancer cells and low cytotoxic against normal cells. Enpp/Carbonic anhydrase-IN-1 induces Apoptosis .

HY-13650R

Indisulam (Standard) E 7070 (Standard)	Molecular Glues Carbonic Anhydrase Reference Standards	Cancer
Indisulam (Standard) is the analytical standard of Indisulam. This product is intended for research and analytical applications. Indisulam (E 7070) is a carbonic anhydrase inhibitor with anticancer activity. Indisulam (E 7070) is a sulfonamide agent that targets the G1 phase of the cell cycle. Indisulam (E 7070) causes a blockade in the G1/S transition through inhibition of the activation of both CDK2 and cyclin E. Indisulam (E 7070) targets splicing by inducing RBM39 degradation via recruitment to DCAF15 .

HY-149498

Carbonic anhydrase inhibitor 15	Carbonic Anhydrase	Neurological Disease Inflammation/Immunology
Carbonic anhydrase inhibitor 15 (Compound 8) is a *carbonic anhydrase* inhibitor (K_i: 8.5 nM for hCA II). Carbonic anhydrase inhibitor 15 has analgesic effect .

HY-159960

Carbonic anhydrase inhibitor 28	Antibiotic Bacterial Carbonic Anhydrase	Infection
Carbonic anhydrase inhibitor 28 (Compound 11) is a Pseudomonas aeruginosa *carbonic anhydrase* inhibitor. Carbonic anhydrase inhibitor 28 exhibits antimicrobial activity, with a MIC of 0.5 μg/mL and a MBC of 1 μg/mL against P. aeruginosa. Carbonic anhydrase inhibitor 28 can be used in anti-infection research .

HY-161686

Carbonic anhydrase inhibitor 24	Carbonic Anhydrase	Cancer
Carbonic anhydrase inhibitor 24 (Compound 11) is a human carbonic anhydrase (carbonic anhydrase) inhibitor. K_i values of Carbonic anhydrase inhibitor 24 for hCAs IX and XII were 10.7 and 7.5 nM, respectively .

HY-115998

Carbonic anhydrase inhibitor 11	Carbonic Anhydrase	Cancer
Carbonic anhydrase inhibitor 11 (compound VI) is a potent, selective carbonic anhydrase inhibitor. Carbonic anhydrase inhibitor 11 shows K_i values of 40, 39, 200 and 900 nM against CA II, IX, and XII, respectively .

HY-115994

Carbonic anhydrase inhibitor 10	Carbonic Anhydrase	Cancer
Carbonic anhydrase inhibitor 10 is a potent hCA IX inhibitor with a K_i value of 6.2 nM. Carbonic anhydrase inhibitor 10 exhibits anti-proliferative activity against MCF-7 cancer cell line with an IC₅₀ of 11.9 μM. Carbonic anhydrase inhibitor 10 can be used for cancer research .

HY-173620

Carbonic anhydrase inhibitor 31	Carbonic Anhydrase	Infection
Carbonic anhydrase inhibitor 31 (Compound 3F4) is a mtCA2 inhibitor (K_i: 5.2 nM). Carbonic anhydrase inhibitor 31 can be used in the research of anti-tuberculosis .

HY-172899

Carbonic anhydrase inhibitor 33	Carbonic Anhydrase Apoptosis CDK	Cancer
Carbonic anhydrase inhibitor 33 (11D) is a dual inhibitor of CA (Carbonic *anhydrase) IX/XII and CDK6, with K_i values of 19.7 nM and 26.1 nM for hCA IX and hCA XII, respectively. Carbonic anhydrase inhibitor* 33 (11D) induces G1 arrest and apoptosis. Carbonic anhydrase inhibitor 33 (11D) can be used in the research for NSCLC .

HY-162226

Carbonic anhydrase inhibitor 19	Carbonic Anhydrase	Others
Carbonic anhydrase inhibitor 19 (compound 26a) inhibits the Glaucoma related isoforms hCA II and hCA XII with K_is of 9.4 nM and 6.7 nM, respectively. Carbonic anhydrase inhibitor 19 reveals an intraocular pressure (IOP) lowering effect .

HY-158078

Carbonic anhydrase inhibitor 21	Carbonic Anhydrase	Cancer
Carbonic anhydrase inhibitor 21 (Compound 5h) is a selective carbonic anhydrase (hCA IX) inhibitor, with a K_i of 15.1?nM, and is highly selective against other investigated isoform. Carbonic anhydrase inhibitor 21 can be used for anticancer research .

HY-132156

Carbonic anhydrase inhibitor 22	Carbonic Anhydrase	Neurological Disease
Carbonic anhydrase inhibitor 22 (Compd 2g), a sulfonamide *carbonic anhydrase* inhibitor, with K_i values of 762 nM (hCA I), 20.3 nM (hCA II), 8.3 nM (hCA VII), 17.9 nM (hCA IX) and 10.5 nM (hCA XII), repectively .

HY-161374

Carbonic anhydrase inhibitor 20	Carbonic Anhydrase	Cancer
Carbonic anhydrase inhibitor 20 (compound 11) is an inhibitor of piperazinosulfonamide carbonic anhydrase (Carbonic *Anhydrase). The Ki of Carbonic anhydrase inhibitor* 20 for hCA I, hCA II, hCA IX, and hCA XII are 47.6 nM, 36.5 nM, 8.3 nM, and 2.7 nM respectively .

HY-173194

Carbonic anhydrase inhibitor 29	Carbonic Anhydrase	Cancer
Carbonic anhydrase inhibitor 29 (Compound 5d) is an inhibitor targeting carbonic anhydrase IX (CA IX) and XII (CA XII), with inhibition constants (K_i) of 26.6 nM for CA IX and 10.9 nM for CA XII. Carbonic anhydrase inhibitor 29 can be used in anticancer research .

HY-115999

Carbonic anhydrase inhibitor 12	Carbonic Anhydrase	Cancer
Carbonic anhydrase inhibitor 12 is a potent CA II inhibitor, also has inhibitory activity in CA I (K_is of 1.72 and 271 nM in CA II and CA I, respectively). Carbonic anhydrase inhibitor 12 has potent anticancer activity against different cancer cell lines .

HY-19213

L-693612	Carbonic Anhydrase	Inflammation/Immunology
L-693612 (Compd 1) is an orally active and topical *carbonic anhydrase* inhibitor .

HY-19213A

L-693612 hydrochloride	Carbonic Anhydrase	Inflammation/Immunology
L-693612 hydrochloride (Compd 1) is an orally active and topical *carbonic anhydrase* inhibitor .

HY-163268

Carbonic anhydrase inhibitor 18	Carbonic Anhydrase	Cancer
Carbonic anhydrase inhibitor 18 (Compound 9) is a human carbonic anhydrase (hCA) isoform inhibitor, with K_is of 604.8, 333.6, 1.9 and 6.7 nM for hCA I, hCA II, hCA IX and hCA XII, respectively. Carbonic anhydrase inhibitor 18 can be used for the research of cancer .

HY-156013

*CA inhibitor* 2**	Carbonic Anhydrase	Endocrinology Cancer
CA inhibitor 2 (Compound 4H) is a *carbonic anhydrase* inhibitor (IC₅₀: 0.033 μM) .

HY-B1480R

Ethoxzolamide (Standard) Redupresin (Standard); L-643786 (Standard); PNU-4191 (Standard)	Carbonic Anhydrase Bacterial Reference Standards	Infection Inflammation/Immunology
Ethoxzolamide (Standard) is the analytical standard of Ethoxzolamide. This product is intended for research and analytical applications. Ethoxzolamide is a carbonic anhydrase inhibitor with Ki of 1 nM.

HY-172816

Carbonic anhydrase inhibitor 32	Carbonic Anhydrase mTOR NKCC	Neurological Disease
Carbonic anhydrase inhibitor 32 (compound 5B) is an orally active and selective *hCA (Carbonic* anhydrase ) II/VII** inhibitor with the K_i values of 6.3 nM, 10.1 nM and 681 nM for hCA II, hCA VII and hCA I,respectively. Carbonic anhydrase inhibitor 32 shows neuroprotective and anticonvulsant potential by reducing mTOR activation, and raising hippocampus KCC2 levels .

HY-147956

hCA VB-IN-1	Carbonic Anhydrase	Neurological Disease Metabolic Disease
hCA VB-IN-1 (compound 15) is a potent and selective hCA VB (carbonic anhydrase) inhibitor, with a K_I of 515.7 nM .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0639

Punicalin 2 Publications Verification	Punica granatum L. Classification of Application Fields Phenols Polyphenols Punicaceae Plants Inflammation/Immunology Disease Research Fields Source Classification	HBV Pyroptosis Carbonic Anhydrase
Punicalin is a species that can be isolated from the leaves of Punica granatum. Punicalin is an active molecule against hepatitis b virus (HBV). Punicalin can induce pyroptosis. Punicalin is a *Carbonic anhydrase* inhibitor. Punicalin blocks the binding of S-glycoprotein and ACE2 receptors. Pnuicalin has anti-inflammatory, antioxidant and antiviral activity .

HY-N0085

Dimethylfraxetin 6,7,8-Trimethoxycoumarin; Fraxetin dimethyl ether	other families Classification of Application Fields Coumarins Phenylpropanoids Plants Disease Research Fields Source Classification Cancer	Carbonic Anhydrase
Dimethylfraxetin is a *Carbonic anhydrase* inhibitor, with a K_i value of 0.0097 μM.

HY-N8411R

Aromadendrene (Standard) (+)-Aromadendrene (Standard)	Structural Classification Microorganisms Terpenoids Sesquiterpenes Myrtaceae Plants Eucalyptus globulus Labill. Source Classification	Bacterial Reference Standards
Benzenesulphonamide (Standard) is the analytical standard of Benzenesulphonamide. This product is intended for research and analytical applications. Benzenesulphonamide (compound 1) is a potent carbonic anhydrase inhibitor. Benzenesulphonamide shows CA II inhibitory activity .

HY-N0639R

Punicalin (Standard)	Structural Classification Punica granatum L. Phenols Polyphenols Punicaceae Plants Source Classification	Reference Standards HBV Pyroptosis Carbonic Anhydrase
Punicalin (Standard) is the analytical standard of Punicalin. This product is intended for research and analytical applications. Punicalin is a species that can be isolated from the leaves of Punica granatum. Punicalin is an active molecule against hepatitis b virus (HBV). Punicalin can induce pyroptosis. Punicalin is a Carbonic anhydrase inhibitor. Punicalin blocks the binding of S-glycoprotein and ACE2 receptors. Pnuicalin has anti-inflammatory, antioxidant and antiviral activity .

HY-W015675R

4-Hydroxycyclohexanecarboxylic acid (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
Lasamide (Standard) is the analytical standard of Lasamide. This product is intended for research and analytical applications. Lasamide is a potent human Carbonic Anhydrase inhibitor with Ki values of 7.54 and 2.76 nM for hCAXII and hCAIX, respectively .

Cat. No.	Product Name	Chemical Structure

HY-108316S

Sulthiame-d4
Sulthiame-d₄ is the deuterium labeled Sultiame. Sultiame is a carbonic anhydrase inhibitor, widely used as an antiepileptic agent .

HY-B0553S

Methazolamide-d6
Methazolamide-d₆ is the deuterium labeled Methazolamide. Methazolamide (L584601) is a sulfonamide derivative used as a carbonic anhydrase inhibitor with a K_i of 14 nM for human carbonic anhydrase II. Methazolamide, an intraocular pressure-lowering agent, reduces intraocular pressure elevations associated with glaucoma and other ocular disorders .

HY-B1480S

Ethoxzolamide-d5
Ethoxzolamide-d₅ (Redupresin-d₅) is deuterium labeled Ethoxzolamide. Ethoxzolamide is a *carbonic anhydrase* inhibitor with K_i of 1 nM.

HY-B0124S2

Zonisamide-13C6

Zonisamide- ¹³C₆ (AD 810- ¹³C₆) is ¹³C labeled Zonisamide. Zonisamide (AD 810) is an orally active carbonic anhydrase inhibitor, with K_is of 35.2 and 20.6 nM for hCA II and hCA V, respectively. Zonisamide exerts neuroprotective effects through anti-apoptosis and upregulating MnSOD levels. Zonisamide also increases the expression of Hrd1, thereby improving cardiac function in AAC rats. Zonisamide can be used in studies of seizure, parkinson’s disease and cardiac hypertrophy .

HY-B0124S3

Zonisamide-15N,d4

Zonisamide- ¹⁵N,d₄ is the ¹⁵N- and deuterium labeled Zonisamide (HY-B0124). Zonisamide (AD 810) is an orally active carbonic anhydrase inhibitor, with K_is of 35.2 and 20.6 nM for hCA II and hCA V, respectively. Zonisamide exerts neuroprotective effects through anti-apoptosis and upregulating MnSOD levels. Zonisamide also increases the expression of Hrd1, thereby improving cardiac function in AAC rats. Zonisamide can be used in studies of seizure, parkinson’s disease and cardiac hypertrophy .

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